RU94020400A - INDOL DERIVATIVES, METHOD OF THEIR PRODUCTION, PHARMACEUTICAL COMPOSITION, HEADACHE TREATMENT METHOD - Google Patents
INDOL DERIVATIVES, METHOD OF THEIR PRODUCTION, PHARMACEUTICAL COMPOSITION, HEADACHE TREATMENT METHODInfo
- Publication number
- RU94020400A RU94020400A RU94020400/04A RU94020400A RU94020400A RU 94020400 A RU94020400 A RU 94020400A RU 94020400/04 A RU94020400/04 A RU 94020400/04A RU 94020400 A RU94020400 A RU 94020400A RU 94020400 A RU94020400 A RU 94020400A
- Authority
- RU
- Russia
- Prior art keywords
- production
- pharmaceutical composition
- headache treatment
- treatment method
- indol derivatives
- Prior art date
Links
- 206010019233 Headache Diseases 0.000 title 1
- 231100000869 headache Toxicity 0.000 title 1
- SIKJAQJRHWYJAI-UHFFFAOYSA-N indole Chemical class C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 206010027599 Migraine Diseases 0.000 claims 1
- 208000008085 Migraine Disorders Diseases 0.000 claims 1
- 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 claims 1
- 230000000875 corresponding Effects 0.000 claims 1
- 238000006114 decarboxylation reaction Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 125000001041 indolyl group Chemical group 0.000 claims 1
- -1 methoxy, benzyl Chemical group 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
Claims (1)
где R1 и R2 каждый представляет водород или алкильную группу, Z представляет кольцо, выбранное из:
в котором n представляет 4, 5 или 6,
в котором R3 представляет водород или алкильную группу и R4 представляет алкильную, метокси, бензильную или R5 NHCO группу, в которой R5 представляет алкильную группу,
в котором R6 представляет алкильную группу, и его фармацевтически приемлемые соли, полезные для лечения мигрени и других заболеваний. Эти соединения получают декарбоксилированием соответствующей индолил 2-карбоновой кислоты.The compound of formula (I)
where R 1 and R 2 each represents hydrogen or an alkyl group, Z represents a ring selected from:
in which n represents 4, 5 or 6,
in which R 3 represents hydrogen or an alkyl group and R 4 represents an alkyl, methoxy, benzyl or R 5 NHCO group, in which R 5 represents an alkyl group,
in which R 6 represents an alkyl group, and its pharmaceutically acceptable salts, useful for the treatment of migraine and other diseases. These compounds are obtained by decarboxylation of the corresponding indolyl 2-carboxylic acid.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9216009.2 | 1992-07-28 | ||
| GB929216009A GB9216009D0 (en) | 1992-07-28 | 1992-07-28 | New indol derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU94020400A true RU94020400A (en) | 1995-11-10 |
| RU2117667C1 RU2117667C1 (en) | 1998-08-20 |
Family
ID=10719423
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU94020400A RU2117667C1 (en) | 1992-07-28 | 1993-07-19 | Indole derivatives, method of their synthesis, pharmaceutical composition showing selective binding activity with respect to 5--htid receptors and vasoconstrictive effect associated with 5-htid agonistic effect and a method of selective binding 5--htid receptors or agonistic effect on 5-htid receptors |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US5565447A (en) |
| EP (1) | EP0605697B1 (en) |
| JP (1) | JP2716585B2 (en) |
| KR (1) | KR100191830B1 (en) |
| CN (1) | CN1035179C (en) |
| AT (1) | ATE177080T1 (en) |
| BR (2) | BR9305589A (en) |
| CA (1) | CA2120028C (en) |
| CZ (1) | CZ282659B6 (en) |
| DE (2) | DE69323712T2 (en) |
| DK (1) | DK0605697T3 (en) |
| EC (1) | ECSP930953A (en) |
| EG (1) | EG20340A (en) |
| FI (1) | FI109998B (en) |
| GB (1) | GB9216009D0 (en) |
| GR (1) | GR3029915T3 (en) |
| HK (1) | HK1011680A1 (en) |
| HU (2) | HUT70518A (en) |
| IL (1) | IL106387A (en) |
| LU (1) | LU90758I2 (en) |
| MX (1) | MX9304524A (en) |
| MY (1) | MY113266A (en) |
| NL (1) | NL300053I2 (en) |
| NO (1) | NO180231C (en) |
| NZ (1) | NZ254152A (en) |
| PL (1) | PL174352B1 (en) |
| RU (1) | RU2117667C1 (en) |
| SG (1) | SG48708A1 (en) |
| TW (1) | TW235297B (en) |
| UA (1) | UA27818C2 (en) |
| UY (1) | UY23624A1 (en) |
| WO (1) | WO1994002460A1 (en) |
| ZA (1) | ZA935316B (en) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2712591B1 (en) * | 1993-11-19 | 1996-02-09 | Pf Medicament | New arylpiperazines derived from indole, their preparation and their therapeutic use. |
| FR2731224B1 (en) * | 1995-03-02 | 1997-05-30 | Pf Medicament | NOVEL BI-TRYPTAMINIC SULFONAMIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS |
| GB9523462D0 (en) * | 1995-11-16 | 1996-01-17 | Merck Sharp & Dohme | Therapeutic agents |
| US8022095B2 (en) | 1996-08-16 | 2011-09-20 | Pozen, Inc. | Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs |
| US6204274B1 (en) | 1998-04-29 | 2001-03-20 | American Home Products Corporation | Indolyl derivatives as serotonergic agents |
| US6310066B1 (en) | 1998-04-29 | 2001-10-30 | American Home Products Corp. | Antipsychotic indolyl derivatives |
| US6066637A (en) * | 1998-06-19 | 2000-05-23 | American Home Products Corporation | Indolyl derivatives as serotonergic agents |
| GB0302094D0 (en) | 2003-01-29 | 2003-02-26 | Pharmagene Lab Ltd | EP4 receptor antagonists |
| GB0324269D0 (en) | 2003-10-16 | 2003-11-19 | Pharmagene Lab Ltd | EP4 receptor antagonists |
| WO2006129190A1 (en) * | 2005-06-03 | 2006-12-07 | Glenmark Pharmaceuticals Limited | Process for the preparation of almotriptan |
| US20070112055A1 (en) * | 2005-09-30 | 2007-05-17 | Glenmark Pharmaceuticals Limited | Crystalline forms of almotriptan and processes for their preparation |
| DE102006027229A1 (en) * | 2006-06-09 | 2007-12-20 | Grünenthal GmbH | 1,3-Disubstituted 4-methyl-1H-pyrrole-2-carboxylic acid amides and their use for the preparation of medicaments |
| JP2010507585A (en) * | 2006-10-19 | 2010-03-11 | オースペックス・ファーマシューティカルズ・インコーポレイテッド | Substituted indole |
| TWI321616B (en) | 2007-03-27 | 2010-03-11 | Coretronic Corp | Centrifugal blower |
| CZ302424B6 (en) * | 2007-06-13 | 2011-05-11 | Zentiva, A. S. | Process for preparing almotriptan of high purity |
| EP2170824A1 (en) * | 2007-08-02 | 2010-04-07 | Generics Ýuk¨Limited | Novel process |
| CN103724252A (en) * | 2012-10-12 | 2014-04-16 | 苏州四同医药科技有限公司 | Preparation method of almotriptan |
| EP3766483A1 (en) | 2019-07-19 | 2021-01-20 | BioPharma Synergies, S. L. | Orodispersible powder composition comprising a triptan |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2082175B (en) * | 1980-08-12 | 1984-05-02 | Glaxo Group Ltd | Heterocyclic compounds |
| GR79215B (en) * | 1982-06-07 | 1984-10-22 | Glaxo Group Ltd | |
| GB2162532B (en) * | 1984-08-04 | 1988-08-03 | Ritchie Swanson John | Decontaminant wash composition |
| GB8431426D0 (en) * | 1984-12-13 | 1985-01-23 | Glaxo Group Ltd | Chemical compounds |
| GB8719167D0 (en) * | 1987-08-13 | 1987-09-23 | Glaxo Group Ltd | Chemical compounds |
| DE19775091I2 (en) * | 1990-06-07 | 2007-05-24 | Astrazeneca Ab | Therapeutic heterocyclic compounds |
-
1992
- 1992-07-28 GB GB929216009A patent/GB9216009D0/en active Pending
-
1993
- 1993-07-19 WO PCT/EP1993/001901 patent/WO1994002460A1/en active IP Right Grant
- 1993-07-19 NZ NZ254152A patent/NZ254152A/en not_active IP Right Cessation
- 1993-07-19 DE DE69323712T patent/DE69323712T2/en not_active Expired - Lifetime
- 1993-07-19 KR KR1019940700865A patent/KR100191830B1/en not_active IP Right Cessation
- 1993-07-19 JP JP6504146A patent/JP2716585B2/en not_active Expired - Lifetime
- 1993-07-19 RU RU94020400A patent/RU2117667C1/en active
- 1993-07-19 EP EP93915953A patent/EP0605697B1/en not_active Expired - Lifetime
- 1993-07-19 PL PL93302917A patent/PL174352B1/en unknown
- 1993-07-19 DE DE2001199016 patent/DE10199016I2/en active Active
- 1993-07-19 SG SG1996000062A patent/SG48708A1/en unknown
- 1993-07-19 DK DK93915953T patent/DK0605697T3/en active
- 1993-07-19 IL IL106387A patent/IL106387A/en not_active IP Right Cessation
- 1993-07-19 HU HU9400869A patent/HUT70518A/en unknown
- 1993-07-19 BR BR9305589A patent/BR9305589A/en not_active Application Discontinuation
- 1993-07-19 AT AT93915953T patent/ATE177080T1/en active
- 1993-07-19 UA UA94005336A patent/UA27818C2/en unknown
- 1993-07-19 CA CA002120028A patent/CA2120028C/en not_active Expired - Lifetime
- 1993-07-19 CZ CZ94664A patent/CZ282659B6/en not_active IP Right Cessation
- 1993-07-21 TW TW082105804A patent/TW235297B/zh not_active IP Right Cessation
- 1993-07-22 ZA ZA935316A patent/ZA935316B/en unknown
- 1993-07-26 EC EC1993000953A patent/ECSP930953A/en unknown
- 1993-07-27 MX MX9304524A patent/MX9304524A/en active IP Right Grant
- 1993-07-28 UY UY23624A patent/UY23624A1/en not_active IP Right Cessation
- 1993-07-28 MY MYPI93001483A patent/MY113266A/en unknown
- 1993-07-28 EG EG47893A patent/EG20340A/en active
- 1993-07-28 CN CN93109364A patent/CN1035179C/en not_active Expired - Lifetime
-
1994
- 1994-03-22 NO NO941019A patent/NO180231C/en not_active IP Right Cessation
- 1994-03-25 FI FI941413A patent/FI109998B/en not_active IP Right Cessation
-
1995
- 1995-05-09 US US08/437,682 patent/US5565447A/en not_active Expired - Lifetime
- 1995-06-30 HU HU95P/P00696P patent/HU211243A9/en unknown
-
1996
- 1996-10-10 BR BR1100061-9A patent/BR1100061A/en active IP Right Grant
-
1998
- 1998-12-02 HK HK98112654A patent/HK1011680A1/en not_active IP Right Cessation
-
1999
- 1999-04-07 GR GR990401006T patent/GR3029915T3/en unknown
-
2001
- 2001-04-11 LU LU90758C patent/LU90758I2/en unknown
- 2001-08-21 NL NL300053C patent/NL300053I2/en unknown
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