RU94012934A - DERIVATIVES 5-ACYLAMINO-1,2,4-TIADIAZOLES, METHOD OF THEIR RECEIVING AND CONTAINING THEIR PHARMACEUTICAL COMPOSITIONS - Google Patents

DERIVATIVES 5-ACYLAMINO-1,2,4-TIADIAZOLES, METHOD OF THEIR RECEIVING AND CONTAINING THEIR PHARMACEUTICAL COMPOSITIONS

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Publication number
RU94012934A
RU94012934A RU94012934/04A RU94012934A RU94012934A RU 94012934 A RU94012934 A RU 94012934A RU 94012934/04 A RU94012934/04 A RU 94012934/04A RU 94012934 A RU94012934 A RU 94012934A RU 94012934 A RU94012934 A RU 94012934A
Authority
RU
Russia
Prior art keywords
alkyl
help
tiadiazoles
acylamino
derivatives
Prior art date
Application number
RU94012934/04A
Other languages
Russian (ru)
Other versions
RU2129550C1 (en
Inventor
Фреель Даниель
Гюлли Даниель
Буасжегрэн Робер
Бадорк Ален
Бра Жан-Пьер
Депейру Пьер
Original Assignee
Елф Санфои
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9304535A external-priority patent/FR2703995B1/en
Application filed by Елф Санфои filed Critical Елф Санфои
Publication of RU94012934A publication Critical patent/RU94012934A/en
Application granted granted Critical
Publication of RU2129550C1 publication Critical patent/RU2129550C1/en

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Claims (1)

Изобретение относится к производным тиадиазола общей формулы (1):
Figure 00000001

в которой Ar обозначает ароматический азотсодержащий гетероцикл, особенно индолильный гетероцикл, замещенный или нет на азоте с помощью CO - (C1 - C4-алкила; с помощью (CH2)nCOR, в котором n обозначает 1 или 2 и R обозначает OR1 или NR2 R2 с R1 и R2, одинаковыми или разными, обозначающими водород или (С1 - С4)-алкил, с помощью гидрокси-(C1 - C4)-алкила, с помощью алкоксиалкила с 2 - 6 C-атомами, тетрагидропиранила, или с помощью цепи - (CH2)3-, последний атом углерода которой фиксирован на фенильном ядре индола с образованием шестичленного цикла, Z обозначает; (а) группу:
Figure 00000002

где A и B, независимо друг от друга, обозначают C, CH или N; и X1, X2, X3, X4, одинаковые или разные, обозначают водород, (C1 - C3)-алкил, (C1 - C3)-алкоксил, Cl, Br или трифторметил, или (б) нафтильную группу, в известных случаях замещенную; также, как к их фармацевтически приемлемым солям.The invention relates to a thiadiazole derivative of the general formula (1):
Figure 00000001

wherein Ar is an aromatic nitrogen-containing heterocycle, especially an indolyl heterocycle, substituted or not on nitrogen with CO - (C 1 - C 4 -alkyl; with (CH 2 ) n COR, in which n is 1 or 2 and R is OR 1 or NR 2 R 2 with R 1 and R 2 , the same or different, denoting hydrogen or (C 1 - C 4 ) -alkyl, with the help of hydroxy- (C 1 - C 4 ) -alkyl, with the help of alkoxyalkyl with 2 - 6 C-atoms, tetrahydropyranyl, or with the help of a chain - (CH 2 ) 3 -, the last carbon atom of which is fixed on the phenyl nucleus of indole with the formation of a six-membered cycle, Z means; (a) c upp:
Figure 00000002

where A and B, independently of one another, denote C, CH or N; and X 1 , X 2 , X 3 , X 4 , identical or different, denote hydrogen, (C 1 - C 3 ) alkyl, (C 1 - C 3 ) alkoxy, Cl, Br or trifluoromethyl, or (b) a naphthyl group, optionally substituted; as well as their pharmaceutically acceptable salts.
RU94012934A 1993-04-16 1994-04-15 Derivatives of 5-acylamino-1,2,4-thiadiazoles, method of their synthesis and pharmaceutical composition showing affinity to cholecystokinin receptors RU2129550C1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9304535A FR2703995B1 (en) 1993-04-16 1993-04-16 5-ACYLAMINO 1,2,4-THIADIAZOLES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
FR9304535 1993-04-16

Publications (2)

Publication Number Publication Date
RU94012934A true RU94012934A (en) 1996-01-27
RU2129550C1 RU2129550C1 (en) 1999-04-27

Family

ID=9446163

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94012934A RU2129550C1 (en) 1993-04-16 1994-04-15 Derivatives of 5-acylamino-1,2,4-thiadiazoles, method of their synthesis and pharmaceutical composition showing affinity to cholecystokinin receptors

Country Status (15)

Country Link
US (1) US5534530A (en)
EP (1) EP0620221A1 (en)
JP (1) JP3029372B2 (en)
CN (1) CN1050128C (en)
AU (1) AU678208B2 (en)
CA (1) CA2121425A1 (en)
FI (1) FI941776A (en)
FR (1) FR2703995B1 (en)
HU (1) HU217549B (en)
IL (1) IL109275A (en)
NO (1) NO301163B1 (en)
NZ (1) NZ260313A (en)
RU (1) RU2129550C1 (en)
TW (1) TW295584B (en)
ZA (1) ZA942577B (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE68593B1 (en) * 1989-12-06 1996-06-26 Sanofi Sa Heterocyclic substituted acylaminothiazoles their preparation and pharmaceutical compositions containing them
JPH11514361A (en) * 1995-10-16 1999-12-07 藤沢薬品工業株式会社 Heterocyclic compounds as H + -ATPase
NZ314105A (en) * 1996-02-02 1997-12-19 Sumitomo Pharma Guanidine derivative substituted with a substituted indole which is peri condensed with a heterocyclic ring
AU6659298A (en) 1997-02-18 1998-09-08 Thomas Jefferson University Compositions that bind to pancreatic cancer cells and methods of using the same
FR2763337B1 (en) * 1997-05-13 1999-08-20 Sanofi Sa NOVEL TRIAZOLE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US6768024B1 (en) 2000-08-04 2004-07-27 Lion Bioscience Ag Triamine derivative melanocortin receptor ligands and methods of using same
FR2815963B1 (en) * 2000-10-26 2003-02-28 Sanofi Synthelabo NOVEL TRIAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
KR20030042035A (en) * 2000-10-26 2003-05-27 사노피-신델라보 Triazole derivatives and pharmaceutical compositions comprising them
EP1314733A1 (en) * 2001-11-22 2003-05-28 Aventis Pharma Deutschland GmbH Indole-2-carboxamides as factor Xa inhibitors
CA2520546A1 (en) 2003-03-28 2005-02-10 Janssen Pharmaceutica, N.V. Benzo[1,2,5]thiadiazole compounds
BRPI0516027A (en) * 2004-09-24 2008-08-19 Janssen Pharmaceutica Nv sulfonamide compounds
US20060177438A1 (en) * 2005-02-08 2006-08-10 New England Medical Center Methods of altering absorption of hydrophobic compounds
CN102757427A (en) * 2012-07-09 2012-10-31 陕西科技大学 2-amino-5-isoindoline-1,3-dimethyl ketone1,3,4-thiadiazole and preparation method thereof
CN103601699A (en) * 2013-11-04 2014-02-26 南京大学 1,3,4-thiadiazol-2-amide derivatives and preparation method thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4874864A (en) * 1988-05-24 1989-10-17 Pfizer Inc. Benzamide protease inhibitors
IE68593B1 (en) * 1989-12-06 1996-06-26 Sanofi Sa Heterocyclic substituted acylaminothiazoles their preparation and pharmaceutical compositions containing them
GB9008123D0 (en) * 1990-04-10 1990-06-06 Lilly Industries Ltd Pharmaceutical compounds
FR2677356B1 (en) * 1991-06-05 1995-03-17 Sanofi Sa HETEROCYCLIC DERIVATIVES OF SUBSTITUTED ACYLAMINO-2 THIAZOLES-5, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME.

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