RU93047029A - HYDROXAMIC ACID DERIVATIVES - Google Patents

HYDROXAMIC ACID DERIVATIVES

Info

Publication number
RU93047029A
RU93047029A RU93047029/04A RU93047029A RU93047029A RU 93047029 A RU93047029 A RU 93047029A RU 93047029/04 A RU93047029/04 A RU 93047029/04A RU 93047029 A RU93047029 A RU 93047029A RU 93047029 A RU93047029 A RU 93047029A
Authority
RU
Russia
Prior art keywords
hydroxamic acid
acid derivatives
well
acid
corresponding new
Prior art date
Application number
RU93047029/04A
Other languages
Russian (ru)
Inventor
Джон Броадхурст Михаэль
Энтони Браун Поль
Генри Джонсон Вильям
Лаутон Джеоффри
Original Assignee
Ф.Хоффманн-Ля Рош Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ф.Хоффманн-Ля Рош Аг filed Critical Ф.Хоффманн-Ля Рош Аг
Publication of RU93047029A publication Critical patent/RU93047029A/en

Links

Claims (1)

Изобретение обеспечивает получение производных гидроксамовой кислоты, а также фармацевтически приемлемые соли этих соединений, являющихся матричными металлопротеиназными ингибиторами, полезными в борьбе или при профилактике дегенеративных суставных заболеваний типа ревматоидного артрита и остеоартрита, или для лечения опухолей инвазивного характера, атеросклероза или рассеянного склероза. Они могут быть приготовлены согласно общеизвестным методам путем снятия защитных группу с соответствующего нового бензилоксиамино-соединения или гидроксиамидирования соответствующей новой аминокислоты или активированного производного этой кислоты.The invention provides derivatives of hydroxamic acid, as well as pharmaceutically acceptable salts of these compounds, which are matrix metalloproteinase inhibitors, useful in the fight or in the prevention of degenerative joint diseases such as rheumatoid arthritis and osteoarthritis, or for the treatment of invasive tumors, atherosclerosis or multiple sclerosis. They can be prepared according to well-known methods by deprotecting the corresponding new benzyloxyamino compound or hydroxyamidating the corresponding new amino acid or an activated derivative of this acid.
RU93047029/04A 1992-06-25 1993-06-25 HYDROXAMIC ACID DERIVATIVES RU93047029A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB921347.3 1992-06-25
GB9307081.1 1993-04-05

Publications (1)

Publication Number Publication Date
RU93047029A true RU93047029A (en) 1996-10-10

Family

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