RU93029233A - Липосомная везикула, стабильная при хранении - Google Patents
Липосомная везикула, стабильная при храненииInfo
- Publication number
- RU93029233A RU93029233A RU93029233/14A RU93029233A RU93029233A RU 93029233 A RU93029233 A RU 93029233A RU 93029233/14 A RU93029233/14 A RU 93029233/14A RU 93029233 A RU93029233 A RU 93029233A RU 93029233 A RU93029233 A RU 93029233A
- Authority
- RU
- Russia
- Prior art keywords
- storage
- liposomal vesicle
- stable
- stable during
- during storage
- Prior art date
Links
- 239000003814 drug Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 claims 1
- 235000010469 Glycine max Nutrition 0.000 claims 1
- 240000007842 Glycine max Species 0.000 claims 1
- 229940067606 Lecithin Drugs 0.000 claims 1
- 229940067631 Phospholipids Drugs 0.000 claims 1
- 230000002378 acidificating Effects 0.000 claims 1
- 238000004220 aggregation Methods 0.000 claims 1
- 230000002776 aggregation Effects 0.000 claims 1
- 229940079593 drugs Drugs 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 235000010445 lecithin Nutrition 0.000 claims 1
- 239000000787 lecithin Substances 0.000 claims 1
- 239000002502 liposome Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 150000003904 phospholipids Chemical class 0.000 claims 1
- 230000002035 prolonged Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 230000002588 toxic Effects 0.000 claims 1
- 231100000331 toxic Toxicity 0.000 claims 1
Claims (1)
- Липосомная везикула, стабильная при хранении, относится к медицине и фармакологии и может быть использована, например, для производства лекарственных препаратов. Изобретение позволяет сохранить размер, структуру (без агрегации и слияния) и химическую природу компонентов липосомной везикулы при длительном хранении. Липосомная везикула, стабильная при хранении, содержит оболочку из лецитина и отрицательно заряженного компонента. В качестве заряженного компонента используется смесь кислых фосфолипидов, выделяемая из соевых фосфатидов как единый компонент. Предлагаемый состав оболочки липосомной везикулы апробирован в лабораторных условиях и позволяет получать суспензии апирогенных, атоксичных липосом, стабильных при хранении в течение года и обладающих хорошими физико-химическими и биологическими свойствами.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU93029233/14A RU2084219C1 (ru) | 1993-06-04 | 1993-06-04 | Липосомная везикула |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU93029233/14A RU2084219C1 (ru) | 1993-06-04 | 1993-06-04 | Липосомная везикула |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU93029233A true RU93029233A (ru) | 1995-11-20 |
| RU2084219C1 RU2084219C1 (ru) | 1997-07-20 |
Family
ID=20142611
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU93029233/14A RU2084219C1 (ru) | 1993-06-04 | 1993-06-04 | Липосомная везикула |
Country Status (1)
| Country | Link |
|---|---|
| RU (1) | RU2084219C1 (ru) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000054750A1 (fr) * | 1999-03-15 | 2000-09-21 | Dmitry Anatolievich Starchenko | Procede de correction des perturbations dans la synthese du collagene et substance bioactive de mise en oeuvre de ce procede |
-
1993
- 1993-06-04 RU RU93029233/14A patent/RU2084219C1/ru not_active IP Right Cessation
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