RU2767784C2 - АНТИ-GARP-TGF-β-АНТИТЕЛА - Google Patents

АНТИ-GARP-TGF-β-АНТИТЕЛА Download PDF

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RU2767784C2
RU2767784C2 RU2019140602A RU2019140602A RU2767784C2 RU 2767784 C2 RU2767784 C2 RU 2767784C2 RU 2019140602 A RU2019140602 A RU 2019140602A RU 2019140602 A RU2019140602 A RU 2019140602A RU 2767784 C2 RU2767784 C2 RU 2767784C2
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antibody
amino acid
tgf
seq
antibodies
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RU2019140602A
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RU2019140602A3 (https=
RU2019140602A (ru
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Себастьян ВАН ДЕР ВОНИНГ
Филип БОРЖИОН
Торстен Драйер
Лор МАРИЕН
Гитте Де Бук
Стефани ЛЬЕНАР
Софи Лукас
Пьер КУЛИ
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Ардженкс Бвба
Юниверсите Католик Де Лувэн
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2019140602A 2017-05-11 2018-05-11 АНТИ-GARP-TGF-β-АНТИТЕЛА RU2767784C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1707561.5A GB201707561D0 (en) 2017-05-11 2017-05-11 GARP-TGF-beta antibodies
GB1707561.5 2017-05-11
PCT/EP2018/062251 WO2018206790A1 (en) 2017-05-11 2018-05-11 GARP-TGF-β ANTIBODIES

Publications (3)

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RU2019140602A RU2019140602A (ru) 2021-06-11
RU2019140602A3 RU2019140602A3 (https=) 2021-07-23
RU2767784C2 true RU2767784C2 (ru) 2022-03-21

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US (4) US10479829B2 (https=)
EP (3) EP3606961B8 (https=)
JP (2) JP7118135B2 (https=)
KR (2) KR102664663B1 (https=)
CN (1) CN110945027B (https=)
AU (2) AU2018265241B2 (https=)
BR (1) BR112019023735A8 (https=)
CA (1) CA3061841C (https=)
CL (1) CL2019003211A1 (https=)
CO (1) CO2019013669A2 (https=)
CR (1) CR20190561A (https=)
CY (1) CY1125674T1 (https=)
DK (1) DK3606961T3 (https=)
DO (1) DOP2019000285A (https=)
EC (1) ECSP19087742A (https=)
ES (1) ES2921015T3 (https=)
GB (1) GB201707561D0 (https=)
HR (1) HRP20220787T1 (https=)
HU (1) HUE059237T2 (https=)
IL (2) IL305613A (https=)
LT (1) LT3606961T (https=)
MX (1) MX385670B (https=)
MY (1) MY199335A (https=)
NZ (1) NZ758647A (https=)
PE (1) PE20200618A1 (https=)
PH (1) PH12019502526A1 (https=)
PL (1) PL3606961T3 (https=)
PT (1) PT3606961T (https=)
RS (1) RS63361B1 (https=)
RU (1) RU2767784C2 (https=)
SG (1) SG10201914130VA (https=)
SI (1) SI3606961T1 (https=)
SM (1) SMT202200284T1 (https=)
UA (1) UA125534C2 (https=)
WO (1) WO2018206790A1 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3960855A1 (en) * 2001-12-28 2022-03-02 Chugai Seiyaku Kabushiki Kaisha Method for stabilizing proteins
EP3436480A4 (en) * 2016-03-30 2019-11-27 Musc Foundation for Research Development METHOD FOR THE TREATMENT AND DIAGNOSIS OF CANCER BY TARGETING GLYCOPROTEIN A REPETITION PREDOMINANT (GARP) AND FOR EFFECTIVE IMMUNOTHERAPY ALONE OR IN COMBINATION
CN114729370B (zh) 2019-08-28 2025-03-21 中外制药株式会社 跨物种抗潜伏TGF-β1抗体和使用方法
US20240190961A1 (en) 2019-10-25 2024-06-13 Daiichi Sankyo Company, Limited Combination of anti-garp antibody and immunomodulator
TW202135862A (zh) * 2020-01-11 2021-10-01 美商供石公司 TGFβ抑制劑及其用途
WO2021167703A1 (en) 2020-02-19 2021-08-26 Nammi Therapeutics, Inc. Formulated and/or co-formulated liposome compositions containing tgfb antagonist prodrugs useful in the treatment of cancer and methods thereof
US20230192867A1 (en) * 2020-05-15 2023-06-22 Bristol-Myers Squibb Company Antibodies to garp
WO2022103705A1 (en) * 2020-11-11 2022-05-19 Versapeutics Inc. Antibody variants against wnt receptor ryk
WO2022116877A1 (en) 2020-12-02 2022-06-09 Shanghai Henlius Biotech, Inc. ANTI-GARP/TGFβ ANTIBODIES AND METHODS OF USE
BR112023014319A2 (pt) * 2021-01-18 2023-09-26 Jiangxi Jemincare Group Co Ltd Anticorpo contra a proteína garp e aplicação do mesmo
US20260013513A1 (en) 2022-05-18 2026-01-15 Vestaron Corporation Pesticidal actx peptide variants
JP2025526336A (ja) 2022-07-22 2025-08-13 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル Ｔ細胞悪性腫瘍におけるバイオマーカー及びバイオターゲットとしてのｇａｒｐ
JP2025524957A (ja) 2022-07-29 2025-08-01 アッヴィ・バイオセラピューティクス・インコーポレイテッド 抗ＧＡＲＰ－ＴＧＦ－β１／ＰＤ－１併用療法
TW202434643A (zh) 2023-01-09 2024-09-01 大陸商北京拓界生物醫藥科技有限公司 ＴＧＦβ１結合分子、ＧＡＲＰ－ＴＧＦβ１結合分子及其醫藥用途
CN118829657A (zh) * 2023-02-06 2024-10-22 贝达药业股份有限公司 多特异性抗体及其应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2455358C2 (ru) * 2003-08-22 2012-07-10 Проекто Де Биомедисина Сима, С.Л. ПРИМЕНЕНИЕ ПОСЛЕДОВАТЕЛЬНОСТИ ДНК, КОТОРАЯ КОДИРУЕТ ПЕПТИД, СПОСОБНЫЙ СВЯЗЫВАТЬСЯ С ТРАНСФОРМИРУЮЩИМ ФАКТОРОМ РОСТА β1 (ВАРИАНТЫ)
WO2015015003A1 (en) * 2013-08-01 2015-02-05 Université Catholique de Louvain Anti-garp protein and uses thereof
WO2016125017A1 (en) * 2015-02-03 2016-08-11 Universite Catholique De Louvain Anti-garp protein and uses thereof

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5892019A (en) 1987-07-15 1999-04-06 The United States Of America, As Represented By The Department Of Health And Human Services Production of a single-gene-encoded immunoglobulin
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
US6673986B1 (en) 1990-01-12 2004-01-06 Abgenix, Inc. Generation of xenogeneic antibodies
ATE207080T1 (de) 1991-11-25 2001-11-15 Enzon Inc Multivalente antigen-bindende proteine
NZ298145A (en) 1994-12-29 1998-08-26 Yamanouchi Pharma Co Ltd Monoclonal antibodies having inhibitory effect on type ii phospholipase a2, proteins forming part thereof, cells producing them, dna encoding them, recombinant vector comprising the dna and medicament
US7709610B2 (en) 2003-05-08 2010-05-04 Facet Biotech Corporation Therapeutic use of anti-CS1 antibodies
US20070048785A1 (en) 2004-06-09 2007-03-01 Lin Laura L Anti-IL-13 antibodies and complexes
WO2006103639A2 (en) 2005-03-31 2006-10-05 Case Western Reserve University Methods and reagents for identifying/isolating t regulatory (treg) cells and for treating individuals
US20110086367A1 (en) 2006-04-03 2011-04-14 Medizinische Hochschule Hannover Pharmaceuticals for influencing the reaction of the human immune system
WO2009073163A1 (en) 2007-12-03 2009-06-11 American Type Culture Collection (Atcc) Avian influenza antibodies, compositions, and methods thereof
GB2461546B (en) 2008-07-02 2010-07-07 Argen X Bv Antigen binding polypeptides
WO2010022341A1 (en) 2008-08-21 2010-02-25 The United State Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of enriching and using regulatory t cells
KR101492052B1 (ko) 2012-06-26 2015-02-10 (주)대창솔루션 액화가스 운반용 탱크
EP2977386A1 (en) 2012-08-31 2016-01-27 Argen-X Nv Method for producing antibody molecules having inter-species, intra-target cross-reactivity
RS61778B1 (sr) 2013-05-06 2021-06-30 Scholar Rock Inc Kompozicije i postupci za modulaciju faktora rasta
EP2832747A1 (en) * 2013-08-01 2015-02-04 Université Catholique de Louvain Anti-GARP protein and uses thereof
DK3354729T5 (da) * 2015-09-24 2024-09-30 Daiichi Sankyo Co Ltd Anti-garp-antistof
CN110049773A (zh) * 2016-07-14 2019-07-23 供石公司 TGFβ抗体、方法和用途

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2455358C2 (ru) * 2003-08-22 2012-07-10 Проекто Де Биомедисина Сима, С.Л. ПРИМЕНЕНИЕ ПОСЛЕДОВАТЕЛЬНОСТИ ДНК, КОТОРАЯ КОДИРУЕТ ПЕПТИД, СПОСОБНЫЙ СВЯЗЫВАТЬСЯ С ТРАНСФОРМИРУЮЩИМ ФАКТОРОМ РОСТА β1 (ВАРИАНТЫ)
WO2015015003A1 (en) * 2013-08-01 2015-02-05 Université Catholique de Louvain Anti-garp protein and uses thereof
WO2016125017A1 (en) * 2015-02-03 2016-08-11 Universite Catholique De Louvain Anti-garp protein and uses thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CUENDE J. et al., Monoclonal antibodies against GARP/TGF-β1 complexes inhibit the immunosuppressive activity of human regulatory T cells in vivo, SCIENCE TRANSLATIONAL MEDICINE, 2015, vol. 7, no. 284, p. 284ra56. *
WANG R. et al., GARP regulates the bioavailability and activation of TGFβ, Molecular biology of the cell, 2012, Vol. 23, No. 6, p.1129-1139. *
WANG R. et al., GARP regulates the bioavailability and activation of TGFβ, Molecular biology of the cell, 2012, Vol. 23, No. 6, p.1129-1139. CUENDE J. et al., Monoclonal antibodies against GARP/TGF-β1 complexes inhibit the immunosuppressive activity of human regulatory T cells in vivo, SCIENCE TRANSLATIONAL MEDICINE, 2015, vol. 7, no. 284, p. 284ra56. *

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JP7118135B2 (ja) 2022-08-15
US20210324061A1 (en) 2021-10-21
CA3061841A1 (en) 2018-11-15
MX385670B (es) 2025-03-18
EP4086286A1 (en) 2022-11-09
RS63361B1 (sr) 2022-07-29
IL270236B1 (en) 2023-10-01
KR102664663B1 (ko) 2024-05-23
BR112019023735A2 (pt) 2020-06-09
US10793627B2 (en) 2020-10-06
JP2022169549A (ja) 2022-11-09
US20200095311A1 (en) 2020-03-26
BR112019023735A8 (pt) 2023-01-31
ECSP19087742A (es) 2020-05-29
CN110945027B (zh) 2023-08-01
IL305613A (en) 2023-11-01
IL270236B2 (en) 2024-02-01
DOP2019000285A (es) 2020-07-15
CL2019003211A1 (es) 2020-04-24
JP2020519308A (ja) 2020-07-02
LT3606961T (lt) 2022-07-11
GB201707561D0 (en) 2017-06-28
EP3606961A1 (en) 2020-02-12
EP3606961B8 (en) 2022-07-13
PE20200618A1 (es) 2020-03-11
CO2019013669A2 (es) 2020-04-01
WO2018206790A1 (en) 2018-11-15
EP4282430A2 (en) 2023-11-29
PT3606961T (pt) 2022-07-04
MX2019013490A (es) 2021-08-26
CN110945027A (zh) 2020-03-31
EP3606961B1 (en) 2022-06-01
PH12019502526A1 (en) 2020-07-20
KR20200027469A (ko) 2020-03-12
SMT202200284T1 (it) 2022-09-14
IL270236A (https=) 2019-12-31
PL3606961T3 (pl) 2022-08-16
CR20190561A (es) 2020-04-04
AU2018265241B2 (en) 2021-11-04
CA3061841C (en) 2022-08-09
UA125534C2 (uk) 2022-04-13
US20190375832A1 (en) 2019-12-12
US10479829B2 (en) 2019-11-19
US10875914B2 (en) 2020-12-29
NZ758647A (en) 2022-07-29
HRP20220787T1 (hr) 2022-09-16
MY199335A (en) 2023-10-24
RU2019140602A3 (https=) 2021-07-23
HUE059237T2 (hu) 2022-11-28
SI3606961T1 (sl) 2022-10-28
AU2018265241A1 (en) 2019-11-21
ES2921015T3 (es) 2022-08-16
EP4282430A3 (en) 2024-04-03
SG10201914130VA (en) 2020-03-30
AU2021240255A1 (en) 2021-10-28
RU2019140602A (ru) 2021-06-11
CY1125674T1 (el) 2025-05-09
DK3606961T3 (da) 2022-07-04
KR20240065192A (ko) 2024-05-14
US20180327487A1 (en) 2018-11-15

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