RU2742938C2 - 4,6-ЗАМЕЩЕННЫЕ ПИРАЗОЛО[1,5-a]ПИРАЗИНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ ЯНУС-КИНАЗЫ - Google Patents

4,6-ЗАМЕЩЕННЫЕ ПИРАЗОЛО[1,5-a]ПИРАЗИНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ ЯНУС-КИНАЗЫ Download PDF

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RU2742938C2
RU2742938C2 RU2017123387A RU2017123387A RU2742938C2 RU 2742938 C2 RU2742938 C2 RU 2742938C2 RU 2017123387 A RU2017123387 A RU 2017123387A RU 2017123387 A RU2017123387 A RU 2017123387A RU 2742938 C2 RU2742938 C2 RU 2742938C2
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Russia
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pyrazol
pyrazolo
pyrazin
alkyl
pentan
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RU2017123387A
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English (en)
Russian (ru)
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RU2017123387A (ru
RU2017123387A3 (OSRAM
Inventor
Брайдон Л. БЕННЕТ
Радж К. РАХЕДЖА
Катерина Лефтерис
Ёситака САТО
Джед ФЕНЕДЖЕР
Роберт Эндрю РИДЖЕР
Лоренс Э. БЁРДЖЕСС
Тони П. ТЭНГ
Джон Э. Робинсон
Эллен ЛЭЙРД
Кристофер Ф. КРЭЙЗЕР
Рональд Джей Хинклин
Эрик Джеймс ХИКЕН
Джон ГАУДИНО
Джон П. Фишер
Джей Брэдфорд Фелл
Марк Дж. ЧИКАРЕЛЛИ
Марк Лоренс БОЙЗ
Шелли АЛЛЕН
Original Assignee
Эррэй Биофарма Инк.
Селджин Корпорейшн
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

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RU2017123387A 2014-12-05 2015-12-04 4,6-ЗАМЕЩЕННЫЕ ПИРАЗОЛО[1,5-a]ПИРАЗИНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ ЯНУС-КИНАЗЫ RU2742938C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462088068P 2014-12-05 2014-12-05
US62/088,068 2014-12-05
PCT/US2015/064062 WO2016090285A1 (en) 2014-12-05 2015-12-04 4,6-SUBSTITUTED-PYRAZOLO[1,5-a]PYRAZINES AS JANUS KINASE INHIBITORS

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RU2021102805A Division RU2021102805A (ru) 2014-12-05 2015-12-04 4,6-ЗАМЕЩЕННЫЕ ПИРАЗОЛО[1,5-a]ПИРАЗИНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ ЯНУС-КИНАЗЫ

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RU2017123387A RU2017123387A (ru) 2019-01-11
RU2017123387A3 RU2017123387A3 (OSRAM) 2019-06-03
RU2742938C2 true RU2742938C2 (ru) 2021-02-11

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RU2017123387A RU2742938C2 (ru) 2014-12-05 2015-12-04 4,6-ЗАМЕЩЕННЫЕ ПИРАЗОЛО[1,5-a]ПИРАЗИНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ ЯНУС-КИНАЗЫ

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US (3) US10189845B2 (OSRAM)
EP (2) EP3227297B1 (OSRAM)
JP (2) JP6641373B2 (OSRAM)
KR (1) KR20170090476A (OSRAM)
CN (1) CN107278203B (OSRAM)
AU (1) AU2015357585B2 (OSRAM)
BR (1) BR112017011798A2 (OSRAM)
CA (1) CA2969709A1 (OSRAM)
CL (1) CL2017001422A1 (OSRAM)
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DK (1) DK3227297T3 (OSRAM)
ES (1) ES2865483T3 (OSRAM)
HR (1) HRP20210501T1 (OSRAM)
HU (1) HUE054371T2 (OSRAM)
IL (1) IL252656A0 (OSRAM)
MX (1) MX386316B (OSRAM)
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PH (1) PH12017501032A1 (OSRAM)
PL (1) PL3227297T3 (OSRAM)
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Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE054371T2 (hu) 2014-12-05 2021-09-28 Array Biopharma Inc 4,6-szubsztituált pirazolo[l,5-A]pirazinok mint janus kináz inhibitorok
AU2017222417B2 (en) 2016-02-24 2020-07-09 Pfizer Inc. Pyrazolo[1,5-a]pyrazin-4-yl derivatives as JAK-inhibitors
US11028080B2 (en) 2016-03-11 2021-06-08 Denali Therapeutics Inc. Substituted pyrimidines as LRKK2 inhibitors
KR102705724B1 (ko) 2016-06-16 2024-09-12 데날리 테라퓨틱스 인크. 신경퇴행성 장애의 치료에서 사용하기 위한 lrrk2 저해제로서 피리미딘-2-일아미노-1h-피라졸
GB201617758D0 (en) * 2016-10-20 2016-12-07 Almac Discovery Limited Pharmaceutical compounds
EP3571203B1 (en) 2017-01-18 2023-06-07 Array BioPharma Inc. Substituted pyrazolo[1,5-a]pyrazine compounds as ret kinase inhibitors
WO2018217946A1 (en) * 2017-05-24 2018-11-29 Denali Therapeutics Inc. Compounds, compositions and methods
EP3668858A1 (en) 2017-08-14 2020-06-24 Pfizer Inc Pyrazolo[1,5-a]pyrazin-4-yl and related derivatives
EP3740491A1 (en) 2018-01-18 2020-11-25 Array Biopharma, Inc. Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors
CA3087578C (en) 2018-01-18 2023-08-08 Array Biopharma Inc. Substituted pyrazolo[3,4-d]pyrimidine compounds as ret kinase inhibitors
CN111615514B (zh) 2018-01-18 2022-10-11 奥瑞生物药品公司 作为ret激酶抑制剂的取代的吡唑并[4,3-c]吡啶化合物
JP2022500383A (ja) 2018-09-10 2022-01-04 アレイ バイオファーマ インコーポレイテッド Ｒｅｔキナーゼ阻害剤としての縮合複素環式化合物
MX2021012487A (es) * 2019-04-12 2021-11-12 Primegene Beijing Co Ltd Compuestos derivados de pirazolopirazina, composicion farmaceutica y uso de la misma.
IL322315A (en) 2019-05-14 2025-09-01 Provention Bio Inc Methods and preparations for preventing type 1 diabetes
CN113150012B (zh) * 2020-01-22 2023-03-24 浙江海正药业股份有限公司 吡唑并[1,5-a]吡嗪类衍生物及其制备方法和用途
CN115715194A (zh) 2020-04-04 2023-02-24 辉瑞公司 治疗冠状病毒疾病2019的方法
MX2022015872A (es) 2020-06-11 2023-05-16 Provention Bio Inc Metodos y composiciones para prevenir diabetes tipo 1.
CA3237632A1 (en) * 2021-11-12 2023-05-19 Changqing WEI Pyrazolo fused ring compound and use thereof
WO2024235167A1 (zh) * 2023-05-12 2024-11-21 海南康哲美丽科技有限公司 一种吡唑并吡嗪类化合物及其晶型的制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011120146A1 (en) * 2010-04-01 2011-10-06 Smart Technologies Ulc Input system with anti-reflective bezel for locating active pointers
EA201201143A1 (ru) * 2010-02-18 2013-03-29 Альмираль, С.А. Производные пиразола в качестве ингибиторов jak
WO2013055645A1 (en) * 2011-10-12 2013-04-18 Array Biopharma Inc. 5,7-substituted-imidazo[1,2-c]pyrimidines

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1105378B1 (en) 1998-08-21 2005-03-30 Parker Hughes Institute Quinazoline derivatives
DE102007032349A1 (de) * 2007-07-11 2009-01-15 Bayer Healthcare Ag Imidazo-, Pyrazolopyrazine und Imidazotriazine und ihre Verwendung
US8440689B2 (en) 2009-12-23 2013-05-14 Takeda Pharmaceutical Company Limited Fused heteroaromatic pyrrolidinones
CA2787714C (en) * 2010-01-22 2019-04-09 Joaquin Pastor Fernandez Inhibitors of pi3 kinase
UA109131C2 (ru) * 2010-04-14 2015-07-27 Еррей Біофарма Інк. 5,7-ЗАМЕЩЕННЫЕ ИМИДАЗО[1,2-c]ПИРИМИДИНЫ КАК ИНГИБИТОРЫ JAK-КИНАЗ
KR102070567B1 (ko) * 2012-03-28 2020-01-29 메르크 파텐트 게엠베하 바이시클릭 피라지논 유도체
HUE054371T2 (hu) 2014-12-05 2021-09-28 Array Biopharma Inc 4,6-szubsztituált pirazolo[l,5-A]pirazinok mint janus kináz inhibitorok

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA201201143A1 (ru) * 2010-02-18 2013-03-29 Альмираль, С.А. Производные пиразола в качестве ингибиторов jak
WO2011120146A1 (en) * 2010-04-01 2011-10-06 Smart Technologies Ulc Input system with anti-reflective bezel for locating active pointers
WO2013055645A1 (en) * 2011-10-12 2013-04-18 Array Biopharma Inc. 5,7-substituted-imidazo[1,2-c]pyrimidines

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CL2017001422A1 (es) 2018-01-05
MX386316B (es) 2025-03-18
EP3878451A1 (en) 2021-09-15
US10730880B2 (en) 2020-08-04
UA120065C2 (uk) 2019-09-25
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