RU2706166C2 - Новые полиморфные формы тримебутина малеата, способ получения и применения - Google Patents

Новые полиморфные формы тримебутина малеата, способ получения и применения Download PDF

Info

Publication number
RU2706166C2
RU2706166C2 RU2017140269A RU2017140269A RU2706166C2 RU 2706166 C2 RU2706166 C2 RU 2706166C2 RU 2017140269 A RU2017140269 A RU 2017140269A RU 2017140269 A RU2017140269 A RU 2017140269A RU 2706166 C2 RU2706166 C2 RU 2706166C2
Authority
RU
Russia
Prior art keywords
maleate
polymorphic form
trimebutin
trimebutine maleate
trimebutine
Prior art date
Application number
RU2017140269A
Other languages
English (en)
Russian (ru)
Other versions
RU2017140269A (ru
RU2017140269A3 (ko
Inventor
Кирилл Константинович Сыров
Владимир Викторович Нестерук
Original Assignee
Общество С Ограниченной Ответственностью "Валента - Интеллект"
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=66540370&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RU2706166(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Общество С Ограниченной Ответственностью "Валента - Интеллект" filed Critical Общество С Ограниченной Ответственностью "Валента - Интеллект"
Priority to RU2017140269A priority Critical patent/RU2706166C2/ru
Priority to CN201880074646.0A priority patent/CN111432811B/zh
Priority to BR112020010135-4A priority patent/BR112020010135A2/pt
Priority to UAA202003442A priority patent/UA124755C2/uk
Priority to KR1020207016962A priority patent/KR102509190B1/ko
Priority to EA202091237A priority patent/EA202091237A1/ru
Priority to PCT/RU2018/000729 priority patent/WO2019098883A1/ru
Publication of RU2017140269A publication Critical patent/RU2017140269A/ru
Publication of RU2017140269A3 publication Critical patent/RU2017140269A3/ru
Publication of RU2706166C2 publication Critical patent/RU2706166C2/ru
Application granted granted Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C219/18—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C219/20—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C219/22—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2017140269A 2017-11-20 2017-11-20 Новые полиморфные формы тримебутина малеата, способ получения и применения RU2706166C2 (ru)

Priority Applications (7)

Application Number Priority Date Filing Date Title
RU2017140269A RU2706166C2 (ru) 2017-11-20 2017-11-20 Новые полиморфные формы тримебутина малеата, способ получения и применения
KR1020207016962A KR102509190B1 (ko) 2017-11-20 2018-11-08 트리메부틴 말레산염의 다형체 및 이의 사용방법
BR112020010135-4A BR112020010135A2 (pt) 2017-11-20 2018-11-08 formas polimórficas de maleato de trimebutina e método de usar as mesmas
UAA202003442A UA124755C2 (uk) 2017-11-20 2018-11-08 Поліморфні форми тримебутину малеату і спосіб застосування
CN201880074646.0A CN111432811B (zh) 2017-11-20 2018-11-08 马来酸曲美布汀的多晶型物及其使用方法
EA202091237A EA202091237A1 (ru) 2017-11-20 2018-11-08 Новые полиморфные формы тримебутина малеата, способ получения и применения
PCT/RU2018/000729 WO2019098883A1 (ru) 2017-11-20 2018-11-08 Полиморфные формы тримебутина малеата и способ применения

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2017140269A RU2706166C2 (ru) 2017-11-20 2017-11-20 Новые полиморфные формы тримебутина малеата, способ получения и применения

Related Child Applications (2)

Application Number Title Priority Date Filing Date
RU2019132971A Division RU2770301C2 (ru) 2019-10-17 2019-10-17 Новые полиморфные формы тримебутина малеата, способ получения и применения
RU2019132977A Division RU2770300C2 (ru) 2019-10-17 2019-10-17 Новые полиморфные формы тримебутина малеата, способ получения и применения

Publications (3)

Publication Number Publication Date
RU2017140269A RU2017140269A (ru) 2019-05-20
RU2017140269A3 RU2017140269A3 (ko) 2019-05-20
RU2706166C2 true RU2706166C2 (ru) 2019-11-14

Family

ID=66540370

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2017140269A RU2706166C2 (ru) 2017-11-20 2017-11-20 Новые полиморфные формы тримебутина малеата, способ получения и применения

Country Status (7)

Country Link
KR (1) KR102509190B1 (ko)
CN (1) CN111432811B (ko)
BR (1) BR112020010135A2 (ko)
EA (1) EA202091237A1 (ko)
RU (1) RU2706166C2 (ko)
UA (1) UA124755C2 (ko)
WO (1) WO2019098883A1 (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2752086C1 (ru) * 2020-04-27 2021-07-22 Общество С Ограниченной Ответственностью "Валента-Интеллект" Новое соединение [2-(диметиламино)-2-фенилбутил]-3,4,5-триметоксибензоата 4-метил-2н-хромен-2-он-7-илсульфат и его применение

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1342547A (en) * 1971-03-12 1974-01-03 Jouveinal Sa Preparation of esters of amino alcohols
WO1998005320A1 (fr) * 1996-08-07 1998-02-12 Jouveinal Comprime de maleate de trimebutine pellicule
EP2481403A1 (en) * 2011-02-01 2012-08-01 Deva Holding Anonim Sirketi Pharmaceutical combination of otilonium and trimebutine
WO2013134869A1 (en) * 2012-03-12 2013-09-19 Gicare Pharma Inc. Novel sulfonate-based trimebutine salts
EA201390014A1 (ru) * 2010-07-16 2013-12-30 Ахн-Гоок Фарма Ко.,Лтд. Таблетка длительного высвобождения, содержащая тримебутин

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102188389B (zh) * 2010-03-18 2014-04-02 杭州赛利药物研究所有限公司 马来酸曲美布汀干混悬剂及其制备方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1342547A (en) * 1971-03-12 1974-01-03 Jouveinal Sa Preparation of esters of amino alcohols
WO1998005320A1 (fr) * 1996-08-07 1998-02-12 Jouveinal Comprime de maleate de trimebutine pellicule
EA201390014A1 (ru) * 2010-07-16 2013-12-30 Ахн-Гоок Фарма Ко.,Лтд. Таблетка длительного высвобождения, содержащая тримебутин
EP2481403A1 (en) * 2011-02-01 2012-08-01 Deva Holding Anonim Sirketi Pharmaceutical combination of otilonium and trimebutine
WO2013134869A1 (en) * 2012-03-12 2013-09-19 Gicare Pharma Inc. Novel sulfonate-based trimebutine salts

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Coquerel G. "Limits of the Co-crystal Concept and Beyond", RSC Drug Discovery Series, 2012, N. 16, P. 300-317. *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2752086C1 (ru) * 2020-04-27 2021-07-22 Общество С Ограниченной Ответственностью "Валента-Интеллект" Новое соединение [2-(диметиламино)-2-фенилбутил]-3,4,5-триметоксибензоата 4-метил-2н-хромен-2-он-7-илсульфат и его применение
WO2021221544A1 (ru) * 2020-04-27 2021-11-04 Общество С Ограниченной Ответственностью "Валента-Интеллект" Новое соединение [2-(диметиламино)-2-фенилбутил]-3,4,5-триметоксибензоата 4-метил-2н-хромен-2-он-7-илсульфат и его применение

Also Published As

Publication number Publication date
CN111432811A (zh) 2020-07-17
UA124755C2 (uk) 2021-11-10
WO2019098883A1 (ru) 2019-05-23
CN111432811B (zh) 2023-06-23
KR102509190B1 (ko) 2023-03-14
BR112020010135A2 (pt) 2021-03-23
RU2017140269A (ru) 2019-05-20
RU2017140269A3 (ko) 2019-05-20
KR20200110308A (ko) 2020-09-23
EA202091237A1 (ru) 2020-08-17

Similar Documents

Publication Publication Date Title
JP5043825B2 (ja) Ｄｐｐ−ｉｖ阻害剤の新規な塩及び多形
ES2351471T3 (es) Nueva sal y polimorfo de inhibidores de dpp-iv.
CN113993853A (zh) 氯苯唑酸及其盐的固态形式
JP5191574B2 (ja) ６，７−不飽和−７−カルバモイルモルヒナン誘導体の結晶およびその製造方法
US9012469B2 (en) Crystalline naloxol-peg conjugate
TW200812943A (en) Processes for preparation of tigecycline crystalline forms I and II
CN101633662A (zh) 普拉格雷的药用酸加成盐及其制备方法和药物应用
BG64824B1 (bg) (+)-норцисаприд, използван при смущения с 5-нт3 и5-нт4 посредници
EA021411B1 (ru) Безводная форма производного пиридина
RU2706166C2 (ru) Новые полиморфные формы тримебутина малеата, способ получения и применения
SU1037841A3 (ru) Способ получени производных 1,8-нафтиридина или их фармацевтически пригодных солей
TWI702210B (zh) 環狀胺衍生物之結晶及其醫藥用途
RU2770301C2 (ru) Новые полиморфные формы тримебутина малеата, способ получения и применения
RU2770300C2 (ru) Новые полиморфные формы тримебутина малеата, способ получения и применения
RU2349585C2 (ru) Стабильные модификации гидромалеата тегасерода
EA041334B1 (ru) Новые полиморфные формы тримебутина малеата, способ получения и применения
EA044497B1 (ru) Новые полиморфные формы тримебутина малеата, способ получения и применения
KR20210042041A (ko) 페놀라민 b형 결정, 제조 방법과 그의 조성물 및 용도
US7482486B2 (en) Methods for the preparation and formulation of magnesium valproate hydrate
JP2005511611A (ja) インテグリン受容体拮抗薬のアミン塩
RU2696277C2 (ru) Новый состав N-карбамоилметил-4-фенил-2-пирролидона
CA2768290C (en) R-7-(3-aminomethyl-4-methoxyimino-3-methyl-pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid and l-aspartic acid salt, process for thepreparation thereof and pharmaceutical composition comprising the same for antimicrobial
WO2021153743A1 (ja) 環状アミン誘導体の結晶及びその医薬用途
KR20190090729A (ko) 토파시티닙의 신규 염, 이의 제조방법 및 이를 포함하는 약학 조성물
KR0146340B1 (ko) (+)1-(3,4,5-트리메톡시)벤질옥시메틸-1-페닐-n,n-디메틸-n-프로필아민, 이의제조방법 및 치료학적용도

Legal Events

Date Code Title Description
QB4A Licence on use of patent

Free format text: LICENCE FORMERLY AGREED ON 20200416

Effective date: 20200416

PD4A Correction of name of patent owner