RU2748652C2 - Производные имидазола как модуляторы формилпептидного рецептора - Google Patents

Производные имидазола как модуляторы формилпептидного рецептора Download PDF

Info

Publication number
RU2748652C2
RU2748652C2 RU2016145596A RU2016145596A RU2748652C2 RU 2748652 C2 RU2748652 C2 RU 2748652C2 RU 2016145596 A RU2016145596 A RU 2016145596A RU 2016145596 A RU2016145596 A RU 2016145596A RU 2748652 C2 RU2748652 C2 RU 2748652C2
Authority
RU
Russia
Prior art keywords
unsubstituted
alkyl
halogen
compound
acid
Prior art date
Application number
RU2016145596A
Other languages
English (en)
Russian (ru)
Other versions
RU2016145596A (ru
RU2016145596A3 (enExample
Inventor
Ричард Л. БИРД
Тьен Т. ДУОНГ
Майкл Е. ГАРСТ
Original Assignee
Аллерган, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Аллерган, Инк. filed Critical Аллерган, Инк.
Publication of RU2016145596A publication Critical patent/RU2016145596A/ru
Publication of RU2016145596A3 publication Critical patent/RU2016145596A3/ru
Application granted granted Critical
Publication of RU2748652C2 publication Critical patent/RU2748652C2/ru

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/04Artificial tears; Irrigation solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/4172Imidazole-alkanecarboxylic acids, e.g. histidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/4174Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2016145596A 2014-05-21 2015-05-21 Производные имидазола как модуляторы формилпептидного рецептора RU2748652C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462001188P 2014-05-21 2014-05-21
US62/001,188 2014-05-21
PCT/US2015/032069 WO2015179707A1 (en) 2014-05-21 2015-05-21 Imidazole derivatives as formyl peptide receptor modulators

Publications (3)

Publication Number Publication Date
RU2016145596A RU2016145596A (ru) 2018-06-21
RU2016145596A3 RU2016145596A3 (enExample) 2018-11-19
RU2748652C2 true RU2748652C2 (ru) 2021-05-28

Family

ID=53276329

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2016145596A RU2748652C2 (ru) 2014-05-21 2015-05-21 Производные имидазола как модуляторы формилпептидного рецептора

Country Status (12)

Country Link
US (2) US10301269B2 (enExample)
EP (1) EP3145916B1 (enExample)
JP (1) JP6660889B2 (enExample)
KR (1) KR20170005121A (enExample)
CN (1) CN106458921B (enExample)
AU (2) AU2015264021B2 (enExample)
BR (1) BR112016027133A8 (enExample)
CA (1) CA2948876A1 (enExample)
DK (1) DK3145916T3 (enExample)
ES (1) ES2788700T3 (enExample)
RU (1) RU2748652C2 (enExample)
WO (1) WO2015179707A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12478503B2 (en) 2009-05-18 2025-11-25 Glaukos Corporation Implants with controlled drug delivery features and methods of using same
US10206813B2 (en) 2009-05-18 2019-02-19 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
PT2770989T (pt) 2011-10-26 2018-12-04 Allergan Inc Derivados de amida de aminoácidos substituídos por n-ureia como moduladores de recetor tipo-1 do recetor de péptidos formil (fprl-1)
CA2899804A1 (en) * 2013-03-06 2014-09-12 Allergan, Inc. Use of agonists of formyl peptide receptor 2 for treating dermatological diseases
AU2014352922B2 (en) 2013-11-21 2018-06-07 Allergan, Inc. Phenylcarbamate derivatives as formyl peptide receptor modulators
US10301269B2 (en) 2014-05-21 2019-05-28 Allergan, Inc. Imidazole derivatives as formyl peptide receptor modulators
CA3020316A1 (en) * 2016-04-12 2017-10-19 Allergan, Inc. Phenyl urea derivatives as n-formyl peptide receptor modulators

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009007748A2 (en) * 2007-07-09 2009-01-15 Astrazeneca Ab Trisubstituted pyrimidine derivatives for the treatment of proliferative diseases
RU2386622C2 (ru) * 2004-01-06 2010-04-20 Ново Нордикс А/С Гетероароматические производные мочевины и их применение в качестве активаторов глюкокиназы
WO2011022953A1 (zh) * 2009-08-24 2011-03-03 中兴通讯股份有限公司 帧序列号的发送方法及节点b和服务无线网络控制器
WO2013062947A1 (en) * 2011-10-26 2013-05-02 Allergan, Inc. Amide derivatives of n-urea substituted amino acids as formyl peptide receptor like-1 (fprl-1) receptor modulators

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2533210A1 (fr) 1982-09-17 1984-03-23 Lyon I Universite Claude Edulcorants de synthese
EP1692502A2 (en) * 2003-11-07 2006-08-23 Acadia Pharmaceuticals Inc. Use of the lipoxin receptor, fprl1, as a tool for identifying compounds effective in the treatment of pain and inflammation
WO2007086584A1 (ja) * 2006-01-30 2007-08-02 Meiji Seika Kaisha, Ltd. 新規FabKおよびFabI/K阻害剤
JP5534811B2 (ja) * 2006-08-24 2014-07-02 アストラゼネカ アクチボラグ 増殖性疾患の治療に有用なモルホリノピリミジン誘導体
WO2009000748A1 (en) 2007-06-27 2008-12-31 Solvay Fluor Gmbh Preparation of compounds with a perfluoroalkylsulfonyl group
CA2819457A1 (en) 2010-12-03 2012-06-07 Allergan, Inc. Pharmaceutical compositions comprising 3,4-dihydroisoquinolin-2(1h)-yl-3-phenylurea derivatives having formyl peptide receptor like-1 (fprl-1) agonist or antagonist activity
WO2012109544A1 (en) 2011-02-11 2012-08-16 Allergan, Inc. Novel 1-(1-oxo-1,2,3,4-tetrahydroisoquinolin-7-yl)urea derivatives as n-formyl peptide receptor like-1 (fprl-1) receptor modulators
CA2841983A1 (en) 2011-07-11 2013-01-17 Allergan, Inc. Polycyclic pyrrolidine-2,5-dione derivatives as -formyl peptide receptor like-1 (fprl-1) receptor modulators
US8541577B2 (en) 2011-11-10 2013-09-24 Allergan, Inc. Aryl urea derivatives as N-formyl peptide receptors like-1 (FPRL-1) receptor modulators
US8492556B2 (en) * 2011-11-10 2013-07-23 Allergan, Inc. 2,5-Dioxoimidazolidin-1-yl-3-phenylurea derivatives as formyl peptide receptor like-1 (FPRL-1) receptor modulators
CA2864893A1 (en) 2012-02-16 2013-08-22 Allergan, Inc. Imidazolidine-2,4-dione derivatives as n-formyl peptide receptor 2 modulators
WO2013158597A1 (en) 2012-04-16 2013-10-24 Allergan, Inc. (2-ureidoacetamido)alkyl derivatives as formyl peptide receptor 2 modulators
RU2663911C2 (ru) 2013-03-06 2018-08-13 Аллерган, Инк. Применение агонистов формилпептидного рецептора 2 для лечения воспалительных заболеваний глаз
CA2899804A1 (en) 2013-03-06 2014-09-12 Allergan, Inc. Use of agonists of formyl peptide receptor 2 for treating dermatological diseases
AU2014290618B2 (en) 2013-07-16 2018-04-05 Allergan, Inc. Derivatives of N-urea substituted amino acids as formyl peptide receptor modulators
AU2014352922B2 (en) 2013-11-21 2018-06-07 Allergan, Inc. Phenylcarbamate derivatives as formyl peptide receptor modulators
US9920013B2 (en) 2014-01-29 2018-03-20 Allergan, Inc. 2,5-dioxoimidazolidin-1-yl-3-urea derivatives as formyl peptide modulators
US9604934B2 (en) 2014-01-29 2017-03-28 Allergan, Inc. Urea hydantoin derivatives as formyl peptide modulators
US9663457B2 (en) 2014-04-09 2017-05-30 Allergan, Inc. Carbamoyl hydrazine derivatives as formyl peptide modulators
US10301269B2 (en) 2014-05-21 2019-05-28 Allergan, Inc. Imidazole derivatives as formyl peptide receptor modulators
WO2017172761A1 (en) 2016-03-28 2017-10-05 Allergan, Inc. Phenyl urea derivatives as n-formyl peptide receptor modulators
CA3020316A1 (en) 2016-04-12 2017-10-19 Allergan, Inc. Phenyl urea derivatives as n-formyl peptide receptor modulators

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2386622C2 (ru) * 2004-01-06 2010-04-20 Ново Нордикс А/С Гетероароматические производные мочевины и их применение в качестве активаторов глюкокиназы
WO2009007748A2 (en) * 2007-07-09 2009-01-15 Astrazeneca Ab Trisubstituted pyrimidine derivatives for the treatment of proliferative diseases
WO2011022953A1 (zh) * 2009-08-24 2011-03-03 中兴通讯股份有限公司 帧序列号的发送方法及节点b和服务无线网络控制器
WO2013062947A1 (en) * 2011-10-26 2013-05-02 Allergan, Inc. Amide derivatives of n-urea substituted amino acids as formyl peptide receptor like-1 (fprl-1) receptor modulators

Also Published As

Publication number Publication date
DK3145916T3 (da) 2020-05-11
AU2015264021A1 (en) 2016-12-01
AU2020203420A1 (en) 2020-06-11
US10301269B2 (en) 2019-05-28
RU2016145596A (ru) 2018-06-21
US20170096401A1 (en) 2017-04-06
WO2015179707A1 (en) 2015-11-26
EP3145916A1 (en) 2017-03-29
RU2016145596A3 (enExample) 2018-11-19
ES2788700T3 (es) 2020-10-22
JP6660889B2 (ja) 2020-03-11
US20200115346A1 (en) 2020-04-16
BR112016027133A2 (pt) 2017-08-15
BR112016027133A8 (pt) 2021-06-29
CN106458921B (zh) 2020-03-24
JP2017520528A (ja) 2017-07-27
EP3145916B1 (en) 2020-02-12
AU2015264021B2 (en) 2020-02-27
AU2020203420B2 (en) 2021-12-16
CA2948876A1 (en) 2015-11-26
KR20170005121A (ko) 2017-01-11
CN106458921A (zh) 2017-02-22
US10800744B2 (en) 2020-10-13

Similar Documents

Publication Publication Date Title
RU2627271C2 (ru) Производные арилмочевины в качестве модуляторов n-формилпептидного-1 рецептора (fprl-1)
RU2629205C2 (ru) Амидные производные n-карбамид-замещенных аминокислот как модуляторы формилпептидного рецептора-1 (fprl-1)
US10800744B2 (en) Imidazole derivatives as formyl peptide receptor modulators
RU2696581C2 (ru) Производные n-мочевинозамещенных аминокислот как модуляторы формил-пептидного рецептора
RU2703725C1 (ru) Производные фенилкарбамата в качестве модуляторов формилпептидного рецептора
US9604934B2 (en) Urea hydantoin derivatives as formyl peptide modulators
US20150080466A1 (en) Diphenyl urea derivatives as formyl peptide receptor modulators
US9868700B2 (en) Carbamoyl hydrazine derivatives as formyl peptide modulators
US9920013B2 (en) 2,5-dioxoimidazolidin-1-yl-3-urea derivatives as formyl peptide modulators