RU2737190C2 - Ингибиторы репликации вируса гриппа, способы их применения и использование - Google Patents
Ингибиторы репликации вируса гриппа, способы их применения и использование Download PDFInfo
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- RU2737190C2 RU2737190C2 RU2018124993A RU2018124993A RU2737190C2 RU 2737190 C2 RU2737190 C2 RU 2737190C2 RU 2018124993 A RU2018124993 A RU 2018124993A RU 2018124993 A RU2018124993 A RU 2018124993A RU 2737190 C2 RU2737190 C2 RU 2737190C2
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Classifications
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K31/52—Purines, e.g. adenine
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
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- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- A—HUMAN NECESSITIES
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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| CN109748915B (zh) * | 2015-12-09 | 2021-03-26 | 广东东阳光药业有限公司 | 流感病毒复制抑制剂及其使用方法和用途 |
| CN109071567B (zh) * | 2016-05-19 | 2021-03-23 | 四川大学 | 抗流感小分子化合物及其制备方法和用途 |
| CN107759571B (zh) | 2016-08-16 | 2021-03-02 | 广东东阳光药业有限公司 | 流感病毒复制抑制剂及其使用方法和用途 |
| CN109641868B (zh) | 2016-08-30 | 2021-12-03 | 广东东阳光药业有限公司 | 流感病毒复制抑制剂及其使用方法和用途 |
| SG11201901894TA (en) | 2016-09-05 | 2019-04-29 | Guangdong Raynovent Biotech Co Ltd | Anti-influenza virus pyrimidine derivatives |
| US10987354B2 (en) | 2016-12-15 | 2021-04-27 | Sunshine Lake Pharma Co., Ltd. | Inhibitors of influenza virus replication and uses thereof |
| WO2018127096A1 (en) | 2017-01-05 | 2018-07-12 | Sunshine Lake Pharma Co., Ltd. | Inhibitors of influenza virus replication and uses thereof |
| US10927118B2 (en) | 2017-03-02 | 2021-02-23 | Sunshine Lake Pharma Co., Ltd. | Inhibitors of influenza virus replication and uses thereof |
| WO2018200425A1 (en) * | 2017-04-24 | 2018-11-01 | Cocrystal Pharma, Inc. | Pyrrolopyrimidine derivatives useful as inhibitors of influenza virus replication |
| CN109384783A (zh) * | 2017-08-09 | 2019-02-26 | 银杏树药业(苏州)有限公司 | 新型杂环化合物及其作为抗流感病毒抑制剂的医药用途 |
| WO2019155468A1 (en) * | 2018-02-08 | 2019-08-15 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Heteroaryl compounds, pharmaceutical compositions thereof, and their therapeutic use |
| JP7031002B2 (ja) * | 2018-03-05 | 2022-03-07 | 広東衆生睿創生物科技有限公司 | ピリジノイミダゾール系化合物の結晶型、塩型及びその製造方法 |
| CN110590768B (zh) * | 2018-06-13 | 2021-02-26 | 银杏树药业(苏州)有限公司 | 杂环化合物、其组合物及其作为抗流感病毒药物的应用 |
| CN114340614B (zh) * | 2019-09-27 | 2024-01-16 | 广东东阳光药业股份有限公司 | 一种奥司他韦制剂 |
| CN110967239B (zh) * | 2020-01-02 | 2022-05-10 | 国家地质实验测试中心 | 一种金属铬溶解氧化方法 |
| CN117362318A (zh) * | 2020-07-10 | 2024-01-09 | 西藏海思科制药有限公司 | Pb2抑制剂及其制备方法和用途 |
| US12274700B1 (en) | 2020-10-30 | 2025-04-15 | Accencio LLC | Methods of treating symptoms of coronavirus infection with RNA polymerase inhibitors |
| US20250289826A1 (en) * | 2022-04-29 | 2025-09-18 | Tsinghua University | Plpro protein inhibitor, and preparation method and application thereof |
| WO2026016541A1 (zh) * | 2024-07-16 | 2026-01-22 | 武汉武药科技有限公司 | 一种新型抗病毒化合物及其用途 |
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| WO2010148197A1 (en) * | 2009-06-17 | 2010-12-23 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
| RU2010119561A (ru) * | 2004-03-30 | 2011-11-20 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Азаиндолы, полезные в качестве ингибиторов jак и других протеинкиназ |
| WO2013019828A1 (en) * | 2011-08-01 | 2013-02-07 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
| WO2015073476A1 (en) * | 2013-11-13 | 2015-05-21 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
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| MX2013006840A (es) * | 2010-12-16 | 2014-01-31 | Vertex Pharma | Inhibidores de la replicacion de los virus de la influenza. |
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| AU2011343642A1 (en) | 2010-12-16 | 2013-05-02 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
| CN103702998A (zh) * | 2011-07-05 | 2014-04-02 | 沃泰克斯药物股份有限公司 | 生产氮杂吲哚类的方法和中间体 |
| EP2858984A1 (en) | 2012-06-08 | 2015-04-15 | Vertex Pharmaceuticals Inc. | Inhibitors of influenza viruses replication |
| KR20160084465A (ko) | 2013-11-13 | 2016-07-13 | 버텍스 파마슈티칼스 인코포레이티드 | 아자인돌 화합물의 제형 |
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2020
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| JP6952695B2 (ja) | 2021-10-20 |
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| US11225477B2 (en) | 2022-01-18 |
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| CA3005921A1 (en) | 2017-06-15 |
| CN109748915A (zh) | 2019-05-14 |
| CN106854205A (zh) | 2017-06-16 |
| EP3362451A1 (en) | 2018-08-22 |
| AU2016368317B2 (en) | 2019-05-23 |
| WO2017097234A1 (en) | 2017-06-15 |
| SG11201804225PA (en) | 2018-06-28 |
| RU2018124993A (ru) | 2020-01-14 |
| EP3362451A4 (en) | 2019-07-03 |
| HK1254668A1 (en) | 2019-07-26 |
| EP3362451B1 (en) | 2023-04-12 |
| CN106854205B (zh) | 2019-07-09 |
| US20200299294A1 (en) | 2020-09-24 |
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