RU2688167C1 - Применение изоксазолиновых соединений на домашней птице - Google Patents
Применение изоксазолиновых соединений на домашней птице Download PDFInfo
- Publication number
- RU2688167C1 RU2688167C1 RU2016129272A RU2016129272A RU2688167C1 RU 2688167 C1 RU2688167 C1 RU 2688167C1 RU 2016129272 A RU2016129272 A RU 2016129272A RU 2016129272 A RU2016129272 A RU 2016129272A RU 2688167 C1 RU2688167 C1 RU 2688167C1
- Authority
- RU
- Russia
- Prior art keywords
- cas
- poultry
- isoxazoline compound
- trifluoromethyl
- drinking water
- Prior art date
Links
- 244000144977 poultry Species 0.000 title claims abstract description 70
- 150000002547 isoxazolines Chemical class 0.000 title description 18
- -1 isoxazoline compound Chemical class 0.000 claims abstract description 91
- 241000238421 Arthropoda Species 0.000 claims abstract description 83
- 230000003071 parasitic effect Effects 0.000 claims abstract description 73
- 239000003651 drinking water Substances 0.000 claims abstract description 61
- 235000020188 drinking water Nutrition 0.000 claims abstract description 61
- MLBZKOGAMRTSKP-UHFFFAOYSA-N fluralaner Chemical compound C1=C(C(=O)NCC(=O)NCC(F)(F)F)C(C)=CC(C=2CC(ON=2)(C=2C=C(Cl)C=C(Cl)C=2)C(F)(F)F)=C1 MLBZKOGAMRTSKP-UHFFFAOYSA-N 0.000 claims abstract description 36
- 229960004498 fluralaner Drugs 0.000 claims abstract description 32
- 230000009545 invasion Effects 0.000 claims abstract description 29
- 230000002265 prevention Effects 0.000 claims abstract description 12
- FLEFKKUZMDEUIP-QFIPXVFZSA-N 1-[6-[(5s)-5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4h-1,2-oxazol-3-yl]spiro[1h-2-benzofuran-3,3'-azetidine]-1'-yl]-2-methylsulfonylethanone Chemical compound C1N(C(=O)CS(=O)(=O)C)CC21C1=CC=C(C=3C[C@](ON=3)(C=3C=C(Cl)C(F)=C(Cl)C=3)C(F)(F)F)C=C1CO2 FLEFKKUZMDEUIP-QFIPXVFZSA-N 0.000 claims abstract description 7
- HDKWFBCPLKNOCK-SFHVURJKSA-N 3-methyl-n-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]-5-[(5s)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4h-1,2-oxazol-3-yl]thiophene-2-carboxamide Chemical compound S1C(C(=O)NCC(=O)NCC(F)(F)F)=C(C)C=C1C1=NO[C@](C(F)(F)F)(C=2C=C(Cl)C(Cl)=C(Cl)C=2)C1 HDKWFBCPLKNOCK-SFHVURJKSA-N 0.000 claims abstract description 7
- OXDDDHGGRFRLEE-UHFFFAOYSA-N 4-[5-[3-chloro-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-4h-1,2-oxazol-3-yl]-n-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]naphthalene-1-carboxamide Chemical compound C12=CC=CC=C2C(C(=O)NCC(=O)NCC(F)(F)F)=CC=C1C(C1)=NOC1(C(F)(F)F)C1=CC(Cl)=CC(C(F)(F)F)=C1 OXDDDHGGRFRLEE-UHFFFAOYSA-N 0.000 claims abstract description 5
- 229960000982 afoxolaner Drugs 0.000 claims abstract 2
- 241001465754 Metazoa Species 0.000 claims description 54
- 238000011282 treatment Methods 0.000 claims description 32
- 241000271566 Aves Species 0.000 claims description 29
- 241001481695 Dermanyssus gallinae Species 0.000 claims description 24
- 230000037396 body weight Effects 0.000 claims description 13
- 150000003839 salts Chemical class 0.000 claims description 3
- 239000012453 solvate Substances 0.000 claims description 3
- 201000001064 tick infestation Diseases 0.000 claims description 3
- BPFUIWLQXNPZHI-UHFFFAOYSA-N 4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-N-[(methoxyamino)methylidene]-2-methylbenzamide Chemical compound C1=C(C)C(C(=O)N\C=N/OC)=CC=C1C1=NOC(C(F)(F)F)(C=2C=C(Cl)C=C(Cl)C=2)C1 BPFUIWLQXNPZHI-UHFFFAOYSA-N 0.000 claims description 2
- FJBGLNSEMHYAPD-UHFFFAOYSA-N 5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4h-1,2-oxazol-3-yl]-3-methyl-n-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]thiophene-2-carboxamide Chemical compound S1C(C(=O)NCC(=O)NCC(F)(F)F)=C(C)C=C1C1=NOC(C(F)(F)F)(C=2C=C(Cl)C=C(Cl)C=2)C1 FJBGLNSEMHYAPD-UHFFFAOYSA-N 0.000 claims description 2
- 229950002303 lotilaner Drugs 0.000 claims description 2
- 229960005393 sarolaner Drugs 0.000 claims description 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 2
- 241000238876 Acari Species 0.000 abstract description 22
- 150000001875 compounds Chemical class 0.000 abstract description 8
- 230000000694 effects Effects 0.000 abstract description 7
- 239000000126 substance Substances 0.000 abstract description 7
- 239000003814 drug Substances 0.000 abstract description 5
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 235000013594 poultry meat Nutrition 0.000 description 66
- 241000287828 Gallus gallus Species 0.000 description 38
- 244000045947 parasite Species 0.000 description 38
- 235000013330 chicken meat Nutrition 0.000 description 30
- 238000004519 manufacturing process Methods 0.000 description 29
- 238000000034 method Methods 0.000 description 29
- 235000013601 eggs Nutrition 0.000 description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 21
- 239000008194 pharmaceutical composition Substances 0.000 description 16
- 239000000203 mixture Substances 0.000 description 13
- 229910052736 halogen Inorganic materials 0.000 description 10
- 239000000243 solution Substances 0.000 description 10
- 241001569691 Ixodes brunneus Species 0.000 description 9
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 9
- 150000002367 halogens Chemical class 0.000 description 9
- 241001674048 Phthiraptera Species 0.000 description 8
- 229910052739 hydrogen Inorganic materials 0.000 description 7
- 239000001257 hydrogen Substances 0.000 description 7
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 7
- 238000009395 breeding Methods 0.000 description 6
- 230000001488 breeding effect Effects 0.000 description 6
- 230000006378 damage Effects 0.000 description 6
- 239000000725 suspension Substances 0.000 description 6
- 230000001225 therapeutic effect Effects 0.000 description 6
- 206010004194 Bed bug infestation Diseases 0.000 description 5
- 241001609899 Ceratophyllus gallinae Species 0.000 description 5
- 241001414835 Cimicidae Species 0.000 description 5
- 241000254173 Coleoptera Species 0.000 description 5
- 241000286209 Phasianidae Species 0.000 description 5
- 239000000428 dust Substances 0.000 description 5
- 230000007613 environmental effect Effects 0.000 description 5
- 238000002347 injection Methods 0.000 description 5
- 239000007924 injection Substances 0.000 description 5
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 4
- 241000272517 Anseriformes Species 0.000 description 4
- 241000238631 Hexapoda Species 0.000 description 4
- 241001467800 Knemidokoptes Species 0.000 description 4
- 241000258242 Siphonaptera Species 0.000 description 4
- 238000011161 development Methods 0.000 description 4
- 230000018109 developmental process Effects 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 239000003937 drug carrier Substances 0.000 description 4
- 125000004970 halomethyl group Chemical group 0.000 description 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 239000000377 silicon dioxide Substances 0.000 description 4
- 241000894007 species Species 0.000 description 4
- 230000001629 suppression Effects 0.000 description 4
- 241001327638 Cimex lectularius Species 0.000 description 3
- 241000566163 Ornithonyssus bursa Species 0.000 description 3
- 241000273374 Ornithonyssus sylviarum Species 0.000 description 3
- 239000007900 aqueous suspension Substances 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 229910052801 chlorine Inorganic materials 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 description 3
- 238000007865 diluting Methods 0.000 description 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 3
- 210000003608 fece Anatomy 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 230000001418 larval effect Effects 0.000 description 3
- 235000013372 meat Nutrition 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 210000002445 nipple Anatomy 0.000 description 3
- 239000007921 spray Substances 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- WEQPBCSPRXFQQS-UHFFFAOYSA-N 4,5-dihydro-1,2-oxazole Chemical compound C1CC=NO1 WEQPBCSPRXFQQS-UHFFFAOYSA-N 0.000 description 2
- 241001481694 Dermanyssus Species 0.000 description 2
- 241001549209 Echidnophaga gallinacea Species 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- 206010061217 Infestation Diseases 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 235000019687 Lamb Nutrition 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 241000292449 Menacanthus stramineus Species 0.000 description 2
- 241000035435 Menopon gallinae Species 0.000 description 2
- 241000273340 Ornithonyssus Species 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 125000004093 cyano group Chemical group *C#N 0.000 description 2
- 125000006255 cyclopropyl carbonyl group Chemical group [H]C1([H])C([H])([H])C1([H])C(*)=O 0.000 description 2
- 229940075557 diethylene glycol monoethyl ether Drugs 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 125000005745 ethoxymethyl group Chemical group [H]C([H])([H])C([H])([H])OC([H])([H])* 0.000 description 2
- 125000004672 ethylcarbonyl group Chemical group [H]C([H])([H])C([H])([H])C(*)=O 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- 210000003746 feather Anatomy 0.000 description 2
- 230000012447 hatching Effects 0.000 description 2
- 230000000366 juvenile effect Effects 0.000 description 2
- 230000033001 locomotion Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 description 2
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 description 2
- 125000004674 methylcarbonyl group Chemical group CC(=O)* 0.000 description 2
- 230000017448 oviposition Effects 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 229920000728 polyester Polymers 0.000 description 2
- 229920000136 polysorbate Polymers 0.000 description 2
- 229950008882 polysorbate Drugs 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 125000005767 propoxymethyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])[#8]C([H])([H])* 0.000 description 2
- 125000004673 propylcarbonyl group Chemical group 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 125000001424 substituent group Chemical group 0.000 description 2
- 241001124203 Alphitobius diaperinus Species 0.000 description 1
- 241001480752 Argas persicus Species 0.000 description 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 1
- JFLRKDZMHNBDQS-UCQUSYKYSA-N CC[C@H]1CCC[C@@H]([C@H](C(=O)C2=C[C@H]3[C@@H]4C[C@@H](C[C@H]4C(=C[C@H]3[C@@H]2CC(=O)O1)C)O[C@H]5[C@@H]([C@@H]([C@H]([C@@H](O5)C)OC)OC)OC)C)O[C@H]6CC[C@@H]([C@H](O6)C)N(C)C.CC[C@H]1CCC[C@@H]([C@H](C(=O)C2=C[C@H]3[C@@H]4C[C@@H](C[C@H]4C=C[C@H]3C2CC(=O)O1)O[C@H]5[C@@H]([C@@H]([C@H]([C@@H](O5)C)OC)OC)OC)C)O[C@H]6CC[C@@H]([C@H](O6)C)N(C)C Chemical compound CC[C@H]1CCC[C@@H]([C@H](C(=O)C2=C[C@H]3[C@@H]4C[C@@H](C[C@H]4C(=C[C@H]3[C@@H]2CC(=O)O1)C)O[C@H]5[C@@H]([C@@H]([C@H]([C@@H](O5)C)OC)OC)OC)C)O[C@H]6CC[C@@H]([C@H](O6)C)N(C)C.CC[C@H]1CCC[C@@H]([C@H](C(=O)C2=C[C@H]3[C@@H]4C[C@@H](C[C@H]4C=C[C@H]3C2CC(=O)O1)O[C@H]5[C@@H]([C@@H]([C@H]([C@@H](O5)C)OC)OC)OC)C)O[C@H]6CC[C@@H]([C@H](O6)C)N(C)C JFLRKDZMHNBDQS-UCQUSYKYSA-N 0.000 description 1
- 241000272201 Columbiformes Species 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 241001481702 Dermanyssidae Species 0.000 description 1
- 241001549210 Echidnophaga Species 0.000 description 1
- 241000258937 Hemiptera Species 0.000 description 1
- 241001495069 Ischnocera Species 0.000 description 1
- 208000019693 Lung disease Diseases 0.000 description 1
- 208000002720 Malnutrition Diseases 0.000 description 1
- 150000001204 N-oxides Chemical class 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 208000030852 Parasitic disease Diseases 0.000 description 1
- 241000269799 Perca fluviatilis Species 0.000 description 1
- 241000932963 Philopteridae Species 0.000 description 1
- 208000035415 Reinfection Diseases 0.000 description 1
- 206010039509 Scab Diseases 0.000 description 1
- 239000005930 Spinosad Substances 0.000 description 1
- 241000254107 Tenebrionidae Species 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- 230000000895 acaricidal effect Effects 0.000 description 1
- 239000000642 acaricide Substances 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 239000003096 antiparasitic agent Substances 0.000 description 1
- 229940125687 antiparasitic agent Drugs 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 238000010420 art technique Methods 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- VEMKTZHHVJILDY-UXHICEINSA-N bioresmethrin Chemical compound CC1(C)[C@H](C=C(C)C)[C@H]1C(=O)OCC1=COC(CC=2C=CC=CC=2)=C1 VEMKTZHHVJILDY-UXHICEINSA-N 0.000 description 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
- 229910052794 bromium Inorganic materials 0.000 description 1
- 150000004657 carbamic acid derivatives Chemical class 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 210000000080 chela (arthropods) Anatomy 0.000 description 1
- 125000003636 chemical group Chemical group 0.000 description 1
- 238000012993 chemical processing Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 230000001066 destructive effect Effects 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- AMTWCFIAVKBGOD-UHFFFAOYSA-N dioxosilane;methoxy-dimethyl-trimethylsilyloxysilane Chemical compound O=[Si]=O.CO[Si](C)(C)O[Si](C)(C)C AMTWCFIAVKBGOD-UHFFFAOYSA-N 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 244000078703 ectoparasite Species 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 238000009408 flooring Methods 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 239000000077 insect repellent Substances 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 230000002262 irrigation Effects 0.000 description 1
- 238000003973 irrigation Methods 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 230000000974 larvacidal effect Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000010871 livestock manure Substances 0.000 description 1
- 230000001071 malnutrition Effects 0.000 description 1
- 235000000824 malnutrition Nutrition 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000005541 medical transmission Effects 0.000 description 1
- 229940126601 medicinal product Drugs 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 210000001640 nerve ending Anatomy 0.000 description 1
- 230000000422 nocturnal effect Effects 0.000 description 1
- 208000015380 nutritional deficiency disease Diseases 0.000 description 1
- 231100000194 ovacidal Toxicity 0.000 description 1
- 230000003151 ovacidal effect Effects 0.000 description 1
- 230000024241 parasitism Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 230000010152 pollination Effects 0.000 description 1
- 230000005195 poor health Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 229940083037 simethicone Drugs 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 229940014213 spinosad Drugs 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 231100000583 toxicological profile Toxicity 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000001238 wet grinding Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13199007 | 2013-12-20 | ||
| EP13199007.9 | 2013-12-20 | ||
| PCT/EP2014/078636 WO2015091900A1 (en) | 2013-12-20 | 2014-12-19 | Use of isoxazoline derivatives for the treatment or prevention of arthropod infestations in poultry |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2019114185A Division RU2796536C9 (ru) | 2013-12-20 | 2014-12-19 | Применение изоксазолиновых соединений на домашней птице |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2016129272A RU2016129272A (ru) | 2018-01-25 |
| RU2688167C1 true RU2688167C1 (ru) | 2019-05-20 |
Family
ID=49911279
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2016129272A RU2688167C1 (ru) | 2013-12-20 | 2014-12-19 | Применение изоксазолиновых соединений на домашней птице |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US10272071B2 (https=) |
| EP (2) | EP3082806B1 (https=) |
| JP (1) | JP6506763B2 (https=) |
| CN (2) | CN105979944A (https=) |
| BR (1) | BR112016014216B1 (https=) |
| ES (2) | ES2950885T3 (https=) |
| HU (2) | HUE063842T2 (https=) |
| MX (2) | MX376210B (https=) |
| PL (2) | PL3082806T3 (https=) |
| PT (1) | PT3082806T (https=) |
| RU (1) | RU2688167C1 (https=) |
| WO (1) | WO2015091900A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4430947A1 (en) | 2023-03-17 | 2024-09-18 | Przedsiebiorstwo Wielobranzowe "Vet-Agro" Sp. Z O.O. | Therapeutic use of isoxazoline compounds, composition of isoxazoline compounds and kit for therapeutic use |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3082806B1 (en) * | 2013-12-20 | 2021-05-12 | Intervet International B.V. | Use of isoxazoline derivatives for the treatment or prevention of arthropod infestations in poultry |
| EP3082867B1 (en) | 2013-12-20 | 2024-01-17 | Intervet International B.V. | Isoxazoline compositions and use thereof in the prevention or treatment of parasite infestations in animals |
| BR112017027855B1 (pt) * | 2015-06-23 | 2022-11-16 | Intervet International B.V. | Composição farmacêutica, seu uso, água potável medicamentosa e método para sua preparação |
| WO2018039508A1 (en) * | 2016-08-25 | 2018-03-01 | Merial, Inc. | Method for reducing unwanted effects in parasiticidal treatments |
| TWI834690B (zh) * | 2018-07-18 | 2024-03-11 | 美商富曼西公司 | 用於防治無脊椎動物害蟲之異噁唑啉化合物 |
| TW202012399A (zh) * | 2018-09-12 | 2020-04-01 | 美商富曼西公司 | 用於防制無脊椎動物害蟲之異口咢唑啉化合物 |
| EP3927341A1 (en) * | 2019-04-03 | 2021-12-29 | Virbac | Low dose fluralaner compositions for protection against parasitic invertebrate pest |
| MX2022007309A (es) * | 2019-12-16 | 2022-07-12 | Intervet Int Bv | Composicion para control de piojos en aves de corral. |
| EP4077286A1 (en) | 2019-12-18 | 2022-10-26 | Elanco Tiergesundheit AG | Isoxazoline derivatives as pesticides |
| KR20230043904A (ko) | 2020-07-24 | 2023-03-31 | 엘랑코 유에스 인코포레이티드 | 이속사졸린 화합물 및 이의 중간체의 제조 공정 |
| CN116744917A (zh) | 2020-09-04 | 2023-09-12 | 礼蓝美国公司 | 适口调配物 |
| US11903962B1 (en) * | 2023-05-07 | 2024-02-20 | Michael Farber | Isoxazoline complexes and compositions thereof |
| PL449854A1 (pl) * | 2024-09-18 | 2026-03-23 | Okoniewski Piotr | Kompozycja farmaceutyczna, lecznicza woda pitna, ich zastosowanie i sposób wytwarzania leczniczej wody pitnej |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009003075A1 (en) * | 2007-06-27 | 2008-12-31 | E.I. Du Pont De Nemours And Company | Animal pest control method |
| WO2012107533A1 (en) * | 2011-02-10 | 2012-08-16 | Novartis Ag | Isoxazoline derivatives for controlling invertebrate pests |
| WO2013026931A1 (en) * | 2011-08-25 | 2013-02-28 | Syngenta Participations Ag | Isoxazoline derivatives as insecticidal compounds |
| WO2013026695A1 (en) * | 2011-08-25 | 2013-02-28 | Syngenta Participations Ag | Isoxazoline derivatives as insecticidal compounds |
| WO2013050302A1 (en) * | 2011-10-03 | 2013-04-11 | Syngenta Participations Ag | Isoxazoline derivatives as insecticidal compounds |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101768129B (zh) * | 2004-03-05 | 2012-05-23 | 日产化学工业株式会社 | 异*唑啉取代苯甲酰胺化合物的制备中间体 |
| AU2006313007C1 (en) | 2005-11-10 | 2019-10-03 | Elanco Australasia Pty Limited | Method of treating parasites |
| TW200803740A (en) | 2005-12-16 | 2008-01-16 | Du Pont | 5-aryl isoxazolines for controlling invertebrate pests |
| TWI412322B (zh) | 2005-12-30 | 2013-10-21 | Du Pont | 控制無脊椎害蟲之異唑啉 |
| TWI430995B (zh) | 2007-06-26 | 2014-03-21 | Du Pont | 萘異唑啉無脊椎有害動物控制劑 |
| TWI556741B (zh) | 2007-08-17 | 2016-11-11 | 英特威特國際股份有限公司 | 異唑啉組成物及其作為抗寄生蟲藥上的應用 |
| TWI411395B (zh) | 2007-12-24 | 2013-10-11 | Syngenta Participations Ag | 殺蟲化合物 |
| CN102149695B (zh) | 2008-07-09 | 2015-02-04 | 日产化学工业株式会社 | 异*唑啉取代的苯甲酰胺化合物的制造方法 |
| MY155497A (en) | 2008-11-19 | 2015-10-30 | Merial Inc | Compositions comprising an aryl pyrazole and/or a formamidine, methods and use thereof |
| US8377942B2 (en) | 2008-12-18 | 2013-02-19 | Novartis Ag | Isoxazolines derivatives and their use as pesticide |
| HUE015568T4 (en) | 2008-12-19 | 2017-10-30 | Elanco Tiergesundheit Ag | Isoxazoline derivatives and their use as pesticides |
| AR081843A1 (es) * | 2010-06-09 | 2012-10-24 | Syngenta Participations Ag | Mezclas pesticidas incluyendo derivados isoxazolina |
| EP2593592B1 (en) | 2010-07-15 | 2018-05-16 | Luxembourg Institute of Science and Technology (LIST) | Separation of master electrode and substrate in ecpr |
| JP6002148B2 (ja) | 2010-12-27 | 2016-10-05 | インターベット インターナショナル ベー． フェー． | 経表面局所イソオキサゾリン製剤 |
| NZ611474A (en) * | 2010-12-27 | 2015-08-28 | Intervet Int Bv | Topical localized isoxazoline formulation comprising glycofurol |
| RS58417B1 (sr) | 2011-09-12 | 2019-04-30 | Merial Inc | Paraziticidne kompozicije koje sadrže izoksazolinsko aktivno sredstvo, postupci i upotrebe povezane sa njima |
| DE102012200815B3 (de) | 2012-01-20 | 2013-01-10 | Dieter Kirsch | Inhalationsunterstützungsvorrichtung und Verfahren zur Inhalationsunterstützung |
| WO2013150055A1 (en) * | 2012-04-04 | 2013-10-10 | Intervet International B.V. | Solid oral pharmaceutical compositions for isoxazoline compounds |
| EP3082806B1 (en) * | 2013-12-20 | 2021-05-12 | Intervet International B.V. | Use of isoxazoline derivatives for the treatment or prevention of arthropod infestations in poultry |
-
2014
- 2014-12-19 EP EP14816243.1A patent/EP3082806B1/en active Active
- 2014-12-19 PT PT148162431T patent/PT3082806T/pt unknown
- 2014-12-19 PL PL14816243T patent/PL3082806T3/pl unknown
- 2014-12-19 HU HUE21166872A patent/HUE063842T2/hu unknown
- 2014-12-19 MX MX2016008119A patent/MX376210B/es active IP Right Grant
- 2014-12-19 WO PCT/EP2014/078636 patent/WO2015091900A1/en not_active Ceased
- 2014-12-19 JP JP2016540559A patent/JP6506763B2/ja active Active
- 2014-12-19 PL PL21166872.8T patent/PL3878281T3/pl unknown
- 2014-12-19 EP EP21166872.8A patent/EP3878281B1/en active Active
- 2014-12-19 US US15/105,197 patent/US10272071B2/en active Active
- 2014-12-19 CN CN201480068597.1A patent/CN105979944A/zh active Pending
- 2014-12-19 RU RU2016129272A patent/RU2688167C1/ru active
- 2014-12-19 BR BR112016014216-0A patent/BR112016014216B1/pt active IP Right Grant
- 2014-12-19 ES ES21166872T patent/ES2950885T3/es active Active
- 2014-12-19 HU HUE14816243A patent/HUE055444T2/hu unknown
- 2014-12-19 ES ES14816243T patent/ES2874054T3/es active Active
- 2014-12-19 CN CN201911241170.8A patent/CN110839641A/zh active Pending
-
2016
- 2016-06-17 MX MX2020010997A patent/MX2020010997A/es unknown
-
2019
- 2019-03-05 US US16/293,024 patent/US10653675B2/en active Active
-
2020
- 2020-04-15 US US16/849,487 patent/US11304934B2/en active Active
-
2022
- 2022-03-08 US US17/653,950 patent/US12128032B2/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009003075A1 (en) * | 2007-06-27 | 2008-12-31 | E.I. Du Pont De Nemours And Company | Animal pest control method |
| WO2012107533A1 (en) * | 2011-02-10 | 2012-08-16 | Novartis Ag | Isoxazoline derivatives for controlling invertebrate pests |
| WO2013026931A1 (en) * | 2011-08-25 | 2013-02-28 | Syngenta Participations Ag | Isoxazoline derivatives as insecticidal compounds |
| WO2013026695A1 (en) * | 2011-08-25 | 2013-02-28 | Syngenta Participations Ag | Isoxazoline derivatives as insecticidal compounds |
| WO2013050302A1 (en) * | 2011-10-03 | 2013-04-11 | Syngenta Participations Ag | Isoxazoline derivatives as insecticidal compounds |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4430947A1 (en) | 2023-03-17 | 2024-09-18 | Przedsiebiorstwo Wielobranzowe "Vet-Agro" Sp. Z O.O. | Therapeutic use of isoxazoline compounds, composition of isoxazoline compounds and kit for therapeutic use |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2016540028A (ja) | 2016-12-22 |
| PL3878281T3 (pl) | 2023-07-31 |
| CN105979944A (zh) | 2016-09-28 |
| US12128032B2 (en) | 2024-10-29 |
| US10653675B2 (en) | 2020-05-19 |
| ES2874054T3 (es) | 2021-11-04 |
| HUE055444T2 (hu) | 2021-11-29 |
| WO2015091900A1 (en) | 2015-06-25 |
| US20190192486A1 (en) | 2019-06-27 |
| MX376210B (es) | 2025-03-07 |
| MX2016008119A (es) | 2016-09-16 |
| US20220193040A1 (en) | 2022-06-23 |
| MX2020010997A (es) | 2020-11-09 |
| EP3082806A1 (en) | 2016-10-26 |
| ES2950885T3 (es) | 2023-10-16 |
| PT3082806T (pt) | 2021-06-04 |
| RU2019114185A (ru) | 2019-06-27 |
| EP3878281B1 (en) | 2023-05-24 |
| EP3878281A1 (en) | 2021-09-15 |
| US20200237727A1 (en) | 2020-07-30 |
| BR112016014216B1 (pt) | 2022-08-30 |
| HUE063842T2 (hu) | 2024-02-28 |
| US20160317502A1 (en) | 2016-11-03 |
| CN110839641A (zh) | 2020-02-28 |
| PL3082806T3 (pl) | 2021-09-13 |
| JP6506763B2 (ja) | 2019-04-24 |
| US10272071B2 (en) | 2019-04-30 |
| RU2016129272A (ru) | 2018-01-25 |
| EP3082806B1 (en) | 2021-05-12 |
| BR112016014216A2 (https=) | 2017-08-08 |
| US11304934B2 (en) | 2022-04-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2688167C1 (ru) | Применение изоксазолиновых соединений на домашней птице | |
| RU2688919C1 (ru) | Изоксазолиновые композиции и их применение в провилактике или лечении паразитарных инвазий животных | |
| RU2673723C1 (ru) | Применение содержащих изоксазолин соединений в качестве противопаразитарных средств | |
| ES2973362T3 (es) | Control de parásitos en rumiantes | |
| WO2021122521A1 (en) | Composition for lice control in poultry | |
| RU2796536C2 (ru) | Применение изоксазолиновых соединений на домашней птице | |
| RU2796536C9 (ru) | Применение изоксазолиновых соединений на домашней птице | |
| CN118593485B (zh) | 异噁唑啉复合物及其组合物 | |
| RU2791637C2 (ru) | Изоксазолиновые композиции и их применение в профилактике или лечении паразитарных инвазий животных | |
| CN1233936A (zh) | 防治温血动物被外寄生物再感染的方法 |