RU93004423A - HINAZOLINE DERIVATIVE, METHOD FOR ITS OBTAINING, PHARMACEUTICAL COMPOSITION ON ITS BASIS AND APPLICATION - Google Patents

HINAZOLINE DERIVATIVE, METHOD FOR ITS OBTAINING, PHARMACEUTICAL COMPOSITION ON ITS BASIS AND APPLICATION

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Publication number
RU93004423A
RU93004423A RU93004423/04A RU93004423A RU93004423A RU 93004423 A RU93004423 A RU 93004423A RU 93004423/04 A RU93004423/04 A RU 93004423/04A RU 93004423 A RU93004423 A RU 93004423A RU 93004423 A RU93004423 A RU 93004423A
Authority
RU
Russia
Prior art keywords
hinazoline
derivative
obtaining
basis
application
Prior art date
Application number
RU93004423/04A
Other languages
Russian (ru)
Other versions
RU2127263C1 (en
Inventor
Джон Баркер Эндрю
Original Assignee
Зенека Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929201095A external-priority patent/GB9201095D0/en
Priority claimed from GB929213572A external-priority patent/GB9213572D0/en
Priority claimed from GB929223735A external-priority patent/GB9223735D0/en
Application filed by Зенека Лимитед filed Critical Зенека Лимитед
Publication of RU93004423A publication Critical patent/RU93004423A/en
Application granted granted Critical
Publication of RU2127263C1 publication Critical patent/RU2127263C1/en

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Claims (1)

Предметом настоящего изобретения являются производные хиназолина формулы
Figure 00000001

в которой m означает 1, 2 или 3 и R1 включает гидрокси, амино, карбокси, карбамоил, уреидо, /1 - 4C/ алкоксикарбонил, N - /1 - 4C/алкилкарбамоил, N, N-ди-[/1 - 4C/алкил]карбамоил, гидроксиамино, /1 - 4C/алкоксиамино, /2 - 4C/алканоилоксиамино, трифторметокси, /1 - 4C/алкил, /1 - 4C/алкокси и /1 - 3C/алкилендиокси; n означает 1 или 2 и R2 включает водород, гидрокси, галоген, трифторметил, амино, нитро, циано и /1 - 4C/алкил; или его фармацевтически приемлемая соль. Способы их получения, фармацевтические составы, содержащие эти соединения, ингибирующие свойства этих соединений в отношении тирозинкиназы рецепторов применимы для лечения раковых заболеваний.The subject of the present invention are quinazoline derivatives of the formula
Figure 00000001

in which m is 1, 2 or 3 and R 1 includes hydroxy, amino, carboxy, carbamoyl, ureido, (1-4C) alkoxycarbonyl, N- / 1-4C / alkylcarbamoyl, N, N-di- [/ 1-4C (alkyl) carbamoyl, hydroxyamino, (1-4C) alkoxyamino, (2-4C) alkanoyloxyamino, trifluoromethoxy, (1-4C) alkyl, (1-4C) alkoxy and (1-3C) alkylenedioxy; n is 1 or 2 and R 2 includes hydrogen, hydroxy, halogen, trifluoromethyl, amino, nitro, cyano and (1-4C) alkyl; or its pharmaceutically acceptable salt. Methods for their preparation, pharmaceutical compositions containing these compounds, inhibiting properties of these compounds in relation to tyrosine kinase receptors are applicable for the treatment of cancer.
RU93004423/04A 1992-01-20 1993-01-19 Derivatives of quinazoline or their pharmaceutically acceptable salts, a method of their synthesis and a pharmaceutical composition based on said RU2127263C1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB929201095A GB9201095D0 (en) 1992-01-20 1992-01-20 Quinazoline derivatives
GB9201095.8 1992-01-20
GB9201095.3 1992-01-20
GB9213572.2 1992-06-26
GB929213572A GB9213572D0 (en) 1992-06-26 1992-06-26 Quinazoline derivatives
GB9223735.3 1992-11-12
GB929223735A GB9223735D0 (en) 1992-11-12 1992-11-12 Quinazoline derivatives

Publications (2)

Publication Number Publication Date
RU93004423A true RU93004423A (en) 1995-05-20
RU2127263C1 RU2127263C1 (en) 1999-03-10

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US (2) US5457105A (en)
EP (1) EP0566226B1 (en)
KR (1) KR100229294B1 (en)
AT (1) ATE130000T1 (en)
AU (1) AU661533B2 (en)
CA (1) CA2086968C (en)
CZ (1) CZ282038B6 (en)
DE (1) DE69300754T2 (en)
DK (1) DK0566226T3 (en)
ES (1) ES2078798T3 (en)
FI (1) FI111631B (en)
GB (1) GB9300059D0 (en)
GR (1) GR3018143T3 (en)
HK (1) HK36497A (en)
HU (2) HU221622B1 (en)
IL (1) IL104479A (en)
NO (1) NO301541B1 (en)
NZ (1) NZ245662A (en)
RU (1) RU2127263C1 (en)
SK (1) SK281551B6 (en)
TW (1) TW283146B (en)
UA (1) UA34426C2 (en)

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