RU2781872C1 - Method for assessment of condition of human body - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention relates to the field of medicine, namely to diagnostic methods; it can be used for assessment of a condition of a human body. Registration and spectral analysis of bioelectric activity of the brain are carried out by acoustic-encephalography (hereinafter – AEG) with subsequent processing of measurement results with the calculation of a criterion for quantitative assessment of the condition of the human body. AEG sensors are installed in the temporoparietal region of left and right hemispheres of the brain. Micro-vibrations of the head are recorded with a recording time of 160 sec in a frequency band from 0.13 to 27 Hz, then, spectral analysis is performed with the allocation of 12,600 frequency harmonics for each hemisphere, while dividing the spectrum into 5 frequency sections: 13.5-27 Hz, 6.9-13.5 Hz, 3.4-6.9 Hz, 1.7-3.4 Hz, 0.13-1.7 Hz. Moreover, a weighting coefficient (Si) for each frequency section is respectively equal to: 2, 5, 7, 6, 3. A value of asymmetry of amplitudes of envelopes of the spectrum of right and left hemispheres is calculated for each frequency section. Amplitudes of envelopes of the spectrum of right and left hemispheres obtained for each section are summed up and multiplied by the weighting coefficient (Si). Then, the search for decentralization zones is carried out by counting a number of spectral harmonics (h) with minimum values (m) of the amplitude of the spectrum in both hemispheres, where m ≤ 0.05, which is multiplied by a weighting factor So = 0.35 and added to the resulting sum of amplitudes of the envelope spectrum. An individual health index (hereinafter – IHI) is obtained. If IHI = 1.2-3.0 units, the human body is healthy with normal development and balanced functions. If IHI is 3.1-3.9 units, the human body is healthy with functional abnormalities, reduced body resistance. If IHI is 4.0-4.9 units, the human body is healthy at a stage of compensation for chronic diseases, functional capabilities of the body are preserved. If IHI is 5.0-5.4 units, patients are at a stage of subcompensation for chronic diseases, functional capabilities of the body are reduced. If IHI is 5.5-6.0 units, patients have an exacerbation of the disease, functional capabilities of the body are significantly reduced. If IHI is 6.1-8.0, patients are at risk of development of cancer.

EFFECT: method provides an increase in the accuracy of assessment of the determination of a condition of a human body, including inflammatory processes and oncological diseases due to determination of IHI.

1 cl, 8 dwg, 1 tbl

Description

FIELD OF TECHNOLOGY

The invention relates to the field of medicine, namely to methods for diagnosing the functional state and level of health of the human body and can be used in various fields of medicine, psychology, sports and in mass use by the population, where monitoring and evaluation of the human condition is required.

BACKGROUND OF THE INVENTION

A known method for non-invasive determination of the state of health of humans and animals with the determination of damage to internal organs (RU 2156108 09/20/2000), which consists in registering the topographic distribution of one of the electrophysiological parameters of the skin - electroskin resistance of symmetrical skin regions that have nervous vegetative connections with all segments of the central nervous system without exception. nervous system. The known method is carried out using a device that includes a computer and measuring electrodes, followed by mathematical processing of the measurement results with the calculation of the criterion, quantitative assessment of the state of the organism. The result of the calculations is:

- the normal state of the body,

- pathological condition of the body (inflammation),

- restoration of the body (regeneration).

The known method has significant drawbacks associated with errors in measuring the state of the epidermis in extremely hot or cold conditions, the quality of the operator's work when measuring the skin microzones of the auricle, which can significantly affect the results of measurements and as a result of significant errors in assessing the state of the human body.

A known method for assessing adaptive risk in prenosological diagnostics (RU 2586041 06/10/2016), implemented on the basis of information on heart rate variability. The known method is based on the formula of the ratio of ergotropic and trophotropic central influences on the sympathetic and parasympathetic mechanisms of heart rate regulation, which characterizes the degree of stress of adaptive mechanisms. At the same time, the stress index SI was calculated using the formula:

where Amo (mode amplitude) is the number of cardiointervals corresponding to the mode value, in % of the sample size;

MxDMn (variation range) reflects the degree of variability of cardio interval values in the studied dynamic series, which is calculated by the difference between the maximum (Mx) and minimum (Mn) values of cardio intervals, expressed in ms;

Mo (mode) - the most common value of the cardio interval in this dynamic range, expressed in ms.

The most successful for assessing the adaptive capabilities of the organism and the level of health is the principle of "traffic light" (Baevsky R.M., Berseneva A.P. Introduction to prenosological diagnostics. M., Firma "Slovo", 2008, 220 p.). The method is clear for patients and presents the test results in the form of signals "Green", "Yellow", "Red". These signals reflect various functional states of the body and the corresponding degree of tension of regulatory systems and their functional reserves (PARS - in terms of the activity of regulatory systems).

The disadvantages of the known methods is that the proposed criteria for assessing the functional state of the body mainly assess the degree of tension of adaptive mechanisms, designed mainly for healthy people. Assessment of the state of patients with various nosological forms by these methods leads to significant errors.

A known method for assessing the psychophysiological state of the human body with remote registration of a vibraimage (RU 2289310 20.12.2006). In the known method, in the spectral analysis of microvibrations of the head and body of the human body, it was possible to distinguish the following psychophysiological states: fatigue, rest, well-being, normal activity, alertness, increased activity and aggression.

The methods described above are designed to assess the psycho-physiological state, the stress of adaptive mechanisms of practically healthy people. They are not fully suitable for measuring the level of health and can give significant errors when examining patients.

The closest analogue to the claimed method is a method for calculating the individual health index (IHI) based on spectral analysis of the bioelectric activity of the brain (Shabanov G.A., Maksimov A.L., Rybchenko A.A. Functional and topical diagnostics of the human body based on the analysis rhythmic activity of the brain. - Vladivostok: Dalnauka, 2011. - 206 p.). When conducting research, it was found that the area of asymmetry of the spectrum envelopes between the right and left hemispheres of the brain is proportional to the severity of the focus of pathologically increased excitation. The entire spectral range was divided into five regions (F1, F2, F3, F4, F5+F6+F7), each of which was responsible for the activity of different groups of visceral receptors and had its own weight coefficient (from 1 to 5.5 units). At the same time, the combination of activity of different parts of the spectrum made it possible to distinguish between the stages of the inflammatory process - spasm of smooth muscles, ischemic hypoxia, active inflammation, venous stasis, organ regeneration. The total area of asymmetry of the spectrum envelopes was calculated over the entire frequency range from 0.13 to 27 Hz, taking into account the weights of each spectral section. The IIS scale was represented by states with the following ranges of changes: 1.2-3.0 units. - healthy with normal development and balanced functions;

3.1-3.8 units - healthy with functional abnormalities, reduced body resistance;

4.0-4.9 units - healthy in the stage of compensation for chronic diseases, the functional capabilities of the body are preserved;

5.0-5.4 units - patients in the stage of subcompensation of chronic diseases, the functionality of the body is reduced;

5.5-6.0 units - patients with an exacerbation of the disease, the functionality of the body is significantly reduced.

Registration and spectral analysis of the bioelectrical activity of the brain were carried out in the temporo-parietal leads. The spectral analysis had some peculiarities: in the frequency range from 0.13 to 27 Hz, 840 spectral harmonics were identified with an information frame summation time of 160 sec. Further, averaging was carried out over 5 information frames with a total study time (5 * 160 sec) equal to 13 minutes.

The disadvantage of the known method was the insensitivity of the IHI index to oncological diseases at any stage of development.

SUMMARY OF THE INVENTION

The task to be solved by the claimed solution is expressed in providing the possibility of a quantitative assessment of a person's individual health, covering the levels of premorbid and nosological conditions.

The technical result of the invention is to increase the accuracy of assessing the state of the human body, the possibility of using it to determine premorbid and nosological conditions, including various stages of inflammatory processes and oncological diseases.

To achieve the stated technical result, a method for assessing the state of the human body is proposed, including registration and spectral analysis of the bioelectric activity of the brain and subsequent processing of the measurement results with the calculation of the criterion, a quantitative assessment of the state of the human body, differs in that they use a spectral analysis of the rhythmic activity of the mechanical microvibrations of the brain, at the same time, the spectrum is divided into n frequency sections (13.5-27 Hz; 6.9-13.5 Hz; 3.4-6.9 Hz; 1.7-3.4 Hz; 0.13-1 ,7 Hz) characterizing the functional state of various groups of visceral reflexes, the summation of the asymmetry of the amplitudes (area) of the spectrum envelopes of the right and left hemispheres for each area, taking into account the weight coefficient Si (2, 5, 7, 6, 3), then the number of spectral harmonics with the minimum values of the amplitude of the spectrum in both hemispheres m (≤0.05) are multiplied by the weighting factor So (0.35) and added to the sum of the areas spectrum envelope asymmetry,

while the ranges of the obtained index of individual health are divided into the following states

1.2-3.0 units - healthy with normal development and balanced functions;

3.1-3.9 units - healthy with functional abnormalities, reduced body resistance;

4.0-4.9 units - healthy in the stage of compensation for chronic diseases, the functional capabilities of the body are preserved;

5.0-5.4 units - patients in the stage of subcompensation of chronic diseases, the functionality of the body is reduced;

5.5-6.0 units - patients with an exacerbation of the disease, the functionality of the body is significantly reduced;

6.1-8.0 - patients at risk of developing cancer,

at the same time, registration and spectral analysis of mechanical microvibrations of the brain were carried out on one information frame lasting 160 seconds,

at the same time, during spectral analysis, the number of spectral harmonics in the frequency range from 0.13 to 27 Hz was increased from 840 to 12600.

DESCRIPTION OF THE DRAWINGS

Fig. 1 - an example of calculating the Individual Health Index when observing a practically healthy person A1; IIS=3.0; belongs to the group "healthy with normal development and balanced functions".

Fig. 2 - an example of calculating the Individual Health Index when observing a practically healthy person A2 with minor functional deviations (blood pressure instability); IIS=3.3; is included in the group of "healthy with functional abnormalities, a decrease in the body's resistance."

Fig. 3 - an example of calculating the Individual Health Index when observing patient G with a chronic disease in remission (chronic gastritis); IIS=4.8; is included in the group "healthy in the stage of compensation for chronic diseases, the functional capabilities of the body are preserved."

Fig. 4 - an example of calculating the Individual Health Index when monitoring patient M with a slight exacerbation of a chronic disease (ischemic heart disease); IIS=5.3; belongs to the group "patients in the stage of subcompensation of chronic diseases, the functional capabilities of the body are reduced."

Fig. 5 - an example of calculating the Individual Health Index when observing patient K with a pronounced exacerbation of a chronic disease (peptic ulcer of the duodenal bulb 12); IIS=5.8; belongs to the group "patients with an exacerbation of the disease, the functional capabilities of the body are significantly reduced."

Fig. 6 - an example of calculating the Individual Health Index when observing patient R with cancer (stage 4 prostate cancer); IIS=7.6; belongs to the group of patients at risk of developing cancer.

Fig. 7 - an example of monitoring the Individual Health Index when observing patient Z1 during treatment (exacerbation of inflammation in the pyloric part of the stomach); IIS changed from 6 to 3 units (from exacerbation of the focus of inflammation to the normal state of the patient).

Fig. 8 - an example of monitoring the Individual Health Index when observing patient Z2 and identifying clusters of high values of IHI = 7.8 units, characteristic of the initial stages of the development of oncological pathology - a precancerous condition (mammary gland). Included in the group "patients at risk of developing cancer."

DETAILED DESCRIPTION OF THE INVENTION

Measurement of the level of health of the human body should cover all possible stages of the development of the pathological process - the tension of adaptive mechanisms, the failure of adaptation and the exacerbation of chronic diseases, all stages of the development of the inflammatory process, the restoration of functions or regeneration of body structures, the presence of proliferative diseases and tumors (mainly epithelial, neuroendocrine, carcinomas).

High-resolution spectral analysis of the bioelectrical activity of the brain using registration of an electroencephalogram or magnetoencephalogram, a long integration time, made it possible to lay the foundations and develop methods for diagnosing the functional state of various groups of somatic and autonomic receptors, to identify foci of pathology, to identify the stages of development of the inflammatory process, the presence of a benign or malignant tumor .

In terms of practical application in medicine of the claimed invention, the speed and reliability of the recorded data are important. The mechanical microvibrations of the brain were studied, which are associated with the neurovascular reflex, mechanical manifestations of changes in the tone of the branched field of intracerebral vessels. Microvibrations of the brain correlate well with the electroencephalogram, which reflect the reflex activity of the brain and in many cases can be successfully used for various operating conditions.

The high noise immunity during registration of brain microvibrations and the reliability of the results obtained made it possible to reduce the registration time from 5 frames in 15 minutes (as in the prototype) to one information frame with a recording time of 160 seconds. The method is implemented using the device "Acoustoencephalogram spectrum recorder" "RS AEG-01".

The claimed method is carried out as follows.

The patient is seated in a chair. For sterility, a disposable cap is put on the head - a surgical cap is taken. Two piezoelectric sensors of mechanical microvibrations are placed in the region of temporal-parietal leads on the left and right hemispheres. The head is placed on the stop, during the recording the person sits motionless. One frame of head microvibrations is recorded for 160 seconds in the frequency band from 0.13 to 27 Hz. Next, signal processing is carried out - spectral analysis with the selection of at least 12600 frequency harmonics for each hemisphere and an integration time of 160 seconds. The spectral harmonics in the frequency band from 0.13 to 27 Hz are separated from the array of the left and right hemispheres, the spectrum is divided into (n=5) frequency sections (13.5-27 Hz; 6.9-13.5 Hz; 3, 4-6.9 Hz; 1.7-3.4 Hz; 0.13-1.7 Hz) characterizing the functional state of various groups of visceral reflexes and calculate the sum (area) of the asymmetry of the amplitudes of the spectrum envelopes of the right and left hemispheres for each spectral section, taking into account their weight coefficient Si (2, 5, 7, 6, 3), then, they search for decentralization zones, while counting the number of spectral harmonics (h) with minimum values of the spectrum amplitude in both hemispheres (≤m=0, 05), are multiplied by the weight coefficient So (0.35) and added to the sum of the areas of asymmetry of the spectrum envelope, while the ranges of the obtained index of individual health are divided into the following states:

1.2-3.0 units - healthy with normal development and balanced functions;

3.1-3.9 units - healthy with functional abnormalities, reduced body resistance;

4.0-4.9 units - healthy in the stage of compensation for chronic diseases, the functional capabilities of the body are preserved;

5.0-5.4 units - patients in the stage of subcompensation of chronic diseases, the functionality of the body is reduced;

5.5-6.0 units - patients with an exacerbation of the disease, the functionality of the body is significantly reduced;

6.1-8.0 units - Patients at risk of developing cancer.

It should be noted that the features of the distinctive part of the claims solve the following functional tasks:

The sign "using a spectral analysis of the rhythmic activity of the mechanical microvibrations of the brain" is fundamentally different from the registration of the bioelectric activity of the brain (electroencephalogram, magnetoencephalogram), which is a new and much more reliable technique that provides a better measurement of the spectrum in the range from 0.13 to 27 Hz, interference-proof and easy-to-use procedure for recording the rhythmic activity of the brain.

The sign “the number of spectral harmonics with minimum values of the spectrum amplitude in both hemispheres (≤m) is calculated, multiplied by the weight coefficient So and added to the sum of the asymmetry areas of the spectrum envelope” provides an opportunity to make more detailed, by the value of the obtained criterion for quantifying the state of individual health of a person than in the prototype, the conclusion about the various levels of the patient's condition. In particular, to make the index sensitive to the risk of developing or having cancer at various stages.

The sign "registration and spectral analysis of mechanical microvibrations of the brain was carried out on one information frame lasting 160 seconds" in contrast to the prototype, where the registration was carried out for 5 frames, i.e. 13 minutes, allows you to significantly expand the scope of the claimed method in medicine, for example, conducting various functional tests. Such a decrease in the registration time became possible due to the high reliability of registration of mechanical microvibrations of the brain, especially in the low-frequency part of the spectrum below one hertz.

The sign “in this case, during spectral analysis, the number of spectral harmonics in the frequency range from 0.13 to 27 Hz is increased from 840 to 12600”, significantly increased the reliability of counting the number of spectral harmonics with minimum amplitude values and it became possible to assess decentralization zones - the most important source and sign oncological disease.

Thus, a comparison of the features of the claimed solution with the features of analogues and prototype indicates its compliance with the criterion of "novelty".

In the prior art, no features have been identified that relate to a similar purpose and provide the claimed technical result. Thus, the claimed invention meets the criterion of patentability "inventive step".

The following examples of the implementation of the claimed invention indicate that the claimed invention meets the criterion of patentability "industrial applicability".

EXAMPLES OF IMPLEMENTATION OF THE CLAIMED INVENTION.

The presented examples of the use of IIS for assessing the state of the human body show their correctness in relation to alternative methods of research, high information content, ease of retrieval of information in conditions of long-term monitoring.

In addition to studies of the IHI index by health status groups (Table 1), data are presented on long-term monitoring of the IDC index in some practically healthy and sick people, Fig. 1 - Fig. 6. At the same time, people were ranked according to their health status from perfect health to stage 4 cancer. The HMI index varied from 3.0 to 7.8 units. On FIG. 7 shows a patient in the process of health monitoring in the treatment of acute inflammation in the pyloric region of the stomach, FIG. 8 shows a patient being monitored for health status and risk of developing breast cancer - a "precancerous condition".

To verify the health status of the examined patient, extracts from preventive examination cards, medical history, and patient interviews were used. For practically healthy people, the apparatus "Varicard" was used for spectral analysis of the heart rhythm, assessment of the tension of adaptive mechanisms, assessment of the level of health in terms of PARS (Traffic light system).

The proposed IMI measurement method can be used to assess the patient's health status in dynamics during the treatment and diagnostic process, mass preventive examinations of the population, systems for screening pathological conditions, systems for monitoring the operator when performing work requiring high responsibility, selecting contingents according to the level of health, etc. P.

Claims (7)

A method for assessing the state of the human body, including registration and spectral analysis of the bioelectrical activity of the brain by means of acoustic encephalography (AEG) with subsequent processing of the measurement results with the calculation of the criterion for quantifying the state of the human body, characterized in that from piezoelectric AEG sensors installed in the temporal-parietal region of the left and the right hemisphere of the brain, record the microvibrations of the head with a recording time of 160 seconds in the frequency band from 0.13 to 27 Hz, then conduct a spectral analysis with the selection of 12600 frequency harmonics for each hemisphere, while dividing the spectrum into 5 frequency sections: 13 .5-27 Hz, 6.9-13.5 Hz, 3.4-6.9 Hz, 1.7-3.4 Hz, 0.13-1.7 Hz, with a weighting factor (Si) for each the frequency section is respectively equal to: 2, 5, 7, 6, 3; then calculate the magnitude of the asymmetry of the amplitudes of the spectrum envelopes of the right and left hemispheres for each frequency section, sum the amplitudes of the spectrum envelopes of the right and left hemispheres obtained for each section and multiply by the weighting factor (Si), then search for decentralization zones by counting the number of spectral harmonics (h) with minimum values (m) of the amplitude of the spectrum in both hemispheres, where m ≤0.05, which is multiplied by the weighting factor So=0.35 and added to the resulting sum of the spectrum envelope amplitudes; receive an individual health index (IHI) and, if it is: 1.2-3.0 units - healthy with normal development and balanced functions; 3.1-3.9 units - healthy with functional abnormalities, reduced body resistance; 4.0-4.9 units - healthy in the stage of compensation for chronic diseases, the functional capabilities of the body are preserved; 5.0-5.4 units - patients in the stage of subcompensation of chronic diseases, the functionality of the body is reduced; 5.5-6.0 units - patients with an exacerbation of the disease, the functionality of the body is significantly reduced; 6.1-8.0 - patients at risk of developing cancer.

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