AU3756393A - Process for the preparation of taxane derivatives - Google Patents

Process for the preparation of taxane derivatives

Info

Publication number
AU3756393A
AU3756393A AU37563/93A AU3756393A AU3756393A AU 3756393 A AU3756393 A AU 3756393A AU 37563/93 A AU37563/93 A AU 37563/93A AU 3756393 A AU3756393 A AU 3756393A AU 3756393 A AU3756393 A AU 3756393A
Authority
AU
Australia
Prior art keywords
radical
general formula
taxane derivatives
preparation
trichloro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU37563/93A
Inventor
Dominique Deprez
Jean-Pierre Pulicani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Rhone Poulenc Rorer SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer SA filed Critical Rhone Poulenc Rorer SA
Publication of AU3756393A publication Critical patent/AU3756393A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
    • C25B3/00—Electrolytic production of organic compounds
    • C25B3/20—Processes
    • C25B3/25—Reduction
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
    • C25B11/00—Electrodes; Manufacture thereof not otherwise provided for
    • C25B11/04—Electrodes; Manufacture thereof not otherwise provided for characterised by the material
    • C25B11/042—Electrodes formed of a single material
    • C25B11/043—Carbon, e.g. diamond or graphene
    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
    • C25B11/00—Electrodes; Manufacture thereof not otherwise provided for
    • C25B11/04—Electrodes; Manufacture thereof not otherwise provided for characterised by the material
    • C25B11/042—Electrodes formed of a single material
    • C25B11/046—Alloys

Abstract

Process for electrochemical preparation of taxane derivatives of general formula (I) based on a product of general formula (II). In general formula (I), Ar denotes an aryl radical, R1? is a benzoyl radical or R2?-O-CO- radical in which R2? is an alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, bicycloalkyl, phenyl or heterocyclyl radical and R is a hydrogen atom of the acetyl radical. In general formula (II), Ar and R are defined as in general formula (I), R' is an acetyl or trichloro-2,2,2 ethoxycarbonyl radical and G1? is a trichloro-2,2,2 ethoxycarbonyl radical and G2? is a hydrogen atom. The products of general formula (I) have outstanding anti-tumoral properties.
AU37563/93A 1992-03-13 1993-03-11 Process for the preparation of taxane derivatives Abandoned AU3756393A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9203000A FR2688518B1 (en) 1992-03-13 1992-03-13 PROCESS FOR THE PREPARATION OF TAXANE DERIVATIVES.
FR9203000 1992-03-13
PCT/FR1993/000243 WO1993018210A1 (en) 1992-03-13 1993-03-11 Process for the preparation of taxane derivatives

Publications (1)

Publication Number Publication Date
AU3756393A true AU3756393A (en) 1993-10-05

Family

ID=9427641

Family Applications (1)

Application Number Title Priority Date Filing Date
AU37563/93A Abandoned AU3756393A (en) 1992-03-13 1993-03-11 Process for the preparation of taxane derivatives

Country Status (21)

Country Link
EP (1) EP0630428B1 (en)
JP (1) JPH07504461A (en)
KR (1) KR950700439A (en)
AT (1) ATE130053T1 (en)
AU (1) AU3756393A (en)
CA (1) CA2117552A1 (en)
CZ (1) CZ218694A3 (en)
DE (1) DE69300766T2 (en)
DK (1) DK0630428T3 (en)
ES (1) ES2079982T3 (en)
FI (1) FI944190A0 (en)
FR (1) FR2688518B1 (en)
GR (1) GR3018036T3 (en)
HU (1) HUT68282A (en)
MX (1) MX9301345A (en)
NO (1) NO943371D0 (en)
RU (1) RU94041682A (en)
SK (1) SK108494A3 (en)
TW (1) TW235961B (en)
WO (1) WO1993018210A1 (en)
ZA (1) ZA931800B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU691804B2 (en) * 1993-03-22 1998-05-28 Florida State University Taxanes having furyl or thienyl substituted side-chain
US6794523B2 (en) 1991-09-23 2004-09-21 Florida State University Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5760251A (en) * 1995-08-11 1998-06-02 Sepracor, Inc. Taxol process and compounds
US6103698A (en) * 1997-03-13 2000-08-15 Basf Aktiengesellschaft Dolastatin-15 derivatives in combination with taxanes
WO2003085110A2 (en) 2002-04-05 2003-10-16 Santaris Pharma A/S Oligomeric compounds for the modulation hif-1alpha expression
US7713738B2 (en) 2003-02-10 2010-05-11 Enzon Pharmaceuticals, Inc. Oligomeric compounds for the modulation of survivin expression
AU2004303464B2 (en) 2003-12-23 2009-10-01 Santaris Pharma A/S Oligomeric compounds for the modulation of BCL-2
US9447138B2 (en) 2004-11-09 2016-09-20 Roche Innovation Center Copenhagen A/S Potent LNA oligonucleotides for the inhibition of HIF-1a expression
NZ555645A (en) 2004-11-09 2009-08-28 Santaris Pharma As LNA oligonucleotides and the treatment of cancer
WO2006050734A2 (en) 2004-11-09 2006-05-18 Santaris Pharma A/S Potent lna oligonucleotides for the inhibition of hif-1a expression

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60187689A (en) * 1984-03-06 1985-09-25 Otsuka Chem Co Ltd Nanufacture of 3-exo-methylenecepham derivative
FR2601675B1 (en) * 1986-07-17 1988-09-23 Rhone Poulenc Sante TAXOL DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR2629818B1 (en) * 1988-04-06 1990-11-16 Centre Nat Rech Scient PROCESS FOR THE PREPARATION OF TAXOL
FR2664894A1 (en) * 1990-07-19 1992-01-24 Rhone Poulenc Sante NOVEL STREPTOGRAMIN DERIVATIVES AND THEIR PREPARATION.

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6794523B2 (en) 1991-09-23 2004-09-21 Florida State University Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them
AU691804B2 (en) * 1993-03-22 1998-05-28 Florida State University Taxanes having furyl or thienyl substituted side-chain

Also Published As

Publication number Publication date
SK108494A3 (en) 1995-02-08
ZA931800B (en) 1993-09-30
ES2079982T3 (en) 1996-01-16
FR2688518A1 (en) 1993-09-17
DE69300766T2 (en) 1996-04-18
EP0630428B1 (en) 1995-11-08
FR2688518B1 (en) 1994-05-06
RU94041682A (en) 1996-07-20
DK0630428T3 (en) 1995-12-27
TW235961B (en) 1994-12-11
HU9402614D0 (en) 1994-11-28
HUT68282A (en) 1995-04-03
EP0630428A1 (en) 1994-12-28
DE69300766D1 (en) 1995-12-14
MX9301345A (en) 1993-09-01
ATE130053T1 (en) 1995-11-15
FI944190A (en) 1994-09-12
CA2117552A1 (en) 1993-09-16
CZ218694A3 (en) 1995-02-15
JPH07504461A (en) 1995-05-18
WO1993018210A1 (en) 1993-09-16
KR950700439A (en) 1995-01-16
NO943371L (en) 1994-09-12
GR3018036T3 (en) 1996-02-29
NO943371D0 (en) 1994-09-12
FI944190A0 (en) 1994-09-12

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