RU93027376A - Получение таблетки, содержащей интерферон-альфа, для энтерального применения и ее состав - Google Patents
Получение таблетки, содержащей интерферон-альфа, для энтерального применения и ее составInfo
- Publication number
- RU93027376A RU93027376A RU93027376/14A RU93027376A RU93027376A RU 93027376 A RU93027376 A RU 93027376A RU 93027376/14 A RU93027376/14 A RU 93027376/14A RU 93027376 A RU93027376 A RU 93027376A RU 93027376 A RU93027376 A RU 93027376A
- Authority
- RU
- Russia
- Prior art keywords
- alpha
- production
- tablet
- eteral
- composition
- Prior art date
Links
- 102000006992 Interferon-alpha Human genes 0.000 title claims 2
- 108010047761 Interferon-alpha Proteins 0.000 title claims 2
- 238000004519 manufacturing process Methods 0.000 title claims 2
- 239000000203 mixture Substances 0.000 title claims 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 2
- CJZGTCYPCWQAJB-UHFFFAOYSA-L Calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 claims 1
- 229920002301 Cellulose acetate Polymers 0.000 claims 1
- GUBGYTABKSRVRQ-UUNJERMWSA-N Lactose Natural products O([C@@H]1[C@H](O)[C@H](O)[C@H](O)O[C@@H]1CO)[C@H]1[C@@H](O)[C@@H](O)[C@H](O)[C@H](CO)O1 GUBGYTABKSRVRQ-UUNJERMWSA-N 0.000 claims 1
- 239000011230 binding agent Substances 0.000 claims 1
- 235000013539 calcium stearate Nutrition 0.000 claims 1
- 239000008116 calcium stearate Substances 0.000 claims 1
- JEKPADUEQKKLDL-AKSHDPDZSA-N calcium;(2R,3R,4S,5S,6R)-2-[(2S,3S,4S,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound [Ca].O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JEKPADUEQKKLDL-AKSHDPDZSA-N 0.000 claims 1
- 239000004359 castor oil Substances 0.000 claims 1
- 235000019438 castor oil Nutrition 0.000 claims 1
- 239000011248 coating agent Substances 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 239000000945 filler Substances 0.000 claims 1
- 238000010353 genetic engineering Methods 0.000 claims 1
- 239000008101 lactose Substances 0.000 claims 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims 1
- 235000019629 palatability Nutrition 0.000 claims 1
- 238000005020 pharmaceutical industry Methods 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
Claims (1)
- Изобретение относится к химико-фармацевтической промышленности, касается получения таблеток, содержащих интерферон-альфа и предназначенных для энтерального применения. В качестве активного компонента используется лиофилизированный человеческий генно-инженерный альфа-2-интерферон. Содержание его в одной таблетке - 1•105 - 1•106 ME. При получении таблетированной формы в качестве основного наполнителя используют стерильную лактозу, в качестве связующего вещества, обеспечивающего сыпучесть таблеток, стабилизитора и придания вкусовых качеств, используют стерильные стеарат кальция и сахарозу. На ядро таблетки, взвешенное в потоке воздуха, напыляется покрытие из раствора ацетилфталилцеллюлозы и касторового масла в смеси ацетона со спиртом.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU93027376A RU2083222C1 (ru) | 1993-05-19 | 1993-05-19 | Способ получения энтерального препарата, содержащего интерферон-альфа и энтеральный препарат, содержащий интерферон-альфа в виде таблеток |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU93027376A RU2083222C1 (ru) | 1993-05-19 | 1993-05-19 | Способ получения энтерального препарата, содержащего интерферон-альфа и энтеральный препарат, содержащий интерферон-альфа в виде таблеток |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU93027376A true RU93027376A (ru) | 1996-09-10 |
| RU2083222C1 RU2083222C1 (ru) | 1997-07-10 |
Family
ID=20141863
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU93027376A RU2083222C1 (ru) | 1993-05-19 | 1993-05-19 | Способ получения энтерального препарата, содержащего интерферон-альфа и энтеральный препарат, содержащий интерферон-альфа в виде таблеток |
Country Status (1)
| Country | Link |
|---|---|
| RU (1) | RU2083222C1 (ru) |
-
1993
- 1993-05-19 RU RU93027376A patent/RU2083222C1/ru active
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