RU2751060C1 - Mobile microbiological safety box - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention relates to the field of medical equipment and can be used when working with pathogenic biological agents. The mobile box contains an insulating working chamber with glove ports, an inflatable rigid base made of AirDeck, a frame, lashing straps for fixing the box on the laboratory bench, and an external filtering unit (EFU) with a box control panel. The working chamber is made of PVC with thickness of 0.5 mm, obtained using the technology of high-temperature splicing, and is equipped with a transfer gate made of polymer material with glove ports. There is a panel with sealed inputs for connecting the EFU on the side surface of the chamber. The frame is made in the form of insulated frame arches made of HDPE (high density polyethylene) located on the lateral sides of the box, equipped with LED lamps, and longitudinal struts to make the box rigid in the longitudinal direction. The working chamber and the transfer gate are made with hermetically sealed zippers.

EFFECT: box has a lightweight collapsible design, easy to transport for work in field conditions.

3 cl, 5 dwg

Description

The invention relates to the field of medical technology and is intended for use when equipping individual workplaces of employees working with pathogenic biological agents (PBA) in the field, and provides protection of the operator and the environment from contamination with aerosols arising from the work with PBA.

Currently, microbiological safety boxes are an integral part of research related to the study of pathogens of dangerous infectious diseases. Microbiological safety boxes are designed to protect the operator, laboratory premises and the environment from aerosols and splashes that may occur when working with pathogenic biological agents, as well as to protect experimental samples from external factors. Boxes are used to equip individual workplaces of employees working with PBA in accordance with the requirements for ensuring biological safety and protecting personnel from contamination.

Traditional boxes for microbiological safety have large dimensions, significant weight (more than 200 kg), which prevents their transportation and use in the field. This indicates a clear need for the development of a mobile, lightweight, foldable and quick-mount microbiological safety cabinet for field teams.

From sources of scientific and technical information, a portable biological safety glove box is known (Patent CN 204431285, IPC B25J 21/02) made of transparent thermoplastic polyurethane (TPU) in the form of a rectangular parallelepiped and having a negative pressure system at one end of the housing, and at the other end - filtration device. In each of the two sides of the body there are two working openings in which disposable medical gloves are located, on the upper side there is an opening for supplying liquid or gas inside, and there are also support rods and a fixing device for fixing the support rod. However, this biosafety glove box is designed for laboratory bench testing, which is not always feasible in the field. Also, this box does not have a device for transferring additional equipment during the research, and the lack of lighting limits research in the dark.

The objective of the invention is to create a mobile, lightweight, quickly collapsible and convenient for transportation by all modes of transport, a microbiological safety box for work by mobile teams in the field with pathogenic biological agents (PBA) of I-IV pathogenicity groups and meeting the requirements of regulatory documents presented to laboratory equipment when working with PBA.

The technical result consists in the implementation of the specified purpose.

The technical result is achieved by the fact that the mobile box for microbiological safety has an insulating working chamber made of PVC 0.5 mm thick by high-temperature splicing with additional sealing of the seams, a transfer gateway with glove ports, an inflatable rigid base made of AirDeck, an external filtering unit (FVU) with a control panel for all boxing functions and an indicator lamp; insulated frame arches made of low pressure polyethylene (HDPE) are installed on the sides of the working chamber and the transfer gateway; on the side surface of the working chamber there is a panel with more than 1 sealed inlet for connecting the FVU and internal filters; on the surface of the box, more than 1 rail washer are installed for attaching longitudinal struts and more than 1 longitudinal brace to stiffen the structure in the longitudinal direction; the front part of the working chamber of the box is made of transparent PVC film, into which the glove ports are built.

In addition, the box has more than 1 lashing strap for fixing the box to the work table;

In addition, the box has more than 1 sealed zipper;

In addition, the box is equipped with an ultraviolet radiation (UFO) lamp;

In addition, the box is equipped with a block of sockets with more than 1 connector for connecting additional electrical equipment in the boxing chamber;

In addition, the box is equipped with more than 1 LED light.

The claimed mobile box for microbiological safety is an insulating means of protection in the form of a ventilated chamber with a transfer gate made of polymeric materials. The reliability and tightness of the seams is ensured by the use of the technology of high-temperature splicing of materials, as well as high-frequency currents. The frame of the inventive box to maintain its shape and overall dimensions in cross-section is made in the form of arcs made of low-pressure polyethylene (HDPE). In the longitudinal direction, the shape and overall dimensions of the box are supported by CFRP struts, which are installed in the rail washers. The transfer gateway with glove ports allows you to safely place the necessary equipment and tools in the work area without turning off the filter ventilation unit (FVU).

The filter ventilation unit maintains the set pressure minus 50 Pa and the volume of air supply and removal required for ventilation of the working chamber. The box control system automatically maintains the specified operating parameters. The supplied and removed air is purified in two stages through the H14 aerosol HEPA filters.

The claimed mobile box for microbiological safety can be operated in the field without using special tabletops and supporting devices. The claimed microbiological safety mobile box is securely fixed on the work table with the help of lashing straps, the inflatable rigid base made of AirDeck creates a flat and firm work surface. This ensures that the work is carried out without the risk of overturning the test samples, laboratory glassware and equipment located in the working area.

The front part of the working chamber is made of a transparent polymer material and has an arched shape, which makes it possible to improve visual control over the work being carried out in the working area of the claimed box, since the operator's visual axis runs perpendicular to the surface of the polyurethane film. For the operator's comfort and greater mobility when performing manipulations in the working area, glove ports are built into the front of the working chamber of the inventive box, to which nitrile gloves are connected, which are impermeable and resistant to aggressive environments. The gloves are fastened to the sleeves of the glove ports of the working chamber and the transfer gateway through a plastic cuff using O-rings.

The zippers of the transfer gate and the working chamber are sealed gas protection zippers with plastic teeth. Sealed zippers are designed in such a way that they exclude the possibility of simultaneous opening on one side and the appearance of unprotected through access to the inside of the box.

An ultraviolet irradiation lamp (UFO) allows disinfection of the working area of the box before placing the sample in the box chamber and after performing work with the PBA.

The block of sockets allows you to connect the necessary additional electrical equipment in the working chamber of the box.

LED lamps, mounted on frame arcs, allow work in poor lighting conditions, as well as in the dark.

The control panel located on the filtering unit (FVU) serves to control all possible functions of the box: turning on and off the FVU, UFO lamp, lighting, setting the UFO lamp triggering timer, choosing the language for displaying information on the display, managing the information menu. The information display allows you to read information about the state of the system (differential pressure level, battery charge, temperature, humidity) and quickly respond based on the data received. With the help of an indicator lamp on the HLF, the operator evaluates the pressure values in the boxing chamber. When the system is operating in normal mode with pressure readings within the required limits, the lamp lights up green. When the pressure is outside the set limits, an audible alarm is triggered, and the indicator lamp flashes red. If the tightness of the box is broken or the filters are clogged, the alarm system is triggered: a sound signal appears, the message “ATTENTION! VIOLATION OF THE REGIME! ". The indicator lamp flashes red. The threshold values of the parameters, upon going beyond which the alarm system is triggered, are: minus 20 Pa minus 90 Pa.

The claimed invention is illustrated by drawings.

FIG. 1 shows a general view of the claimed mobile box for microbiological safety, where 1 is the working chamber of the box; 2 - transfer gateway; 3 - latching belts; 4 - inflatable rigid base made of Airdeck; 5 - frame arcs; 6 - rail washers; 7 - longitudinal struts; 8 - block of sockets; 9 - glove ports of the working chamber; 10 - glove ports of the gateway; 11 - sealed zippers; 12 - internal filters; 13 - external filters; 14 - air ducts; 15 - filtering unit; 16 - control panel; 17 - information display; 18 - indicator lamp; 19 - panel with leads for connecting FVU; 20 - ultraviolet irradiation lamp (UFO); 21 - LED lamps.

FIG. 2 shows a diagram of the control panel of the filtering unit (FVU), where 1 is an indicator lamp, 2 is an information display, 3 is a pressure sensor.

FIG. 3. - distribution of zones of the declared boxing.

FIG. 4 shows a diagram of the connection of gloves to the sleeves of the glove ports, where 1 is a glove; 2 - o-rings of the glove; 3 - plastic cuff; 4 - sleeve sealing ring; 5 - sleeve; 6 - sleeve edging; 7 - hem of the glove.

FIG. 5 declared box in the assembled state. The box is stored folded in the transport bag. Preparation for operation of the claimed box is carried out as follows.

Open the transport bag and remove the isolation chamber and HLF from it. Straighten the camera on the work surface by unfastening the airtight zippers to release the air. Then the base of the box is inflated using a compressor. Install the longitudinal spacers in the rail washers. The box is fixed on the working surface with the help of the lashing straps. The tensioning force of the belts is carried out by adjusting them along the length. Next, the HLF is connected to the box. Fully unfasten the outer and inner sealed zippers and screw in the inner filters. The UFO lamp is placed in the upper part of the working chamber in retaining loops, fixed with clamps and connected to the corresponding connector inside the working chamber of the box. Install gloves in the glove ports of the working chamber and the transfer lock. The working chamber of the box is disinfected using a UFO lamp. Then all the necessary equipment and tools are placed in the working chamber of the box. Devices operating from a 220 V network are connected to the socket block. Close the internal airtight zipper of the transfer lock, then fasten the external airtight zipper of the transfer lock. The FVU is switched on, after which the FVU automatically creates a pressure drop in the working chamber relative to the ambient pressure minus 50 ± 10 Pa, the indicator lamp lights up green. Working negative pressure is maintained automatically.

If it is necessary to place additional equipment in the working chamber of the box during operation (with the HLF turned on), you must make sure that the internal sealed zipper is closed all the way, and only then the external sealed zipper is unbuttoned. All necessary additional equipment is placed in the transfer gateway, an external airtight zipper is fastened. Then the internal airtight zipper is opened using the glove port of the airlock and the equipment is moved into the working chamber, after which the internal airtight zipper is closed.

After completion of the work, disinfection is performed using UFO. Turn off the power supply to the FVU, unfasten the outer and inner sealed zippers of the transfer gateway. Then the surfaces and contents of the working chamber and the transfer gate are sanitized with a liquid disinfectant. After disinfection, the equipment and tools used for work are removed from the working chamber and the transfer gateway. Disconnect the UFO lamp from the power connector, loosen the clips holding the lamp and remove it from the working chamber. Unscrew the internal and external filters and immerse them in a container filled with a 6% hydrogen peroxide solution with the addition of 0.5% detergent. The holding time of the filters is at least 2 hours. After disinfection, the filters are disposed of. Disconnect the HLF from the box. Fasten the inner and outer sealed zippers so that 10-15 cm remain unbuttoned. Remove the longitudinal spacers from the rail washers. Unfasten the pull straps, remove air from the base. By sliding the side parts of the box in the longitudinal direction towards each other, the box is assembled and placed in a transport bag.

The design features and technical characteristics of the claimed mobile lightweight box for microbiological safety provide the necessary conditions for working with PBA I-IV pathogenicity groups and meet the requirements of regulatory documents for laboratory equipment when working with PBA. The inventive box has a low weight and small dimensions, is convenient for transportation by all types of transport, easy to use and is designed for field teams to work in the field, where the promptness of deployment and compliance with biological safety measures is a prerequisite.

The applicant has made a prototype of a mobile lightweight box for microbiological safety, which has passed tests that have confirmed its compliance with the requirements of regulatory documents for laboratory equipment when working with PBA.

Claims (3)

1. A mobile box for microbiological safety, containing an insulating working chamber with glove ports, characterized in that it is equipped with an inflatable rigid base made of AirDeck, a frame, pulling straps for fixing the box on a work table and an external filtering unit (FVU) with a box control panel and an indicator lamp, while the insulating working chamber is made of PVC with a thickness of 0.5 mm, obtained using the technology of high-temperature splicing, and is equipped with a transfer gateway made of polymer material, made with glove ports, and a panel located on the side surface with sealed inputs for connecting the FVU, frame made in the form of insulated frame arches made of HDPE low-pressure polyethylene located on the sides of the box, equipped with LED lamps, and longitudinal spacers to make the box stiff in the longitudinal direction, installed in rail washers, and an insulating working chamber and a transfer gateway are made They are equipped with airtight zippers to provide access to the aforementioned transfer sluice and working chamber when unbuttoned. 2. A box according to claim 1, characterized in that it is equipped with an ultraviolet lamp. 3. Boxing according to claim 1, characterized in that it is provided with a block of sockets with connectors for connecting additional electrical equipment in the working chamber.

Images