RU2773824C2 - New composition - Google Patents

Abstract

FIELD: personal hygiene.

SUBSTANCE: invention relates to a composition of a toothbrushing product with a high content of sodium bicarbonate. The proposed composition includes from 50 to 70 wt.% of sodium bicarbonate and from 2 to 4 wt.% of a surfactant system consisting of at least 0.3 wt.% of cocoamidopropylbetaine in combination with at least 1.5 wt.% of sodium lauryl sulfate (hereinafter – SLS).

EFFECT: composition of a toothbrushing product with a high content of sodium bicarbonate shows stability, gives a good foam volume and has pleasant organoleptic properties, which is provided by the above-mentioned combination of surfactants of SLS and cocoamidopropylbetaine.

7 cl, 2 dwg, 4 tbl, 4 ex

Description

Technical field

The present invention relates to an aqueous sodium bicarbonate dentifrice composition comprising a novel surfactant system. In particular, the invention relates to a dentifrice composition containing sodium bicarbonate and a combination of surfactants including betaine and sodium lauryl sulfate. Such a dentifrice composition exhibits stability, good lather volume and pleasant organoleptic properties.

State of the art

The use of sodium bicarbonate in dentifrices is well known. One example is the commercial product Parodontax, which contains 67 wt. % sodium bicarbonate. Any dentifrice, in particular a sodium bicarbonate dentifrice, must be acceptable to the consumer and exhibit, for example, acceptable taste, texture and adequate foaming when brushing the teeth. Any such composition should also be stable and should not be subject to syneresis, which is a decrease in the volume of the gel, accompanied by separation of the liquid.

These organoleptic properties can be difficult to achieve, for example, as described in WO2006/052743 (Church & Dwight Co., hie), which discloses an aqueous cleaning composition containing at least 20 wt. % alkali metal bicarbonate and a surfactant containing sodium decyl sulfate, which is claimed to have superior properties over other surfactant systems tested. Sodium decyl sulfate is claimed as the surfactant of choice because sodium lauryl sulfate (SLS) becomes insoluble and produces very little foam when formulated into a bicarbonate-containing dentifrice. In addition, sodium lauryl sarcosinate (SLS), although forming a rich foam, causes phase separation of the bicarbonate-containing dentifrice even at room temperature. In addition, combinations of SLS and LSON did not result in a dentifrice composition that produces rich foam and is phase stable at room temperature. Another commercially approved surfactant, namely cocamidopropyl betaine (CAPB), has been claimed to produce significant foam in the presence of bicarbonate, but causes phase separation in dentifrice containing bicarbonate, and it has been found that combinations of SLS and CAPS do not provide a dentifrice composition that produces significant foam and remains stable.

It has now been found that the combination of SLS surfactants and betaine in a toothpaste containing at least 50 wt. % sodium bicarbonate, provides good foaming properties and maintaining phase stability without syneresis. This is unexpected given the information from WO2006/052743 that the combination of SLS and CABP (cocamidopropyl betaine) does not provide a bicarbonate-based dentifrice that is both phase stable and produces a significant amount of foam.

Brief Description of the Invention The present invention provides a dentifrice composition comprising at least 50 wt. % sodium bicarbonate and from 2 wt. % up to 4 wt. % system of surfactants, consisting of at least 0.3 wt. % betaine in combination with at least 0.5 wt. % sodium lauryl sulfate (SLS).

Brief description of the drawings

On FIG. 1 is a graph of the foam test for prototypes and a control toothpaste.

On FIG. 2 presents our own sensory examination of the level of foam and consistency of the test samples and the control sample of toothpaste.

Detailed description of the invention Sodium bicarbonate may be present in an amount of 55 wt. % up to 90 wt. %, preferably from 60 wt. % up to 80 wt. %, more preferably from 65 wt. % up to 70 wt. %; for example, from 66 wt. % up to 68 wt. %.

The composition according to the invention comprises a surfactant system. The surfactant system consists of the surfactant betaine and the surfactant sodium lauryl sulfate present in a total amount of 2 wt. % up to 4 wt. %, preferably in a total amount of 2 wt. % up to 3 wt. %.

In their structure, betaine compounds contain an anionic functional group such as a carboxylate functional group and a cationic functional group such as a quaternary nitrogen functional group separated by a methylene group. These include n-alkyl betaines such as cetyl betaine and behenyl betaine and n-alkyl amido betaines such as cocoamidopropyl betaine. In one embodiment, the betaine is cocoamidopropyl betaine, commercially available from Evonik Industries AG under the tradename TEGO Betain C60.

Preferably, betaine is present in an amount of 0.3 wt. % to 2 wt. %, for example, from 0.4 wt. % to 1.5 wt. % and preferably from 0.5 wt. % to 0.7 wt. %. A suitable betaine is TEGO Betain C60, which can be purchased and prepared as a 47% aqueous solution, and the figures given in brackets in the examples indicate the active substance content of cocoamidopropyl betaine in a 47% solution.

Preferably, the surfactant sodium lauryl sulfate (SLS) is present in an amount of from 0.5 to 3.5 wt. %, preferably in an amount of from 1.0 to 3.0 wt. %, more preferably in an amount of from 1.5 to 2.5 wt. % and most preferably in an amount of from 1.75 to 2.25 wt. %.

In addition to the above ingredients, the compositions of the present invention may include a fluoride ion source, a desensitizing agent, an anti-plaque agent, an anti-tartar agent, a whitening agent, an anti-malodorous agent, an anti-inflammatory agent, for example, monoammonium glycyrrhizinate (GMA) , an antimicrobial agent, such as isopropylmethylphenol (IPMF), an antioxidant, an antifungal agent, a wound healing agent, such as hyaluronic acid, or a mixture of at least two of them. Such funds can be added in an amount that provides the desired therapeutic effect.

Suitable sources of fluoride ions for use in the compositions of the present invention include an alkali metal fluoride such as sodium fluoride, an alkali metal monofluorophosphate such as sodium monofluorophosphate, tin fluoride, or amine fluoride in an amount providing from 25 to 3500 ppm (parts per million). ) fluoride ions, preferably from 100 to 1500 ppm. A typical source of fluoride ions is sodium fluoride, for example, the composition may contain from 0.1 to 0.5 wt. % sodium fluoride, for example 0.204 wt. % (which corresponds to 927 ppm fluoride ions), 0.2542 wt. % (corresponding to 1150 ppm fluoride ions) or 0.315 wt. % (corresponding to 1426 ppm fluoride ions).

Such fluoride ions promote tooth remineralization and can increase the acid resistance of dental hard tissues to combat caries, dental erosion (ie, acid wear), and/or tooth wear.

Sodium bicarbonate imparts abrasive properties to the composition, however, an additional abrasive, such as silica, which has good cleaning properties, may be present. Examples of good cleaning silica abrasives include those commercially available under the trade names Zeodent 124, Tixosil 63, Sorbosil AC39, Sorbosil AC43 and Sorbosil AC35 and may be present in a suitable amount, for example up to 20 wt. %, or from 5 to 10 wt. %, preferably from 1.5 to 7 wt. %, for example 2 wt. %, based on the total weight of the composition.

Suitable humectants in the compositions of the invention include glycerin, xylitol, sorbitol, propylene glycol or polyethylene glycol, or mixtures of at least two of these substances; moreover, the humectant may be present in an amount of from 1.0 wt. % up to 20 wt. %, for example from 5 wt. % up to 15 wt. % or from 7 wt. % up to 10 wt. %, based on the total weight of the composition.

The compositions of the present invention contain additional formulating agents such as flavors, sweeteners, opacifiers or colorants and preservatives selected from those commonly used in the art of formulating oral hygiene compositions for such purposes.

Suitable sweeteners include sodium saccharinate and/or a natural product such as stevia which is a steviol glycoside sweetener which is an extract from the stevia plant and can be obtained from Tate & Lyle (known as TASTEVA stevia sweetener) or Cargill ( known as TRUVIA RA80 stevia leaf extract).

Preferably, the composition of the present invention includes a sweetener based on steviol glycosides in an amount of from 0.025 to 0.4 wt. %, preferably from 0.05 to 0.2 wt. %, more preferably from 0.075 to 0.125 wt. %.

The composition of the present invention may be prepared by mixing the components in an appropriate relative amount in any order that is convenient and suitable for preparing a dentifrice.

Example 1 Stability Study The aim of the study was to determine the stability profile for formulations

containing a combination of SLS and Tego Betain compared to a formulation containing a combination of Adinol and Tego Betain.

The test samples were placed under conditions of accelerated stability testing, including a temperature of 40°C and a relative humidity of 75%, for 2 months and tracked their physical properties to study the physical stability of the products. The compositions of toothpastes are given below.

Experimental samples 1 and 3 are compositions of the present invention, and experimental samples 2 and 4 are comparative examples.

results

Conclusion

SLS/Tego formulations with a total surfactant content of 2.4 and 2.53 wt. % were stable for 2 months and the corresponding AD/Tego formulations were not stable and showed syneresis.

Example 2 Foam Tests Foam volume was determined for formulations containing SLS alone (Trial 5), Tego Betain alone (Trial 7) and SLS with Tego Betain (Trials 6 and 8). All prototypes contained stevia. The control is a commercial Parodontax Ultra Clean containing 2.553% Tego Betain (1.2% active) and does not contain stevia.

Study

Foam properties were evaluated using SITA Foam Testing R2000. Samples were prepared at a ratio of paste to water of 1:9, ie 100 mg of paste was suspended in 900 ml of water to obtain a suspension sample which was stirred for 90 minutes (750 rpm). Samples were analyzed in three parallel tests and 31 measurements were made within 60 minutes.

SLS, Tego Betain, and Tasteva Stevia sweetener were tested in the amounts shown below. The results are presented graphically in Fig. one.

results

From the in vitro results shown in FIG. 1, it can be seen that Test Sample 6 (SLS/Tego Betain Inventive Formulation) has a similar foam volume to Test Sample 5 (SLS only).

Conclusion

The foaming properties of Prototype 7 (Tego Betain formulation only) are slightly improved by the addition of stevia sweetener, compared to the Tego Betain control without stevia. Test Samples 6 and 8 (SLS/Tego Betain formulations of the invention), also with Stevia, showed good foam volume values, especially Test Sample 6, in which SLS was present at 2.0 wt. % together with Tego Betain surfactant.

Example 3 Additional Foaming Studies

Conducted additional studies of foaming and consistency of the foam for the prototype 5, prototype 6 and prototype 7 in comparison with the control composition (as above).

Research

Individuals in the expert group received approximately 1.5 g of toothpaste dispensed per brush and then submerged the toothbrush in water. They brushed their teeth for 1 minute without swallowing and spit out the remnants.

Individuals in the expert group assessed certain sensory signs immediately after spitting, then rinsed their mouth thoroughly once with about 30 ml of water and spit again. The amount of foam and its consistency were evaluated, and for each sample, the evaluation was carried out three times.

results

From the in vivo results it can be seen that Prototype 6 (SLS/Tego Betaine combination) had a better foam consistency than Prototype 5 (SLS only) and Prototype 7 (Tego Betaine only) and the control, but in terms of foam amount it was at the same level as the control sample. The control sample showed a significantly higher level of foaming and consistency than the composition of the prototype 7.

The results are also presented graphically as shown in FIG. 2. The amount of foam is shown in the first column for each sample, and the consistency of the foam is shown in the second column.

Conclusion

The selection of Prototype 6 (SLS/Tego Betaine combination) as the cleaning system in the dentifrice formulation provides an advantage in organoleptic properties over Prototype 7 (Tego Betain only), Prototype 5 (SLS only), or control. The consumer will experience more foam and a thicker texture during brushing.

Example 4 Other Formulations of the Invention

Claims (7)

1. Composition means for cleaning teeth, including from 50 to 70 wt. % sodium bicarbonate and from 2 to 4 wt. % system of surfactants, consisting of at least 0.3 wt. % cocoamidopropyl betaine in combination with at least 1.5 wt. % sodium lauryl sulfate (SLS). 2. The composition according to p. 1, in which cocoamidopropyl betaine is present in an amount of from 0.3 to 2.0 wt. %. 3. The composition according to claim 1 or 2, in which SLS is present in an amount of from 1.5 to 3.5 wt. %. 4. The composition according to any one of paragraphs. 1-3, in which sodium bicarbonate is present in an amount of from 55 to 70 wt. % composition. 5. A composition according to any one of the preceding claims, comprising a stevia sweetener. 6. The composition according to p. 5, in which the stevia is present in an amount of from 0.025 to 0.4 wt. %. 7. The composition according to any one of paragraphs. 1-6 further comprising a fluoride ion source, a desensitizing agent, an antiplaque agent, an antitartar agent, a whitening agent, an antimalodorous agent, an anti-inflammatory agent, an antimicrobial agent, an antioxidant, an antifungal agent, a wound healing agent, or a mixture of at least two of them.

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