RU2730852C2 - Composition of ingredients for treating fungal skin diseases of feet and nails (versions) - Google Patents

Abstract

FIELD: medicine.SUBSTANCE: group of inventions refers to means for treating skin diseases of feet and nails. Composition of ingredients for treating fungal skin diseases of feet and nails contains wine, glycolic, citric, lactic acid, as a medicinal agent and water, characterized in that it additionally contains salicylic acid, malic acid, sodium hydroxide and hydrogel glycerate, with the following ratio of components, wt %: malic acid—5–15, tartaric acid—5–15, citric acid—5–15, glycolic acid—3–8, salicylic acid—1–3, lactic acid—10–20, sodium hydroxide—10–30, hydrogel glycerate—5–10, distilled water—the rest. Also disclosed are other versions of the ingredients compositions for treating fungal skin diseases of feet and nails.EFFECT: group of inventions provides higher clinical effectiveness, reduced length of treatment, recovered skin of feet and nail plate.4 cl, 10 ex

Description

The invention relates to medicine, in particular to a composition of ingredients for the treatment of skin diseases of the feet, specifically hyperhidrosis, onychomycosis caused by microorganisms T. Rubrum, psoriasis, mycosis, hyperkeratosis, onychomycosis caused by microorganisms of the genus Candida.

Currently, there are two main areas of treatment for fungal infections of the nails of the toes and hands: oral systemic drugs and topical drugs. Nail fungus is treated with oral antifungals such as terbinafine, itraconazole. Oral drugs are absorbed into the circulation, eventually reaching the nail bed and nail plate.

Medicines or topical preparations such as varnishes and antimicrobial liquids are sold without a prescription and are usually presented as a coating or nail polish that forms an impervious film on the nail plate. Over time, the drug penetrates through the coating or varnish into the nail plate and then in the direction of the nail bed, where it destroys dermatophytes and yeasts by direct pharmacological action on them. For example, WO 2007/147052 and US 2005/181999 describe topical compositions for the treatment of fungal nail infections, such compositions comprising biologically active substances. Biologically active agents can be antifungal agents, antibacterial agents, anti-inflammatory agents, or antiviral agents.

Most of the research was directed to the creation of pharmaceutical compositions with prolonged action due to film-forming coatings (RF patent No. 2574962).

Hyperkeratosis of the feet is currently treated in a hospital by deep burns with acid compounds, which requires adherence to bed rest for three weeks, followed by restriction of movement for a month. For home use, patients with hyperkeratosis are recommended to use pharmaceutical preparations for external use, usually containing 20-30% carbamide (http://bd.patent.su/2292000-2292999/pat/servl/servletada9/html).

Among the methods of treating hyperhidrosis, several directions can be distinguished: surgical, cosmetology, physiotherapy and medication.

Surgical destruction of the sweat glands requires a long recovery period. The cosmetological method consists in injecting drugs under the skin, mainly Botox, which block the sweat glands. The disadvantage of radical methods, in which sweat glands are completely blocked in a certain part of the body, is that sweat glands are activated in other areas.

Medicines against hyperhidrosis include various ointments and powders, (http://ru-patent.info/20/30-34/2031649.html).

The composition described in the description of the invention to US patent No. 4234599 was selected as a prototype of the composition according to options I, II, IV, V, which contains the following general components:

a) medicinal product;

b) carrier (vehicle).

As a drug, the composition contains a component selected from the group consisting of - hydroxybutyric acid: alpha-hydroxyisobutyric acid, α-hydroxyisocaproic acid, α-hydroxyisovaleric acid, atroal acid, β-hydroxybutyric acid, β-phenyl lactic acid, β-phenylpyruvic acid , citric acid, ethylpyruvate, galacturonic acid, glucoheptonic acid, glucoepton 1,4-lactone, gluconic acid, gluconolactone, glucuronic acid, glucuronolactone, glycolic acid, isopropylpyruvate, mandelic acid, methylpyruvate, mucinic acid, saccharic acid 1,4-lactone, tartaric acid, lactic acid and tartronic acid in a pharmaceutically acceptable carrier.

As an acceptable carrier, this composition contains a mixture of water, ethyl alcohol and propylene glycol.

The composition described in the description of the invention to US patent No. 4291062, which contains the following general components, is selected as a prototype of the claimed composition according to the III variant:

- urea;

- a carrier (in patent No. 4291062 it is a glycerol tri-ester). The formulations of US patents No. 4234599 and 4291062 have the following disadvantages:

- long term of treatment, which ranges from six months to two years;

- low degree of treatment ≈46-50%, associated with shallow penetration of medicinal components.

In addition, these compositions are unsuitable for phonophoresis and electrophoresis due to the presence of hydrophobic and high molecular weight compounds.

From the medical and patent literature, the applicant has not found an agent for the treatment of foot hyperhidrosis caused by hormonal disruption, smoking, in composition close to the claimed composition according to the VI option.

The basis of the invention is to create a composition of ingredients for the treatment of skin diseases of the feet, in which, by the original combination of components and their ratio to each other, to ensure a reduction in the treatment time for onychomycosis, hyperkeratosis and hyperhidrosis, increase the effectiveness of treatment while increasing convenience for patients by accelerating skin recovery. feet and nail plate.

The problem is solved by six variants of the composition of ingredients for the treatment of skin diseases of the feet.

In option I, the problem is solved by a composition of ingredients for the treatment of foot hyperhidrosis containing tartaric, glycolic, citric, lactic acids as a medicine and distilled water in that it additionally contains salicylic and malic acids, in the following ratio of these components, wt. %:

Apple acid 3-15 wine acid 3-15 lemon acid 3-15 glycolic acid 3-5 salicylic acid 1-3 lactic acid 5-20 distilled water rest

For the treatment of onychomycosis caused by microorganisms T. Rubrum chronic course, the composition of the ingredients according to option I additionally contains sodium hydroxide and a hydrogel of silicon glycerate, with the following ratio of these components, wt. %:

Apple acid 5-15 wine acid 5-15 lemon acid 5-15 glycolic acid 3-8 salicylic acid 1-3 lactic acid 10-20 sodium hydroxide 10-30 glycerate hydrogel silicon 5-10 distilled water rest

For the treatment of onychomycosis and mycosis of the feet caused by microorganisms T. Rubrum, the composition of the ingredients according to option I additionally contains imidazole, with the following ratio of these components, wt. %:

Apple acid 5-15 wine acid 5-15 lemon acid 5-15 glycolic acid 5-15 salicylic acid 1-3 lactic acid 10-20 sodium hydroxide 10-30 glycerate hydrogel silicon 5-10 imidazole 2-5 distilled water rest

In option II, for the treatment of foot hyperkeratosis, the task is solved by a composition containing tartaric, glycolic, citric, lactic acids and water in that it additionally contains malic acid, sodium hydroxide and silicon glycerate hydrogel, with the following ratio of these components, wt. %:

Apple acid 5-15 wine acid 5-15 lemon acid 5-10 glycolic acid 5-10 lactic acid 10-20 sodium hydroxide 20-30 glycerate hydrogel silicon 10-15 distilled water rest

In variant III, the problem is solved by a composition for the treatment of hyperkeratosis of the feet caused by improper treatment of the feet during pedicure, containing urea and a carrier in that it additionally contains water, and as a carrier the composition contains a silicon glycerate hydrogel, with the following ratio of these components, wt. %:

urea 20-50 glycerate hydrogel silicon 10-15 distilled water rest

In variant IV, the problem is solved by a composition for the treatment of foot candidiasis and onychomycosis caused by yeasts of the genus Candida, containing a drug, ethanol and water, so that it additionally contains chloroform, and the composition contains fluconosole as a drug, with the following ratio of these components, wt. %:

fluconosole 2-7 ethanol 60-70 chloroform 20-30 distilled water rest

In Variant V, the problem is solved by a composition for the treatment of onychomycosis and mycosis of the feet caused by T. Rubrum microorganisms, containing a drug, acid, ethanol and water, in that it additionally contains dimethyl sulfoxide, as a drug it contains terbinafine, and as an acid - hydrochloric acid, with the following ratio of these components, wt. %:

terbinafine 1-10 ethanol 40-60 dimethyl sulfoxide 5-10 hydrochloric acid 0.5-2.0 distilled water rest

In the VI version, the problem is solved by a composition for the treatment of hyperhidrosis of the feet caused by hormonal disruption, smoking and thermoregulation disorders, containing aluminum chloride, zinc chloride, colloidal solution of silver iodide, sodium salicylate and distilled water, with the following ratio of these components, wt. %:

aluminum chloride 2-10 zinc chloride 2-10 colloidal solution silver iodide 5-20 sodium salicylate 1-5 distilled water rest

Examples confirming the implementation of the invention.

Example 1. Option I. Patient V., 29 years old, came with a diagnosis of foot hyperhidrosis caused by nervous overexcitation, complicated by obesity and smoking. The duration of the disease is about 5 years. The diagnosis was confirmed by a dermatologist by visual examination and anamnesis. The patient underwent electrophoresis once every 2 days. The course of procedures - 10. The duration of the procedure is 15-20 minutes on a two-channel device "MIT-EF2" (manufactured by LLC "NMC Medintech"). The current strength for the procedure was in the range of 0.1-30 mA, the range of set therapeutic frequencies was 25 Hz. A gauze bandage soaked in a solution containing, by weight, was applied to the feet under the electrode. %:

Apple acid ten wine acid ten lemon acid ten glycolic acid 3 salicylic acid 3 lactic acid ten distilled water 54

In parallel with the course of treatment of hyperhidrosis, the patient was treated with sedatives under the supervision of a neuropathologist.

After three courses of electrophoresis of an aqueous solution of the specified composition with a break between courses - two months, the patient had no complaints of symptoms of hyperhidrosis. The condition of the feet on visual examination improved. The patient is recommended to repeat the course after nine to twelve months.

Example 2. Option I. Patient N., 43 years old, came with a diagnosis of onychomycosis caused by T. Rubrum chronic course. The defeat of the nail plates by onychomycosis was about 40% (distal-lateral form). The duration of the disease is about 5 years. The diagnosis was confirmed by laboratory tests.

Removal of the affected part of the nail was carried out using a hardware pedicure device. Hardware processing was performed once before laser therapy procedures.

Physiotherapy procedures were prescribed. Irradiation with a neodymium laser: treatment frequency - once every seven days. Course of procedures - 5.

Laser treatment was combined with electrophoresis. The frequency of procedures is 1 time in 3 days. The course of procedures - 10. A gauze bandage soaked in a solution containing, by weight, was applied to the nail plate under the electrode. %:

Apple acid five wine acid five lemon acid five glycolic acid five salicylic acid 1 lactic acid ten sodium hydroxide fourteen silicon glycerate hydrogel five distilled water 50

Between procedures, the patient applied a solution of "Nitrofugin-neo" to all nail plates.

After 10 procedures of electrophoresis with the specified composition, in combination with 5 procedures of laser therapy, the condition of the nail plates improved: the healthy plate grew back by 100%. Laboratory studies have confirmed the absence of the pathogen in the nail plates. After 3 months, the patient did not develop symptoms of onychomycosis.

Example 3. Option I. Patient E., 44 years old, a history of psoriasis of the nail plates, eczema. Has addressed with an acute form of onychomycosis caused by T. Rubrum. The defeat of the nail plates by onychomycosis was about 10-20%. The diagnosis was confirmed by laboratory tests.

Removal of the affected part of the nail was carried out using a hardware pedicure device. The specified hardware processing was carried out once before physiotherapy.

The following physiotherapy procedures were prescribed. Irradiation with a neodymium laser: electrophoresis - once every 2 days. The course of procedures - 10. A gauze bandage soaked in a solution containing, by weight, was applied to the nail plate under the electrode. %:

Apple acid 15 wine acid 15 lemon acid 15 glycolic acid five salicylic acid 1 lactic acid 15 sodium hydroxide fourteen silicon glycerate hydrogel five distilled water 15

Between procedures, the patient applied a solution of "Nitrofugin-neo" to all nail plates.

After 10 procedures of electrophoresis with the specified solution in combination with 5 procedures of laser therapy, the condition of the nail plates improved: the healthy plate grew back by 100%. Laboratory studies have confirmed the absence of the pathogen in the nail plates. After 2 months, the patient did not develop symptoms of onychomycosis.

Example 4. Option I. Patient A., 32 years old, came with a diagnosis of onychomycosis and mycosis of the foot caused by T. Rubrum chronic course. The defeat of the nail plates by onychomycosis was about 100% (total form). The duration of the disease is more than 12 years. The diagnosis was confirmed by laboratory tests.

Removal of the affected part of the nail was carried out using a device for hardware pedicure (podological installation "Kart" for eight instruments, PE "Galit", Ternopil, Ukraine). The protruding part of the nail was cut with pedicure nippers. Then the hyperkeratotic masses were cleaned off with a medium ceramic bur with a cross cut. With a small ceramic cutter with oblique transverse grooves, hyperkeratotic masses were removed along the edge of the healthy part of the nail up to the nail bed. After that, a ceramic grinder was used to polish the healthy part of the nail and the entire nail bed. After polishing, the nail was treated with an antiseptic solution. The specified hardware processing was carried out once a week during the course of physiotherapy procedures.

The following physiotherapy procedures were prescribed. Irradiation of nail plates with a neodymium laser (Q-Switch Nd: YAG Laser CML-202) with a wavelength of 1064 nm. The duration of exposure for one nail was at least 5 minutes. The frequency of the procedures was once every seven days. The course of treatment consisted of 5 procedures with a repetition rate of the course in 30 days.

In parallel with the use of laser therapy, electrophoresis was used. The frequency of the procedures is 1 time in 2 days. Course of procedures - 10. The procedure was carried out on a two-channel device "MIT-EF2" (manufactured by LLC "NMC Medintech"). The duration of the procedure was 15-20 minutes. The current strength for the procedure was in the range of 0-30 mA, the range of set therapeutic frequencies was 25 Hz. A gauze bandage soaked in a solution containing, by weight, was applied to the nail plates under the electrode. %:

Apple acid 15 wine acid 15 lemon acid 15 glycolic acid five salicylic acid 1 lactic acid 15 sodium hydroxide 15 imidazole 2 silicon glycerate hydrogel five distilled water 12

Between the procedures, the patient independently applied Exoderil solution to all nail plates and Terbizil cream to the feet. After 10 procedures of electrophoresis with the specified solution in combination with 5 procedures of laser therapy, the condition of the nail plates improved: the healthy plate grew by 30%. The patient continued the course of treatment until complete recovery.

Example 5. Option II. Patient O., 42 years old, came with a diagnosis of hyperkeratosis of the feet caused by improper processing of the feet during pedicure with excessive removal of the stratum corneum, complicated by hyperhidrosis due to wearing improperly selected shoes. The duration of the disease is about 7 years. The diagnosis was confirmed by a dermatologist by visual examination and anamnesis.

The following procedures are assigned. Irradiation of foci of hyperkeratosis with a neodymium laser with a wavelength of 1064 nm lasting at least 15 minutes of one foot with a frequency of once every seven days. The course of procedures - 5 times. In parallel with the use of laser therapy, electrophoresis was used once every 2 days. The course of procedures - 10. The duration of the procedure is 15-20 minutes on a two-channel device "MIT-EF2" (manufactured by LLC "NMC Medintech"). The current strength for the procedure was in the range of 0.1-30 mA, the range of set therapeutic frequencies was 25 Hz. A 40% carbamide solution was applied to the feet to improve the permeability of the stratum corneum. Then, a gauze bandage soaked in a solution containing, by weight, was applied to the feet under the electrode. %:

Apple acid five wine acid five lemon acid five glycolic acid five lactic acid ten sodium hydroxide 20 silicon glycerate hydrogel ten distilled water 40

After two courses of electrophoresis with the specified solution in combination with laser therapy with a break between courses - two months, the condition of the feet improved by 100%, upon visual examination by a dermatologist. After a year, the patient did not develop symptoms of hyperkeratosis.

Example 6. Option III. Patient O., 48 years old, came with a diagnosis of hyperkeratosis of the feet, caused by improper processing of the feet during pedicure with excessive removal of the stratum corneum. The duration of the disease is about 20 years. The diagnosis was confirmed by a dermatologist by visual examination and anamnesis.

The patient underwent hardware treatment of hyperkeratosis and a course of phonophoresis with 40% aqueous solution of urea to normalize the exfoliation of the stratum corneum. The duration of the procedure is 15-20 minutes, the radiation frequency is 1 MHz, the power is 3 W / cm2. The course of procedures - 10 times every other day.

Pharmaceutical composition for phonophoresis in the treatment of foot hyperkeratosis, wt. %:

urea 40 silicon glycerate hydrogel ten distilled water 50

Laser therapy was used simultaneously with the course of phonophoresis. The skin of the feet in places of hyperkeratosis was irradiated with a neodymium laser for 15 minutes. The course of procedures - 5 (once every seven days).

Every day the patient applied preparations with keratollic action to her feet.

After 10 phonophoresis procedures with the specified solution in combination with laser therapy, the area of keratinized tissue decreased, the condition of the skin of the feet improved by 60%.

Example 7. Option IV. Egor is 48 years old. Diagnosis of condidosis of the feet.

Confirmed by laboratory tests.

The feet were treated using the hardware pedicure technique and a composition containing, by weight, was applied every other day. %:

fluconosole 5.0 ethanol 65.0 chloroform 25.0 distilled water 5.0

After that, phonophoresis was performed. Number of procedures 10. Once a week the client underwent laser therapy 5 times. One month of break and repeated course.

At the end of the treatment, laboratory tests did not confirm the presence of candidiasis on the patient's feet. Diagnosis: healthy.

Example 8. Option IV. Patient I., 54 years old, came with a diagnosis of onychomycosis caused by yeast fungi of the genus Candida, chronic course. The defeat of the nail plates by onychomycosis was about 30%. The duration of the disease is about 3 years. The diagnosis was confirmed by laboratory tests.

Hardware removal of the affected part of the nail was performed once a week. The following physiotherapy procedures were prescribed. Irradiation with a neodymium laser, phonophoresis on the "CareShow" CS-638A apparatus (China) with a radiation frequency of 1 MHz, a power of 3 W / cm2. Before the procedure, the nail plates were treated with a carbamide solution to increase permeability.

Then a napkin made of non-woven material (spunlace) soaked in a solution containing, by weight, was applied to the nail plates. %:

fluconosole 5.0 ethanol 65.0 chloroform 25 distilled water 5.0

The duration of the procedure for the toes of one leg is 15 minutes, once every 2 days. The course of procedures - 10.

After 10 phonophoresis procedures with the specified fluconazole solution in combination with 5 laser therapy procedures, the condition of the nail plates improved: a healthy plate grows by 60-80%. The patient was in the process of treatment until he fully recovered.

Example 9. Option V. Patient O. 32, came with a diagnosis of onychomycosis and mycosis of the feet caused by T. Rubrum chronic course. The defeat of the nail plates by onychomycosis was about 15-20% (distal-lateral form). The duration of the disease is more than 5 years. The diagnosis was confirmed by laboratory tests.

Removal of the affected part of the nail was carried out using a device for hardware pedicure (podological installation "Kart" for eight instruments, PE "Galit", Ternopil, Ukraine). The protruding part of the nail was cut with pedicure nippers. Then the hyperkeratotic masses were cleaned off with a medium ceramic bur with a cross cut. A fine ceramic cutter with oblique transverse grooves removed hyperkeratotic masses along the edge of the healthy part of the nail up to the nail bed. After that, a ceramic grinder was used to polish the healthy part of the nail and the entire nail bed. After polishing, the nail was treated with an antiseptic solution. The specified hardware processing was carried out once a week during the course of physiotherapy procedures.

The feet were also simultaneously treated with disposable grinding caps of different grain sizes, while removing keratinization on the feet and peeling

The following physiotherapy procedures were prescribed. Irradiation of nail plates with a neodymium laser (Q-Switch Nd: YAG Laser CML-202) with a wavelength of 1064 nm. The duration of exposure for one nail was at least 5-7 minutes. The frequency of procedures was once every seven days. The course of treatment consisted of 5 procedures with a repetition rate of the course in 30 days.

Irradiation of feet with a neodymium laser (Q-Switch Nd: YAG Laser CML-202) with a wavelength of 1064 nm. The duration of exposure to one foot was at least 10-12-15 minutes. The frequency of the procedures was once every seven days. The course of treatment consisted of 5 procedures with a repetition rate of the course in 30 days.

In parallel with the use of laser therapy, electrophoresis was used. The frequency of the procedures is 1 time in 2 days. Course of procedures - 10. The procedure was carried out on a two-channel device "MIT-EF2" (manufactured by LLC "NMC Medintech"). The duration of the procedure was 20-25 minutes. The current strength for the procedure was in the range of 0.1-30 mA, the range of set therapeutic frequencies was 25 Hz. A gauze bandage soaked in a solution containing, by weight, was applied to the nail plates under the electrode. %:

terbinafine 5.0 ethyl alcohol 50.0 dimethyl sulfide 7.0 hydrochloric acid 1,2 distilled water 36.8

Then, the electrodes were reinstalled to affect the skin of the foot in the same way, for 25 minutes under the electrode "+" by applying a gauze napkin with the claimed composition.

The set of procedures was repeated after 30 days.

The procedures were repeated three times; at the end of the treatment, laboratory tests did not confirm the presence of mycelium on the patient's feet and nails. Diagnosis: healthy.

Example 10. Option VI. Patient I., 19 years old, was diagnosed with hyperhidrosis of the feet caused by hormonal disruption, smoking and impaired thermoregulation due to wearing uncomfortable and low-quality shoes. The duration of the disease is about 4 years. The diagnosis was confirmed by a dermatologist by visual examination and anamnesis.

The patient underwent electrophoresis once every 2 days. The course of procedures - 10. The duration of the procedure is 15-20 minutes on a two-channel device "MIT-EF2". The current strength for the procedure was in the range of 0.1-30 mA, the range of set therapeutic frequencies was 25 Hz. Then, a gauze bandage soaked in a solution containing, by weight, was applied to the feet under the electrode. %:

aluminum chloride 2 zinc chloride five colloidal silver iodide solution five sodium salicylate 4 distilled water 84

After two courses of electrophoresis using the specified composition with a break between courses - two months, the patient had no complaints of symptoms of hyperhidrosis. The condition of the feet on visual examination improved. The patient is recommended to repeat the course in six months.

The above examples confirm the feasibility and effectiveness of the claimed compositions for the treatment of fungal diseases of the feet, hyperkeratosis, hyperhidrosis of the feet using phonophoresis and electrophoresis. The compositions have the necessary properties for their application by phonophoresis and electrophoresis. First, it is a liquid consistency, which is the condition for the penetration of the drug into the epidermis. Secondly, the active ingredients are selected taking into account their solubility, which ensures sufficiently high concentrations of the active ingredients in the compositions. Thirdly, compositions for electrophoresis are developed on the basis of ionic compounds, which ensures their penetration into the skin under the action of an electric current.

The combination of physiotherapeutic methods with the proposed pharmaceutical compositions leads to an improvement in their effectiveness, prolongation of their action, and in some cases can be an alternative to hospital treatment and long-term recovery.

In the period from 2015 to March 2018. The claimed method was tested on 700 patients, 600 of whom are women and 100 are men.

The treatment was carried out using compositions with different content of components within the claimed limits.

Of the 700 patients who were treated using the claimed compositions, 30% recovered completely, and 70% of patients returned and recovered completely after a second course of treatment.

The advantage of the proposed compositions is the reduction of the treatment time for onychomycosis, hyperkeratosis and hyperhidrosis, while increasing the convenience for patients by accelerating the recovery of the skin of the feet and nail plate. Thus, treatment using the claimed compositions does not require a change in the patient's lifestyle in the treatment of skin diseases of the feet.

Claims (8)

1. Composition of ingredients for the treatment of fungal skin diseases of feet and nails, containing tartaric, glycolic, citric, lactic acid, as a drug, and water, characterized in that it additionally contains salicylic, malic acids, sodium hydroxide and hydrogel of silicon glycerate, with the following ratio of these components, wt%: Apple acid 5-15 wine acid 5-15 lemon acid 5-15 glycolic acid 3-8 salicylic acid 1-3 lactic acid 10-20 sodium hydroxide 10-30 silicon glycerate hydrogel 5-10 distilled water rest 2. Composition of ingredients for the treatment of fungal skin diseases of feet and nails, containing tartaric, glycolic, citric, lactic acids, as a drug, a base and water, characterized in that it additionally contains malic acid and a hydrogel of silicon glycerate, and as a base - sodium hydroxide, with the following ratio of these components, wt%: Apple acid 5-15 wine acid 5-15 lemon acid 5-10 glycolic acid 5-10 lactic acid 10-20 sodium hydroxide 20-30 silicon glycerate hydrogel 10-15 distilled water rest 3. Composition of ingredients for the treatment of fungal skin diseases of feet and nails, containing a drug, ethyl alcohol and water, characterized in that it additionally contains chloroform, and as a drug the composition contains fluconazole, in the following ratio of these components, wt%: fluconazole 2-7 ethanol 60-70 chloroform 20-30 distilled water rest 4. Composition of ingredients for the treatment of skin diseases of feet and nails, containing a drug, acid, ethyl alcohol and water, characterized in that it additionally contains dimethyl sulfoxide, as a drug it contains terbinafine, and as an acid - hydrochloric acid, with the following the ratio of these components, wt%: terbinafine 1-10 ethanol 40-60 dimethyl sulfoxide 5-10 hydrochloric acid 0.5-2.0 distilled water rest