RU2737719C2 - Модулирование экспрессии аполипопротеина с-iii (аросiii) у пациентов с липодистрофией - Google Patents

Модулирование экспрессии аполипопротеина с-iii (аросiii) у пациентов с липодистрофией Download PDF

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RU2737719C2
RU2737719C2 RU2017133142A RU2017133142A RU2737719C2 RU 2737719 C2 RU2737719 C2 RU 2737719C2 RU 2017133142 A RU2017133142 A RU 2017133142A RU 2017133142 A RU2017133142 A RU 2017133142A RU 2737719 C2 RU2737719 C2 RU 2737719C2
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nucleic acid
modified
antisense
apociii
lipodystrophy
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RU2017133142A
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Russian (ru)
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RU2017133142A3 (enExample
RU2017133142A (ru
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Андрес ДИХЕНИО
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Ионис Фармасьютикалз, Инк.
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N2310/31—Chemical structure of the backbone
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
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    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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    • C12N2310/34—Spatial arrangement of the modifications
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    • C12N2310/35—Nature of the modification
    • C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
    • C12N2310/3525—MOE, methoxyethoxy
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  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
RU2017133142A 2015-02-27 2016-02-26 Модулирование экспрессии аполипопротеина с-iii (аросiii) у пациентов с липодистрофией RU2737719C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562126439P 2015-02-27 2015-02-27
US62/126,439 2015-02-27
PCT/US2016/019728 WO2016138355A1 (en) 2015-02-27 2016-02-26 Modulation of apolipoprotein c-iii (apociii) expression in lipodystrophy populations

Publications (3)

Publication Number Publication Date
RU2017133142A RU2017133142A (ru) 2019-03-28
RU2017133142A3 RU2017133142A3 (enExample) 2019-08-12
RU2737719C2 true RU2737719C2 (ru) 2020-12-02

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RU2017133142A RU2737719C2 (ru) 2015-02-27 2016-02-26 Модулирование экспрессии аполипопротеина с-iii (аросiii) у пациентов с липодистрофией

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US (2) US20180245076A1 (enExample)
EP (1) EP3270931A4 (enExample)
JP (1) JP2018511555A (enExample)
KR (1) KR20170122769A (enExample)
CN (1) CN107405358A (enExample)
AU (1) AU2016222548A1 (enExample)
BR (1) BR112017015307A2 (enExample)
CA (1) CA2977971A1 (enExample)
HK (1) HK1248522A1 (enExample)
IL (1) IL253346A0 (enExample)
MX (1) MX2017011009A (enExample)
RU (1) RU2737719C2 (enExample)
WO (1) WO2016138355A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2019002818A (es) * 2016-09-12 2019-08-29 Aegerion Pharmaceuticals Inc Metodos para detectar anticuerpos neutralizantes anti-leptina.
AU2017368050A1 (en) 2016-11-29 2019-06-20 Puretech Lyt, Inc. Exosomes for delivery of therapeutic agents
WO2022072244A1 (en) * 2020-10-02 2022-04-07 Ionis Pharmaceuticals, Inc. Methods for reducing apociii expression
JP2024525800A (ja) * 2021-07-16 2024-07-12 スーチョウ リボ ライフ サイエンス カンパニー、リミテッド 核酸、当該核酸を含む組成物及び複合体ならびに調製方法と使用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014127268A2 (en) * 2013-02-14 2014-08-21 Isis Pharmaceuticals, Inc. Modulation of apolipoprotein c-iii (apociii) expression in lipoprotein lipase deficient (lpld) populations

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7598227B2 (en) * 2003-04-16 2009-10-06 Isis Pharmaceuticals Inc. Modulation of apolipoprotein C-III expression
PL2670486T3 (pl) * 2011-01-31 2016-08-31 Cadila Healthcare Ltd Leczenie lipodystrofii
UA115309C2 (uk) * 2011-04-27 2017-10-25 Іоніс Фармасьютікалз, Інк. Модуляція експресії аполіпопротеїну ciii (apociii)
US9909124B2 (en) * 2013-06-21 2018-03-06 Ionis Pharmaceuticals, Inc. Compounds and methods for modulating apolipoprotein C-III expression for improving a diabetic profile
US20150045431A1 (en) * 2013-08-06 2015-02-12 Amarin Pharmaceuticals Ireland Limited Methods of treating a cardiovascular disorder in a subject on apo-c3 modulating therapy

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014127268A2 (en) * 2013-02-14 2014-08-21 Isis Pharmaceuticals, Inc. Modulation of apolipoprotein c-iii (apociii) expression in lipoprotein lipase deficient (lpld) populations

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RU2017133142A3 (enExample) 2019-08-12
AU2016222548A1 (en) 2017-07-27
US20180245076A1 (en) 2018-08-30
EP3270931A1 (en) 2018-01-24
CN107405358A (zh) 2017-11-28
RU2017133142A (ru) 2019-03-28
EP3270931A4 (en) 2018-10-03
JP2018511555A (ja) 2018-04-26
US20200095581A1 (en) 2020-03-26
HK1248522A1 (zh) 2018-10-19
MX2017011009A (es) 2017-10-20
KR20170122769A (ko) 2017-11-06
BR112017015307A2 (pt) 2018-01-16
IL253346A0 (en) 2017-09-28
CA2977971A1 (en) 2016-09-01
WO2016138355A1 (en) 2016-09-01

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