RU93054537A - DERIVATIVES OF GUANIDINALKYL-1,1-BISPHOSPHONIC ACID, METHOD FOR PRODUCING AND USING THEM - Google Patents
DERIVATIVES OF GUANIDINALKYL-1,1-BISPHOSPHONIC ACID, METHOD FOR PRODUCING AND USING THEMInfo
- Publication number
- RU93054537A RU93054537A RU93054537/04A RU93054537A RU93054537A RU 93054537 A RU93054537 A RU 93054537A RU 93054537/04 A RU93054537/04 A RU 93054537/04A RU 93054537 A RU93054537 A RU 93054537A RU 93054537 A RU93054537 A RU 93054537A
- Authority
- RU
- Russia
- Prior art keywords
- guanidinalkyl
- derivatives
- producing
- bisphosphonic acid
- formula
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 2
- 208000003432 Bone Disease Diseases 0.000 claims 1
- 230000003412 degenerative Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drugs Drugs 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
Claims (1)
где R - остаток формулы
являются эффективными соединениями для лечения и профилактики дегенеративных заболеваний костей. Они находят применение в качестве лекарственных средств.The compound of the tautomeric formula Ia, IB or IC
where R is the remainder of the formula
are effective compounds for the treatment and prevention of degenerative bone diseases. They find use as medicines.
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4240422 | 1992-12-02 | ||
| DEP4240422.3 | 1992-12-02 | ||
| DEP4316019.0 | 1993-05-13 | ||
| DE19934316019 DE4316019A1 (en) | 1993-05-13 | 1993-05-13 | Benzoylguanidine alkyl-1,1-bisphosphonic acids, process for their preparation and their use |
| DEP4332362.6 | 1993-09-23 | ||
| DE4332362 | 1993-09-23 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU93054537A true RU93054537A (en) | 1996-12-27 |
| RU2114855C1 RU2114855C1 (en) | 1998-07-10 |
Family
ID=27204511
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU93054537A RU2114855C1 (en) | 1992-12-02 | 1993-12-01 | Guanidinealkyl-1,1-bis- phosphonic acid derivatives, and method of preparing thereof |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US5395826A (en) |
| EP (1) | EP0600371B1 (en) |
| JP (1) | JP3499905B2 (en) |
| KR (1) | KR100347423B1 (en) |
| AT (1) | ATE176476T1 (en) |
| AU (1) | AU663983B2 (en) |
| BR (1) | BR9304910A (en) |
| CA (1) | CA2110443C (en) |
| DE (1) | DE59309360D1 (en) |
| DK (1) | DK0600371T3 (en) |
| ES (1) | ES2129485T3 (en) |
| FI (1) | FI108034B (en) |
| GR (1) | GR3030020T3 (en) |
| NZ (1) | NZ250322A (en) |
| RU (1) | RU2114855C1 (en) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4223940A1 (en) * | 1992-07-21 | 1994-01-27 | Boehringer Mannheim Gmbh | New acyclic diphosphonic acid derivatives containing amidine groups, processes for their preparation and medicaments containing these compounds |
| DE59309360D1 (en) * | 1992-12-02 | 1999-03-18 | Hoechst Ag | Guanidine alkyl-1, 1-bisphosphonic acid derivatives, process for their preparation and their use |
| US6169107B1 (en) | 1993-04-28 | 2001-01-02 | Sumitomo Pharmaceutical Co., Ltd. | Indoloylguanidine derivatives |
| DE4404183A1 (en) * | 1994-02-10 | 1995-08-17 | Merck Patent Gmbh | 4-amino-1-piperidylbenzoylguanidine |
| DE4421495A1 (en) * | 1994-06-20 | 1995-12-21 | Merck Patent Gmbh | Heterocyclyloxy-benzoylguanidines |
| CA2160600A1 (en) * | 1994-10-18 | 1996-04-19 | Masahumi Kitano | Indoloylguanidine derivatives |
| DE19540995A1 (en) * | 1995-11-03 | 1997-05-07 | Hoechst Ag | Substituted sulfonimidamides, process for their preparation, their use as a medicament or diagnostic agent, and medicament containing them |
| DE19542306A1 (en) * | 1995-11-14 | 1997-05-15 | Hoechst Ag | Sulfonylamino-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic agent, and medicament containing them |
| PL316439A1 (en) * | 1995-11-20 | 1997-05-26 | Hoechst Ag | Novel substituted derivatives of benzoyloguanidine, method of obtaining them, their application in production of pharmaceutic and diagnostic agents and pharmaceutic agent as such |
| DE19601303A1 (en) * | 1996-01-16 | 1997-07-17 | Boehringer Ingelheim Kg | Novel benzoylguanidine derivatives, process for their preparation and their use in the manufacture of medicaments |
| US6284748B1 (en) | 1997-03-07 | 2001-09-04 | Metabasis Therapeutics, Inc. | Purine inhibitors of fructose 1,6-bisphosphatase |
| US6110903A (en) * | 1997-03-07 | 2000-08-29 | Sankyo Company Ltd. | Benzimidazole inhibitors of fructose 1,6-bisphosphatase |
| WO1998039342A1 (en) | 1997-03-07 | 1998-09-11 | Metabasis Therapeutics, Inc. | Novel indole and azaindole inhibitors of fructose-1,6-bisphosphatase |
| US6558784B1 (en) | 1999-03-02 | 2003-05-06 | Adc Composites, Llc | Composite footwear upper and method of manufacturing a composite footwear upper |
| EP1267888A4 (en) * | 2000-01-04 | 2005-12-28 | Univ California | Use of low dosage bisphosphonates to inhibit cardiac and arterial calcification |
| CN100345549C (en) * | 2001-05-02 | 2007-10-31 | 诺瓦提斯公司 | Method of administration of bisphosphonates by inhalation in the treatment or prevention of bone resorption and osteoporosis |
| KR100620672B1 (en) * | 2002-12-14 | 2006-09-13 | 주식회사 하이닉스반도체 | Photoresist composition |
| WO2005090370A1 (en) * | 2004-02-05 | 2005-09-29 | The Regents Of The University Of California | Pharmacologically active agents containing esterified phosphonates and methods for use thereof |
| WO2006110656A2 (en) * | 2005-04-08 | 2006-10-19 | Chimerix, Inc. | Compounds, compositions and methods for the treatment of viral infections and other medical disorders |
| EP1868628B1 (en) | 2005-04-08 | 2014-06-11 | Chimerix, Inc. | Compounds, compositions and methods for the treatment of poxvirus infections |
| AU2007324044A1 (en) * | 2006-11-21 | 2008-05-29 | Teikoku Pharma Usa, Inc. | Biphosphonate inhalant formulations and methods for using the same |
| WO2009094190A2 (en) * | 2008-01-25 | 2009-07-30 | Chimerix, Inc. | Methods of treating viral infections |
| US20100034752A1 (en) * | 2008-08-11 | 2010-02-11 | Toru Hibi | Inhalant formulations comprising a bisphosphonate and a pyrazolone derivative and methods for using the same |
| US8614200B2 (en) | 2009-07-21 | 2013-12-24 | Chimerix, Inc. | Compounds, compositions and methods for treating ocular conditions |
| US20120164104A1 (en) | 2009-08-03 | 2012-06-28 | Chimerix, Inc. | Composition and Methods of Treating Viral Infections and Viral Induced Tumors |
| HUE032860T2 (en) | 2010-02-12 | 2017-11-28 | Chimerix Inc | Methods of treating viral infection |
| WO2011139709A2 (en) | 2010-04-26 | 2011-11-10 | Chimerix, Inc. | Methods of treating retroviral infections and related dosage regimes |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2838437A1 (en) * | 1978-09-02 | 1980-03-20 | Benckiser Gmbh Joh A | N, N'-DIALKYL-UREIDOMETHANE DIPHOSPHONIC ACID, THEIR PRODUCTION AND USE |
| IL77243A (en) * | 1984-12-21 | 1996-11-14 | Procter & Gamble | Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds |
| DE3623397A1 (en) * | 1986-07-11 | 1988-01-14 | Boehringer Mannheim Gmbh | NEW DIPHOSPHONIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS |
| IL86951A (en) * | 1987-07-06 | 1996-07-23 | Procter & Gamble Pharma | Methylene phosphonoalkyl-phosphinates and pharmaceutical compositions containing them |
| JPH0248587A (en) * | 1988-08-10 | 1990-02-19 | Yamanouchi Pharmaceut Co Ltd | Heteroring-substituted bisphosphonic acid derivative and medicine thereof |
| DE3929582A1 (en) * | 1989-09-06 | 1991-03-07 | Hoechst Ag | BENZOYLGUANIDINE, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS A MEDICINE AND THE MEDICINE CONTAINING IT |
| TW222637B (en) * | 1991-12-12 | 1994-04-21 | Hoechst Ag | |
| DE59309360D1 (en) * | 1992-12-02 | 1999-03-18 | Hoechst Ag | Guanidine alkyl-1, 1-bisphosphonic acid derivatives, process for their preparation and their use |
-
1993
- 1993-11-25 DE DE59309360T patent/DE59309360D1/en not_active Expired - Fee Related
- 1993-11-25 EP EP93118992A patent/EP0600371B1/en not_active Expired - Lifetime
- 1993-11-25 DK DK93118992T patent/DK0600371T3/en active
- 1993-11-25 ES ES93118992T patent/ES2129485T3/en not_active Expired - Lifetime
- 1993-11-25 AT AT93118992T patent/ATE176476T1/en not_active IP Right Cessation
- 1993-11-30 NZ NZ250322A patent/NZ250322A/en unknown
- 1993-11-30 FI FI935360A patent/FI108034B/en not_active IP Right Cessation
- 1993-11-30 US US08/159,119 patent/US5395826A/en not_active Expired - Fee Related
- 1993-11-30 AU AU52040/93A patent/AU663983B2/en not_active Ceased
- 1993-12-01 BR BR9304910A patent/BR9304910A/en not_active Application Discontinuation
- 1993-12-01 CA CA002110443A patent/CA2110443C/en not_active Expired - Fee Related
- 1993-12-01 JP JP30142893A patent/JP3499905B2/en not_active Expired - Fee Related
- 1993-12-01 RU RU93054537A patent/RU2114855C1/en not_active IP Right Cessation
- 1993-12-02 KR KR1019930026202A patent/KR100347423B1/en not_active IP Right Cessation
-
1994
- 1994-11-23 US US08/346,239 patent/US5498617A/en not_active Expired - Fee Related
-
1996
- 1996-03-01 US US08/609,473 patent/US5661174A/en not_active Expired - Fee Related
-
1999
- 1999-04-21 GR GR990401101T patent/GR3030020T3/en unknown
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