RU41979U1 - DEVICE FOR EXTRACORPORAL PHOTOMODIFICATION OF BIOLOGICAL LIQUID - Google Patents

Abstract

A device for extracorporeal photomodification of biological fluid belongs to the field of medicine, namely to therapy, and can be used in the treatment of a large group of diseases (surgical, infectious, viral, etc.) both as an independent treatment method and in combination with other traditional methods of treatment. provides high efficiency of photomodification of biological fluid, allows you to expand the scope of application, the design of the device is simple and does not require expensive parts to manufacture. I, the device comprises a body with mounted therein a source of ultraviolet radiation, coupled with the power supply and the flow cell connected to the lines of the supply and removal of the biological fluid. The device further comprises monochromatic light sources connected to an additional power supply, ultraviolet radiation sources are mounted vertically and mounted on the housing by means of holders. Between the sources of ultraviolet radiation is a flow cell, connected on both sides by lines of supply and removal of biological fluid.

Description

The proposed utility model relates to the field of medicine, namely to therapy, and can be used in the treatment of a large group of diseases (surgical, infectious, viral, etc.) both as an independent treatment method and in combination with other traditional methods of treatment.

In recent years, the incidence of complications caused by the use of drugs has been increasing. According to the literature, the frequency of occurrence of such complications reaches 40%, the number of patients with diseases of the immune system is growing. In this regard, an increasing attention is being paid to non-drug methods of treatment, one of which is blood photomodification

- A variant of quantum hemotherapy, therapeutic effects on the blood with quanta of electromagnetic radiation of various wavelengths.

There is a significant number of publications in the literature on both the description of devices for photomodification of biological fluids and the mechanism of its action.

Available devices, as a rule, include the necessary components:

- a source of ultraviolet radiation connected to the power supply

- a cuvette with a special window or other inserts transparent to UV radiation, to which blood collection and return systems are connected;

- a pump for pumping blood or its absence, if its extracorporeal administration is carried out (see RF, patent No. 2110296 publ. in BI No. 13, 1998)

As sources of optical radiation in various devices, as a rule, mercury-quartz low-pressure discharge lamps, such as DRB, LE, LB, LUFT or high-pressure mercury-quartz lamps like PRK, DRG, DRZh, are used (see RF patent No. 2103035 published in BI No. 3.1998; No. 2085229 published in BI No. 21.1997);

Capacities (cuvettes, tubes) differ from each other in design, shape, size (see RF patent No. 2038105 publ. In BI No. 18, 1995), as well as the material from which they are made (RF patent No. 2169022 publ. in BI No. 17, 2001). However, for the most part they are made of quartz glass, approved for use in medical practice. The design features of the cuvette should provide quick, reliable, repeated pre-sterilization treatment and sterilization by chemical radiation or thermal methods.

It should be noted that quartz glass parts contribute to the adhesion of fibrin and blood cells. There are certain difficulties in their pre-sterilization and sterilization treatment. There is a risk of thrombosis of the needle located in the vein, as well as the occurrence of an embolism with air bubbles at the time of return of blood. In addition, quartz glass is quite expensive.

For the prototype of the proposed utility model, a well-known device for extracorporeal photomodification of blood is selected, comprising a housing with an ultraviolet radiation source installed in it, connected to a power supply unit and a flow cell (see RF patent No. 2053813 "Device for irradiating blood with ultraviolet rays" auth. Provotorov V. M. et al. Publ. Bull. No. 4 of 02/10/1996).

In the device’s body there is a point source of UV radiation, for example, an IVR lamp (SGP, CPS. 374.284.), A reflector-radiator, on which there is a board of an RF excitation generator of a UV lamp with an inductor, a screen that protects blood from exposure to an RF electromagnetic field, quartz glass , a ditch and a spring-loaded clip. The cuvette consists of a body with ribs and tubes and inlet and outlet openings.

The known device operates as follows. Sterile blood tubes are connected to the tubes with the inlet and outlet openings of the sterile cuvette. To do this, use a disposable system for blood transfusion. The cuvette is installed in the body of the device and, with the help of clamps, is fixed to the outer surface of the window, transparent for UV radiation, to quartz glass. The generator is turned on, and after the beginning of the glow of the UV lamp, blood is supplied into the internal cavity of the cell. After a single use, the cell must be disposed of. The authors note that the design of the cuvette in the form of a rigid body with ribs and a transparent window made of a polymer film fixed with a bandage provides low cost and high manufacturability of the cell, allowing it to be used once. At the same time, the design of the cell ensures the flow of blood without stagnant zones and bubbles.

However, the known device has several disadvantages. Although the inventors use disposable cuvettes, which ensures the sterility and interchangeability of the system, however, the modified cuvette equipped with additional ribs dictates their special production in sufficient quantities, which cannot but affect the cost of the device.

The objective of the proposed utility model is to simplify and cheapen the design of the device while ensuring high efficiency of photomodification of blood, as well as expanding the functionality of the device.

The problem is solved in that, in the known device for extracorporeal photomodification of a biological fluid, comprising a body with an installed ultraviolet radiation source connected to a power supply unit and a flow cell with biological fluid supply and removal lines, the device is additionally equipped with monochromatic light sources connected to additional power supply, ultraviolet radiation sources are mounted vertically and fixed to the housing by means of holders, m Between the sources of ultraviolet radiation there is a flow cell, connected on both sides by supply and drain lines of the irradiated biological fluid.

The proposed device is illustrated in the drawing. Figure 1 shows the proposed device for extracorporeal photomodification of biological fluid

The device comprises a housing 1, in which, through the holders 2, sources of ultraviolet radiation 3 are installed. The sources of ultraviolet radiation are connected to a power supply unit (not shown in FIG. 1) located behind the housing. The device is equipped with monochromatic light sources 4 installed, for example, in the upper part of the housing 1 and connected to an additional power supply 5. A flow cell 6 is placed between the UV radiation sources on both sides and connected to the supply and exhaust lines (7, 8) of the irradiated biological fluid.

The housing of the proposed device is a tablet on which UV and monochromatic radiation sources are fixed, as well as a flow cell. The tablet is suspended from an ordinary stand for blood transfusion. Ultraviolet lamps of the DRB, DR, MUFT 6, LK 6 type are used in the device. Monochromatic radiation sources can be made either in the form of optical fibers providing red light or in the form of ordinary small red bulbs for Christmas lights. For UV lamps, a standard power supply is used, monochromatic light sources are connected to a constant current source. UV radiation sources are mounted using holders that allow you to quickly replace one type of lamp with another. In the proposed device, photomodification of biological fluid is carried out through the wall of the dropper, as well as through the walls of the lines of supply and removal of biological fluid, for example, a disposable device such as PK 11-05, 11-07, PR 11-02. Measurements made by the authors of the proposed device and performed on an SF-42 spectrophotometer showed that the dropper wall, as well as the walls of the inlet and outlet tubes, transmit at least 10% of UV radiation in the range of 250-300 nm, which is significant for modifying biological fluids

ultraviolet radiation. The stock of light intensity from the gas-discharge light sources indicated in the application also ensures the effectiveness of the procedures, taking into account the partial absorption of radiation in the walls of the cuvette and inlet and outlet tubes.

The proposed utility model meets the criterion of "novelty", as the patent information research conducted did not reveal sources of patent literature that discredited the novelty of the proposed device. The proposed utility model meets the criterion of "inventive step", since no technical solutions with essential features of the proposed device have been identified.

A device for photomodification of biological fluid was used in 241 patients, 104 of them with a surgical pathology, 83 patients with a therapeutic pathology, 18 patients with gynecological pathology, 15 patients with skin and subcutaneous tissue diseases, and 7 patients with another pathology. Performed 1238 photomodifications of blood. The dose of irradiated blood is from 50 to 150 ml (0.5-2 ml per 1 kg of patient weight). Blood flow rate of 50-60 drops per minute (2 ml per minute). Based on clinical data, when using the proposed utility model, the following positive effect is obtained.

Irradiation of blood or other biological fluid with monochromatic light can improve the rheological properties of blood, enhance the energy processes in cells and, along with the UV effect, compensate for possible negative effects on the membrane from UV rays. The possibility of using radiation of various characteristics (monochromatic light, shortwave, longwave, UV radiation) in various combinations and separately allows you to significantly expand the functionality of the device. The arsenal of therapeutic effects on the patient is expanding, which allows us to correct the state of health of patients depending on the disease, stage of treatment and the presence of concomitant pathology and thus treat patients, not the disease. The use of disposable systems such as PK 11-05 and PR 11-02, which have a permeability for UV rays in the range from 250 nm and higher, ensures the effectiveness of the procedures taking into account the partial absorption of radiation by the walls of the cuvette and the walls of the inlet and outlet systems. The device is easy to carry and assemble. Its use is possible both in a hospital and in an outpatient setting. Since the components of the device are made of everyday parts, it is easy to manufacture and does not require large financial costs.

The proposed device operates as follows.

The patient is sampled at a rate of 0.75-1.5 ml per 1 kg of patient body weight by gravity flow into the vial. The bottle is placed on the rack for blood transfusion and through

the supply line is connected to a flow cell. They include UV lamps and monochromatic light sources. UV and monochromatic light sources can also be used individually, depending on the treatment program. Phototherapy is carried out as planned. Irradiated blood along the withdrawal line is administered directly to the patient or in an additional vial for subsequent administration.

Examples of specific performance are given in the form of lists from medical histories. Patient C. 51 years old - erysipelatous inflammation of the left lower leg bullous form. The condition is severe, severe fever. The temperature is up to 41 C. The limb is increased in volume in the middle third of the leg by 5 cm. Hyperemia of the skin, detachment of the epidermis, blisters filled with hemorrhagic fluid. Against the background of traditional drug treatment, 10 sessions of blood photomodification were performed with the proposed device in a dose of 50 to 100 ml of blood every other day. Sources of radiation: DRB in combination with monochromatic sources of red light. The dynamics are positive. Discharged home in satisfactory condition with fully stopped local and general manifestations.

Patient B., 45 years old, diagnosed with purulent-necrotic phlegmon of the right foot. The condition is serious. Abundant purulent discharge, necrosis of the skin, subcutaneous tissue with the phenomena of lymphadenitis and lymphangitis. Against the background of drug treatment with massive doses of antibiotics, the process is prone to spread. The decision of the consultation is the amputation of the foot along the tapar.

The patient was taken for treatment: photomodification of blood with irradiation with DRB 8-1, LE-8 lamps, as well as monochromatic red light. Dose from 60 to 120 ml, flow rate of 60 drops per minute. Performed 8 sessions of photomodification of blood with an interval of 2 days. The inflammatory process was completely stopped. Discharged in satisfactory condition. Foot function restored.

Patient A., 47 years old. The diagnosis is common psoriasis. The disease is 15 years old. Received with severe exacerbation. On the scalp, upper and lower extremities, the body has psoriatic plaques in places of a draining character, with combs. The dose of irradiated blood is from 50 to 100 ml. Irradiation with a DRB lamp 8-1. An improvement in the course of the disease was observed after the first treatment session. Marked disappearance of skin manifestations after 5 sessions of photomodification of blood. In this case, UV irradiation of blood was carried out on an outpatient basis, like monotherapy. A total of 7 procedures were performed. Discharged in satisfactory condition with stopping the phenomena of psoriasis.

Patient S., 48 years old. The diagnosis is gynecological sepsis, pelvioperitonitis. Severe endogenous intoxication with fever, fever up to 41 C. Headache, tremendous chills. Against the background of drug therapy, photomodification of blood was prescribed in a dose of 60 to 110 ml. Irradiation of DRB 8-1 6 procedures were performed. Improvement after the first exposure. The patient was discharged in satisfactory condition.

Patient L., 58 years old. The diagnosis is general allergosis. Severe effects of polyradiculoneuritis, pain, stiffness of movements, difficulty breathing due to pain. Treatment of the patient was difficult due to the almost complete intolerance to drugs. Irradiation DRB8-1, LUFT, monochromatic red color. Dose 6-80ml. Directly during the treatment session, the patient noted an improvement, a decrease in pain, an increase in breathing. After the second procedure, in a day the expressed improvement. In this regard, arbitrarily stopped treatment. Currently working, feels satisfactory.

Claims (1)

A device for extracorporeal photomodification of a biological fluid, comprising a housing with a UV source installed in it, connected to a power supply unit, and a flow cell connected to the supply and removal lines of biological fluid, characterized in that the device is additionally equipped with monochromatic light sources connected to an additional unit power supply, ultraviolet radiation sources are mounted vertically and mounted on the housing by means of holders, between the source and UV flow cell is connected to both sides of the supply and discharge lines of the irradiated biological fluid.