RU2714733C2 - Технологии мультимеризации - Google Patents
Технологии мультимеризации Download PDFInfo
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- RU2714733C2 RU2714733C2 RU2015143166A RU2015143166A RU2714733C2 RU 2714733 C2 RU2714733 C2 RU 2714733C2 RU 2015143166 A RU2015143166 A RU 2015143166A RU 2015143166 A RU2015143166 A RU 2015143166A RU 2714733 C2 RU2714733 C2 RU 2714733C2
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- Prior art keywords
- ser
- gly
- thr
- gln
- tyr
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| WO2018094143A1 (en) | 2016-11-17 | 2018-05-24 | Siamab Therapeutics, Inc. | Glycan-interacting compounds and methods of use |
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| US11046768B2 (en) * | 2017-01-27 | 2021-06-29 | Memorial Sloan Kettering Cancer Center | Bispecific HER2 and CD3 binding molecules |
| EP3583133A4 (en) * | 2017-02-20 | 2021-04-14 | Dragonfly Therapeutics, Inc. | GD2, NKG2D AND CD16 BINDING PROTEINS |
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| WO2020113164A1 (en) * | 2018-11-30 | 2020-06-04 | Memorial Sloan Kettering Cancer Center | Heterodimeric tetravalency and specificity antibody compositions and uses thereof |
| KR20210128399A (ko) * | 2019-02-20 | 2021-10-26 | 더 리서치 인스티튜트 앳 네이션와이드 칠드런스 하스피탈 | 암-표적화되고, 바이러스-암호화된, 조절 가능한 t 세포 (catvert) 또는 nk 세포 (catvern) 링커 |
| EP3966227A1 (en) | 2019-05-07 | 2022-03-16 | Voyager Therapeutics, Inc. | Compositions and methods for the vectored augmentation of protein destruction, expression and/or regulation |
| KR102503349B1 (ko) | 2019-05-14 | 2023-02-23 | 프로벤션 바이오, 인코포레이티드 | 제1형 당뇨병을 예방하기 위한 방법 및 조성물 |
| US12006366B2 (en) | 2020-06-11 | 2024-06-11 | Provention Bio, Inc. | Methods and compositions for preventing type 1 diabetes |
| WO2022006564A1 (en) * | 2020-07-03 | 2022-01-06 | The Trustees Of Columbia University In The City Of New York | Polyfunctional orthogonal protein chimeras |
| WO2023023055A1 (en) | 2021-08-16 | 2023-02-23 | Renagade Therapeutics Management Inc. | Compositions and methods for optimizing tropism of delivery systems for rna |
| EP4402121A1 (en) | 2021-09-14 | 2024-07-24 | Renagade Therapeutics Management Inc. | Acyclic lipids and methods of use thereof |
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| CA3255619A1 (en) | 2022-04-07 | 2023-10-12 | Renagade Therapeutics Man Inc | CYCLIC LIPIDS AND LIPID NANOPARTICLES (LPNs) FOR THE SUPPLY OF NUCLEIC ACIDS OR PEPTIDES INTENDED FOR USE IN VACCINATION AGAINST INFECTIOUS AGENTS |
| JP2025525035A (ja) * | 2022-07-25 | 2025-08-01 | バイロネクシス バイオセラピューティクス インコーポレイテッド | アデノ随伴ウイルスベクターならびに転移のリスク低減、処置、および予防のためのそれらの使用方法 |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2228202C2 (ru) * | 1998-04-21 | 2004-05-10 | Микромет Аг | Cd19xcd3-специфические полипептиды и их применение |
| US20060228300A1 (en) * | 2005-04-06 | 2006-10-12 | Ibc Pharmaceuticals, Inc. | Stably tethered structures of defined compositions with multiple functions or binding specificities |
| US20070298041A1 (en) * | 2002-06-28 | 2007-12-27 | Tomlinson Ian M | Ligands That Enhance Endogenous Compounds |
| EP2050764A1 (en) * | 2007-10-15 | 2009-04-22 | sanofi-aventis | Novel polyvalent bispecific antibody format and uses thereof |
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| GB0230202D0 (en) * | 2002-12-27 | 2003-02-05 | Domantis Ltd | Ligand |
| EP1293514B1 (en) * | 2001-09-14 | 2006-11-29 | Affimed Therapeutics AG | Multimeric single chain tandem Fv-antibodies |
| DK1517921T3 (da) * | 2002-06-28 | 2006-10-09 | Domantis Ltd | Immunglobulin-enkeltvariable antigen-bindende domæner og dobbeltspecifikke konstruktioner deraf |
| KR20070034512A (ko) * | 2004-06-18 | 2007-03-28 | 암브룩스, 인코포레이티드 | 신규 항원-결합 폴리펩티드 및 이의 용도 |
| AU2006232310B9 (en) * | 2005-04-06 | 2011-07-21 | Ibc Pharmaceuticals, Inc. | Improved stably tethered structures of defined compositions with multiple functions or binding specificities |
| AU2011268110B2 (en) * | 2010-06-19 | 2016-05-19 | Memorial Sloan-Kettering Cancer Center | Anti-GD2 antibodies |
| KR102090356B1 (ko) | 2013-03-15 | 2020-03-18 | 메모리얼 슬로안 케터링 캔서 센터 | 다량체화 기술 |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2228202C2 (ru) * | 1998-04-21 | 2004-05-10 | Микромет Аг | Cd19xcd3-специфические полипептиды и их применение |
| US20070298041A1 (en) * | 2002-06-28 | 2007-12-27 | Tomlinson Ian M | Ligands That Enhance Endogenous Compounds |
| US20060228300A1 (en) * | 2005-04-06 | 2006-10-12 | Ibc Pharmaceuticals, Inc. | Stably tethered structures of defined compositions with multiple functions or binding specificities |
| EP2050764A1 (en) * | 2007-10-15 | 2009-04-22 | sanofi-aventis | Novel polyvalent bispecific antibody format and uses thereof |
Non-Patent Citations (2)
| Title |
|---|
| YANKELEVICH M. et al. "Anti-CD3 × Anti-GD2 Bispecific Antibody Redirects T-Cell Cytolytic Activity to Neuroblastoma Targets", Pediatr Blood Cancer, 2012, Vol. 59, Is. 7, pp. 1198-1205. * |
| YANKELEVICH M. et al. "Anti-CD3 × Anti-GD2 Bispecific Antibody Redirects T-Cell Cytolytic Activity to Neuroblastoma Targets", Pediatr Blood Cancer, 2012, Vol. 59, Is. 7, pp. 1198-1205. * |
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| US20160168211A1 (en) | 2016-06-16 |
| CN105530959A (zh) | 2016-04-27 |
| CA2902561C (en) | 2022-08-02 |
| JP6480907B2 (ja) | 2019-03-13 |
| WO2014144573A2 (en) | 2014-09-18 |
| RU2015143166A (ru) | 2017-04-20 |
| US9802995B2 (en) | 2017-10-31 |
| EP2968547A2 (en) | 2016-01-20 |
| WO2014144573A3 (en) | 2015-10-29 |
| CA2902561A1 (en) | 2014-09-18 |
| AU2014228962B2 (en) | 2019-03-14 |
| US20180251503A1 (en) | 2018-09-06 |
| BR112015022978A8 (pt) | 2018-01-23 |
| EP2968547A4 (en) | 2016-11-09 |
| AU2014228962A1 (en) | 2015-09-10 |
| HK1216145A1 (en) | 2016-10-21 |
| KR20150132420A (ko) | 2015-11-25 |
| JP2016516049A (ja) | 2016-06-02 |
| BR112015022978A2 (pt) | 2017-11-14 |
| KR102090356B1 (ko) | 2020-03-18 |
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