RU2766353C2 - Synp198, промотор для специфической экспрессии генов в ганглионарных клетках сетчатки, избирательных в отношении направления - Google Patents

Synp198, промотор для специфической экспрессии генов в ганглионарных клетках сетчатки, избирательных в отношении направления Download PDF

Info

Publication number
RU2766353C2
RU2766353C2 RU2019115117A RU2019115117A RU2766353C2 RU 2766353 C2 RU2766353 C2 RU 2766353C2 RU 2019115117 A RU2019115117 A RU 2019115117A RU 2019115117 A RU2019115117 A RU 2019115117A RU 2766353 C2 RU2766353 C2 RU 2766353C2
Authority
RU
Russia
Prior art keywords
nucleic acid
cell
expression
gene
isolated
Prior art date
Application number
RU2019115117A
Other languages
English (en)
Russian (ru)
Other versions
RU2019115117A (ru
RU2019115117A3 (OSRAM
Inventor
Доминик ХАРТЛЬ
Жозефин ЮТТНЕР
Арнауд КРЕБС
Ботонд Роска
Дирк ШУБЕЛЕР
Original Assignee
Фридрих Мишер Инститьют Фор Байомедикал Рисерч
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Фридрих Мишер Инститьют Фор Байомедикал Рисерч filed Critical Фридрих Мишер Инститьют Фор Байомедикал Рисерч
Publication of RU2019115117A publication Critical patent/RU2019115117A/ru
Publication of RU2019115117A3 publication Critical patent/RU2019115117A3/ru
Application granted granted Critical
Publication of RU2766353C2 publication Critical patent/RU2766353C2/ru

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0618Cells of the nervous system
    • C12N5/0619Neurons
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0618Cells of the nervous system
    • C12N5/0621Eye cells, e.g. cornea, iris pigmented cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C12N2015/8527Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic for producing animal models, e.g. for tests or diseases
    • C12N2015/859Animal models comprising reporter system for screening tests
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00Genetically modified cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00Uses of viruses
    • C12N2799/02Uses of viruses as vector
    • C12N2799/021Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/022Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00Nucleic acids vectors
    • C12N2800/10Plasmid DNA
    • C12N2800/106Plasmid DNA for vertebrates

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Cell Biology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2019115117A 2016-11-02 2017-11-01 Synp198, промотор для специфической экспрессии генов в ганглионарных клетках сетчатки, избирательных в отношении направления RU2766353C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16196818 2016-11-02
EP16196818.5 2016-11-02
PCT/IB2017/056792 WO2018083607A1 (en) 2016-11-02 2017-11-01 Synp198, a promoter for the specific expression of genes in direction selective retinal ganglion cells

Publications (3)

Publication Number Publication Date
RU2019115117A RU2019115117A (ru) 2020-12-03
RU2019115117A3 RU2019115117A3 (OSRAM) 2021-03-23
RU2766353C2 true RU2766353C2 (ru) 2022-03-15

Family

ID=57223559

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2019115117A RU2766353C2 (ru) 2016-11-02 2017-11-01 Synp198, промотор для специфической экспрессии генов в ганглионарных клетках сетчатки, избирательных в отношении направления

Country Status (11)

Country Link
US (1) US11525145B2 (OSRAM)
EP (1) EP3534966B1 (OSRAM)
JP (1) JP7023279B2 (OSRAM)
KR (1) KR20190077471A (OSRAM)
CN (1) CN110072557B (OSRAM)
AU (1) AU2017354086C1 (OSRAM)
BR (1) BR112019008488A2 (OSRAM)
CA (1) CA3042197A1 (OSRAM)
IL (1) IL266115A (OSRAM)
RU (1) RU2766353C2 (OSRAM)
WO (1) WO2018083607A1 (OSRAM)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2010011467A (es) 2008-04-18 2011-02-15 Novartis Forschungsstiftung Novedosas herramientas y metodos terapeuticos para tratar la ceguera.
EP3289090B1 (en) 2015-04-30 2019-06-26 Friedrich Miescher Institute for Biomedical Research Promoter for the specific expression of genes in müller cells
US10857241B2 (en) 2015-09-15 2020-12-08 Friedrich Miescher Institute For Biomedical Research Therapeutical tools and methods for treating blindness by targeting photoreceptors
EP3362101B1 (en) 2015-10-14 2021-05-19 Friedrich Miescher Institute for Biomedical Research Promoter for the specific expression of genes in retinal endothelial cells
US10995344B2 (en) 2015-12-03 2021-05-04 Friedrich Miescher Institute For Biomedical Research SYNP159, a promoter for the specific expression of genes in rod photoreceptors
CN108474001B (zh) 2015-12-03 2022-04-08 弗里德里克·米谢尔生物医学研究所 SynP160,用于基因在视杆光感受器中特异性表达的启动子
WO2017093936A1 (en) 2015-12-03 2017-06-08 Friedrich Miescher Institute For Biomedical Research Synp162, a promoter for the specific expression of genes in rod photoreceptors
ES2761328T3 (es) 2015-12-03 2020-05-19 Friedrich Miescher Institute For Biomedical Res SynP161, un promotor para la expresión específica de genes en fotorreceptores de bastón
KR20190077471A (ko) 2016-11-02 2019-07-03 프리드리히 미셔 인스티튜트 포 바이오메디칼 리서치 방향 선택적인 망막 신경절 세포에서의 유전자의 특이적 발현을 위한 프로모터, synp198
CN110392582A (zh) 2017-02-08 2019-10-29 弗里德里克·米谢尔生物医学研究所 用于使基因在视网膜神经节细胞中特异性表达的启动子SynP88
SG11202004205YA (en) 2017-11-15 2020-06-29 Friedrich Miescher Institute For Biomedical Res Primate retinal pigment epithelium cell-specific promoter
AU2018376259A1 (en) 2017-11-30 2020-06-11 Friedrich Miescher Institute For Biomedical Research SynPIII, a promoter for the specific expression of genes in retinal pigment epithelium
EP3870242A1 (en) * 2018-10-25 2021-09-01 Friedrich Miescher Institute for Biomedical Research Synp151 (proc29), a promoter for the specific expression of genes in retinal ganglion cells
WO2022178410A1 (en) * 2021-02-22 2022-08-25 The Regents Of The University Of Colorado, A Body Corporate Viral vector-based gene therapy for ocular conditions

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA022418B1 (ru) * 2008-10-22 2015-12-30 Кварк Фармасьютикалс, Инк. Способы лечения заболеваний глаз

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2685900A1 (en) * 2006-05-04 2007-11-15 Wayne State University Restoration of visual responses by in vivo delivery of rhodopsin nucleic acids
EP1891976A1 (en) 2006-08-23 2008-02-27 Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute for Biomedical Research Use of light sensitive genes
MX2010011467A (es) 2008-04-18 2011-02-15 Novartis Forschungsstiftung Novedosas herramientas y metodos terapeuticos para tratar la ceguera.
EP2776459A1 (en) * 2011-11-08 2014-09-17 Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research Rod cell-specific promoter
US9579399B2 (en) 2012-08-27 2017-02-28 Friedrich Miescher Institute For Biomedical Research Retinal OFF circuit-specific promoter
CA2912525A1 (en) * 2013-05-16 2014-11-20 Applied Genetic Technologies Corporation Promoters, expression cassettes, vectors, kits, and methods for the treatment of achromatopsia and other diseases
EP3007730A1 (en) 2013-06-11 2016-04-20 Friedrich Miescher Institute for Biomedical Research Retinal on bipolar cells-specific artificial promoter
EP3104895A1 (en) 2014-02-10 2016-12-21 Friedrich Miescher Institute for Biomedical Research Aii retinal amacrine cell-specific promoter
WO2015121793A1 (en) 2014-02-11 2015-08-20 Friedrich Miescher Institute For Biomedical Research Müller cell-specific promoter
EP3289090B1 (en) 2015-04-30 2019-06-26 Friedrich Miescher Institute for Biomedical Research Promoter for the specific expression of genes in müller cells
US10857241B2 (en) 2015-09-15 2020-12-08 Friedrich Miescher Institute For Biomedical Research Therapeutical tools and methods for treating blindness by targeting photoreceptors
EP3362101B1 (en) 2015-10-14 2021-05-19 Friedrich Miescher Institute for Biomedical Research Promoter for the specific expression of genes in retinal endothelial cells
WO2017093936A1 (en) 2015-12-03 2017-06-08 Friedrich Miescher Institute For Biomedical Research Synp162, a promoter for the specific expression of genes in rod photoreceptors
CN108474001B (zh) 2015-12-03 2022-04-08 弗里德里克·米谢尔生物医学研究所 SynP160,用于基因在视杆光感受器中特异性表达的启动子
ES2761328T3 (es) 2015-12-03 2020-05-19 Friedrich Miescher Institute For Biomedical Res SynP161, un promotor para la expresión específica de genes en fotorreceptores de bastón
US10995344B2 (en) 2015-12-03 2021-05-04 Friedrich Miescher Institute For Biomedical Research SYNP159, a promoter for the specific expression of genes in rod photoreceptors
KR102312253B1 (ko) 2015-12-04 2021-10-15 쏘흐본느 유니베흐시테 프로모터 및 이의 용도
EP3458476A1 (en) 2016-05-17 2019-03-27 Friedrich Miescher Institute for Biomedical Research Novel therapeutic tools and methods for treating blindness
KR20190077471A (ko) 2016-11-02 2019-07-03 프리드리히 미셔 인스티튜트 포 바이오메디칼 리서치 방향 선택적인 망막 신경절 세포에서의 유전자의 특이적 발현을 위한 프로모터, synp198
US20190376082A1 (en) 2016-12-01 2019-12-12 Friedrich Miescher Institute For Biomedical Research Synp107, a promoter for the specific expression of genes in interneurons
CN110072558A (zh) 2016-12-01 2019-07-30 弗里德里克·米谢尔生物医学研究所 用于使基因在中间神经元中特异性表达的启动子SynPI
CN110392582A (zh) 2017-02-08 2019-10-29 弗里德里克·米谢尔生物医学研究所 用于使基因在视网膜神经节细胞中特异性表达的启动子SynP88
SG11202004205YA (en) 2017-11-15 2020-06-29 Friedrich Miescher Institute For Biomedical Res Primate retinal pigment epithelium cell-specific promoter
BR112020010775A2 (pt) 2017-11-30 2020-11-24 Friedrich Miescher Institute For Biomedical Research synp61, promotor específico à célula de epitélio de pigmento retiniano de primata
AU2018376259A1 (en) 2017-11-30 2020-06-11 Friedrich Miescher Institute For Biomedical Research SynPIII, a promoter for the specific expression of genes in retinal pigment epithelium
CN112912111A (zh) 2018-10-25 2021-06-04 弗里德里克·米谢尔生物医学研究所 用于视网膜神经节细胞中特异表达基因的启动子SynP17(ProB1)
WO2020084539A1 (en) 2018-10-25 2020-04-30 Friedrich Miescher Institute For Biomedical Research Synp57 (proa14), a promoter for the specific expression of genes in photoreceptors
US20210353773A1 (en) 2018-10-25 2021-11-18 Friedrich Miescher Institute For Biomedical Research Synp194 (prob15), a promoter for the specific expression of genes in retinal ganglion cells
EP3870709A1 (en) 2018-10-25 2021-09-01 Friedrich Miescher Institute for Biomedical Research Synp27 (prob12), a promoter for the specific expression of genes in protoplasmic astrocytes
EP3870242A1 (en) 2018-10-25 2021-09-01 Friedrich Miescher Institute for Biomedical Research Synp151 (proc29), a promoter for the specific expression of genes in retinal ganglion cells
JP2022512784A (ja) 2018-10-25 2022-02-07 フリードリッヒ ミーシェー インスティトゥート フォー バイオメディカル リサーチ 網膜神経節細胞中の遺伝子の特異的発現のためのプロモーターSynP78(ProA27)
EP3914300A1 (en) 2019-01-24 2021-12-01 Friedrich Miescher Institute for Biomedical Research Synp66 (proa21), a promoter for the specific expression of genes in retinal ganglion cells
WO2020152624A1 (en) 2019-01-24 2020-07-30 Friedrich Miescher Institute For Biomedical Research Synp35 (proc8), a promoter for the specific expression of genes in retinal ganglion cells
WO2020152623A1 (en) 2019-01-24 2020-07-30 Friedrich Miescher Institute For Biomedical Research Synp5 (proa9), a promoter for the specific expression of genes in retinal ganglion cells
WO2020152626A1 (en) 2019-01-24 2020-07-30 Friedrich Miescher Institute For Biomedical Research Synp166 (proa36), a promoter for the specific expression of genes in photoreceptors
JP2022520875A (ja) 2019-02-25 2022-04-01 ノバルティス アーゲー Biettiクリスタリン網膜症を治療するための組成物及び方法
EP3931334A1 (en) 2019-02-25 2022-01-05 Novartis AG Compositions and methods to treat bietti crystalline dystrophy

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA022418B1 (ru) * 2008-10-22 2015-12-30 Кварк Фармасьютикалс, Инк. Способы лечения заболеваний глаз

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BARLOW H. et al.The Mechanism of Directionally Selective Units in Rabbit's Retina, The Journal of Physiology, 1965, v. 178, n.3, p. 477-504. *
DATABASE EMBL, SEQ ID NO: AC133200, Mus musculus BAC clone RP23-292C19 from 3, 10.09.2002. DATABASE EMBL, SEQ ID NO: AC127260, Mus musculus BAC clone RP24-315I3 from chromosome 3, 18.07.2002. *
DATABASE EMBL, SEQ ID NO: AC133200, Mus musculus BAC clone RP23-292C19 from 3, 10.09.2002. DATABASE EMBL, SEQ ID NO: AC127260, Mus musculus BAC clone RP24-315I3 from chromosome 3, 18.07.2002. DOLFERUS R. et al. Differential interactions of promoter elements in stress responses of the Arabidopsis Adh gene, Plant Physiol, 1994, v. 105, n. 4, p. 1075-87. KIM J. et al. A 20 nucleotide upstream element is essential for the nopaline synthase (nos) promoter activity, Plant Molecular Biology, 1994, v. 24, n. 1, p.: 105-117. BARLOW H. et al.The Mechanism of Directionally Selective Units in Rabbit's Retina, The Journal of Physiology, 1965, v. 178, n.3, p. 477-504. *
DOLFERUS R. et al. Differential interactions of promoter elements in stress responses of the Arabidopsis Adh gene, Plant Physiol, 1994, v. 105, n. 4, p. 1075-87. *
KIM J. et al. A 20 nucleotide upstream element is essential for the nopaline synthase (nos) promoter activity, Plant Molecular Biology, 1994, v. 24, n. 1, p.: 105-117. *

Also Published As

Publication number Publication date
AU2017354086C1 (en) 2021-05-06
AU2017354086A1 (en) 2019-05-09
CN110072557A (zh) 2019-07-30
WO2018083607A1 (en) 2018-05-11
US11525145B2 (en) 2022-12-13
IL266115A (en) 2019-06-30
CN110072557B (zh) 2022-11-11
RU2019115117A (ru) 2020-12-03
CA3042197A1 (en) 2018-05-11
KR20190077471A (ko) 2019-07-03
JP7023279B2 (ja) 2022-02-21
AU2017354086B2 (en) 2021-01-28
US20190276847A1 (en) 2019-09-12
EP3534966B1 (en) 2024-06-19
EP3534966A1 (en) 2019-09-11
JP2019537437A (ja) 2019-12-26
RU2019115117A3 (OSRAM) 2021-03-23
BR112019008488A2 (pt) 2019-07-09

Similar Documents

Publication Publication Date Title
RU2766353C2 (ru) Synp198, промотор для специфической экспрессии генов в ганглионарных клетках сетчатки, избирательных в отношении направления
AU2020203733B2 (en) SynP161, a promoter for the specific expression of genes in rod photoreceptors
US11591618B2 (en) SynP159, a promoter for the expression of genes
US11883507B2 (en) Expression cassette with a SynP160 promoter
US11608365B2 (en) SYNP162, a promoter for the expression of genes
JP7112414B2 (ja) 網膜神経節細胞中の遺伝子の特異的発現のためのプロモーターsynp88
EP3362101B1 (en) Promoter for the specific expression of genes in retinal endothelial cells
EP3176177A1 (en) Synp157, a promoter for the specific expression of genes in rod photoreceptors