KR20170122769A - 지방이상증 집단에서 아포지단백질 C-III (ApoCIII) 발현의 조절 - Google Patents

지방이상증 집단에서 아포지단백질 C-III (ApoCIII) 발현의 조절 Download PDF

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KR20170122769A
KR20170122769A KR1020177025758A KR20177025758A KR20170122769A KR 20170122769 A KR20170122769 A KR 20170122769A KR 1020177025758 A KR1020177025758 A KR 1020177025758A KR 20177025758 A KR20177025758 A KR 20177025758A KR 20170122769 A KR20170122769 A KR 20170122769A
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Prior art keywords
certain embodiments
compound
apociii
animal
lipodystrophy
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Korean (ko)
Inventor
안드레스 디제니오
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아이오니스 파마수티컬즈, 인코포레이티드
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Publication of KR20170122769A publication Critical patent/KR20170122769A/ko
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/32—Chemical structure of the sugar
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    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
    • C12N2310/3525—MOE, methoxyethoxy
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    • C12N2320/30—Special therapeutic applications
    • C12N2320/32—Special delivery means, e.g. tissue-specific

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  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
KR1020177025758A 2015-02-27 2016-02-26 지방이상증 집단에서 아포지단백질 C-III (ApoCIII) 발현의 조절 Ceased KR20170122769A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562126439P 2015-02-27 2015-02-27
US62/126,439 2015-02-27
PCT/US2016/019728 WO2016138355A1 (en) 2015-02-27 2016-02-26 Modulation of apolipoprotein c-iii (apociii) expression in lipodystrophy populations

Publications (1)

Publication Number Publication Date
KR20170122769A true KR20170122769A (ko) 2017-11-06

Family

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KR1020177025758A Ceased KR20170122769A (ko) 2015-02-27 2016-02-26 지방이상증 집단에서 아포지단백질 C-III (ApoCIII) 발현의 조절

Country Status (13)

Country Link
US (2) US20180245076A1 (enExample)
EP (1) EP3270931A4 (enExample)
JP (1) JP2018511555A (enExample)
KR (1) KR20170122769A (enExample)
CN (1) CN107405358A (enExample)
AU (1) AU2016222548A1 (enExample)
BR (1) BR112017015307A2 (enExample)
CA (1) CA2977971A1 (enExample)
HK (1) HK1248522A1 (enExample)
IL (1) IL253346A0 (enExample)
MX (1) MX2017011009A (enExample)
RU (1) RU2737719C2 (enExample)
WO (1) WO2016138355A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2019002818A (es) * 2016-09-12 2019-08-29 Aegerion Pharmaceuticals Inc Metodos para detectar anticuerpos neutralizantes anti-leptina.
AU2017368050A1 (en) 2016-11-29 2019-06-20 Puretech Lyt, Inc. Exosomes for delivery of therapeutic agents
WO2022072244A1 (en) * 2020-10-02 2022-04-07 Ionis Pharmaceuticals, Inc. Methods for reducing apociii expression
JP2024525800A (ja) * 2021-07-16 2024-07-12 スーチョウ リボ ライフ サイエンス カンパニー、リミテッド 核酸、当該核酸を含む組成物及び複合体ならびに調製方法と使用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7598227B2 (en) * 2003-04-16 2009-10-06 Isis Pharmaceuticals Inc. Modulation of apolipoprotein C-III expression
PL2670486T3 (pl) * 2011-01-31 2016-08-31 Cadila Healthcare Ltd Leczenie lipodystrofii
UA115309C2 (uk) * 2011-04-27 2017-10-25 Іоніс Фармасьютікалз, Інк. Модуляція експресії аполіпопротеїну ciii (apociii)
DK2956176T3 (en) * 2013-02-14 2018-08-27 Ionis Pharmaceuticals Inc MODULATION OF APOLIPOPROTEIN C-III (APOCIII) EXPRESSION IN LIPOPROTEIN LIPASE DEFICIENT (LPLD) POPULATIONS
US9909124B2 (en) * 2013-06-21 2018-03-06 Ionis Pharmaceuticals, Inc. Compounds and methods for modulating apolipoprotein C-III expression for improving a diabetic profile
US20150045431A1 (en) * 2013-08-06 2015-02-12 Amarin Pharmaceuticals Ireland Limited Methods of treating a cardiovascular disorder in a subject on apo-c3 modulating therapy

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RU2017133142A3 (enExample) 2019-08-12
AU2016222548A1 (en) 2017-07-27
US20180245076A1 (en) 2018-08-30
EP3270931A1 (en) 2018-01-24
CN107405358A (zh) 2017-11-28
RU2017133142A (ru) 2019-03-28
EP3270931A4 (en) 2018-10-03
JP2018511555A (ja) 2018-04-26
US20200095581A1 (en) 2020-03-26
HK1248522A1 (zh) 2018-10-19
MX2017011009A (es) 2017-10-20
BR112017015307A2 (pt) 2018-01-16
IL253346A0 (en) 2017-09-28
CA2977971A1 (en) 2016-09-01
RU2737719C2 (ru) 2020-12-02
WO2016138355A1 (en) 2016-09-01

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