RU2711452C2 - Усовершенствованная стратификация пациентов для оценки пригодности терапии - Google Patents
Усовершенствованная стратификация пациентов для оценки пригодности терапии Download PDFInfo
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Title |
---|
HALES E.C. et al. New insights into Notch1 regulation of the PI3K-AKT-mTOR1 signaling axis: targeted therapy of γ-secretase inhibitor resistant T-cell acute lymphoblastic leukemia.Cell Signal. 2014 Jan; 26(1): 149-61. doi: 10.1016/j.cellsig.2013.09.021. Epub 2013, Oct 16. * |
POULARD C. et al. Activation of rapid oestrogen signalling in aggressive human breast cancers. EMBO Mol Med. 2012 Nov; 4(11): 1200-13. doi: 10.1002/emmm.201201615. Epub 2012, Oct 15. * |
POULARD C. et al. Activation of rapid oestrogen signalling in aggressive human breast cancers. EMBO Mol Med. 2012 Nov; 4(11): 1200-13. doi: 10.1002/emmm.201201615. Epub 2012, Oct 15. DIAZ FLAQUE M.C. et al. Progesterone receptor assembly of a transcriptional complex along with activator protein 1, signal transducer and activator of transcription 3 and ErbB-2 governs breast cancer growth and predicts response to endocrine therapy. Breast Cancer Res. 2013, Dec 17; 15(6): R118. doi: 10.1186/bcr3587. SHUBBAR E. et al. High levels of γ-glutamyl hydrolase (GGH) are associated with poor prognosis and unfavorable clinical outcomes in invasive breast cancer. BMC Cancer. 2013 Feb 1; 13:47. doi: 10.1186/1471-2407-13-47. HALES E.C. et al. New insights into Notch1 regulation of the PI3K-AKT-mTOR1 signaling axis: targeted therapy of γ-secretase inhibitor resistant T-cell acute lymphoblastic leukemia.Cell Signal. 2014 Jan; 26(1): 149-61. doi: 10.1016/j.cellsig.2013.09.021. Epub 2013, Oct 16. * |
SHUBBAR E. et al. High levels of γ-glutamyl hydrolase (GGH) are associated with poor prognosis and unfavorable clinical outcomes in invasive breast cancer. BMC Cancer. 2013 Feb 1; 13:47. doi: 10.1186/1471-2407-13-47 * |
SHUBBAR E. et al. High levels of γ-glutamyl hydrolase (GGH) are associated with poor prognosis and unfavorable clinical outcomes in invasive breast cancer. BMC Cancer. 2013 Feb 1; 13:47. doi: 10.1186/1471-2407-13-47. * |
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EP3097421B1 (en) | 2019-11-13 |
WO2015110440A1 (en) | 2015-07-30 |
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