RU2711452C2 - Усовершенствованная стратификация пациентов для оценки пригодности терапии - Google Patents

Усовершенствованная стратификация пациентов для оценки пригодности терапии Download PDF

Info

Publication number
RU2711452C2
RU2711452C2 RU2016133965A RU2016133965A RU2711452C2 RU 2711452 C2 RU2711452 C2 RU 2711452C2 RU 2016133965 A RU2016133965 A RU 2016133965A RU 2016133965 A RU2016133965 A RU 2016133965A RU 2711452 C2 RU2711452 C2 RU 2711452C2
Authority
RU
Russia
Prior art keywords
patient
cascade
family
stage
protein
Prior art date
Application number
RU2016133965A
Other languages
English (en)
Russian (ru)
Other versions
RU2016133965A (ru
RU2016133965A3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html
Inventor
Дэвид ХАЛЬТЕР
Райнхольд ВИМБЕРГЕР-ФРИДЛЬ
ДЕ СТОЛЬПЕ Аня ВАН
ХЕМЕРТ Фрек ВАН
ВЕН Геске Кристина ДАМ-ДЕ
Original Assignee
Конинклейке Филипс Н.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Конинклейке Филипс Н.В. filed Critical Конинклейке Филипс Н.В.
Publication of RU2016133965A publication Critical patent/RU2016133965A/ru
Publication of RU2016133965A3 publication Critical patent/RU2016133965A3/ru
Application granted granted Critical
Publication of RU2711452C2 publication Critical patent/RU2711452C2/ru

Links

Images

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407Specifically defined cancers
    • G01N33/57415Specifically defined cancers of breast
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407Specifically defined cancers
    • G01N33/57434Specifically defined cancers of prostate
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/743Steroid hormones
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
RU2016133965A 2014-01-22 2015-01-21 Усовершенствованная стратификация пациентов для оценки пригодности терапии RU2711452C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14152183.1 2014-01-22
EP14152183 2014-01-22
PCT/EP2015/051051 WO2015110440A1 (en) 2014-01-22 2015-01-21 Improved stratification of patients for assessing the suitability of a therapy

Publications (3)

Publication Number Publication Date
RU2016133965A RU2016133965A (ru) 2018-02-28
RU2016133965A3 RU2016133965A3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 2018-09-27
RU2711452C2 true RU2711452C2 (ru) 2020-01-17

Family

ID=49999759

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2016133965A RU2711452C2 (ru) 2014-01-22 2015-01-21 Усовершенствованная стратификация пациентов для оценки пригодности терапии

Country Status (7)

Country Link
US (1) US11199546B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP3097421B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JP6700186B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CN (1) CN105917231B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BR (1) BR112016016675B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
RU (1) RU2711452C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
WO (1) WO2015110440A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190128899A1 (en) * 2016-06-13 2019-05-02 Koninklijke Philips N.V. Method for inferring activity of a transcription factor of a signal transduction pathway in a subject

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001011361A2 (en) * 1999-08-04 2001-02-15 Dako A/S Kit and method to assess the malignancy of neoplasias
WO2011109440A1 (en) * 2010-03-01 2011-09-09 Caris Life Sciences Luxembourg Holdings Biomarkers for theranostics

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9708676D0 (en) * 1997-04-30 1997-06-18 Imp Cancer Res Tech Chemical compounds
WO2000066767A1 (en) * 1999-04-30 2000-11-09 North Shore Long Island Jewish Health System Estrogen signalling pathway regulators and uses thereof
CA2663595A1 (en) 2006-08-07 2008-02-14 The Board Of Regents Of The University Of Texas System Proteomic patterns of cancer prognostic and predictive signatures
WO2009089521A2 (en) 2008-01-10 2009-07-16 Nuvera Biosciences, Inc. Predictors for evaluating response to cancer therapy
WO2010006291A1 (en) 2008-07-10 2010-01-14 Nodality, Inc. Methods for diagnosis, prognosis and treatment
CA2753971C (en) 2009-01-28 2018-10-02 Steven Buechler Accelerated progression relapse test
DE102009034665A1 (de) 2009-07-24 2011-01-27 Neumayer Tekfor Holding Gmbh Befestigungsvorrichtung und Befestigungssystem
US20130065786A1 (en) * 2010-03-31 2013-03-14 Sividon Diagnostics Gmbh Method for breast cancer recurrence prediction under endocrine treatment
EP2877853A1 (en) * 2012-07-27 2015-06-03 Centre Léon Bérard Detection of the er /src/pi3k complex as predictive marker in breast cancer

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001011361A2 (en) * 1999-08-04 2001-02-15 Dako A/S Kit and method to assess the malignancy of neoplasias
WO2011109440A1 (en) * 2010-03-01 2011-09-09 Caris Life Sciences Luxembourg Holdings Biomarkers for theranostics

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
HALES E.C. et al. New insights into Notch1 regulation of the PI3K-AKT-mTOR1 signaling axis: targeted therapy of γ-secretase inhibitor resistant T-cell acute lymphoblastic leukemia.Cell Signal. 2014 Jan; 26(1): 149-61. doi: 10.1016/j.cellsig.2013.09.021. Epub 2013, Oct 16. *
POULARD C. et al. Activation of rapid oestrogen signalling in aggressive human breast cancers. EMBO Mol Med. 2012 Nov; 4(11): 1200-13. doi: 10.1002/emmm.201201615. Epub 2012, Oct 15. *
POULARD C. et al. Activation of rapid oestrogen signalling in aggressive human breast cancers. EMBO Mol Med. 2012 Nov; 4(11): 1200-13. doi: 10.1002/emmm.201201615. Epub 2012, Oct 15. DIAZ FLAQUE M.C. et al. Progesterone receptor assembly of a transcriptional complex along with activator protein 1, signal transducer and activator of transcription 3 and ErbB-2 governs breast cancer growth and predicts response to endocrine therapy. Breast Cancer Res. 2013, Dec 17; 15(6): R118. doi: 10.1186/bcr3587. SHUBBAR E. et al. High levels of γ-glutamyl hydrolase (GGH) are associated with poor prognosis and unfavorable clinical outcomes in invasive breast cancer. BMC Cancer. 2013 Feb 1; 13:47. doi: 10.1186/1471-2407-13-47. HALES E.C. et al. New insights into Notch1 regulation of the PI3K-AKT-mTOR1 signaling axis: targeted therapy of γ-secretase inhibitor resistant T-cell acute lymphoblastic leukemia.Cell Signal. 2014 Jan; 26(1): 149-61. doi: 10.1016/j.cellsig.2013.09.021. Epub 2013, Oct 16. *
SHUBBAR E. et al. High levels of γ-glutamyl hydrolase (GGH) are associated with poor prognosis and unfavorable clinical outcomes in invasive breast cancer. BMC Cancer. 2013 Feb 1; 13:47. doi: 10.1186/1471-2407-13-47 *
SHUBBAR E. et al. High levels of γ-glutamyl hydrolase (GGH) are associated with poor prognosis and unfavorable clinical outcomes in invasive breast cancer. BMC Cancer. 2013 Feb 1; 13:47. doi: 10.1186/1471-2407-13-47. *

Also Published As

Publication number Publication date
RU2016133965A (ru) 2018-02-28
US20160334405A1 (en) 2016-11-17
CN105917231A (zh) 2016-08-31
RU2016133965A3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 2018-09-27
BR112016016675B1 (pt) 2024-01-16
CN105917231B (zh) 2021-05-11
JP6700186B2 (ja) 2020-05-27
EP3097421A1 (en) 2016-11-30
JP2017508137A (ja) 2017-03-23
US11199546B2 (en) 2021-12-14
BR112016016675A2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 2017-08-08
EP3097421B1 (en) 2019-11-13
WO2015110440A1 (en) 2015-07-30

Similar Documents

Publication Publication Date Title
Ross et al. The HER-2 receptor and breast cancer: ten years of targeted anti–HER-2 therapy and personalized medicine
Kraus et al. Semi-quantitative immunohistochemical assay versus oncotype DX® qRT-PCR assay for estrogen and progesterone receptors: an independent quality assurance study
Nuciforo et al. Quantification of HER family receptors in breast cancer
Dekker et al. Reliability of core needle biopsy for determining ER and HER2 status in breast cancer
Qian et al. Heregulin and HER3 are prognostic biomarkers in oropharyngeal squamous cell carcinoma
JP2012177706A (ja) 個別化抗癌化学療法(pac)のための包括的な診断試験
US20160274114A1 (en) Methods for diagnosing cancer and determining the overall survival and disease-free survival of cancer patients
Makhlouf et al. The clinical and biological significance of estrogen receptor-low positive breast cancer
Kawase et al. FOXA1 expression after neoadjuvant chemotherapy is a prognostic marker in estrogen receptor-positive breast cancer
Endo et al. High estrogen receptor expression and low Ki67 expression are associated with improved time to progression during first-line endocrine therapy with aromatase inhibitors in breast cancer
Di Gioia et al. Serum HER2 supports HER2-testing in tissue at the time of primary diagnosis of breast cancer
Seferina et al. Reliability of receptor assessment on core needle biopsy in breast cancer patients
Aftimos et al. Molecular biology of breast cancer
Kim et al. Prognostic significance of high expression of ER-beta in surgically treated ER-positive breast cancer following endocrine therapy
US20160273047A1 (en) Epithelial-mesenchymal transition in circulating tumor cells (ctcs) negatives for cytokeratin (ck) expression in patients with non-metastatic breast cancer
RU2711452C2 (ru) Усовершенствованная стратификация пациентов для оценки пригодности терапии
JP6936231B2 (ja) 転移性去勢抵抗性前立腺癌(mCRPC)患者における治療選択のためのバイオマーカーとしてのアンドロゲン受容体バリアント7
US11448650B2 (en) Methods for diagnosing high-risk cancer using polysialic acid and one or more tissue-specific biomarkers
Van Rooijen et al. Limited human epidermal growth factor receptor 2 discordance in metastatic breast cancer patients treated with trastuzumab, a population based study
Lee et al. The predictive value of serum HER2/neu for response to anthracycline-based and trastuzumab-based neoadjuvant chemotherapy
Pehlivanoglu et al. Comparison of HER2 status determination methods in HER2 (2+) patients: Manual fluorescent in situ hybridization (FISH) vs. dual silver enhanced in situ hybridization (SISH)
Sari et al. Clinical Aspects of Estrogen and Progesterone Receptors and ERBB2 Testing
US20200271652A1 (en) Methods of Prognosing Early Stage Breast Lesions
KR102737876B1 (ko) 유방암 환자의 선행 항암화학요법 후 예후 예측을 위한 바이오마커 및 이의 용도
EP3580570B1 (en) Method for determining breast cancer risk

Legal Events

Date Code Title Description
MM4A The patent is invalid due to non-payment of fees

Effective date: 20210122