RU2742938C2 - 4,6-ЗАМЕЩЕННЫЕ ПИРАЗОЛО[1,5-a]ПИРАЗИНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ ЯНУС-КИНАЗЫ - Google Patents

4,6-ЗАМЕЩЕННЫЕ ПИРАЗОЛО[1,5-a]ПИРАЗИНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ ЯНУС-КИНАЗЫ Download PDF

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RU2742938C2
RU2742938C2 RU2017123387A RU2017123387A RU2742938C2 RU 2742938 C2 RU2742938 C2 RU 2742938C2 RU 2017123387 A RU2017123387 A RU 2017123387A RU 2017123387 A RU2017123387 A RU 2017123387A RU 2742938 C2 RU2742938 C2 RU 2742938C2
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pyrazol
pyrazolo
pyrazin
alkyl
pentan
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RU2017123387A
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Russian (ru)
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RU2017123387A3 (https=
RU2017123387A (ru
Inventor
Брайдон Л. БЕННЕТ
Радж К. РАХЕДЖА
Катерина Лефтерис
Ёситака САТО
Джед ФЕНЕДЖЕР
Роберт Эндрю РИДЖЕР
Лоренс Э. БЁРДЖЕСС
Тони П. ТЭНГ
Джон Э. Робинсон
Эллен ЛЭЙРД
Кристофер Ф. КРЭЙЗЕР
Рональд Джей Хинклин
Эрик Джеймс ХИКЕН
Джон ГАУДИНО
Джон П. Фишер
Джей Брэдфорд Фелл
Марк Дж. ЧИКАРЕЛЛИ
Марк Лоренс БОЙЗ
Шелли АЛЛЕН
Original Assignee
Эррэй Биофарма Инк.
Селджин Корпорейшн
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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RU2017123387A 2014-12-05 2015-12-04 4,6-ЗАМЕЩЕННЫЕ ПИРАЗОЛО[1,5-a]ПИРАЗИНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ ЯНУС-КИНАЗЫ RU2742938C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462088068P 2014-12-05 2014-12-05
US62/088,068 2014-12-05
PCT/US2015/064062 WO2016090285A1 (en) 2014-12-05 2015-12-04 4,6-SUBSTITUTED-PYRAZOLO[1,5-a]PYRAZINES AS JANUS KINASE INHIBITORS

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RU2021102805A Division RU2021102805A (ru) 2014-12-05 2015-12-04 4,6-ЗАМЕЩЕННЫЕ ПИРАЗОЛО[1,5-a]ПИРАЗИНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ ЯНУС-КИНАЗЫ

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RU2017123387A RU2017123387A (ru) 2019-01-11
RU2017123387A3 RU2017123387A3 (https=) 2019-06-03
RU2742938C2 true RU2742938C2 (ru) 2021-02-11

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RU2021102805A RU2021102805A (ru) 2014-12-05 2015-12-04 4,6-ЗАМЕЩЕННЫЕ ПИРАЗОЛО[1,5-a]ПИРАЗИНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ ЯНУС-КИНАЗЫ

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US (3) US10189845B2 (https=)
EP (2) EP3878451A1 (https=)
JP (2) JP6641373B2 (https=)
KR (1) KR20170090476A (https=)
CN (1) CN107278203B (https=)
AU (1) AU2015357585B2 (https=)
BR (1) BR112017011798A2 (https=)
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PL (1) PL3227297T3 (https=)
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US11168090B2 (en) 2017-01-18 2021-11-09 Array Biopharma Inc. Substituted pyrazolo[1,5-a]pyrazines as RET kinase inhibitors
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WO2019034973A1 (en) 2017-08-14 2019-02-21 Pfizer Inc. PYRAZOLO [1,5-A] PYRAZIN-4-YL AND RELATED DERIVATIVES
CN111615514B (zh) 2018-01-18 2022-10-11 奥瑞生物药品公司 作为ret激酶抑制剂的取代的吡唑并[4,3-c]吡啶化合物
WO2019143991A1 (en) 2018-01-18 2019-07-25 Array Biopharma Inc. SUBSTITUTED PYRAZOLO[3,4-d]PYRIMIDINE COMPOUNDS AS RET KINASE INHIBITORS
EP3740491A1 (en) 2018-01-18 2020-11-25 Array Biopharma, Inc. Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors
EP3849986B1 (en) 2018-09-10 2022-06-08 Array Biopharma, Inc. Fused heterocyclic compounds as ret kinase inhibitors
CN113924301B (zh) * 2019-04-12 2024-08-16 北京普祺医药科技股份有限公司 一种吡唑并吡嗪衍生的化合物、药物组合物以及其用途
IL322315A (en) 2019-05-14 2025-09-01 Provention Bio Inc Methods and preparations for preventing type 1 diabetes
CN113150012B (zh) * 2020-01-22 2023-03-24 浙江海正药业股份有限公司 吡唑并[1,5-a]吡嗪类衍生物及其制备方法和用途
MX2022012135A (es) 2020-04-04 2023-01-18 Pfizer Métodos para tratar la enfermedad de coronavirus de 2019.
AU2021287998B2 (en) 2020-06-11 2026-03-12 Benaroya Research Institute At Virginia Mason Methods and compositions for preventing type 1 diabetes
US12565529B2 (en) 2021-05-24 2026-03-03 Provention Bio, Inc. Methods for treating type 1 diabetes
AU2022387652B2 (en) * 2021-11-12 2025-10-16 Cms Research & Development Pte. Ltd. Pyrazolo fused ring compound and use thereof
CN121568938A (zh) * 2023-05-12 2026-02-24 海南德镁医药科技有限责任公司 一种吡唑并吡嗪类化合物及其晶型的制备方法

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ES2865483T3 (es) 2021-10-15
US20190177328A1 (en) 2019-06-13
RU2021102805A (ru) 2021-02-12
SG11201704542SA (en) 2017-07-28
US10189845B2 (en) 2019-01-29
US20170362240A1 (en) 2017-12-21
WO2016090285A1 (en) 2016-06-09
TWI725004B (zh) 2021-04-21
JP6641373B2 (ja) 2020-02-05
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