RU94022730A - Method of synthesis of adamantane-2-one - Google Patents

Method of synthesis of adamantane-2-one

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Publication number
RU94022730A
RU94022730A RU94022730/04A RU94022730A RU94022730A RU 94022730 A RU94022730 A RU 94022730A RU 94022730/04 A RU94022730/04 A RU 94022730/04A RU 94022730 A RU94022730 A RU 94022730A RU 94022730 A RU94022730 A RU 94022730A
Authority
RU
Russia
Prior art keywords
adamantanone
adamantane
oxidation
reaction
reaction mass
Prior art date
Application number
RU94022730/04A
Other languages
Russian (ru)
Other versions
RU2109727C1 (en
Inventor
Б.М. Пятин
Н.В. Климова
Н.И. Авдюнина
Н.М. Зайцева
О.Л. Самсонова
Г.В. Пушкарь
Р.Ф. Большакова
Original Assignee
Научно-исследовательский институт фармакологии РАМН
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Научно-исследовательский институт фармакологии РАМН filed Critical Научно-исследовательский институт фармакологии РАМН
Priority to RU94022730A priority Critical patent/RU2109727C1/en
Publication of RU94022730A publication Critical patent/RU94022730A/en
Application granted granted Critical
Publication of RU2109727C1 publication Critical patent/RU2109727C1/en

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

FIELD: organic chemistry and technology. SUBSTANCE: method involves oxidation of adamantane with concentrated sulfuric acid or with addition of catalytic amount of sulfur trioxide. Oxidation is carried out up to absence of adamantane and an intermediate adamantanol in reaction mass. After reaction termination mass is poured on ice and neutralized with alkaline agent. Adamantanone is distilled off with steam, filtered off and additional adamantanone amount is extracted with organic solvent from an aqueous filtrate. EFFECT: increased yield, improved quality and ecology.

Claims (1)

Предлагается способ получения адамантанона окислением адамантана концентрированной серной кислотой или с добавкой каталитических количеств серного ангидрида. Окисление ведут до отсутствия в реакционной массе адамантана и промежуточно образующегося адамантанола. По окончании реакции реакционную массу выливают на лед, нейтрализуют щелочным агентом, адамантанон отгоняют с паром, отфильтровывают, из водного фильтрата экстрагируют органическим растворителем дополнительное количество адамантанона. Предлагаемый способ позволяет повысить выход и улучшить качество целевого продукта, удлинить срок эксплуатации оборудования и улучшить экологию.A method for producing adamantanone by oxidizing adamantane with concentrated sulfuric acid or with the addition of catalytic amounts of sulfuric anhydride is proposed. Oxidation is carried out to the absence of adamantane and intermediate adamantanol in the reaction mass. At the end of the reaction, the reaction mass is poured onto ice, neutralized with an alkaline agent, adamantanone is distilled off with steam, filtered, an additional amount of adamantanone is extracted from the aqueous filtrate with an organic solvent. The proposed method allows to increase the yield and improve the quality of the target product, extend the life of the equipment and improve the environment.
RU94022730A 1994-06-10 1994-06-10 Method of synthesis of adamantane-2-one RU2109727C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU94022730A RU2109727C1 (en) 1994-06-10 1994-06-10 Method of synthesis of adamantane-2-one

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU94022730A RU2109727C1 (en) 1994-06-10 1994-06-10 Method of synthesis of adamantane-2-one

Publications (2)

Publication Number Publication Date
RU94022730A true RU94022730A (en) 1997-04-10
RU2109727C1 RU2109727C1 (en) 1998-04-27

Family

ID=20157237

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94022730A RU2109727C1 (en) 1994-06-10 1994-06-10 Method of synthesis of adamantane-2-one

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RU (1) RU2109727C1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2475475C1 (en) * 2011-12-26 2013-02-20 Открытое акционерное общество "Каустик" (ОАО "Каустик") Method of producing terephthalic acid diamide
CN112423742B (en) * 2018-06-27 2024-03-19 阿尔杰农制药股份有限公司 Prevention or treatment of renal fibrosis or kidney disease using aclitali

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Publication number Publication date
RU2109727C1 (en) 1998-04-27

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