RU93054526A - Quinazoline derivatives, method for their preparation, use - Google Patents
Quinazoline derivatives, method for their preparation, useInfo
- Publication number
- RU93054526A RU93054526A RU93054526/04A RU93054526A RU93054526A RU 93054526 A RU93054526 A RU 93054526A RU 93054526/04 A RU93054526/04 A RU 93054526/04A RU 93054526 A RU93054526 A RU 93054526A RU 93054526 A RU93054526 A RU 93054526A
- Authority
- RU
- Russia
- Prior art keywords
- group
- fragment
- alkyl
- amino
- alkoxy
- Prior art date
Links
- 125000002294 quinazolinyl group Chemical class N1=C(N=CC2=CC=CC=C12)* 0.000 title claims 2
- 125000003277 amino group Chemical group 0.000 claims 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000004429 atoms Chemical group 0.000 claims 1
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 1
- 125000001951 carbamoylamino group Chemical group C(N)(=O)N* 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 125000005842 heteroatoms Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- -1 hydroxylamino group Chemical group 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 125000004043 oxo group Chemical group O=* 0.000 claims 1
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N oxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 102000027656 receptor tyrosine kinases Human genes 0.000 claims 1
- 108091007921 receptor tyrosine kinases Proteins 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 1
Claims (1)
где m = 1, 2 или 3, а каждый радикал R1 независимо является гидроксильной группой, аминогруппой, уреидогруппой, гидроксиламиногруппой, трифторметоксигруппой, C1 - C4-алкильной группой, C1 - C4-алкоксигруппой, C1 - C3- алкилендиоксигруппой, а Q является 9- или 10-членным бициклическим гетероциклическим фрагментом, содержащим один или два азотных гетероатома и дополнительно имеющим еще один гетероатом, выбранный из атома азота, кислорода, серы, или же Q является 9- или 10-членным бициклическим арильным фрагментом, при этом гетероциклический или арильный фрагмент может дополнительно содержать один или два заместителя, выбранных из атома галогена, оксигруппы, оксогруппы, аминогруппы, нитрогруппы, карбамоильной группы, С1 - C4- алкильной группы, C1 - C4-алкоксигруппы, C1 - C4-алкиламиногруппы, ди-[(C1 - C4-алкил]аминогруппы, и C2 - C4-алканоиламиногруппы; или их фармацевтически приемлемая соль; способ их получения, фармацевтический состав, содержащий их, и использование ингибирующих свойств соединений по отношению к рецепторной тирозинкиназе при лечении рака.The invention relates to quinazoline derivatives of the general formula
where m = 1, 2, or 3 and each radical R 1 independently is a hydroxyl group, amino group, ureido group, a hydroxylamino group, trifluoromethoxy group, C 1 - C 4 alkyl group, C 1 - C 4 alkoxy, C 1 - C 3 - alkylenedioxy group, and Q is a 9- or 10-membered bicyclic heterocyclic fragment containing one or two nitrogen heteroatoms and additionally having another heteroatom selected from an atom of nitrogen, oxygen, sulfur, or Q is a 9- or 10-membered bicyclic aryl fragment while heterocyclic or aryl the fragment may further contain one or two substituents selected from a halogen atom, an oxy group, an oxo group, an amino group, a nitro group, a carbamoyl group, a C 1 - C 4 alkyl group, a C 1 - C 4 alkoxy group, a C 1 - C 4 alkylamino group, di - [(C 1 -C 4 -alkyl] amino groups, and C 2 -C 4 -alkanoylamino groups; or a pharmaceutically acceptable salt thereof; method for their preparation, pharmaceutical composition containing them, and use of the inhibitory properties of compounds with respect to receptor tyrosine kinase in cancer treatment.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9225765.8 | 1992-12-10 | ||
| GB9310248.1 | 1993-05-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU93054526A true RU93054526A (en) | 1996-12-27 |
Family
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