RU2706007C2 - Конденсированные бициклические соединения для лечения заболевания - Google Patents

Конденсированные бициклические соединения для лечения заболевания Download PDF

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Publication number
RU2706007C2
RU2706007C2 RU2017121588A RU2017121588A RU2706007C2 RU 2706007 C2 RU2706007 C2 RU 2706007C2 RU 2017121588 A RU2017121588 A RU 2017121588A RU 2017121588 A RU2017121588 A RU 2017121588A RU 2706007 C2 RU2706007 C2 RU 2706007C2
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RU
Russia
Prior art keywords
optionally substituted
compound
formula
alkyl
alkylene
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RU2017121588A
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Russian (ru)
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RU2017121588A (ru
RU2017121588A3 (OSRAM
Inventor
Бенджамин Энтони ПРАТТ
Раджу Мохан
Original Assignee
Акарна Терапьютикс, Лтд.
Бенджамин Энтони ПРАТТ
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Publication of RU2017121588A3 publication Critical patent/RU2017121588A3/ru
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
RU2017121588A 2014-11-21 2015-11-20 Конденсированные бициклические соединения для лечения заболевания RU2706007C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462083031P 2014-11-21 2014-11-21
US62/083,031 2014-11-21
PCT/US2015/062017 WO2016081918A1 (en) 2014-11-21 2015-11-20 Fused bicyclic compounds for the treatment of disease

Publications (3)

Publication Number Publication Date
RU2017121588A RU2017121588A (ru) 2018-12-24
RU2017121588A3 RU2017121588A3 (OSRAM) 2019-05-21
RU2706007C2 true RU2706007C2 (ru) 2019-11-13

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
RU2017121588A RU2706007C2 (ru) 2014-11-21 2015-11-20 Конденсированные бициклические соединения для лечения заболевания

Country Status (17)

Country Link
US (5) US10233187B2 (OSRAM)
EP (1) EP3221321B1 (OSRAM)
JP (3) JP7224102B2 (OSRAM)
KR (1) KR20170117020A (OSRAM)
CN (2) CN107207513B (OSRAM)
AU (2) AU2015349687B2 (OSRAM)
CA (1) CA2968434A1 (OSRAM)
CL (1) CL2017001289A1 (OSRAM)
CO (1) CO2017005784A2 (OSRAM)
ES (1) ES2911293T3 (OSRAM)
IL (1) IL252309B (OSRAM)
MX (1) MX370480B (OSRAM)
MY (1) MY192927A (OSRAM)
RU (1) RU2706007C2 (OSRAM)
SA (1) SA517381566B1 (OSRAM)
SG (2) SG11201703953WA (OSRAM)
WO (1) WO2016081918A1 (OSRAM)

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EP2545964A1 (en) 2011-07-13 2013-01-16 Phenex Pharmaceuticals AG Novel FXR (NR1H4) binding and activity modulating compounds
SG11201700777VA (en) 2014-08-04 2017-02-27 Nuevolution As Optionally fused heterocyclyl-substituted derivatives of pyrimidine useful for the treatment of inflammatory, metabolic, oncologic and autoimmune diseases
MX370480B (es) * 2014-11-21 2019-12-16 Akarna Therapeutics Ltd Compuestos bicíclicos fusionados para el tratamiento de enfermedades.
WO2016151403A1 (en) * 2015-03-26 2016-09-29 Akarna Therapeutics, Ltd. Fused bicyclic compounds for the treatment of disease
CA3025007A1 (en) * 2016-05-25 2017-11-30 Akarna Therapeutics, Ltd. Combination therapies with farnesoid x receptor (fxr) modulators
CA3252823A1 (en) 2016-06-13 2025-02-25 Gilead Sciences Inc Fxr (nr1h4) modulating compounds
SI3730487T1 (sl) 2016-06-13 2022-08-31 Gilead Sciences, Inc. Azetidinski derivati kot modulatorji FXR (NR1H4)
JP6906626B2 (ja) 2017-03-28 2021-07-21 ギリアード サイエンシーズ， インコーポレイテッド 肝疾患を処置するための治療的組み合わせ
CA3065313A1 (en) * 2017-06-02 2018-12-06 Akarna Therapeutics, Ltd. Fused bicyclic compounds
US11225473B2 (en) 2019-01-15 2022-01-18 Gilead Sciences, Inc. FXR (NR1H4) modulating compounds
EP3927683A1 (en) 2019-02-19 2021-12-29 Gilead Sciences, Inc. Solid forms of fxr agonists
CN111825653A (zh) * 2019-04-19 2020-10-27 安道麦马克西姆有限公司 取代吡唑类化合物的制备及其作为邻氨基苯甲酰胺前体的用途
WO2021014350A1 (en) 2019-07-23 2021-01-28 Novartis Ag Combination treatment of liver diseases using fxr agonists
EP4003350A1 (en) 2019-07-23 2022-06-01 Novartis AG Treatment comprising fxr agonists
EP4025248A1 (en) 2019-09-03 2022-07-13 Novartis AG Treatment of liver disease or disorder comprising actrii receptor antagonists
EP4031137A1 (en) 2019-09-19 2022-07-27 Novartis AG Treatment comprising fxr agonists
JP2022550312A (ja) 2019-09-30 2022-12-01 ノバルティス アーゲー Ｆｘｒアゴニストの使用を含む処置
EP4076661A1 (en) 2019-12-20 2022-10-26 Nuevolution A/S Compounds active towards nuclear receptors
EP4076657A1 (en) 2019-12-20 2022-10-26 Nuevolution A/S Compounds active towards nuclear receptors
JP2023507364A (ja) 2019-12-20 2023-02-22 ノバルティス アーゲー インテグリン阻害剤を使用する肝疾患の治療の組み合わせ
EP4126875A1 (en) 2020-03-31 2023-02-08 Nuevolution A/S Compounds active towards nuclear receptors
WO2021198955A1 (en) 2020-03-31 2021-10-07 Nuevolution A/S Compounds active towards nuclear receptors
TW202227405A (zh) * 2020-08-24 2022-07-16 以色列商安道麥馬克西姆有限公司 用於製備經取代的吡唑之方法
WO2022101853A1 (en) 2020-11-16 2022-05-19 Novartis Ag Method of determining liver fibrosis

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US20070015746A1 (en) * 2003-07-23 2007-01-18 X-Ceptor Therapeutics Inc. Azepine derivaties as pharmaceutical agents
US20090137554A1 (en) * 2007-10-22 2009-05-28 Wyeth 1,4,5,6-TETRAHYDRO -PYRROLO[2,3-d]AZEPINES AND -IMIDAZO[4,5-d]AZEPINES AS MODULATORS OF NUCLEAR RECEPTOR ACTIVITY
RU2423363C2 (ru) * 2003-12-02 2011-07-10 Экселиксис, Инк. Производные азепиноиндола в качестве фармацевтических средств

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AU2004283196B2 (en) 2003-09-17 2011-08-25 Janssen Pharmaceutica, N.V. Fused heterocyclic compounds
US20090215748A1 (en) * 2007-12-20 2009-08-27 Wyeth FXR agonists for treating vitamin D associated diseases
EP2334681A1 (en) 2008-09-26 2011-06-22 Wyeth LLC 1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate nuclear receptor inhibitors
US8252826B2 (en) 2010-03-24 2012-08-28 Hoffmann-La Roche Inc. Cyclopentyl- and cycloheptylpyrazoles
MX370480B (es) * 2014-11-21 2019-12-16 Akarna Therapeutics Ltd Compuestos bicíclicos fusionados para el tratamiento de enfermedades.
BR112018074231A2 (pt) * 2016-05-25 2019-03-06 Akarna Therapeutics, Ltd. compostos bicíclicos fundidos para o tratamento de doença

Patent Citations (3)

* Cited by examiner, † Cited by third party
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US20070015746A1 (en) * 2003-07-23 2007-01-18 X-Ceptor Therapeutics Inc. Azepine derivaties as pharmaceutical agents
RU2423363C2 (ru) * 2003-12-02 2011-07-10 Экселиксис, Инк. Производные азепиноиндола в качестве фармацевтических средств
US20090137554A1 (en) * 2007-10-22 2009-05-28 Wyeth 1,4,5,6-TETRAHYDRO -PYRROLO[2,3-d]AZEPINES AND -IMIDAZO[4,5-d]AZEPINES AS MODULATORS OF NUCLEAR RECEPTOR ACTIVITY

Non-Patent Citations (1)

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MARINOZZI MAURA et al., "Pyrazole[3,4-e][1,4]thiazepin-7-one derivatives as a novel class of Farnesoic X Receptor (FXR) agonists", Bioorganic and Medicinal Chemistry, 2012, vol. 20, pages 3429-3445. *

Also Published As

Publication number Publication date
CN111662297A (zh) 2020-09-15
CA2968434A1 (en) 2016-05-26
US20190308977A1 (en) 2019-10-10
US20210147426A1 (en) 2021-05-20
JP2023011731A (ja) 2023-01-24
KR20170117020A (ko) 2017-10-20
SG11201703953WA (en) 2017-06-29
RU2017121588A (ru) 2018-12-24
CL2017001289A1 (es) 2018-03-02
US20250171446A1 (en) 2025-05-29
EP3221321A1 (en) 2017-09-27
AU2015349687B2 (en) 2020-07-09
HK1244802A1 (zh) 2018-08-17
AU2015349687A1 (en) 2017-06-29
IL252309B (en) 2021-01-31
ES2911293T3 (es) 2022-05-18
US10233187B2 (en) 2019-03-19
AU2020250270B2 (en) 2022-08-25
JP2017535614A (ja) 2017-11-30
CN107207513B (zh) 2020-07-28
EP3221321B1 (en) 2021-12-15
JP7224102B2 (ja) 2023-02-17
WO2016081918A1 (en) 2016-05-26
US20230183247A1 (en) 2023-06-15
MX370480B (es) 2019-12-16
US20170355699A1 (en) 2017-12-14
IL252309A0 (en) 2017-07-31
MY192927A (en) 2022-09-15
JP2021011482A (ja) 2021-02-04
SG10202010386PA (en) 2020-11-27
CO2017005784A2 (es) 2017-10-31
SA517381566B1 (ar) 2021-05-16
RU2017121588A3 (OSRAM) 2019-05-21
CN107207513A (zh) 2017-09-26
AU2020250270A1 (en) 2020-11-05
EP3221321A4 (en) 2018-04-25
MX2017006694A (es) 2018-03-16
BR112017010627A2 (pt) 2018-02-14

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