RU2746601C2 - Орвепитант для лечения хронического кашля - Google Patents
Орвепитант для лечения хронического кашля Download PDFInfo
- Publication number
- RU2746601C2 RU2746601C2 RU2018122121A RU2018122121A RU2746601C2 RU 2746601 C2 RU2746601 C2 RU 2746601C2 RU 2018122121 A RU2018122121 A RU 2018122121A RU 2018122121 A RU2018122121 A RU 2018122121A RU 2746601 C2 RU2746601 C2 RU 2746601C2
- Authority
- RU
- Russia
- Prior art keywords
- chronic
- chronic cough
- cough
- orvepitant
- pharmaceutically acceptable
- Prior art date
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662276237P | 2016-01-08 | 2016-01-08 | |
| US62/276,237 | 2016-01-08 | ||
| US201662408921P | 2016-10-17 | 2016-10-17 | |
| US62/408,921 | 2016-10-17 | ||
| PCT/EP2016/082698 WO2017118584A1 (en) | 2016-01-08 | 2016-12-27 | Orvepitant for the treatment of chronic cough |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2018122121A RU2018122121A (ru) | 2020-02-11 |
| RU2018122121A3 RU2018122121A3 (hu) | 2020-06-26 |
| RU2746601C2 true RU2746601C2 (ru) | 2021-04-16 |
Family
ID=57629591
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2018122121A RU2746601C2 (ru) | 2016-01-08 | 2016-12-27 | Орвепитант для лечения хронического кашля |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US9750739B2 (hu) |
| EP (1) | EP3377064B1 (hu) |
| JP (1) | JP6621534B2 (hu) |
| KR (1) | KR102136017B1 (hu) |
| CN (2) | CN113274392A (hu) |
| AU (1) | AU2016384267B2 (hu) |
| BR (1) | BR112018013903B1 (hu) |
| CA (1) | CA3009283C (hu) |
| CY (1) | CY1122170T1 (hu) |
| DK (1) | DK3377064T3 (hu) |
| ES (1) | ES2738678T3 (hu) |
| HR (1) | HRP20191725T1 (hu) |
| HU (1) | HUE045764T2 (hu) |
| LT (1) | LT3377064T (hu) |
| MX (1) | MX371178B (hu) |
| PL (1) | PL3377064T3 (hu) |
| PT (1) | PT3377064T (hu) |
| RS (1) | RS59313B1 (hu) |
| RU (1) | RU2746601C2 (hu) |
| SI (1) | SI3377064T1 (hu) |
| WO (1) | WO2017118584A1 (hu) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20180235931A1 (en) * | 2017-01-17 | 2018-08-23 | Menlo Therapeutics Inc. | Use of neurokinin-1 antagonists as antitussives |
| EP3826635A4 (en) * | 2018-07-23 | 2022-04-27 | Trevi Therapeutics, Inc. | TREATMENT OF CHRONIC COUGH, DIFFICULT BREATHING AND DYSPNEA |
| CN112823795B (zh) * | 2019-11-20 | 2023-04-14 | 天津医科大学总医院 | 一种特发性肺纤维化药物组合及其应用 |
| EP4125875A1 (en) | 2020-04-03 | 2023-02-08 | NeRRe Therapeutics Limited | An nk-1 receptor antagonist for treating a disease selecting from sepsis, septic shock,, acute respiratory distress syndrome (ards) or multiple organ dysfunction syndrome (mods) |
| BR112022024208A2 (pt) | 2020-06-02 | 2022-12-20 | Nerre Therapeutics Ltd | Antagonistas do receptor de neurocinina (nk)-1 para uso no tratamento de condições de fibrose pulmonar promovidas por lesão mecânica aos pulmões |
| CN114732818B (zh) * | 2022-04-29 | 2023-02-10 | 首都医科大学附属北京胸科医院 | 一种抗特发性肺纤维化药物尼达尼布在结核病治疗中的应用 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA000909B1 (ru) * | 1995-10-30 | 2000-06-26 | Жансен Фармасетика Н.В. | Производные 1-(1,2-дизамещенный пиперидинил)-4-замещенного пиперазина |
| WO2003066635A1 (en) * | 2002-02-08 | 2003-08-14 | Glaxo Group Limited | Piperidine derivatives |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0806652D0 (en) * | 2008-04-11 | 2008-05-14 | Glaxo Group Ltd | Anhydrous crystal form of orvepitant maleate |
| SG11201501867UA (en) * | 2012-10-11 | 2015-04-29 | Nerre Therapeutics Ltd | Novel uses |
-
2016
- 2016-12-27 AU AU2016384267A patent/AU2016384267B2/en active Active
- 2016-12-27 CA CA3009283A patent/CA3009283C/en active Active
- 2016-12-27 CN CN202110372520.5A patent/CN113274392A/zh active Pending
- 2016-12-27 WO PCT/EP2016/082698 patent/WO2017118584A1/en active Application Filing
- 2016-12-27 SI SI201630402T patent/SI3377064T1/sl unknown
- 2016-12-27 RU RU2018122121A patent/RU2746601C2/ru active
- 2016-12-27 RS RSP20191236 patent/RS59313B1/sr unknown
- 2016-12-27 HU HUE16819325A patent/HUE045764T2/hu unknown
- 2016-12-27 US US15/390,770 patent/US9750739B2/en active Active
- 2016-12-27 JP JP2018532045A patent/JP6621534B2/ja active Active
- 2016-12-27 PL PL16819325T patent/PL3377064T3/pl unknown
- 2016-12-27 KR KR1020187022777A patent/KR102136017B1/ko active IP Right Grant
- 2016-12-27 CN CN201680078401.6A patent/CN108430475B/zh active Active
- 2016-12-27 EP EP16819325.8A patent/EP3377064B1/en active Active
- 2016-12-27 LT LTEP16819325.8T patent/LT3377064T/lt unknown
- 2016-12-27 DK DK16819325.8T patent/DK3377064T3/da active
- 2016-12-27 MX MX2018008439A patent/MX371178B/es active IP Right Grant
- 2016-12-27 ES ES16819325T patent/ES2738678T3/es active Active
- 2016-12-27 PT PT16819325T patent/PT3377064T/pt unknown
- 2016-12-27 BR BR112018013903-3A patent/BR112018013903B1/pt active IP Right Grant
-
2017
- 2017-08-01 US US15/665,640 patent/US20170326140A1/en not_active Abandoned
-
2019
- 2019-09-03 CY CY20191100924T patent/CY1122170T1/el unknown
- 2019-09-24 HR HRP20191725TT patent/HRP20191725T1/hr unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA000909B1 (ru) * | 1995-10-30 | 2000-06-26 | Жансен Фармасетика Н.В. | Производные 1-(1,2-дизамещенный пиперидинил)-4-замещенного пиперазина |
| WO2003066635A1 (en) * | 2002-02-08 | 2003-08-14 | Glaxo Group Limited | Piperidine derivatives |
Non-Patent Citations (5)
| Title |
|---|
| BELVISI M. G. et al. Cough-7: Current and future drugs for the treatment of chronic cough, Thorax, 2004, v. 59, no. 5, p. 438-440. * |
| EL-HASHIM A. Z. et al. Effect of novel NK1 receptor selective antagonist (NKP608) on citric acid induced cough and airway obstruction, Pulmornary Pharmacology and Therapeutics, 2004, v. 17, no. 1, p. 11-18. * |
| MUNOZ M. et al. NK-1 Receptor Antagonists: A New Paradigm in Pharmacological Therapy, Current Medicinal Chemistry, 2011, v. 18, no. 12, p. 1820-1831. * |
| MUNOZ M. et al. NK-1 Receptor Antagonists: A New Paradigm in Pharmacological Therapy, Current Medicinal Chemistry, 2011, v. 18, no. 12, p. 1820-1831. EL-HASHIM A. Z. et al. Effect of novel NK1 receptor selective antagonist (NKP608) on citric acid induced cough and airway obstruction, Pulmornary Pharmacology and Therapeutics, 2004, v. 17, no. 1, p. 11-18. BELVISI M. G. et al. Cough-7: Current and future drugs for the treatment of chronic cough, Thorax, 2004, v. 59, no. 5, p. 438-440. PAVORD I. D. et al. Management of chronic cough, The Lancet, 2008, v. 371, no. 9621, p. 1375-1384. * |
| PAVORD I. D. et al. Management of chronic cough, The Lancet, 2008, v. 371, no. 9621, p. 1375-1384. * |
Also Published As
| Publication number | Publication date |
|---|---|
| US20170326140A1 (en) | 2017-11-16 |
| MX2018008439A (es) | 2018-08-14 |
| CN108430475A (zh) | 2018-08-21 |
| SI3377064T1 (sl) | 2019-11-29 |
| RU2018122121A (ru) | 2020-02-11 |
| MX371178B (es) | 2020-01-21 |
| AU2016384267B2 (en) | 2022-02-03 |
| BR112018013903B1 (pt) | 2023-11-07 |
| RS59313B1 (sr) | 2019-10-31 |
| CN113274392A (zh) | 2021-08-20 |
| BR112018013903A2 (pt) | 2018-12-18 |
| EP3377064B1 (en) | 2019-06-26 |
| CA3009283C (en) | 2023-10-03 |
| US20170196860A1 (en) | 2017-07-13 |
| EP3377064A1 (en) | 2018-09-26 |
| DK3377064T3 (da) | 2019-09-23 |
| JP2019501162A (ja) | 2019-01-17 |
| HUE045764T2 (hu) | 2020-01-28 |
| CY1122170T1 (el) | 2020-11-25 |
| LT3377064T (lt) | 2019-09-10 |
| PL3377064T3 (pl) | 2020-02-28 |
| HRP20191725T1 (hr) | 2019-12-27 |
| CA3009283A1 (en) | 2017-07-13 |
| ES2738678T3 (es) | 2020-01-24 |
| RU2018122121A3 (hu) | 2020-06-26 |
| KR20180100651A (ko) | 2018-09-11 |
| AU2016384267A1 (en) | 2018-07-05 |
| WO2017118584A1 (en) | 2017-07-13 |
| KR102136017B1 (ko) | 2020-07-20 |
| JP6621534B2 (ja) | 2019-12-18 |
| CN108430475B (zh) | 2021-03-16 |
| US9750739B2 (en) | 2017-09-05 |
| PT3377064T (pt) | 2019-07-23 |
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