RU2738545C1 - Method for producing nanocapsules of dry extract of wild yam - Google Patents

Abstract

FIELD: nanotechnologies.

SUBSTANCE: invention relates to nanotechnology, in particular to a method of producing nanocapsules, and describes a method of producing Hawthorn tincture nanocapsules in a gellan gum shell. Method is characterized by that dry extract of wild yam is added to a suspension of xanthum gum in benzene in presence of 0.01 g of glycerol ester with one or two molecules of food fatty acids and one or two molecules of citric acid as surfactant while stirring 700 rpm, then cyclohexane is added, obtained suspension of nanocapsules is filtered and dried at room temperature, wherein weight ratio of core: shell is 1:1, 1:2 or 1:3.

EFFECT: method provides a simplification and acceleration of the process of producing nanocapsules, a reduction in losses in the preparation of nanocapsules and can be used in the pharmaceutical and food industries.

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Description

The invention relates to the field of nanotechnology, medicine, pharmacology, cosmetics and food industry.

Methods for preparing microcapsules were previously known.

In US Pat. 2173140 IPC A61K 009/50, A61K 009/127 Russian Federation published on September 10, 2001, a method for producing organosilicon microcapsules using a rotary cavitation unit with high shear forces and powerful hydroacoustic phenomena of the sound and ultrasonic range for dispersion is proposed.

The disadvantage of this method is the use of special equipment - a rotary cavitation unit, which has an ultrasonic effect, which affects the formation of microcapsules and can cause side reactions due to the fact that ultrasound has a destructive effect on protein polymers, therefore the proposed method is applicable when working with polymers of synthetic origin

In US Pat. 2359662 IPC A61K 009/56, A61J 003/07, B01J 013/02, A23L 001/00 published on June 27, 2009 The Russian Federation proposed a method for producing sodium chloride microcapsules using spray cooling in a Niro spray cooling tower under the following conditions: air inlet temperature 10 ° C, outlet air temperature 28 ° C, spray drum rotation speed 10000 rpm. The microcapsules of the invention have improved stability and provide controlled and / or prolonged release of the active ingredient.

The disadvantages of the proposed method are the duration of the process and the use of special equipment, a set of certain conditions (air temperature at the inlet 10 ° C, air temperature at the outlet 28 ° C, the rotation speed of the spray drum 10000 rpm).

The closest method is the method proposed in US Pat. 2134967 IPC A01N 53/00, A01N 25/28 published on August 27, 1999 Russian Federation (1999). A solution of a mixture of natural lipids and a pyrethroid insecticide in a weight ratio of 2-4: 1 in an organic solvent is dispersed in water, which simplifies the microencapsulation method.

The disadvantage of this method is dispersion in an aqueous medium, which makes the proposed method inapplicable for obtaining microcapsules of water-soluble drugs in water-soluble polymers.

The technical problem is to simplify and accelerate the process of obtaining nanocapsules, reduce losses during the production of nanocapsules (increase the yield by weight).

The solution to the technical problem is achieved by the method of obtaining nanocapsules, characterized in that xanthan gum is used as a shell of nanocapsules, and a dry extract of wild yam is used as a core, when nanocapsules are obtained by precipitation with a non-solvent using cyclohexane as a precipitant.

A distinctive feature of the proposed method is the production of nanocapsules by precipitation with a non-solvent using cyclohexane as a precipitant, as well as the use of xanthan gum as a particle shell and a dry extract of wild yam as a core.

The result of the proposed method is the production of nanocapsules of dry extract of wild yam.

EXAMPLE 1 Obtaining nanocapsules of dry extract of wild yam, the ratio of core: shell 1: 3

1 g of dry extract of wild yam is added to a suspension of 3 g of xanthan gum in benzene in the presence of 0.01 g of the preparation E472c (an ester of glycerol with one or two molecules of edible fatty acids and one or two molecules of citric acid, and citric acid, as tribasic, can be esterified with other glycerides and as an oxo acid with other fatty acids Free acid groups can be neutralized with sodium) as surfactant with stirring at 700 rpm. Then 6 ml of cyclohexane are added. The resulting suspension is filtered and dried at room temperature.

Received 4 g of powder nanocapsules. The yield was 100%.

EXAMPLE 2 Obtaining nanocapsules of dry extract of wild yam, the ratio of core: shell 1: 1

1 g of dry extract of wild yam is added to a suspension of 1 g of xanthan gum in benzene in the presence of 0.01 g of E472c as a surfactant with stirring at 700 rpm. Then 6 ml of cyclohexane are added. The resulting suspension is filtered and dried at room temperature.

Received 2 g of powder of nanocapsules. The yield was 100%.

Example 3 Obtaining nanocapsules of dry extract of wild yam, core: shell ratio 1: 2

1 g of dry extract of wild yam is added to a suspension of 2 g of xanthan gum in benzene in the presence of 0.01 g of E472c as a surfactant with stirring at 700 rpm. Then 6 ml of cyclohexane are added. The resulting suspension is filtered and dried at room temperature.

Received 3 g of nanocapsule powder. The yield was 100%.

Claims (1)

A method of obtaining nanocapsules of a dry extract of wild yam, characterized in that the dry extract of wild yam is added to a suspension of xanthan gum in benzene in the presence of 0.01 g of a glycerol ester with one or two molecules of edible fatty acids and one or two molecules of citric acid as a surface -active substance with stirring at 700 rpm, then cyclohexane is added, the resulting suspension of nanocapsules is filtered and dried at room temperature, while the mass ratio of the core: shell is 1: 1, 1: 2 or 1: 3.