RU2738082C1 - Method for production of dry leather bergenia extract nanocapsules - Google Patents

Abstract

FIELD: nanotechnology; medicine; food industry.

SUBSTANCE: invention relates to nanotechnology, medicine, and food industry. Distinctive feature of the proposed method is using as a kernel of a dry extract of leather bergenia and a shell of nanocapsules of sodium carboxymethyl cellulose, as well as use of precipitant - hexafluobenzene in producing nanocapsules by physical-chemical non-solvent deposition method.

EFFECT: technical task of invention is to simplify and accelerate process of production of nanocapsules and increase mass output.

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Description

The invention relates to the field of nanotechnology, medicine, pharmacology and food industry.

Methods for preparing microcapsules were previously known.

Patent 2173140 IPC A61K 009/50, A61K 009/127 Russian Federation published on 10.09.2001 proposes a method for producing organosilicon microcapsules using a rotary cavitation unit with high shear forces and powerful hydroacoustic phenomena of sound and ultrasonic range for dispersion.

The disadvantage of this method is the use of special equipment - a rotary cavitation unit, which has an ultrasonic effect, which affects the formation of microcapsules and, at the same time, can cause side reactions due to the fact that ultrasound has a destructive effect on polymers of protein nature, therefore, the proposed method is applicable when work with polymers of synthetic origin.

In US Pat. 2359662 IPC A61K 009/56, A61J 003/07, B01J 013/02, A23L 001/00 published on June 27, 2009 The Russian Federation proposed a method for producing sodium chloride microcapsules using spray cooling in a Niro spray cooling tower under the following conditions: air inlet temperature 10 ° C, outlet air temperature 28 ° C, spray drum rotation speed 10000 rpm. The microcapsules of the invention have improved stability and provide controlled and / or prolonged release of the active ingredient.

The disadvantages of the proposed method are the duration of the process and the use of special equipment, a set of certain conditions (air temperature at the inlet 10 ° C, air temperature at the outlet 28 ° C, the rotation speed of the spray drum 10000 rpm).

The closest method is the method proposed in US Pat. 2134967 IPC A01N 53/00, A01N 25/28 published on August 27, 1999 Russian Federation (1999). A solution of a mixture of natural lipids and a pyrethroid insecticide in a weight ratio of 2-4: 1 in an organic solvent is dispersed in water, which simplifies the microencapsulation method.

The disadvantage of this method is dispersion in an aqueous medium, which makes the proposed method inapplicable for obtaining microcapsules of water-soluble drugs in water-soluble polymers.

The technical problem is to simplify and accelerate the process of obtaining nanocapsules, reduce losses during the production of nanocapsules (increase the yield by weight).

The solution to the technical problem is achieved by the method of obtaining nanocapsules, characterized in that sodium carboxymethylcellulose is used as the shell of the nanocapsules, and the dry extract of badan is used as the core, when nanocapsules are obtained by precipitation with a non-solvent using hexafluorobenzene as a precipitant.

A distinctive feature of the proposed method is the production of nanocapsules by precipitation with a non-solvent using hexafluorobenzene as a precipitant, as well as the use of sodium carboxymethyl cellulose as a particle shell and a dry extract of badan as a core.

The result of the proposed method is to obtain nanocapsules of dry extract of badan.

EXAMPLE 1. Obtaining nanocapsules of dry extract of badan, the ratio of core: shell 1: 3

1 g of dry extract of badan is added to a suspension of 3 g of sodium carboxymethylcellulose in methanol in the presence of 0.01 g of E472c (an ester of glycerol with one or two molecules of edible fatty acids and one or two molecules of citric acid, and citric acid, as a tribasic one, can be esterified with other glycerides and as an oxo acid with other fatty acids Free acid groups can be neutralized with sodium) as surfactant with stirring at 700 rpm. Then add 6 ml of hexafluorobenzene. The resulting suspension is filtered off and dried at room temperature.

Received 4 g of powder nanocapsules. The yield was 100%.

EXAMPLE 2. Obtaining nanocapsules of dry extract of badan, the ratio of the core: the slurry 1: 1

1 g of dry extract of badan is added to a suspension of 1 g of sodium carboxymethyl cellulose in methanol in the presence of 0.01 g of E472c as a surfactant with stirring at 700 rpm. Then add 6 ml of hexafluorobenzene. The resulting suspension is filtered off and dried at room temperature.

Received 2 g of powder of nanocapsules. The yield was 100%.

EXAMPLE 3. Obtaining nanocapsules of dry extract of badan, the ratio of the core: the cake 1: 2

1 g of dry extract of badan is added to a suspension of 2 g of sodium carboxymethylcellulose in methanol in the presence of 0.01 g of E472c as a surfactant with stirring at 700 rpm. Then add 6 ml of hexafluorobenzene. The resulting suspension is filtered off and dried at room temperature.

Received 3 g of nanocapsule powder. The output was 100.

Claims (1)

A method of obtaining nanocapsules of dry extract of badan, characterized in that the dry extract of badan is added to a suspension of sodium carboxymethylcellulose in methanol in the presence of 0.01 g of a glycerol ester with one or two molecules of food fatty acids and one or two molecules of citric acid as a surfactant substances with stirring at 700 rpm, then hexafluorobenzene is added, the resulting suspension of nanocapsules is filtered and dried at room temperature, while the mass ratio of core: shell is 1: 1, 1: 2 or 1: 3.