RU2721460C1 - Method of non-surgical correction of face shape - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely, to cosmetology. On the basis of visual inspection and palpation of the face, the areas requiring correction are selected by detecting the intertissue liquid content disorder and subcutaneous fat development. Based on the examination and palpation results in the identified areas requiring correction, within 1 procedure, the preparation is administered GAG Complex "DVL Capyl" formula and/or Estetic Form "Phyto Slim" formula. If observing interstitial fluid accumulation in the zone of increased accumulation and high subcutaneous fat development, the entire area is treated by intradermal administration of preparations GAG Complex "DVL Capyl" formula and Estetic Form "Phyto Slim" formula. If observing intra-tissue fluid accumulation and subcutaneous fat reduction in the zone, the entire area is treated by intradermal administration of the preparation GAG Complex "DVL Capyl" formula. If observing subcutaneous fat in the area of increased development and no increased accumulation of interstitial fluid, the entire area is treated by intradermal administration of the preparation Estetic Form "Phyto Slim" formula. On the injection area, a compress is applied, consisting of: a nonsteroidal anti-inflammatory agent – a phenylacetic acid derivative, a dimexide concentrate and water in ratio of their volumes of 3:1:5. Procedure is completed by putting on the face of the compression bandage. Therapeutic course is 3 procedures.

EFFECT: method enables correcting the required face shape in 3 procedures by eliminating smoothness of facial soft tissues and reduced skin turgor.

3 cl, 2 ex, 2 tbl

Description

The invention relates to medicine, namely to cosmetology, and can be used as non-surgical correction of the shape of the face.

Age-related changes in facial skin are a natural result of the general biological aging of the body. This process is accelerated by both external and internal factors. The inhabitants of the metropolis are significantly affected by the aggressive external environment, which in combination with other factors significantly accelerates the aging process.

In recent years, there has been a shift in emphasis in rejuvenation from operating methods to non-surgical techniques. This is due to a lower risk of developing complications hazardous to health, and a shorter recovery period.

One of the effective methods of non-surgical face correction is mesotherapy, the essence of which is the introduction of intradermal preparations. Against the background of mesotherapy in the dermis, mitotic activity increases and the level of fibroblast metabolism increases. At the same time, mesotherapy affects all pathogenetic mechanisms of skin aging.

The closest analogue to the method we have developed is a mesotherapy method using a complex of drugs - Ubiquinone compositum and Placenta compositum (Rozhanets A.R. et al. Effect of mesotherapy on age-related skin changes. Vestnik of regenerative medicine. 2010, 3 (37), p. 75- 78). The drugs are mixed in one syringe just before the procedure. Injections of drugs are carried out along wrinkles, in the region of the nasolabial triangle, forehead, outer corner of the eyes, along the contour of the face and in the chin area. Procedures are carried out 2-3 times a week, a course of 10 procedures.

However, in practice, the known method has several disadvantages. So, injections of the same composition in all problem areas lead to an uneven effect - in some areas after the end of the course the desired effect is achieved, and in some areas the effect is either not achieved or deterioration is observed (wrinkles, irregularities remain). In our opinion, this is due to an initially different clinical situation - different development of subcutaneous fat, different levels of interstitial fluid. This generally does not allow in some cases, even in 10 procedures, to achieve the required level of face shape correction.

In this connection, we have solved the technical problem of achieving the effect of the required correction of the face shape in a shorter time, taking into account the individual characteristics of the face structures.

The technical result is to achieve the desired face shape in 3 procedures, including by eliminating the pastiness of the soft tissues of the face.

The achievement of the specified technical result is due to the following set of essential features:

on the basis of visual inspection and palpation of the face, zones requiring correction are selected by detecting a violation of the content of interstitial fluid and the development of subcutaneous fat,

Mesotherapy consists of the following techniques, carried out during one procedure, a course of 3 procedures:

Based on the results of examination and palpation, the GAG Complex "DVL Capyl" formula and / or Estetic Form "Phyto Slim" formula are injected intracutaneously into the identified areas that require correction:

in case of detection in the zone of increased accumulation of interstitial fluid and increased development of subcutaneous fat, the entire area is treated by intradermal administration of the preparations GAG Complex "DVL Capyl" formula and Estetic Form "Phyto Slim" formula;

in case of detection of increased accumulation of interstitial fluid in the area and reduction of subcutaneous fat, the entire area is treated by the intradermal administration of the preparation GAG Complex "DVL Capyl" formula;

in case of detection in the zone of increased development of subcutaneous fat and lack of increased accumulation of interstitial fluid, the entire area is treated by intradermal administration of the Estetic Form "Phyto Slim" formula,

a compress is applied to the injection area, consisting of: a non-steroidal anti-inflammatory drug - a phenylacetic acid derivative, dimexide concentrate and water in a ratio of their volumes of 3: 1: 5,

complete the procedure by putting on a compressive bandage on the face.

The next day after the procedure, microcurrent therapy of zones that require correction is performed.

Compress is applied for 2 hours.

Long-term use of various drugs and complexes used in mesotherapy, observation of the results obtained, allowed to get an unexpected result when using GAG Complex "DVL Capyl" formula and Estetic Form "Phyto Slim" formula preparations, selected in each case taking into account individual characteristics.

So, for the first time, we revealed that with fewer procedures (3 procedures), it is possible to achieve an increase in the duration of preservation of the desired effect, if:

- In certain areas and zones to introduce drugs GAG Complex "DVL Capyl" formula, Estetic Form "Phyto Slim" formula;

- having previously performed a detailed examination and palpation of all problem areas (areas requiring correction), to assess in each of them violations of the interstitial fluid content and the development of subcutaneous fat, and, depending on the revealed violations, treat the entire zone with a drug or drugs: GAG Complex "DVL Capyl "formula and / or Estetic Form" Phyto Slim "formula, thereby mesodraining problem areas;

- after completion of the injection, a compress is applied, consisting of: a non-steroidal anti-inflammatory drug - a derivative of phenylacetic acid, dimexide and water in a ratio of their volumes of 3: 1: 5,

- complete the procedure by putting on a compressive bandage on the face.

The preparations we use are well-known agents for mesotherapy:

- drug GAG Complex "DVL Capyl" formula (MESOPHARM catalog, http://www.mesopharm.ru/item/479-GAG-Complex-DVL-Capyl-fl-4),

- Estetic Form "Phyto Slim" formula (MESOPHARM catalog, http://www.mesopharm.ru/item/219-Estetic-Form-fl-4-ml).

Each drug was administered in accordance with the instructions for use of a medical device: total dose, dose in a single injection, method of drug administration:

1. Estetic Form "Phyto Slim" formula (http://www.mesopharm.ru/item/219-Estetic-Form-fl-4-ml)

1.1. The amount of drug administered depends on the size of the correction area.

1.2. Used as a therapy for hydrolipodystrophy.

2. GAG Complex "DVL Capyl" formula (http://www.mesopharm.ru/item/479-GAG-Complex-DVL-Capyl-fl-4)

2.1. The amount of drug administered depends on the size of the correction area.

2.2. It has drainage and capillary-protective effects.

It should be noted that the amount of the drug administered in a single dose, the total volume and dose of the drug used, the mesotherapeutic technique of drug administration are not the subject of the present invention. The technique of administering the drug can be used any of the known for a specific area of the face and the identified violations, should also take into account the recommendations of the manufacturer of the drug. As for the doses and volume of the drug administered, they are also determined taking into account the instructions for use of the drug.

Using a compress from: a non-steroidal anti-inflammatory drug - a derivative of phenylacetic acid, dimexide and water in a ratio of their volumes of 3: 1: 5 allows you to relieve inflammation (by affecting various parts of its pathogenesis), thereby reducing the duration of such post-injection standard manifestations as traces of injections, swelling. It is also known that these manifestations persist on the face for an average of about 2 days (https://www.martinex.ru/articles/meso-errors/).

The use of the developed complex personalized effect allows achieving the indicated results by slowing down the degradation of the injected drugs, prolonging the stimulation of dermal cells that produce the components of the dermal matrix, and increasing the duration of fibroblast stimulation. All this leads to the fact that fewer procedures provide a lasting effect of the required correction of the shape of the face.

Example 1

Patient Bn, 41 years old. Complains of pastes of the upper eyelids, dark circles under the eyes, puffiness under the eyes, deficiency in the zygomatic area, cheekbones of the furrow, nasolabial wrinkles, wrinkles of the puppet, deficiency of the chin. Complaints about an asymmetric chin are narrower on the one hand and wider, locally fatty deposits in the buccal region on the other. Oval of the face: complaints of bryl, the second chin, the floated oval of the face, swelling of the face.

The patient was assigned the procedure according to the claimed method.

After the procedures, the edema of the upper eyelids decreased significantly, the look became more open. In the region of the middle third, edema of the lower eyelids has been eliminated, the zygomatic arch has become more defined. The effect of the "tired look" disappeared. The oval of the face has become clearer, the nasal ridges have decreased in size, the buccal fat packs have also decreased in volume. The chin lengthened, and the corners of the lower jaw became more defined. The second chin decreased in volume.

The indicated effect was achieved in 3 procedures carried out at intervals of 5 and 7 days. Post-injection manifestations - swelling, traces of injections disappeared 6 hours after the procedure. Subsequent monitoring of the patient for 8 months showed the preservation of the facial shape obtained after the procedure throughout this period.

The method allowed to reduce up to a day the duration of such post-injection standard manifestations as: traces of injections, swelling.

Example 2

Patient B-a, 44 years old. Complaints of forehead wrinkles, overhanging forehead, forehead swelling, eyebrow wrinkles. In the middle third: complaints of the overhanging upper eyelids, pasty of the upper eyelids, nasolacrimal grooves, swelling under the eyes, deficiency in the zygomatic region, pronounced paint bags. In the lower third: complaints of nasolabial wrinkles, puppet wrinkles, chin volume deficit, chin shape (wide), chin asymmetry, lowered corners of the lips, localized fat deposits in the buccal region, fuzzy angles of the jaw. Oval of the face: complaints of bryl, the second chin, the floated oval of the face, swelling of the face.

The patient was assigned 3 procedures according to the claimed method.

After the procedures, the swelling from the upper eyelids disappeared, the look became more open. In the region of the middle third, edema from the lower eyelids has gone, the zygomatic arch has become more defined, and retreats in this area have gone. The effect of the "tired look" disappeared. The nasolacrimal sulcus is gone. Gone are the masked fat packs. The oval of the face has become clearer, the nasal ridges have decreased in size, the buccal fat packs have also decreased in volume. The chin lengthened, and the corners of the lower jaw became more defined. The second chin decreased in volume. The nasolabial folds and wrinkles of the puppet became less noticeable and decreased in volume.

The indicated effect was achieved for 3 procedures carried out with an interval of 7 days each. Post-injection manifestations - traces of injections, swelling, passed 10 hours after the procedure. Subsequent monitoring of the patient for 7 months showed the preservation of the facial shape obtained after the procedure throughout this period.

To confirm the results, we conducted a comparative study of the effectiveness of the developed complex method (group 1) and the well-known method from the prototype (group 2).

Group 1 consisted of 27 people (18 women whose average age was 43 ± 0.4 years, and 9 men whose average age was 49 ± 0.2 years) who underwent a course of treatment for 1-3 procedures.

Group 2 consisted of 14 people (10 women, whose average age was 43 ± 0.2 years, and 4 men, whose average age was 52 ± 0.3 years), who underwent a course of 10 procedures.

Before and after the course of the procedures, all patients underwent examination, including laser Doppler flowmetry, corneometry, sebometry, ultrasound examination of the facial skin.

The results obtained (tables 1-2) demonstrate an assessment of the microcirculation and moisture content of the epidermis after the procedures in both group 1 and group 2 (expressed in the form of symmetry of the recorded parameters). However, after 6 months, only after the set of procedures developed by us, the uniformity of the evaluated characteristics achieved immediately after the procedures was preserved (group 1). In group 2, a violation of symmetry was noted.

An ultrasound examination of the facial skin was also carried out (determination of the thickness of the skin layers). It is known that reduced echogenicity of the subepidermal layer indicates the presence of structural disorganization of the papillary dermis. An increase in the area of hypoechoic areas in the dermal layer, the formation of a subepidermal hypoechoic layer, as well as the appearance of linear hyperechoic zones are signs of structural disorganization of collagen and elastin fibers observed with age-related skin changes (Barinova O.A., Gallyamova Yu.A. Morphofunctional study of the skin of women’s face Russian Journal of Skin and Sexually Transmitted Diseases. 2012, 6, p. 62-65). The study was conducted before and after the course of procedures, as well as 6 months after the exposure. After the course of the procedures, patients of group 1 decreased the area of hypoechoic sites by 65%, and in group 2 by 39%. A study conducted after 6 months and a comparison of its results with data obtained after exposure showed that in group 1 the area of hypoechoic areas increased (compared with the measurement carried out immediately after the course of exposure) by only 12%, while in group 2 an increase amounted to 26%.

It seems to us that the best results obtained 6 months after exposure in group 1 compared with the results of group 2 are due to the fact that when conducting mesotherapy according to the method developed by us, each drug was injected into a specific area and taking into account the anatomical and clinical features.

We also conducted a study of the effect of the compress of the composition developed by us on the duration of the preservation of post-injection manifestations (hematomas, traces of injections, swelling). Based on clinical observations, we found that in the case of applying a compress to the injection area consisting of: a solution for injection of a non-steroidal anti-inflammatory drug - a phenylacetic acid derivative (for example, diclofenac, voltaren), dimexide concentrate, and also water in the ratio of their volumes 3: 1: 5, the duration of preservation of post-injection manifestations is significantly reduced (up to a day).

We have tested the following compresses:

Composition 1 (the composition we use): a solution for injection of a non-steroidal anti-inflammatory drug - a derivative of phenylacetic acid (for example, diclofenac, voltaren), dimexide concentrate, and also water in the ratio of their volumes 3: 1: 5.

Composition 2: dimexide concentrate and water in the ratio of their volumes 1: 5.

Composition 3: ketoprofen injection (non-steroidal anti-inflammatory drug - derivatives of propionic acid), dimexide concentrate and water in the ratio of their volumes 3: 1: 5.

Composition 4: a solution for injection of a non-steroidal anti-inflammatory drug - a derivative of phenylacetic acid (for example, diclofenac, voltaren), dimexide concentrate, and also water in the ratio of their volumes 6: 2: 6.

The indicated compositions in the form of a compress for 2 hours were applied to the injection zone after mesotherapy. Each composition was used in 7 women aged: 30-35 years old, 40-45 years old, 50-55 years old. A day after exposure, an examination of these women was performed, which showed the following:

- after using the composition 1 was not revealed any post-injection manifestations.

- after using composition 2, facial puffiness was recorded in 5 women, hematomas in 2 women, and in 3 women partially remained traces of injections.

- after using composition 3, facial swelling was recorded in 4 women, hematomas in 2 women.

- after using composition 4, no post-injection manifestations were detected, however, 2 women in the compress area showed an allergic reaction in the form of redness and burning.

The results obtained suggest that it is composition 1 that affects the prevention of postinjection complications. As for the results of using composition 4, it is likely that a proportional increase in the parts of the components does not affect the result provided, however, it can cause an allergic reaction.

We also evaluated the effectiveness of the developed individual approach to the choice of the drug - GAG Complex "DVL Capyl" formula and / or Estetic Form "Phyto Slim" formula, depending on the violation of the interstitial fluid content and the development of subcutaneous fat in the area requiring correction.

Why did we examine two groups of patients:

- group 1, consisted of 18 women aged 46 ± 4 years and 4 men aged 49 ± 3 years;

- group 2, consisted of 13 women aged 44 ± 7 years and 2 men aged 46 and 53 years.

In group 1, the impact was developed by us in an integrated way, course 3 of the procedure.

In group 2, GAG Complex “DVL Capyl” formula or Estetic Form “Phyto Slim” formula was administered, the injection area was treated with traumeel ointment, course 3 of the procedure.

Before the exposure, an ultrasound examination of the facial skin was carried out (determination of the thickness of the skin layers), and after the course, after 6 months. After a course of procedures, the area of hypoechoic sites in patients of group 1 decreased by an average of 75%, and in group 2 by 39%. A study conducted after 6 months and a comparison of its results with data obtained after exposure showed that in group 1 the area of hypoechoic areas increased by only 18%, while in group 2 the increase was 25%.

As already mentioned above, the best results obtained 6 months after exposure in group 1 compared with the results of group 2, we explain by the fact that when carrying out mesotherapy according to the method developed by us, each drug was administered in a specific area and taking into account the anatomical and clinical features.

Claims (3)

1. A method of correcting the shape of the face, including conducting mesotherapy, characterized in that on the basis of a visual examination and palpation of the face, zones requiring correction are selected by detecting a violation of the interstitial fluid content and the development of subcutaneous fat, mesotherapy consists of the following techniques, carried out during one procedure, a course of 3 procedures: based on the results of examination and palpation in the identified areas requiring correction, enter the drug GAG Complex "DVL Capyl" formula and / or Estetic Form "Phyto Slim" formula: in case of detection in the zone of increased accumulation of interstitial fluid and increased development of subcutaneous fat, the entire area is treated by intradermal administration of the preparations GAG Complex "DVL Capyl" formula and Estetic Form "Phyto Slim" formula; in case of detection of increased accumulation of interstitial fluid in the area and reduction of subcutaneous fat, the entire area is treated by the intradermal administration of the preparation GAG Complex "DVL Capyl" formula; in case of detection in the zone of increased development of subcutaneous fat and lack of increased accumulation of interstitial fluid, the entire area is treated by intradermal administration of the Estetic Form "Phyto Slim" formula, a compress consisting of: a non-steroidal anti-inflammatory drug - a derivative of phenylacetic acid is applied to the injection area, Dimexide concentrate and water in the ratio of their volumes 3: 1: 5, complete the procedure by putting on a compressive bandage on the face. 2. The method according to p. 1, characterized in that the next day after the procedure, microcurrent therapy of zones that require correction is performed. 3. The method according to p. 1, characterized in that the compress is applied for 2 hours.