AU2017354086C1 - SynP198, a promoter for the specific expression of genes in direction selective retinal ganglion cells - Google Patents
SynP198, a promoter for the specific expression of genes in direction selective retinal ganglion cells Download PDFInfo
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- AU2017354086C1 AU2017354086C1 AU2017354086A AU2017354086A AU2017354086C1 AU 2017354086 C1 AU2017354086 C1 AU 2017354086C1 AU 2017354086 A AU2017354086 A AU 2017354086A AU 2017354086 A AU2017354086 A AU 2017354086A AU 2017354086 C1 AU2017354086 C1 AU 2017354086C1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0619—Neurons
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
- C12N2015/8527—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic for producing animal models, e.g. for tests or diseases
- C12N2015/859—Animal models comprising reporter system for screening tests
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/106—Plasmid DNA for vertebrates
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Neurology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16196818.5 | 2016-11-02 | ||
| EP16196818 | 2016-11-02 | ||
| PCT/IB2017/056792 WO2018083607A1 (en) | 2016-11-02 | 2017-11-01 | Synp198, a promoter for the specific expression of genes in direction selective retinal ganglion cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| AU2017354086A1 AU2017354086A1 (en) | 2019-05-09 |
| AU2017354086B2 AU2017354086B2 (en) | 2021-01-28 |
| AU2017354086C1 true AU2017354086C1 (en) | 2021-05-06 |
Family
ID=57223559
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2017354086A Ceased AU2017354086C1 (en) | 2016-11-02 | 2017-11-01 | SynP198, a promoter for the specific expression of genes in direction selective retinal ganglion cells |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US11525145B2 (OSRAM) |
| EP (1) | EP3534966B1 (OSRAM) |
| JP (1) | JP7023279B2 (OSRAM) |
| KR (1) | KR20190077471A (OSRAM) |
| CN (1) | CN110072557B (OSRAM) |
| AU (1) | AU2017354086C1 (OSRAM) |
| BR (1) | BR112019008488A2 (OSRAM) |
| CA (1) | CA3042197A1 (OSRAM) |
| IL (1) | IL266115A (OSRAM) |
| RU (1) | RU2766353C2 (OSRAM) |
| WO (1) | WO2018083607A1 (OSRAM) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2271369E (pt) | 2008-04-18 | 2014-07-10 | Novartis Forschungsstiftung | Novas ferramentas terapêuticas e métodos para tratar a cegueira |
| US10941417B2 (en) | 2015-04-30 | 2021-03-09 | Friedrich Miescher Institute For Biomedical Research | Promoter for the specific expression of genes in Müller cells |
| ES2926677T3 (es) | 2015-09-15 | 2022-10-27 | Friedrich Miescher Institute For Biomedical Res | Herramientas y métodos terapéuticos novedosos para tratar la ceguera mediante el direccionamiento a los fotorreceptores |
| EP3362101B1 (en) | 2015-10-14 | 2021-05-19 | Friedrich Miescher Institute for Biomedical Research | Promoter for the specific expression of genes in retinal endothelial cells |
| ES2886664T3 (es) | 2015-12-03 | 2021-12-20 | Friedrich Miescher Institute For Biomedical Res | SynP162, un promotor para la expresión específica de genes en fotorreceptores de bastón |
| CA3006952A1 (en) | 2015-12-03 | 2017-06-08 | Friedrich Miescher Institute For Biomedical Research | Synp161, a promoter for the specific expression of genes in rod photoreceptors |
| ES2900486T3 (es) | 2015-12-03 | 2022-03-17 | Friedrich Miescher Institute For Biomedical Res | SynP160, un promotor para la expresión específica de genes en los fotorreceptores de los bastones |
| WO2017093931A1 (en) | 2015-12-03 | 2017-06-08 | Friedrich Miescher Institute For Biomedical Research | Synp159, a promoter for the specific expression of genes in rod photoreceptors |
| RU2766353C2 (ru) | 2016-11-02 | 2022-03-15 | Фридрих Мишер Инститьют Фор Байомедикал Рисерч | Synp198, промотор для специфической экспрессии генов в ганглионарных клетках сетчатки, избирательных в отношении направления |
| WO2018146588A1 (en) | 2017-02-08 | 2018-08-16 | Friedrich Miescher Institute For Biomedical Research | Synp88, a promoter for the specific expression of genes in retinal ganglion cells |
| CA3082080A1 (en) | 2017-11-15 | 2019-05-23 | Friedrich Miescher Institute For Biomedical Research | Primate retinal pigment epithelium cell-specific promoter |
| CN111542611A (zh) | 2017-11-30 | 2020-08-14 | 弗里德里克·米谢尔生物医学研究所 | 用于使基因在视网膜色素上皮中特异性表达的启动子SynPIII |
| JP2022505517A (ja) * | 2018-10-25 | 2022-01-14 | フリードリッヒ ミーシェー インスティトゥート フォー バイオメディカル リサーチ | 網膜神経節細胞中の遺伝子の特異的発現のためのプロモーターＳｙｎＰ１５１（ＰｒｏＣ２９） |
| KR20230148207A (ko) * | 2021-02-22 | 2023-10-24 | 더 리전츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코퍼레이트 | 안구 병태에 대한 바이러스 벡터-기반 유전자 요법 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3437473A1 (en) * | 2006-05-04 | 2019-02-06 | Wayne State University | Restoration of visual responses by in vivo delivery of rhodopsin nucleic acids |
| EP1891976A1 (en) | 2006-08-23 | 2008-02-27 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute for Biomedical Research | Use of light sensitive genes |
| PT2271369E (pt) | 2008-04-18 | 2014-07-10 | Novartis Forschungsstiftung | Novas ferramentas terapêuticas e métodos para tratar a cegueira |
| AU2009308380B2 (en) * | 2008-10-22 | 2015-05-28 | Suzhou Ribo Life Science Co., Ltd. | Methods for treating eye disorders |
| US20140287510A1 (en) * | 2011-11-08 | 2014-09-25 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute | Rod cell-specific promoter |
| WO2014033095A1 (en) | 2012-08-27 | 2014-03-06 | Friedrich Miescher Institute For Biomedical Research | Retinal off circuit-specific promoter |
| EP3517135B1 (en) * | 2013-05-16 | 2025-11-19 | Beacon Therapeutics (USA), Inc. | Promoters, expression cassettes, vectors, kits, and methods for the treatment of achromatopsia and other diseases |
| US9862970B2 (en) | 2013-06-11 | 2018-01-09 | Friedrich Miescher Institute For Biomedical Research | Retinal on bipolar cells-specific artificial promoter |
| WO2015118507A1 (en) | 2014-02-10 | 2015-08-13 | Friedrich Miescher Institute For Biomedical Research | Aii retinal amacrine cell-specific promoter |
| ES2748282T3 (es) | 2014-02-11 | 2020-03-16 | Friedrich Miescher Institute For Biomedical Res | Promotor específico de células de Müller |
| US10941417B2 (en) | 2015-04-30 | 2021-03-09 | Friedrich Miescher Institute For Biomedical Research | Promoter for the specific expression of genes in Müller cells |
| ES2926677T3 (es) | 2015-09-15 | 2022-10-27 | Friedrich Miescher Institute For Biomedical Res | Herramientas y métodos terapéuticos novedosos para tratar la ceguera mediante el direccionamiento a los fotorreceptores |
| EP3362101B1 (en) | 2015-10-14 | 2021-05-19 | Friedrich Miescher Institute for Biomedical Research | Promoter for the specific expression of genes in retinal endothelial cells |
| WO2017093931A1 (en) | 2015-12-03 | 2017-06-08 | Friedrich Miescher Institute For Biomedical Research | Synp159, a promoter for the specific expression of genes in rod photoreceptors |
| ES2900486T3 (es) | 2015-12-03 | 2022-03-17 | Friedrich Miescher Institute For Biomedical Res | SynP160, un promotor para la expresión específica de genes en los fotorreceptores de los bastones |
| ES2886664T3 (es) | 2015-12-03 | 2021-12-20 | Friedrich Miescher Institute For Biomedical Res | SynP162, un promotor para la expresión específica de genes en fotorreceptores de bastón |
| CA3006952A1 (en) | 2015-12-03 | 2017-06-08 | Friedrich Miescher Institute For Biomedical Research | Synp161, a promoter for the specific expression of genes in rod photoreceptors |
| JP6966442B2 (ja) | 2015-12-04 | 2021-11-17 | ソルボンヌ・ユニヴェルシテSorbonne Universite | プロモーター及びその使用 |
| WO2017199156A1 (en) | 2016-05-17 | 2017-11-23 | Friedrich Miescher Institute For Biomedical Research | Novel therapeutic tools and methods for treating blindness |
| RU2766353C2 (ru) | 2016-11-02 | 2022-03-15 | Фридрих Мишер Инститьют Фор Байомедикал Рисерч | Synp198, промотор для специфической экспрессии генов в ганглионарных клетках сетчатки, избирательных в отношении направления |
| CN110072559A (zh) | 2016-12-01 | 2019-07-30 | 弗里德里克·米谢尔生物医学研究所 | 用于使基因在中间神经元中特异性表达的启动子SynP107 |
| EP3548094A1 (en) | 2016-12-01 | 2019-10-09 | Friedrich Miescher Institute for Biomedical Research | Synpi, a promoter for the specific expression of genes in interneurons |
| WO2018146588A1 (en) | 2017-02-08 | 2018-08-16 | Friedrich Miescher Institute For Biomedical Research | Synp88, a promoter for the specific expression of genes in retinal ganglion cells |
| CA3082080A1 (en) | 2017-11-15 | 2019-05-23 | Friedrich Miescher Institute For Biomedical Research | Primate retinal pigment epithelium cell-specific promoter |
| CN111542611A (zh) | 2017-11-30 | 2020-08-14 | 弗里德里克·米谢尔生物医学研究所 | 用于使基因在视网膜色素上皮中特异性表达的启动子SynPIII |
| JP7390290B2 (ja) | 2017-11-30 | 2023-12-01 | フリードリッヒ ミーシェー インスティトゥート フォー バイオメディカル リサーチ | 霊長類網膜色素上皮細胞特異的プロモーターＳｙｎＰ６１ |
| JP2022505516A (ja) | 2018-10-25 | 2022-01-14 | フリードリッヒ ミーシェー インスティトゥート フォー バイオメディカル リサーチ | 網膜神経節細胞中の遺伝子の特異的発現のためのプロモーターＳｙｎＰ１７（ＰｒｏＢ１） |
| JP2022505517A (ja) | 2018-10-25 | 2022-01-14 | フリードリッヒ ミーシェー インスティトゥート フォー バイオメディカル リサーチ | 網膜神経節細胞中の遺伝子の特異的発現のためのプロモーターＳｙｎＰ１５１（ＰｒｏＣ２９） |
| JP2022512784A (ja) | 2018-10-25 | 2022-02-07 | フリードリッヒ ミーシェー インスティトゥート フォー バイオメディカル リサーチ | 網膜神経節細胞中の遺伝子の特異的発現のためのプロモーターＳｙｎＰ７８（ＰｒｏＡ２７） |
| US20210388385A1 (en) | 2018-10-25 | 2021-12-16 | Friedrich Miescher Institute For Biomedical Research | Synp27 (prob12), a promoter for the specific expression of genes in protoplasmic astrocytes |
| WO2020084542A1 (en) | 2018-10-25 | 2020-04-30 | Friedrich Miescher Institute For Biomedical Research | Synp194 (prob15), a promoter for the specific expression of genes in retinal ganglion cells |
| WO2020084539A1 (en) | 2018-10-25 | 2020-04-30 | Friedrich Miescher Institute For Biomedical Research | Synp57 (proa14), a promoter for the specific expression of genes in photoreceptors |
| WO2020152626A1 (en) | 2019-01-24 | 2020-07-30 | Friedrich Miescher Institute For Biomedical Research | Synp166 (proa36), a promoter for the specific expression of genes in photoreceptors |
| EP3914299A1 (en) | 2019-01-24 | 2021-12-01 | Friedrich Miescher Institute for Biomedical Research | Synp5 (proa9), a promoter for the specific expression of genes in retinal ganglion cells |
| EP3914300A1 (en) | 2019-01-24 | 2021-12-01 | Friedrich Miescher Institute for Biomedical Research | Synp66 (proa21), a promoter for the specific expression of genes in retinal ganglion cells |
| EP3914721A1 (en) | 2019-01-24 | 2021-12-01 | Friedrich Miescher Institute for Biomedical Research | Synp35 (proc8), a promoter for the specific expression of genes in retinal ganglion cells |
| US20220154211A1 (en) | 2019-02-25 | 2022-05-19 | Novartis Ag | Compositions and methods to treat bietti crystalline dystrophy |
| MX2021010149A (es) | 2019-02-25 | 2021-09-14 | Novartis Ag | Composiciones y metodos para tratar la distrofia cristalina de bietti. |
-
2017
- 2017-11-01 RU RU2019115117A patent/RU2766353C2/ru active
- 2017-11-01 BR BR112019008488A patent/BR112019008488A2/pt not_active Application Discontinuation
- 2017-11-01 JP JP2019522550A patent/JP7023279B2/ja not_active Expired - Fee Related
- 2017-11-01 CA CA3042197A patent/CA3042197A1/en not_active Abandoned
- 2017-11-01 WO PCT/IB2017/056792 patent/WO2018083607A1/en not_active Ceased
- 2017-11-01 CN CN201780067090.8A patent/CN110072557B/zh not_active Expired - Fee Related
- 2017-11-01 US US16/346,680 patent/US11525145B2/en active Active
- 2017-11-01 KR KR1020197015426A patent/KR20190077471A/ko not_active Ceased
- 2017-11-01 AU AU2017354086A patent/AU2017354086C1/en not_active Ceased
- 2017-11-01 EP EP17811378.3A patent/EP3534966B1/en active Active
-
2019
- 2019-04-17 IL IL266115A patent/IL266115A/en unknown
Non-Patent Citations (2)
| Title |
|---|
| "Mus musculus BAC clone RP23-292C19 from 3, complete sequence.", EMBL, (2002-09-10), Database accession no. AC133200, URL: EBI * |
| "Mus musculus BAC clone RP24-315I3 from chromosome 3, complete sequence.", EMBL, (2002-07-18), Database accession no. AC127260, URL: EBI * |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2017354086A1 (en) | 2019-05-09 |
| AU2017354086B2 (en) | 2021-01-28 |
| CA3042197A1 (en) | 2018-05-11 |
| RU2019115117A (ru) | 2020-12-03 |
| JP2019537437A (ja) | 2019-12-26 |
| WO2018083607A1 (en) | 2018-05-11 |
| US20190276847A1 (en) | 2019-09-12 |
| KR20190077471A (ko) | 2019-07-03 |
| CN110072557B (zh) | 2022-11-11 |
| IL266115A (en) | 2019-06-30 |
| JP7023279B2 (ja) | 2022-02-21 |
| RU2766353C2 (ru) | 2022-03-15 |
| EP3534966B1 (en) | 2024-06-19 |
| RU2019115117A3 (OSRAM) | 2021-03-23 |
| CN110072557A (zh) | 2019-07-30 |
| US11525145B2 (en) | 2022-12-13 |
| BR112019008488A2 (pt) | 2019-07-09 |
| EP3534966A1 (en) | 2019-09-11 |
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| AU2017354086B2 (en) | SynP198, a promoter for the specific expression of genes in direction selective retinal ganglion cells | |
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Legal Events
| Date | Code | Title | Description |
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| DA2 | Applications for amendment section 104 |
Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 27 JAN 2021 |
|
| DA3 | Amendments made section 104 |
Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT FILED 27 JAN 2021 |
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