RU94002133A - 6-хлор-5-фтор-3-(2-теноил)-2-оксиндол-1-карбоксамид как аналгезирующее и противовоспалительное средство - Google Patents
6-хлор-5-фтор-3-(2-теноил)-2-оксиндол-1-карбоксамид как аналгезирующее и противовоспалительное средствоInfo
- Publication number
- RU94002133A RU94002133A RU94002133/14A RU94002133A RU94002133A RU 94002133 A RU94002133 A RU 94002133A RU 94002133/14 A RU94002133/14 A RU 94002133/14A RU 94002133 A RU94002133 A RU 94002133A RU 94002133 A RU94002133 A RU 94002133A
- Authority
- RU
- Russia
- Prior art keywords
- carboxamide
- animaterative
- analogesic
- tenoil
- ftor
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 1
- BHOXPFBZNIRMQF-UHFFFAOYSA-N 6-chloro-5-fluoro-2-oxo-3-(thiophene-2-carbonyl)-3H-indole-1-carboxamide Chemical compound C12=CC(F)=C(Cl)C=C2N(C(=O)N)C(=O)C1C(=O)C1=CC=CS1 BHOXPFBZNIRMQF-UHFFFAOYSA-N 0.000 claims 1
- 230000003110 anti-inflammatory Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 201000001474 proteinuria Diseases 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
Claims (1)
- Способ достижения обезболивания и лечения противовоспалительного расстройства у человека без появления протеинурии посредством введения 6-хлор-5-фтор-3-(2-теноил)-2-оксиндол-1-карбоксамида или его фармацевтически приемлемой основной соли.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/007,217 US5298522A (en) | 1993-01-22 | 1993-01-22 | 6-chloro-5-fluoro-3-(2-thenoyl)-2-oxindole-1-carboxamide as an analgesic and anti-inflammatory agent while maintaining a normal urine protein/creatinine ratio |
| US08/007,217 | 1993-01-22 | ||
| US08/007.217 | 1993-01-22 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU94002133A true RU94002133A (ru) | 1995-10-27 |
| RU2109293C1 RU2109293C1 (ru) | 1998-04-20 |
Family
ID=21724888
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU94002133A RU2109293C1 (ru) | 1993-01-22 | 1994-01-20 | Способ аналгезии и снятия воспалительной реакции у человека |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5298522A (ru) |
| EP (1) | EP0608058A1 (ru) |
| JP (1) | JPH072666A (ru) |
| KR (1) | KR970009885B1 (ru) |
| CN (1) | CN1099614A (ru) |
| AU (1) | AU653902B2 (ru) |
| CA (1) | CA2113916C (ru) |
| HU (1) | HUT69690A (ru) |
| IL (1) | IL108327A (ru) |
| MX (1) | MX9400630A (ru) |
| MY (1) | MY110402A (ru) |
| NZ (1) | NZ250730A (ru) |
| RU (1) | RU2109293C1 (ru) |
| ZA (2) | ZA94404B (ru) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ182895A3 (en) * | 1993-01-22 | 1996-01-17 | Pfizer | Lysine salt of 6-chloro-5-fluoro-3-(2-thenoyl)-2-oxindole-1-carboxamide per se and for treating diseases, and pharmaceutical composition based thereon |
| CA2450073C (en) | 2001-07-25 | 2017-08-29 | Biomarin Pharmaceutical Inc. | Compositions and methods for modulating blood-brain barrier transport |
| MY144968A (en) | 2005-04-11 | 2011-11-30 | Xenon Pharmaceuticals Inc | Spiro-oxindole compounds and their uses as therapeutic agents |
| AR053710A1 (es) | 2005-04-11 | 2007-05-16 | Xenon Pharmaceuticals Inc | Compuestos espiroheterociclicos y sus usos como agentes terapeuticos |
| AR056317A1 (es) * | 2005-04-20 | 2007-10-03 | Xenon Pharmaceuticals Inc | Compuestos de oxindol y composicion farmaceutica |
| PT1889198E (pt) | 2005-04-28 | 2015-03-06 | Proteus Digital Health Inc | Sistema fármaco-informático |
| ATE545416T1 (de) | 2006-10-12 | 2012-03-15 | Xenon Pharmaceuticals Inc | Verwendung von spiro-oxindol-verbindungen als therapeutika |
| US8795627B2 (en) | 2007-03-21 | 2014-08-05 | Raptor Pharmaceuticals Inc. | Treatment of liver disorders by administration of RAP conjugates |
| CA2741024A1 (en) | 2008-10-17 | 2010-04-22 | Xenon Pharmaceuticals Inc. | Spiro-oxindole compounds and their use as therapeutic agents |
| CA2741029A1 (en) | 2008-10-17 | 2010-04-22 | Xenon Pharmaceuticals Inc. | Spiro-oxindole compounds and their use as therapeutic agents |
| WO2010095940A2 (en) | 2009-02-20 | 2010-08-26 | To-Bbb Holding B.V. | Glutathione-based drug delivery system |
| NZ596876A (en) | 2009-05-06 | 2014-01-31 | Lab Skin Care Inc | Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same |
| AR077252A1 (es) | 2009-06-29 | 2011-08-10 | Xenon Pharmaceuticals Inc | Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos |
| NZ712378A (en) | 2009-10-14 | 2017-05-26 | Xenon Pharmaceuticals Inc | Synthetic methods for spiro-oxindole compounds |
| EP2538919B1 (en) | 2010-02-26 | 2017-07-12 | Xenon Pharmaceuticals Inc. | Pharmaceutical compositions of spiro-oxindole compound for topical administration and their use as therapeutic agents |
| US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
| TW201636017A (zh) | 2015-02-05 | 2016-10-16 | 梯瓦製藥國際有限責任公司 | 以螺吲哚酮化合物之局部調配物治療帶狀疱疹後遺神經痛之方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN163263B (ru) * | 1984-02-07 | 1988-08-27 | Pfizer | |
| US4556672A (en) * | 1984-03-19 | 1985-12-03 | Pfizer Inc. | 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents |
| IN162090B (ru) * | 1984-03-19 | 1988-03-26 | Pfizer | |
| US4569942A (en) * | 1984-05-04 | 1986-02-11 | Pfizer Inc. | N,3-Disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents |
| US4853409A (en) * | 1988-04-13 | 1989-08-01 | Pfizer Inc. | 3-substituted-2-oxindole-1-carboxamides for suppressing T-cell function |
| US4861794A (en) * | 1988-04-13 | 1989-08-29 | Pfizer Inc. | 3-substituted-2-oxindole-1-carboxamides as inhibitors of interleukin-1 biosynthesis |
| US5047554A (en) * | 1989-04-18 | 1991-09-10 | Pfizer Inc. | 3-substituted-2-oxindole derivatives |
| US5008283A (en) * | 1990-03-19 | 1991-04-16 | Pfizer Inc. | Use of tenidap to inhibit activation of collagenase and to inhibit the activity of myeloperoxidase |
| DE4111306C2 (de) * | 1991-04-08 | 1994-06-01 | Mack Chem Pharm | Pharmazeutische Zubereitungen, die ein 2-Oxindol-l-carboxamid-derivat enthalten und zur Injektion bestimmt sind |
| DE4111305C2 (de) * | 1991-04-08 | 1994-12-01 | Mack Chem Pharm | Pharmazeutische Zubereitung zur rektalen Applikation, die ein 2-Oxindol-l-carboxamid-derivat enthält |
-
1993
- 1993-01-22 US US08/007,217 patent/US5298522A/en not_active Expired - Fee Related
- 1993-12-28 JP JP5338015A patent/JPH072666A/ja active Pending
-
1994
- 1994-01-10 EP EP94300145A patent/EP0608058A1/en not_active Withdrawn
- 1994-01-13 IL IL10832794A patent/IL108327A/xx not_active IP Right Cessation
- 1994-01-18 MY MYPI94000136A patent/MY110402A/en unknown
- 1994-01-20 ZA ZA94404A patent/ZA94404B/xx unknown
- 1994-01-20 CA CA002113916A patent/CA2113916C/en not_active Expired - Fee Related
- 1994-01-20 RU RU94002133A patent/RU2109293C1/ru active
- 1994-01-21 ZA ZA94436A patent/ZA94436B/xx unknown
- 1994-01-21 MX MX9400630A patent/MX9400630A/es not_active IP Right Cessation
- 1994-01-21 CN CN94101054A patent/CN1099614A/zh active Pending
- 1994-01-21 HU HU9400179A patent/HUT69690A/hu unknown
- 1994-01-21 NZ NZ250730A patent/NZ250730A/en unknown
- 1994-01-21 AU AU53957/94A patent/AU653902B2/en not_active Ceased
- 1994-01-21 KR KR94001099A patent/KR970009885B1/ko not_active IP Right Cessation
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