RU2740096C2 - Bifidobacterium longum для лечения ожирения и ассоциированных метаболических расстройств - Google Patents
Bifidobacterium longum для лечения ожирения и ассоциированных метаболических расстройств Download PDFInfo
- Publication number
- RU2740096C2 RU2740096C2 RU2018119287A RU2018119287A RU2740096C2 RU 2740096 C2 RU2740096 C2 RU 2740096C2 RU 2018119287 A RU2018119287 A RU 2018119287A RU 2018119287 A RU2018119287 A RU 2018119287A RU 2740096 C2 RU2740096 C2 RU 2740096C2
- Authority
- RU
- Russia
- Prior art keywords
- obesity
- composition
- strain
- ncimb
- longum ncimb
- Prior art date
Links
- 241001608472 Bifidobacterium longum Species 0.000 title claims abstract description 108
- 208000008589 Obesity Diseases 0.000 title claims abstract description 50
- 235000020824 obesity Nutrition 0.000 title claims abstract description 50
- 229940009291 bifidobacterium longum Drugs 0.000 title claims abstract description 8
- 208000030159 metabolic disease Diseases 0.000 title description 5
- 239000000203 mixture Substances 0.000 claims abstract description 69
- 239000006041 probiotic Substances 0.000 claims abstract description 17
- 235000018291 probiotics Nutrition 0.000 claims abstract description 17
- 230000000529 probiotic effect Effects 0.000 claims abstract description 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 11
- 235000013305 food Nutrition 0.000 claims abstract description 11
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 11
- 208000001145 Metabolic Syndrome Diseases 0.000 claims abstract description 10
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims abstract description 10
- 239000002775 capsule Substances 0.000 claims abstract description 10
- 201000010099 disease Diseases 0.000 claims abstract description 10
- 235000013406 prebiotics Nutrition 0.000 claims abstract description 10
- 239000000843 powder Substances 0.000 claims abstract description 8
- 235000013336 milk Nutrition 0.000 claims abstract description 7
- 239000008267 milk Substances 0.000 claims abstract description 7
- 210000004080 milk Anatomy 0.000 claims abstract description 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 7
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 7
- 235000013618 yogurt Nutrition 0.000 claims abstract description 6
- 239000002671 adjuvant Substances 0.000 claims abstract description 5
- 238000013270 controlled release Methods 0.000 claims abstract description 5
- 210000001035 gastrointestinal tract Anatomy 0.000 claims abstract description 5
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 5
- 239000003826 tablet Substances 0.000 claims abstract description 5
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims abstract description 3
- 150000001720 carbohydrates Chemical class 0.000 claims abstract description 3
- 229930195712 glutamate Natural products 0.000 claims abstract description 3
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims abstract description 3
- 229910052500 inorganic mineral Inorganic materials 0.000 claims abstract description 3
- 150000002632 lipids Chemical class 0.000 claims abstract description 3
- 235000014059 processed cheese Nutrition 0.000 claims abstract description 3
- 235000015067 sauces Nutrition 0.000 claims abstract description 3
- 239000011782 vitamin Substances 0.000 claims abstract description 3
- 235000013343 vitamin Nutrition 0.000 claims abstract description 3
- 229940088594 vitamin Drugs 0.000 claims abstract description 3
- 229930003231 vitamin Natural products 0.000 claims abstract description 3
- 239000012141 concentrate Substances 0.000 claims abstract 2
- 235000008504 concentrate Nutrition 0.000 claims abstract 2
- 150000003722 vitamin derivatives Chemical class 0.000 claims abstract 2
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims description 29
- 230000002265 prevention Effects 0.000 claims description 13
- 239000003814 drug Substances 0.000 claims description 6
- 229940079593 drug Drugs 0.000 claims description 5
- 239000003937 drug carrier Substances 0.000 claims description 4
- 235000014633 carbohydrates Nutrition 0.000 claims description 2
- 235000015140 cultured milk Nutrition 0.000 claims description 2
- 235000010755 mineral Nutrition 0.000 claims description 2
- 239000011573 trace mineral Substances 0.000 claims description 2
- 235000013619 trace mineral Nutrition 0.000 claims description 2
- 239000002366 mineral element Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 22
- 239000000126 substance Substances 0.000 abstract description 7
- 239000011707 mineral Substances 0.000 abstract description 2
- 235000013361 beverage Nutrition 0.000 abstract 1
- 229920002444 Exopolysaccharide Polymers 0.000 description 35
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 24
- 230000006698 induction Effects 0.000 description 24
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 21
- DCAYPVUWAIABOU-UHFFFAOYSA-N hexadecane Chemical compound CCCCCCCCCCCCCCCC DCAYPVUWAIABOU-UHFFFAOYSA-N 0.000 description 20
- 210000004027 cell Anatomy 0.000 description 19
- 241000894006 Bacteria Species 0.000 description 18
- 238000000034 method Methods 0.000 description 18
- 235000009200 high fat diet Nutrition 0.000 description 17
- 241000699670 Mus sp. Species 0.000 description 16
- 210000004369 blood Anatomy 0.000 description 15
- 239000008280 blood Substances 0.000 description 15
- 235000019197 fats Nutrition 0.000 description 15
- 241000186660 Lactobacillus Species 0.000 description 14
- 229940039696 lactobacillus Drugs 0.000 description 13
- 210000004185 liver Anatomy 0.000 description 13
- 241001465754 Metazoa Species 0.000 description 12
- 230000003110 anti-inflammatory effect Effects 0.000 description 12
- 230000000638 stimulation Effects 0.000 description 12
- 150000003626 triacylglycerols Chemical class 0.000 description 12
- 108091023242 Internal transcribed spacer Proteins 0.000 description 11
- 238000003556 assay Methods 0.000 description 11
- 230000001580 bacterial effect Effects 0.000 description 11
- 102000004127 Cytokines Human genes 0.000 description 10
- 108090000695 Cytokines Proteins 0.000 description 10
- 102100040247 Tumor necrosis factor Human genes 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 9
- 235000012000 cholesterol Nutrition 0.000 description 9
- 238000004519 manufacturing process Methods 0.000 description 9
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 8
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 7
- 210000000577 adipose tissue Anatomy 0.000 description 7
- 238000004458 analytical method Methods 0.000 description 7
- 239000008103 glucose Substances 0.000 description 7
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 6
- 108091028043 Nucleic acid sequence Proteins 0.000 description 6
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 6
- 238000010172 mouse model Methods 0.000 description 6
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- 230000009467 reduction Effects 0.000 description 6
- 206010061218 Inflammation Diseases 0.000 description 5
- 230000037396 body weight Effects 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 5
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 5
- 230000002068 genetic effect Effects 0.000 description 5
- 244000005709 gut microbiome Species 0.000 description 5
- 230000004054 inflammatory process Effects 0.000 description 5
- 230000002503 metabolic effect Effects 0.000 description 5
- 244000005700 microbiome Species 0.000 description 5
- 239000002953 phosphate buffered saline Substances 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 5
- 241000186000 Bifidobacterium Species 0.000 description 4
- 108020004414 DNA Proteins 0.000 description 4
- 108010023302 HDL Cholesterol Proteins 0.000 description 4
- 206010022489 Insulin Resistance Diseases 0.000 description 4
- 108010028554 LDL Cholesterol Proteins 0.000 description 4
- 238000005119 centrifugation Methods 0.000 description 4
- 230000008859 change Effects 0.000 description 4
- 230000001684 chronic effect Effects 0.000 description 4
- 238000000576 coating method Methods 0.000 description 4
- 239000000306 component Substances 0.000 description 4
- 230000001186 cumulative effect Effects 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 235000005911 diet Nutrition 0.000 description 4
- 230000037213 diet Effects 0.000 description 4
- 239000003651 drinking water Substances 0.000 description 4
- 235000020188 drinking water Nutrition 0.000 description 4
- 230000037406 food intake Effects 0.000 description 4
- 235000012631 food intake Nutrition 0.000 description 4
- 150000004676 glycans Chemical class 0.000 description 4
- 229920001282 polysaccharide Polymers 0.000 description 4
- 239000005017 polysaccharide Substances 0.000 description 4
- 230000000770 proinflammatory effect Effects 0.000 description 4
- 230000002829 reductive effect Effects 0.000 description 4
- 239000013049 sediment Substances 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 210000004003 subcutaneous fat Anatomy 0.000 description 4
- 206010002091 Anaesthesia Diseases 0.000 description 3
- 206010020772 Hypertension Diseases 0.000 description 3
- 238000008214 LDL Cholesterol Methods 0.000 description 3
- 241000699666 Mus <mouse, genus> Species 0.000 description 3
- 206010033307 Overweight Diseases 0.000 description 3
- 108010069201 VLDL Cholesterol Proteins 0.000 description 3
- 108010062497 VLDL Lipoproteins Proteins 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 230000037005 anaesthesia Effects 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 210000001072 colon Anatomy 0.000 description 3
- 230000003247 decreasing effect Effects 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 230000012010 growth Effects 0.000 description 3
- 230000002209 hydrophobic effect Effects 0.000 description 3
- 238000000338 in vitro Methods 0.000 description 3
- 238000003780 insertion Methods 0.000 description 3
- 230000037431 insertion Effects 0.000 description 3
- 235000014655 lactic acid Nutrition 0.000 description 3
- 239000004310 lactic acid Substances 0.000 description 3
- 239000002773 nucleotide Substances 0.000 description 3
- 125000003729 nucleotide group Chemical group 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 208000024172 Cardiovascular disease Diseases 0.000 description 2
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 2
- 208000032928 Dyslipidaemia Diseases 0.000 description 2
- 102000015779 HDL Lipoproteins Human genes 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- 208000017170 Lipid metabolism disease Diseases 0.000 description 2
- 101000872823 Xenopus laevis Probable histone deacetylase 1-A Proteins 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 230000010065 bacterial adhesion Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 239000006285 cell suspension Substances 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 230000008021 deposition Effects 0.000 description 2
- 231100000673 dose–response relationship Toxicity 0.000 description 2
- 201000010063 epididymitis Diseases 0.000 description 2
- ZMMJGEGLRURXTF-UHFFFAOYSA-N ethidium bromide Chemical compound [Br-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CC)=C1C1=CC=CC=C1 ZMMJGEGLRURXTF-UHFFFAOYSA-N 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 230000029142 excretion Effects 0.000 description 2
- 235000021588 free fatty acids Nutrition 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 230000007407 health benefit Effects 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 210000000936 intestine Anatomy 0.000 description 2
- 210000001596 intra-abdominal fat Anatomy 0.000 description 2
- 235000015263 low fat diet Nutrition 0.000 description 2
- 239000003550 marker Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 239000003094 microcapsule Substances 0.000 description 2
- 239000006187 pill Substances 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 230000002269 spontaneous effect Effects 0.000 description 2
- 238000007619 statistical method Methods 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 239000000829 suppository Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 239000006188 syrup Substances 0.000 description 2
- 235000020357 syrup Nutrition 0.000 description 2
- -1 troches Substances 0.000 description 2
- 229960005486 vaccine Drugs 0.000 description 2
- DRCWOKJLSQUJPZ-DZGCQCFKSA-N (4ar,9as)-n-ethyl-1,4,9,9a-tetrahydrofluoren-4a-amine Chemical compound C1C2=CC=CC=C2[C@]2(NCC)[C@H]1CC=CC2 DRCWOKJLSQUJPZ-DZGCQCFKSA-N 0.000 description 1
- 229920000936 Agarose Polymers 0.000 description 1
- 206010003497 Asphyxia Diseases 0.000 description 1
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 206010070545 Bacterial translocation Diseases 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- 102100040840 C-type lectin domain family 7 member A Human genes 0.000 description 1
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 1
- 230000008836 DNA modification Effects 0.000 description 1
- 230000009946 DNA mutation Effects 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 229920003134 Eudragit® polymer Polymers 0.000 description 1
- 206010016654 Fibrosis Diseases 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 230000005526 G1 to G0 transition Effects 0.000 description 1
- 229920001503 Glucan Polymers 0.000 description 1
- 208000002705 Glucose Intolerance Diseases 0.000 description 1
- 101001008429 Homo sapiens Nucleobindin-2 Proteins 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- PIWKPBJCKXDKJR-UHFFFAOYSA-N Isoflurane Chemical compound FC(F)OC(Cl)C(F)(F)F PIWKPBJCKXDKJR-UHFFFAOYSA-N 0.000 description 1
- 102000007330 LDL Lipoproteins Human genes 0.000 description 1
- 244000199866 Lactobacillus casei Species 0.000 description 1
- 235000013958 Lactobacillus casei Nutrition 0.000 description 1
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 1
- 102100027441 Nucleobindin-2 Human genes 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 206010039897 Sedation Diseases 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000008351 acetate buffer Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000011149 active material Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 210000003486 adipose tissue brown Anatomy 0.000 description 1
- 239000011543 agarose gel Substances 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 1
- 150000001413 amino acids Chemical group 0.000 description 1
- 238000000540 analysis of variance Methods 0.000 description 1
- 229940124599 anti-inflammatory drug Drugs 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- 230000007375 bacterial translocation Effects 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 238000012742 biochemical analysis Methods 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000002051 biphasic effect Effects 0.000 description 1
- 210000000476 body water Anatomy 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 238000004422 calculation algorithm Methods 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 235000019577 caloric intake Nutrition 0.000 description 1
- 210000004534 cecum Anatomy 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000007882 cirrhosis Effects 0.000 description 1
- 208000019425 cirrhosis of liver Diseases 0.000 description 1
- 238000011260 co-administration Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 230000021615 conjugation Effects 0.000 description 1
- 239000007799 cork Substances 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 238000012864 cross contamination Methods 0.000 description 1
- 108010025838 dectin 1 Proteins 0.000 description 1
- 238000012217 deletion Methods 0.000 description 1
- 230000037430 deletion Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 210000005069 ears Anatomy 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 229960005542 ethidium bromide Drugs 0.000 description 1
- 230000003090 exacerbative effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 235000013861 fat-free Nutrition 0.000 description 1
- 230000002550 fecal effect Effects 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 235000021001 fermented dairy product Nutrition 0.000 description 1
- 235000021107 fermented food Nutrition 0.000 description 1
- 235000012041 food component Nutrition 0.000 description 1
- 239000005428 food component Substances 0.000 description 1
- 239000010794 food waste Substances 0.000 description 1
- 229930182830 galactose Natural products 0.000 description 1
- 208000020694 gallbladder disease Diseases 0.000 description 1
- 238000012239 gene modification Methods 0.000 description 1
- 238000012252 genetic analysis Methods 0.000 description 1
- 230000005017 genetic modification Effects 0.000 description 1
- 235000013617 genetically modified food Nutrition 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 229920006158 high molecular weight polymer Polymers 0.000 description 1
- 230000013632 homeostatic process Effects 0.000 description 1
- 230000002519 immonomodulatory effect Effects 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 210000002490 intestinal epithelial cell Anatomy 0.000 description 1
- 210000004347 intestinal mucosa Anatomy 0.000 description 1
- 229960002725 isoflurane Drugs 0.000 description 1
- 229940017800 lactobacillus casei Drugs 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 239000008176 lyophilized powder Substances 0.000 description 1
- 238000002595 magnetic resonance imaging Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 230000010034 metabolic health Effects 0.000 description 1
- 230000037353 metabolic pathway Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 231100000350 mutagenesis Toxicity 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 150000005830 nonesterified fatty acids Chemical class 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 238000001543 one-way ANOVA Methods 0.000 description 1
- 201000008482 osteoarthritis Diseases 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000000902 placebo Substances 0.000 description 1
- 229940068196 placebo Drugs 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 108091033319 polynucleotide Proteins 0.000 description 1
- 239000002157 polynucleotide Substances 0.000 description 1
- 102000040430 polynucleotide Human genes 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 235000010333 potassium nitrate Nutrition 0.000 description 1
- 238000011533 pre-incubation Methods 0.000 description 1
- 201000009104 prediabetes syndrome Diseases 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 229940063638 ridaura Drugs 0.000 description 1
- 230000036280 sedation Effects 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 210000002027 skeletal muscle Anatomy 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 235000019722 synbiotics Nutrition 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 238000011285 therapeutic regimen Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- PIEPQKCYPFFYMG-UHFFFAOYSA-N tris acetate Chemical compound CC(O)=O.OCC(N)(CO)CO PIEPQKCYPFFYMG-UHFFFAOYSA-N 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 241001515965 unidentified phage Species 0.000 description 1
- 238000011870 unpaired t-test Methods 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/30—Dietetic or nutritional methods, e.g. for losing weight
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/745—Bifidobacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/32—Foods, ingredients or supplements having a functional effect on health having an effect on the health of the digestive tract
- A23V2200/3204—Probiotics, living bacteria to be ingested for action in the digestive tract
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/332—Promoters of weight control and weight loss
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Child & Adolescent Psychology (AREA)
- Immunology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15199660 | 2015-12-11 | ||
| EP15199660.0 | 2015-12-11 | ||
| PCT/EP2016/080454 WO2017097987A1 (en) | 2015-12-11 | 2016-12-09 | Bifidobacterium longum for treating obesity and associated metabolic disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2018119287A RU2018119287A (ru) | 2020-01-13 |
| RU2018119287A3 RU2018119287A3 (enExample) | 2020-06-30 |
| RU2740096C2 true RU2740096C2 (ru) | 2021-01-11 |
Family
ID=55070675
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2018119287A RU2740096C2 (ru) | 2015-12-11 | 2016-12-09 | Bifidobacterium longum для лечения ожирения и ассоциированных метаболических расстройств |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US10973862B2 (enExample) |
| EP (1) | EP3386523B1 (enExample) |
| JP (1) | JP6843140B2 (enExample) |
| KR (1) | KR102819885B1 (enExample) |
| CN (1) | CN109069552B (enExample) |
| AU (1) | AU2016368527B2 (enExample) |
| BR (1) | BR112018011665A2 (enExample) |
| CA (1) | CA3006176C (enExample) |
| DK (1) | DK3386523T3 (enExample) |
| ES (1) | ES2760076T3 (enExample) |
| MX (1) | MX378890B (enExample) |
| PL (1) | PL3386523T3 (enExample) |
| RU (1) | RU2740096C2 (enExample) |
| WO (1) | WO2017097987A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016070151A1 (en) | 2014-10-31 | 2016-05-06 | Whole Biome. Inc. | Methods and compositions relating to microbial treatment and diagnosis of disorders |
| CN110392734A (zh) | 2017-02-28 | 2019-10-29 | 营养健康有限公司 | 可以有益地调节针对呼吸道病毒感染的免疫应答的长双歧杆菌 |
| EP3673044A1 (en) | 2017-08-25 | 2020-07-01 | University College Cork-National University of Ireland, Cork | Bifidobacterium longum for treating obesity and weight management |
| JP2020532515A (ja) | 2017-08-30 | 2020-11-12 | ペンデュラム セラピューティクス， インコーポレイテッド | マイクロバイオーム関連障害の処置のための方法および組成物 |
| CN117701424A (zh) * | 2018-04-11 | 2024-03-15 | 韩国生命工学研究院 | 具有肥胖预防或治疗效果的新的鼠李糖乳杆菌菌株及其用途 |
| CN113164526A (zh) | 2018-07-19 | 2021-07-23 | 潘德勒姆治疗公司 | 用于微生物植入的方法和组合物 |
| KR102224072B1 (ko) * | 2019-08-19 | 2021-03-10 | 주식회사 빙그레 | 면역 조절능력과 혈중콜레스테롤 감소 능력이 모두 뛰어난 비피도박테리엄 롱검 아종 균주 및 이의 용도 |
| WO2021180973A1 (en) | 2020-03-13 | 2021-09-16 | Precisionbiotics Group Limited | Bifidobacterium longum |
| CN113564069B (zh) * | 2021-05-28 | 2023-09-29 | 中山大学 | 一种长双歧杆菌、长双歧杆菌胞外多糖及其提取方法和应用 |
| CN115466689B (zh) * | 2022-02-09 | 2023-06-16 | 中国科学技术大学 | 用于预防和/或治疗代谢类疾病的益生菌组合物及其应用 |
| BG67720B1 (bg) * | 2022-03-18 | 2025-04-30 | "Ел Би Булгарикум" ЕАД | Щам bifidobacterium longum ssp. longum и бифидобактериален препарат с хиполипидемичен ефект, противовъзпалителен имуномодулиращ ефект и с намаляващ инсулиновата резистентност ефект |
| CN115637237B (zh) * | 2022-09-07 | 2024-09-17 | 辽宁贝克瑞生物科技有限公司 | 一株长双歧杆菌及其应用 |
| KR102789455B1 (ko) * | 2025-02-05 | 2025-04-04 | 주식회사 리스큐어바이오사이언시스 | 체지방 저감, 혈당 개선 및 근육 기능 강화 활성이 우수한 비피도박테리움 롱검 아종 롱검 lbmb322020 균주 및 이를 포함하는 대사성 질환 예방, 개선 또는 치료용 조성물 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010055499A2 (en) * | 2008-11-11 | 2010-05-20 | Alimentary Health Limited | Bifidobacterium longum |
| WO2011058535A1 (en) * | 2009-11-11 | 2011-05-19 | Alimentary Health Limited | Probiotic bifidobacterium strain |
| RU2473681C2 (ru) * | 2007-03-28 | 2013-01-27 | Элиментари Хелт Лимитед | ПРОБИОТИЧЕСКИЙ ШТАММ Bifidobacterium longum, КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ ТАКОЙ ШТАММ, И ЕГО ПРИМЕНЕНИЕ |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1974734A1 (en) * | 2007-03-28 | 2008-10-01 | Nestec S.A. | Probiotics for reduction of risk of obesity |
| JP2010526055A (ja) * | 2007-05-04 | 2010-07-29 | アリメンタリー・ヘルス・リミテッド | エキソ多糖 |
| EP2308499A1 (en) * | 2009-09-30 | 2011-04-13 | Nestec S.A. | Bifidobacterium longum ATCC BAA-999 (BL999) and weight control |
| CA3092318A1 (en) * | 2012-09-20 | 2014-03-27 | Prothera, Inc. | Probiotic compositions and methods for the treatment of obesity and obesity-related conditions |
-
2016
- 2016-12-09 KR KR1020187016182A patent/KR102819885B1/ko active Active
- 2016-12-09 WO PCT/EP2016/080454 patent/WO2017097987A1/en not_active Ceased
- 2016-12-09 US US16/060,765 patent/US10973862B2/en active Active
- 2016-12-09 MX MX2018006905A patent/MX378890B/es unknown
- 2016-12-09 CN CN201680079991.4A patent/CN109069552B/zh active Active
- 2016-12-09 JP JP2018530515A patent/JP6843140B2/ja active Active
- 2016-12-09 BR BR112018011665A patent/BR112018011665A2/pt not_active Application Discontinuation
- 2016-12-09 EP EP16820183.8A patent/EP3386523B1/en active Active
- 2016-12-09 ES ES16820183T patent/ES2760076T3/es active Active
- 2016-12-09 RU RU2018119287A patent/RU2740096C2/ru active
- 2016-12-09 DK DK16820183.8T patent/DK3386523T3/da active
- 2016-12-09 CA CA3006176A patent/CA3006176C/en active Active
- 2016-12-09 AU AU2016368527A patent/AU2016368527B2/en active Active
- 2016-12-09 PL PL16820183T patent/PL3386523T3/pl unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2473681C2 (ru) * | 2007-03-28 | 2013-01-27 | Элиментари Хелт Лимитед | ПРОБИОТИЧЕСКИЙ ШТАММ Bifidobacterium longum, КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ ТАКОЙ ШТАММ, И ЕГО ПРИМЕНЕНИЕ |
| WO2010055499A2 (en) * | 2008-11-11 | 2010-05-20 | Alimentary Health Limited | Bifidobacterium longum |
| RU2570557C2 (ru) * | 2008-11-11 | 2015-12-10 | Алиментари Хелс Лимитед | ПРОБИОТИЧЕСКАЯ БИФИДОБАКТЕРИЯ Bifidobacterium Longum |
| WO2011058535A1 (en) * | 2009-11-11 | 2011-05-19 | Alimentary Health Limited | Probiotic bifidobacterium strain |
Also Published As
| Publication number | Publication date |
|---|---|
| RU2018119287A (ru) | 2020-01-13 |
| WO2017097987A1 (en) | 2017-06-15 |
| DK3386523T3 (da) | 2020-01-06 |
| MX378890B (es) | 2025-03-10 |
| US20190111090A1 (en) | 2019-04-18 |
| CA3006176A1 (en) | 2017-06-15 |
| JP6843140B2 (ja) | 2021-03-17 |
| CA3006176C (en) | 2023-10-31 |
| CN109069552B (zh) | 2023-01-24 |
| CN109069552A (zh) | 2018-12-21 |
| MX2018006905A (es) | 2018-08-24 |
| AU2016368527B2 (en) | 2023-01-12 |
| JP2018536427A (ja) | 2018-12-13 |
| PL3386523T3 (pl) | 2020-03-31 |
| KR20180083352A (ko) | 2018-07-20 |
| AU2016368527A1 (en) | 2018-07-12 |
| RU2018119287A3 (enExample) | 2020-06-30 |
| EP3386523B1 (en) | 2019-10-09 |
| EP3386523A1 (en) | 2018-10-17 |
| US10973862B2 (en) | 2021-04-13 |
| BR112018011665A2 (pt) | 2018-12-04 |
| KR102819885B1 (ko) | 2025-06-12 |
| ES2760076T3 (es) | 2020-05-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2740096C2 (ru) | Bifidobacterium longum для лечения ожирения и ассоциированных метаболических расстройств | |
| US11490643B2 (en) | Lactobacillus casei for treating obesity and associated metabolic disorders | |
| Zhao et al. | Bacillus coagulans 13002 and fructo-oligosaccharides improve the immunity of mice with immunosuppression induced by cyclophosphamide through modulating intestinal-derived and fecal microbiota | |
| Bodera et al. | Immunomodulatory effect of probiotic bacteria | |
| IL271536A (en) | Compositions comprising bacterial blautia strains for treating visceral hypersensitivity | |
| TWI594758B (zh) | 包含雙歧桿菌的組合物、其製備方法及其用途 | |
| KR102224072B1 (ko) | 면역 조절능력과 혈중콜레스테롤 감소 능력이 모두 뛰어난 비피도박테리엄 롱검 아종 균주 및 이의 용도 | |
| US20240115625A1 (en) | Roseburia hominis, eubacterium eligens, and combinations thereof as biotherapeutics | |
| EP4081231A1 (en) | Compositions comprising microbes and methods of use and making thereof | |
| Scarpellini et al. | Probiotics: which and when? | |
| Jang et al. | Encapsulation of probiotics with poly-γ-glutamic acid alters gut microbiota and short-chain fatty acid content by maintaining cell viability in the gastrointestinal tract | |
| JP2024529268A (ja) | ラクトバチルス属の菌株３種を含む組成物、およびその用途 | |
| HK40000357A (en) | Bifidobacterium longum for treating obesity and associated metabolic disorders | |
| HK40000368A (en) | Lactobacillus casei for treating obesity and associated metabolic disorders | |
| Zafar et al. | Lacticaseibacillus rhamnosus FM9 and Limosilactobacillus fermentum Y57 Are as Effective as Statins at Improving Blood Lipid Profile in High Cholesterol, High-Fat Diet Model in Male Wistar Rats. Nutrients. 2022 Apr 15; 14 (8): 1654 | |
| Lauritano et al. | Probiotics: Which and When? | |
| BALCI | PROBIOTIC NUTRITIONS, HEALTH AND OBESITY |