RU94021110A - COMPLEX ETHERS OF NUCLEOSIDE AND ITS DERIVATIVES, PHARMACEUTICAL COMPOSITION ON THEIR BASIS AND METHOD OF TREATMENT - Google Patents
COMPLEX ETHERS OF NUCLEOSIDE AND ITS DERIVATIVES, PHARMACEUTICAL COMPOSITION ON THEIR BASIS AND METHOD OF TREATMENTInfo
- Publication number
- RU94021110A RU94021110A RU94021110/04A RU94021110A RU94021110A RU 94021110 A RU94021110 A RU 94021110A RU 94021110/04 A RU94021110/04 A RU 94021110/04A RU 94021110 A RU94021110 A RU 94021110A RU 94021110 A RU94021110 A RU 94021110A
- Authority
- RU
- Russia
- Prior art keywords
- nucleoside
- derivatives
- pharmaceutical composition
- basis
- treatment
- Prior art date
Links
- 239000002777 nucleoside Substances 0.000 title claims 4
- 150000003833 nucleoside derivatives Chemical class 0.000 title claims 3
- 239000008194 pharmaceutical composition Substances 0.000 title claims 2
- 150000002170 ethers Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- -1 Nucleoside esters Chemical class 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 230000000840 anti-viral Effects 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 150000004665 fatty acids Chemical class 0.000 claims 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N oxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
Claims (1)
Nu- O -Fa,
где O является кислородом, Nu является нуклеозидом или аналогом нуклеозида и Fa является ацилом мононенасыщенной C1 8 или C2 0 жирной кислоты. Изобретение также относится к противовирусным фармацевтическим или ветеринарным композициям, содержащим соединение формулы, одно или в сочетании с фармацевтически приемлемым носителем.Nucleoside esters and its derivatives are provided with a pharmaceutical composition based on them and a method for their preparation. New compounds of general formula:
Nu- O -Fa,
where O is oxygen, Nu is a nucleoside or nucleoside analog, and Fa is an acyl mono-unsaturated C 1 8 or C 2 0 fatty acid. The invention also relates to antiviral pharmaceutical or veterinary compositions containing a compound of the formula, alone or in combination with a pharmaceutically acceptable carrier.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9121257.1 | 1991-10-07 | ||
| GB9121257A GB2260319B (en) | 1991-10-07 | 1991-10-07 | Acyl derivatives of nucleosides and nucleoside analogues having anti-viral activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU94021110A true RU94021110A (en) | 1995-12-20 |
| RU2126417C1 RU2126417C1 (en) | 1999-02-20 |
Family
ID=10702531
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU94021110/04A RU2126417C1 (en) | 1991-10-07 | 1992-09-30 | Nucleoside esters and pharmaceutical composition |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6548486B1 (en) |
| EP (1) | EP0642525B1 (en) |
| JP (1) | JP2873313B2 (en) |
| KR (1) | KR100272732B1 (en) |
| AT (1) | ATE152454T1 (en) |
| CA (1) | CA2120725C (en) |
| CH (1) | CH0642525H1 (en) |
| CZ (1) | CZ288153B6 (en) |
| DE (1) | DE69219482T2 (en) |
| DK (1) | DK0642525T3 (en) |
| FI (2) | FI105035B (en) |
| GB (1) | GB2260319B (en) |
| GR (1) | GR3024149T3 (en) |
| HK (1) | HK1007430A1 (en) |
| HU (1) | HU219400B (en) |
| IL (1) | IL103351A (en) |
| MX (1) | MX9205715A (en) |
| NO (1) | NO300014B1 (en) |
| NZ (1) | NZ244535A (en) |
| PL (1) | PL170846B1 (en) |
| RU (1) | RU2126417C1 (en) |
| SG (1) | SG47759A1 (en) |
| SK (1) | SK281903B6 (en) |
| TW (1) | TW347333B (en) |
| UA (1) | UA41296C2 (en) |
| WO (1) | WO1993007163A1 (en) |
| ZA (1) | ZA927432B (en) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9307043D0 (en) * | 1993-04-05 | 1993-05-26 | Norsk Hydro As | Chemical compounds |
| US6703394B2 (en) | 1996-02-16 | 2004-03-09 | Medivir Ab | Acyclic nucleoside derivatives |
| US5869493A (en) * | 1996-02-16 | 1999-02-09 | Medivir Ab | Acyclic nucleoside derivatives |
| GB2321455A (en) * | 1997-01-24 | 1998-07-29 | Norsk Hydro As | Lipophilic derivatives of biologically active compounds |
| GB0201179D0 (en) * | 2002-01-18 | 2002-03-06 | Angeletti P Ist Richerche Bio | Therapeutic agents |
| TWI332507B (en) | 2002-11-19 | 2010-11-01 | Hoffmann La Roche | Antiviral nucleoside derivatives |
| US8114847B2 (en) | 2005-03-16 | 2012-02-14 | Case Western Reserve University | Selective inhibitors of translesion DNA replication |
| US9029345B2 (en) * | 2005-03-16 | 2015-05-12 | Case Western Reserve University | Selective inhibitors of translesion DNA replication |
| NO324263B1 (en) * | 2005-12-08 | 2007-09-17 | Clavis Pharma Asa | Chemical compounds, their use in the treatment of cancer, and pharmaceutical compositions comprising such compounds |
| US8497292B2 (en) * | 2005-12-28 | 2013-07-30 | Translational Therapeutics, Inc. | Translational dysfunction based therapeutics |
| WO2008150438A1 (en) * | 2007-06-01 | 2008-12-11 | Luitpold Pharmaceuticals, Inc. | Pmea lipid conjugates |
| MX2010000424A (en) | 2007-07-09 | 2010-08-10 | Easter Virginia Medical School | Substituted nucleoside derivatives with antiviral and antimicrobial properties. |
| KR20100102092A (en) * | 2007-09-26 | 2010-09-20 | 마운트 시나이 스쿨 오브 메디신 | Azacytidine analogues and uses thereof |
| US9988680B2 (en) | 2011-09-01 | 2018-06-05 | Case Western Reserve University | Non-natural nucleosides as theranostic agents |
| US9493500B2 (en) | 2012-07-19 | 2016-11-15 | Richard Daifuku | Fluorinated pyrimidine analogs and methods of use thereof |
| US9821173B2 (en) | 2013-02-08 | 2017-11-21 | Case Western Reserve University | Anti-cancer agents and methods of use |
| RU2621145C2 (en) * | 2015-11-03 | 2017-05-31 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Воронежский государственный университет" (ФГБОУ ВПО "ВГУ") | Method for liposomes obtaining |
| JP2021515771A (en) * | 2018-03-07 | 2021-06-24 | グラクソスミスクライン、インテレクチュアル、プロパティー、（ナンバー２）、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ （Ｎｏ．２） Ｌｉｍｉｔｅｄ | Compounds useful for HIV therapy |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3920630A (en) * | 1970-09-24 | 1975-11-18 | Upjohn Co | 2,2{40 -Anhydro-ara-cytidine compounds and process of preparation |
| GB1325797A (en) * | 1970-09-24 | 1973-08-08 | Upjohn Co | Medicines comprising cytidine derivatives |
| US4211773A (en) * | 1978-10-02 | 1980-07-08 | Sloan Kettering Institute For Cancer Research | 5-Substituted 1-(2'-Deoxy-2'-substituted-β-D-arabinofuranosyl)pyrimidine nucleosides |
| DE3100478A1 (en) | 1981-01-09 | 1982-08-12 | Dr. Thilo & Co GmbH, 8021 Sauerlach | 5'ESTERS OF PYRIMIDINE NUCLEOSIDES WITH ANTIVIRAL EFFECTIVENESS, METHOD FOR THE PRODUCTION AND MEDICINAL PRODUCTS THEREOF |
| US4355032B2 (en) | 1981-05-21 | 1990-10-30 | 9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent | |
| NZ201662A (en) | 1981-08-26 | 1986-07-11 | Merck & Co Inc | 9-(1,3-(and 2,3)-dihydroxy-1-(and 2)-propoxy-methyl)guanine derivatives and methods for their preparation |
| US4816447A (en) | 1981-08-26 | 1989-03-28 | Merck & Co., Inc. | Anti-viral guanine compounds |
| US5250535A (en) * | 1982-02-01 | 1993-10-05 | Syntex Inc. | Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent |
| US4556659A (en) * | 1982-08-09 | 1985-12-03 | Syntex (U.S.A.) Inc. | Substituted 9-(1-0- or 3-0-monosubstituted or 1,3-Di-0-substituted propoxymethyl)-purines as antiviral agents |
| JPH0655755B2 (en) * | 1985-01-23 | 1994-07-27 | 富山化学工業株式会社 | Novel 5-fluoro-2'-deoxyuridine-3'-phosphate derivative and salt thereof |
| US4684631A (en) | 1984-10-09 | 1987-08-04 | Toyama Chemical Co., Ltd. | Novel 5-fluoro-2-deoxyuridine derivatives and salts thereof, process for producing the same, and antitumor agents containing the same |
| US5223263A (en) * | 1988-07-07 | 1993-06-29 | Vical, Inc. | Liponucleotide-containing liposomes |
| JPS6483092A (en) * | 1987-09-24 | 1989-03-28 | Arakawa Chotaro & Co | Novel n6,n6-dimethyladenosine derivative having carcinostatic activity, its production and carcinostatic agent containing said derivative as active component |
| WO1989003838A1 (en) * | 1987-10-28 | 1989-05-05 | Pro-Neuron, Inc. | Acyl deoxyribonucleoside derivatives and uses thereof |
| JPH0278696A (en) * | 1988-09-13 | 1990-03-19 | Shoichiro Ozaki | 5-fluorouracil derivative |
| IE980216A1 (en) | 1989-04-17 | 2000-02-23 | Scotia Holdings Plc | Anti-virals |
| FI105556B (en) * | 1991-09-30 | 2000-09-15 | Sankyo Co | Process for the preparation of drug-useful pyrimidine nucleoside derivatives with anti-tumor effect |
-
1991
- 1991-10-07 GB GB9121257A patent/GB2260319B/en not_active Expired - Fee Related
-
1992
- 1992-09-28 ZA ZA927432A patent/ZA927432B/en unknown
- 1992-09-29 NZ NZ244535A patent/NZ244535A/en not_active IP Right Cessation
- 1992-09-30 DE DE69219482T patent/DE69219482T2/en not_active Expired - Lifetime
- 1992-09-30 JP JP5506814A patent/JP2873313B2/en not_active Expired - Lifetime
- 1992-09-30 KR KR1019940701120A patent/KR100272732B1/en not_active IP Right Cessation
- 1992-09-30 SK SK397-94A patent/SK281903B6/en not_active IP Right Cessation
- 1992-09-30 EP EP92922008A patent/EP0642525B1/en not_active Expired - Lifetime
- 1992-09-30 WO PCT/NO1992/000162 patent/WO1993007163A1/en active IP Right Grant
- 1992-09-30 HU HU9400988A patent/HU219400B/en unknown
- 1992-09-30 DK DK92922008.5T patent/DK0642525T3/en active
- 1992-09-30 AT AT92922008T patent/ATE152454T1/en active
- 1992-09-30 US US08/211,386 patent/US6548486B1/en not_active Expired - Lifetime
- 1992-09-30 SG SG1996004250A patent/SG47759A1/en unknown
- 1992-09-30 UA UA94005489A patent/UA41296C2/en unknown
- 1992-09-30 PL PL92303098A patent/PL170846B1/en unknown
- 1992-09-30 CH CH92922008.5T patent/CH0642525H1/en unknown
- 1992-09-30 CA CA002120725A patent/CA2120725C/en not_active Expired - Lifetime
- 1992-09-30 RU RU94021110/04A patent/RU2126417C1/en active
- 1992-09-30 CZ CZ1994805A patent/CZ288153B6/en not_active IP Right Cessation
- 1992-10-03 TW TW081107870A patent/TW347333B/en not_active IP Right Cessation
- 1992-10-05 IL IL10335192A patent/IL103351A/en not_active IP Right Cessation
- 1992-10-06 MX MX9205715A patent/MX9205715A/en unknown
-
1994
- 1994-04-06 FI FI941574A patent/FI105035B/en not_active IP Right Cessation
- 1994-04-07 NO NO941269A patent/NO300014B1/en not_active IP Right Cessation
-
1997
- 1997-07-16 GR GR970401799T patent/GR3024149T3/en unknown
-
1998
- 1998-06-17 HK HK98105563A patent/HK1007430A1/en not_active IP Right Cessation
-
1999
- 1999-02-10 FI FI990270A patent/FI990270A/en unknown
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