RU2756219C2 - Ингалятор с полостью определенного размера - Google Patents
Ингалятор с полостью определенного размера Download PDFInfo
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- RU2756219C2 RU2756219C2 RU2019116591A RU2019116591A RU2756219C2 RU 2756219 C2 RU2756219 C2 RU 2756219C2 RU 2019116591 A RU2019116591 A RU 2019116591A RU 2019116591 A RU2019116591 A RU 2019116591A RU 2756219 C2 RU2756219 C2 RU 2756219C2
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- Life Sciences & Earth Sciences (AREA)
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- Pulmonology (AREA)
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- Heart & Thoracic Surgery (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16201578 | 2016-11-30 | ||
| EP16201578.8 | 2016-11-30 | ||
| PCT/IB2017/057220 WO2018100462A1 (en) | 2016-11-30 | 2017-11-17 | Inhaler with sized cavity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2019116591A RU2019116591A (ru) | 2021-01-11 |
| RU2019116591A3 RU2019116591A3 (enExample) | 2021-04-07 |
| RU2756219C2 true RU2756219C2 (ru) | 2021-09-28 |
Family
ID=57460378
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2019116591A RU2756219C2 (ru) | 2016-11-30 | 2017-11-17 | Ингалятор с полостью определенного размера |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US11260184B2 (enExample) |
| EP (1) | EP3548126B1 (enExample) |
| JP (1) | JP7061123B2 (enExample) |
| KR (1) | KR102545359B1 (enExample) |
| CN (1) | CN109922851B (enExample) |
| AR (1) | AR110274A1 (enExample) |
| AU (1) | AU2017369978A1 (enExample) |
| BR (1) | BR112019008497A2 (enExample) |
| CA (1) | CA3037824A1 (enExample) |
| IL (1) | IL266804A (enExample) |
| MX (1) | MX2019005888A (enExample) |
| PH (1) | PH12019500695A1 (enExample) |
| RU (1) | RU2756219C2 (enExample) |
| WO (1) | WO2018100462A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3589146B1 (en) | 2017-02-28 | 2023-04-05 | Philip Morris Products S.A. | Aerosol-generating device comprising a powder de-agglomerating actuator |
| US11744960B2 (en) | 2017-12-28 | 2023-09-05 | Philip Morris Products S.A. | Inhaler with vortex tunnel |
| WO2021059094A1 (en) * | 2019-09-26 | 2021-04-01 | Philip Morris Products S.A. | Inhaler article with a twisted distal end element |
| AU2020370228B2 (en) * | 2019-10-25 | 2025-11-13 | Philip Morris Products S.A. | Holder for inhaler article |
| WO2021079343A1 (en) * | 2019-10-25 | 2021-04-29 | Philip Morris Products S.A. | Inhaler article with open distal end, and inhaler system |
| AU2020372031B2 (en) * | 2019-10-25 | 2025-10-30 | Philip Morris Products S.A. | Inhaler article with folded distal end |
| CN110812635A (zh) * | 2019-11-18 | 2020-02-21 | 德必来福有限公司 | 一种吸入粉雾剂给药装置 |
| BR112022014726A2 (pt) * | 2020-02-26 | 2022-10-11 | Philip Morris Products Sa | Bocal de inalador com canal de ar de aroma separado |
| US20230263238A1 (en) * | 2020-07-24 | 2023-08-24 | Philip Morris Products S.A. | Inhaler article |
| EP4210516A1 (en) * | 2020-09-07 | 2023-07-19 | JT International SA | An aerosol generating article and an aerosol generating system |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2399637A1 (en) * | 2009-02-23 | 2011-12-28 | Japan Tobacco, Inc. | Non-heating type tobacco flavor inhaler |
| RU121737U1 (ru) * | 2012-05-28 | 2012-11-10 | Александр Игоревич Тверезовский | Персональный ингалятор аэрозольного действия (варианты) |
| US20130327327A1 (en) * | 2012-06-06 | 2013-12-12 | Aerodesigns, Inc. | Aerosol dispenser with replaceable cartridge |
| WO2015166350A2 (en) * | 2014-04-28 | 2015-11-05 | Philip Morris Products S.A. | Flavoured nicotine powder inhaler |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2722935A (en) * | 1949-03-22 | 1955-11-08 | Robert E Thompson | Powder dispenser |
| US2569720A (en) * | 1949-03-22 | 1951-10-02 | Package Devices Inc | Medicinal inhaler |
| US2946332A (en) * | 1957-12-23 | 1960-07-26 | Nysco Lab Inc | Insufflator |
| US4069819A (en) * | 1973-04-13 | 1978-01-24 | Societa Farmaceutici S.P.A. | Inhalation device |
| US3888252A (en) * | 1974-01-23 | 1975-06-10 | Anthony J Side | Powder inhaler |
| IT1016489B (it) | 1974-03-18 | 1977-05-30 | Isf Spa | Inalatore |
| GB1521000A (en) * | 1975-06-13 | 1978-08-09 | Syntex Puerto Rico Inc | Inhalation device |
| US3991791A (en) * | 1975-11-24 | 1976-11-16 | Mueller Co. | Bayonet-type closure for line stopper fittings |
| DE3345722A1 (de) * | 1983-12-17 | 1985-06-27 | Boehringer Ingelheim KG, 6507 Ingelheim | Inhalator |
| IT1228459B (it) * | 1989-02-23 | 1991-06-19 | Phidea S R L | Inalatore con svuotamento regolare e completo della capsula. |
| US5797391A (en) * | 1991-03-28 | 1998-08-25 | Rhone-Poulenc Rorer Limited | Inhaler |
| US5727546A (en) * | 1993-08-18 | 1998-03-17 | Fisons Plc | Powder inhaler with breath flow regulation valve |
| US6123070A (en) * | 1996-06-07 | 2000-09-26 | Valois S.A. | Device for enhancing the emptying of an inhaler metering chamber |
| US6595210B2 (en) * | 2000-11-27 | 2003-07-22 | Unisia Jecs Corporation | Inhalator for administering powder composition |
| DE10129703A1 (de) * | 2001-06-22 | 2003-01-02 | Sofotec Gmbh & Co Kg | Zerstäubungssystem für eine Pulvermischung und Verfahren für Trockenpulverinhalatoren |
| US20030094173A1 (en) | 2001-11-14 | 2003-05-22 | Inhale Therapeutic Systems, Inc. | Aerosolization device with improved endpiece connection |
| ITMI20020078A1 (it) * | 2002-01-16 | 2003-07-16 | Fabrizio Niccolai | Dispositivo utilizzabile nel tratamento di affezzioni delle vie respiratorie |
| DE10258360A1 (de) * | 2002-12-12 | 2004-06-24 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pulverinhalator mit Kapselkammer zum Aufnehmen einer mit Wirkstoff gefüllten Einwegkapsel |
| US20040206350A1 (en) * | 2002-12-19 | 2004-10-21 | Nektar Therapeutics | Aerosolization apparatus with non-circular aerosolization chamber |
| US20040173211A1 (en) | 2003-01-14 | 2004-09-09 | Boehringer Ingelheim International Gmbh | Powder inhaler |
| CA2519228C (en) * | 2003-03-20 | 2014-10-14 | Galephar M/F | Improved dry powder inhaler system |
| US8869794B1 (en) * | 2003-04-09 | 2014-10-28 | Novartis Pharma Ag | Aerosolization apparatus with capsule puncturing member |
| ES2383367T5 (es) | 2003-04-09 | 2021-03-31 | Novartis Ag | Aparato de pulverización en forma de aerosol con protección de entrada de aire |
| GB2405798A (en) * | 2003-09-15 | 2005-03-16 | Vectura Ltd | Dry powder inhaler with primary and secondary piercing elements and a medicament pack for use with an inhalation device. |
| EP1797780A1 (en) * | 2005-12-15 | 2007-06-20 | Gallaher Limited | Smoking article |
| DE102006006647B3 (de) * | 2006-02-14 | 2007-01-18 | Braunform Gmbh | Vorrichtung zum Inhalieren eines in einer Kapsel sich befindenden Pulvers |
| DE102006016903A1 (de) * | 2006-04-11 | 2007-10-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Inhalator |
| EP3272379A1 (en) * | 2008-02-07 | 2018-01-24 | The University of Washington | Circumferential aerosol device |
| WO2012105236A1 (en) * | 2011-01-31 | 2012-08-09 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal delivery devices |
| JP2014516660A (ja) * | 2011-05-12 | 2014-07-17 | フォン・シュックマン、アルフレッド | 粉末状物質吸入用装置 |
| US10220165B2 (en) * | 2011-05-27 | 2019-03-05 | Boehringer Ingelheim International Gmbh | Inhalator and capsule for an inhalator |
| DE102012103482A1 (de) * | 2012-04-20 | 2013-10-24 | Alfred Von Schuckmann | Vorrichtung zum Inhalieren pulverförmiger Substanzen |
| US20140150787A1 (en) * | 2012-12-04 | 2014-06-05 | Civitas Therapeutics, Inc. | Devices and methods for puncturing a capsule to release a powdered medicament therefrom |
| US20150027468A1 (en) * | 2013-07-25 | 2015-01-29 | Altria Client Services Inc. | Electronic smoking article |
| US11116914B2 (en) * | 2014-11-09 | 2021-09-14 | Sipnose Ltd. | Device and method for aerosolized delivering of substance to a natural orifice of the body |
| WO2015042412A1 (en) * | 2013-09-20 | 2015-03-26 | E-Nicotine Technology. Inc. | Devices and methods for modifying delivery devices |
| SG11201604937XA (en) * | 2013-12-20 | 2016-07-28 | Philip Morris Products Sa | Smoking article having a filter including a capsule |
| MY185741A (en) * | 2014-05-02 | 2021-06-02 | Japan Tobacco Inc | Non-burning-type flavor inhaler and computer-readable medium |
| EP3157364B1 (en) | 2014-06-20 | 2018-08-22 | Philip Morris Products S.a.s. | Nicotine powder delivery system with airflow management means |
| EP3283148B1 (en) | 2015-04-15 | 2023-12-27 | Philip Morris Products S.A. | Dry powder inhalers with partial dosage delivery |
| CN204910375U (zh) * | 2015-08-04 | 2015-12-30 | 中山市美捷时包装制品有限公司 | 一种旋转立式胶囊干粉型吸入装置 |
-
2017
- 2017-11-17 CA CA3037824A patent/CA3037824A1/en not_active Abandoned
- 2017-11-17 RU RU2019116591A patent/RU2756219C2/ru active
- 2017-11-17 JP JP2019528800A patent/JP7061123B2/ja active Active
- 2017-11-17 US US16/464,790 patent/US11260184B2/en active Active
- 2017-11-17 WO PCT/IB2017/057220 patent/WO2018100462A1/en not_active Ceased
- 2017-11-17 BR BR112019008497A patent/BR112019008497A2/pt not_active Application Discontinuation
- 2017-11-17 EP EP17808605.4A patent/EP3548126B1/en active Active
- 2017-11-17 AU AU2017369978A patent/AU2017369978A1/en not_active Abandoned
- 2017-11-17 MX MX2019005888A patent/MX2019005888A/es unknown
- 2017-11-17 CN CN201780068583.3A patent/CN109922851B/zh active Active
- 2017-11-17 KR KR1020197012707A patent/KR102545359B1/ko active Active
- 2017-11-29 AR ARP170103332A patent/AR110274A1/es unknown
-
2019
- 2019-03-29 PH PH12019500695A patent/PH12019500695A1/en unknown
- 2019-05-22 IL IL266804A patent/IL266804A/en unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2399637A1 (en) * | 2009-02-23 | 2011-12-28 | Japan Tobacco, Inc. | Non-heating type tobacco flavor inhaler |
| RU121737U1 (ru) * | 2012-05-28 | 2012-11-10 | Александр Игоревич Тверезовский | Персональный ингалятор аэрозольного действия (варианты) |
| US20130327327A1 (en) * | 2012-06-06 | 2013-12-12 | Aerodesigns, Inc. | Aerosol dispenser with replaceable cartridge |
| WO2015166350A2 (en) * | 2014-04-28 | 2015-11-05 | Philip Morris Products S.A. | Flavoured nicotine powder inhaler |
Also Published As
| Publication number | Publication date |
|---|---|
| BR112019008497A2 (pt) | 2019-07-09 |
| WO2018100462A1 (en) | 2018-06-07 |
| RU2019116591A (ru) | 2021-01-11 |
| EP3548126B1 (en) | 2021-07-14 |
| CN109922851B (zh) | 2022-05-27 |
| KR20190089859A (ko) | 2019-07-31 |
| AR110274A1 (es) | 2019-03-13 |
| MX2019005888A (es) | 2019-08-14 |
| AU2017369978A1 (en) | 2019-04-11 |
| EP3548126A1 (en) | 2019-10-09 |
| KR102545359B1 (ko) | 2023-06-20 |
| CA3037824A1 (en) | 2018-06-07 |
| CN109922851A (zh) | 2019-06-21 |
| JP2019536453A (ja) | 2019-12-19 |
| JP7061123B2 (ja) | 2022-04-27 |
| PH12019500695A1 (en) | 2019-12-02 |
| US20190282769A1 (en) | 2019-09-19 |
| US11260184B2 (en) | 2022-03-01 |
| RU2019116591A3 (enExample) | 2021-04-07 |
| IL266804A (en) | 2019-07-31 |
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