RU93032307A - METHOD OF OBTAINING 6,6-DIBROMPENICILLANIC ACID - Google Patents

METHOD OF OBTAINING 6,6-DIBROMPENICILLANIC ACID

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Publication number
RU93032307A
RU93032307A RU93032307/04A RU93032307A RU93032307A RU 93032307 A RU93032307 A RU 93032307A RU 93032307/04 A RU93032307/04 A RU 93032307/04A RU 93032307 A RU93032307 A RU 93032307A RU 93032307 A RU93032307 A RU 93032307A
Authority
RU
Russia
Prior art keywords
acid
dibromopenicillanic
interaction
yield
aqueous
Prior art date
Application number
RU93032307/04A
Other languages
Russian (ru)
Other versions
RU2064932C1 (en
Inventor
А.А. Филатова
Е.Я. Зинченко
Е.А. Поваляева
Original Assignee
А.А. Филатова
Е.Я. Зинченко
Е.А. Поваляева
Filing date
Publication date
Application filed by А.А. Филатова, Е.Я. Зинченко, Е.А. Поваляева filed Critical А.А. Филатова
Priority to RU93032307A priority Critical patent/RU2064932C1/en
Priority claimed from RU93032307A external-priority patent/RU2064932C1/en
Publication of RU93032307A publication Critical patent/RU93032307A/en
Application granted granted Critical
Publication of RU2064932C1 publication Critical patent/RU2064932C1/en

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Claims (1)

Способ относится к химии, в частности к технологии получения 6,6-дибромпенициллановой кислоты - промежуточного продукта в синтезе 1,1-диоксида пенициллановой кислоты (сульбактами). Цель изобретения - упрощение процесса, увеличение выхода и улучшение качества 6,6-дибромпенициллановой кислоты. Поставленная цель достигается проведением последовательных реакций образования бромирующей смеси при взаимодействии брома и нитрита натрия в растворе серной кислоты или бромистого калия с концентрированной азотной кислотой и взаимодействием бромирующей смеси с водной или водно-спиртовой (низший С1 - С3) суспензией 6-аминопенициллановой кислоты, причем концентрация спирта не превышает 8,5% от общего объема реакционной массы. Способ обеспечивает получение 6,6-дибромпенициллановой кислоты высокого качества 99,0 - 99,5% с выходом 80 - 85%, что на 46 - 51% выше, чем по прототипу, сокращает продолжительность процесса в два раза.The method relates to chemistry, in particular to the technology of producing 6,6-dibromopenicillanic acid - an intermediate product in the synthesis of 1,1-dioxide penicillanic acid (sulbacts). The purpose of the invention is to simplify the process, increase the yield and improve the quality of 6,6-dibromopenicillanic acid. This goal is achieved by conducting successive reactions of formation of the brominating mixture in the interaction of bromine and sodium nitrite in a solution of sulfuric acid or potassium bromide with concentrated nitric acid and the interaction of the brominating mixture with aqueous or aqueous-alcoholic (lower C 1 - C 3 ) suspension of 6-aminopenicillanic acid moreover, the alcohol concentration does not exceed 8.5% of the total reaction mass. The method provides obtaining high quality 6,6-dibromopenicillanic acid 99.0 - 99.5% with a yield of 80 - 85%, which is 46 - 51% higher than in the prototype, reduces the process time by half.
RU93032307A 1993-06-18 1993-06-18 Method of synthesis of 6,6-dibromopenicillanic acid RU2064932C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU93032307A RU2064932C1 (en) 1993-06-18 1993-06-18 Method of synthesis of 6,6-dibromopenicillanic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU93032307A RU2064932C1 (en) 1993-06-18 1993-06-18 Method of synthesis of 6,6-dibromopenicillanic acid

Publications (2)

Publication Number Publication Date
RU93032307A true RU93032307A (en) 1996-01-27
RU2064932C1 RU2064932C1 (en) 1996-08-10

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Family Applications (1)

Application Number Title Priority Date Filing Date
RU93032307A RU2064932C1 (en) 1993-06-18 1993-06-18 Method of synthesis of 6,6-dibromopenicillanic acid

Country Status (1)

Country Link
RU (1) RU2064932C1 (en)

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