KR920702352A - Bicyclo Asymmetric Compound - Google Patents

Abstract

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Description

Bicyclo Asymmetric Compound

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Claims (18)

Compounds of the general structures I (a) and / or I (b) and / or I (c) [Wherein R ¹ is a methyl group or a general formula -CH ₂ .SO ₂ .R ² or -CH ₂ .SO ₂ .NR ² R ³ , wherein each of R ² and R ³ is independently alkyl, cyclo Alkyl or optionally substituted phenyl or phenalkyl group), each of R ⁴ , R ⁵ and R ⁶ independently represents a hydrogen atom or a methyl group, X represents a group of the formula C (CH ₃ ) ₂ or When R ⁵ and R ⁶ both represent a methyl group, it also represents a group of the formula CH ₂ , Q represents an oxygen or sulfur atom, Y represents a hydrogen atom, an alkali metal atom or a general formula -COA where A is a halogen atom or phenyl , An alkyl or alkoxy group optionally substituted by a cycloalkyl, alkoxy or alkylcarbonyl group. The compound of claim 1, wherein the optionally substituted phenyl or phenalkyl groups R ² and / or R ³ have one or more inert substituents. 3. Compounds according to claim 2, wherein the substituents are selected from halogen atoms and alkyl, alkoxy, haloalkyl, haloalkoxy, nitro, alkylcarbonyl and alkoxycarbonyl groups. 4. The compound of claim 3, wherein the alkyl group has 1 to 4 carbon atoms. The compound according to claim 2, wherein the substituted phenyl group has 3 or less substituents. The compound of claim 2, wherein the alkyl portion of the phenalkyl group has 1 to 4 carbon atoms. The compound according to any one of claims 1 to 6, wherein the alkyl groups R ² and / or R ³ have up to 20 carbon atoms. 8. Compounds according to claim 7, wherein the alkyl groups R ² and / or R ³ have 4 to 8 carbon atoms. The compound according to any one of claims 1 to 8, wherein the alkyl or alkoxy group A has up to 30 carbon atoms. The compound according to claim 1 or 9, which is a cycloalkyl substituent cyclopentyl or cyclohexyl group on the alkyl or alkoxy group A. The compound of claim 1, wherein the alkoxy or alkylcarbonyl substituent A has up to 6 carbon atoms in the alkyl moiety. The compound of claim 1 wherein Q represents an oxygen atom. Compound of the general formula (II) [Wherein R ¹ is a methyl group or a general formula -CH ₂ .SO ₂ .R ² or -CH ₂ .SO ₂ .NR ² R ³ (wherein each of R ² and R ³ is independently alkyl, cycloalkyl Or an optionally substituted phenyl or phenalkyl group), each of R ⁴ , R ⁵ and R ⁶ independently represents a hydrogen atom or a methyl group, and Z represents a -N ₃ group or a general structural formula -NH.O.SO ₂ ㆍ R ⁷ (wherein R ⁷ represents an optionally substituted phenyl group). A process for preparing a compound according to any one of claims 1 to 12, which induces ring closure of the compound according to claim 13. The enantiomeric mixture of a compound capable of reacting with the compound according to any one of claims 1 to 12 is contacted with the compound according to any one of claims 1 to 12 and then the product components of the mixture are separated. Separation method of the enantiomer. A method for preparing a compound having an optically inert carbon atom, wherein the compound according to any one of claims 1 to 12, wherein A is an optionally substituted alkyl group, is reacted with an alkylating agent. The method of claim 16, wherein the alkylating agent is an aldehyde, ketone, keto-acid, alkyl halide or epoxide. A compound containing an optically active carbon atom prepared according to claim 16. ※ Note: The disclosure is based on the initial application.