RU2675928C2 - Композиции клеток, полученные из дедифференцированных перепрограммированных клеток - Google Patents

Композиции клеток, полученные из дедифференцированных перепрограммированных клеток Download PDF

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RU2675928C2
RU2675928C2 RU2015131279A RU2015131279A RU2675928C2 RU 2675928 C2 RU2675928 C2 RU 2675928C2 RU 2015131279 A RU2015131279 A RU 2015131279A RU 2015131279 A RU2015131279 A RU 2015131279A RU 2675928 C2 RU2675928 C2 RU 2675928C2
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cells
cell
endoderm
pancreatic
pdx1
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RU2015131279A
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Russian (ru)
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RU2015131279A (ru
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Алан Д. Агулник
Оливия КЕЛЛИ
Юки ОХИ
Аллан РОБИНС
Томас ШУЛЬЦ
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Виасайт, Инк.
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Priority claimed from US13/761,078 external-priority patent/US9109245B2/en
Application filed by Виасайт, Инк. filed Critical Виасайт, Инк.
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0012—Cell encapsulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C12N2501/72—Transferases [EC 2.]
    • C12N2501/727—Kinases (EC 2.7.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
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  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
RU2015131279A 2013-02-06 2014-02-06 Композиции клеток, полученные из дедифференцированных перепрограммированных клеток RU2675928C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/761,078 2013-02-06
US13/761,078 US9109245B2 (en) 2009-04-22 2013-02-06 Cell compositions derived from dedifferentiated reprogrammed cells
PCT/US2014/015156 WO2014124172A1 (en) 2013-02-06 2014-02-06 Cell compositions derived from dedifferentiated reprogrammed cells

Related Child Applications (1)

Application Number Title Priority Date Filing Date
RU2018144412A Division RU2754089C2 (ru) 2013-02-06 2014-02-06 Композиции клеток, полученные из дедифференцированных перепрограммированных клеток

Publications (2)

Publication Number Publication Date
RU2015131279A RU2015131279A (ru) 2017-03-13
RU2675928C2 true RU2675928C2 (ru) 2018-12-25

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RU2015131279A RU2675928C2 (ru) 2013-02-06 2014-02-06 Композиции клеток, полученные из дедифференцированных перепрограммированных клеток
RU2018144412A RU2754089C2 (ru) 2013-02-06 2014-02-06 Композиции клеток, полученные из дедифференцированных перепрограммированных клеток

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RU2018144412A RU2754089C2 (ru) 2013-02-06 2014-02-06 Композиции клеток, полученные из дедифференцированных перепрограммированных клеток

Country Status (8)

Country Link
EP (1) EP2954045A1 (https=)
JP (5) JP6517702B2 (https=)
AU (5) AU2014214879A1 (https=)
CA (2) CA3212301A1 (https=)
HK (1) HK1218139A1 (https=)
IL (5) IL311689B2 (https=)
RU (2) RU2675928C2 (https=)
WO (1) WO2014124172A1 (https=)

Families Citing this family (15)

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US9109245B2 (en) 2009-04-22 2015-08-18 Viacyte, Inc. Cell compositions derived from dedifferentiated reprogrammed cells
AU2015300020B2 (en) 2014-08-04 2021-04-08 Orizuru Therapeutics, Inc. Method for proliferation of pancreatic progenitor cells
DK3443073T3 (da) * 2016-04-14 2024-09-02 Janssen Biotech Inc Differentiering af pluripotente stamceller til intestinale mellemtarmendodermceller
CN111334463B (zh) * 2016-05-18 2024-02-20 学校法人庆应义塾 类器官培养用细胞培养基、培养方法及类器官
EP3587560A4 (en) 2017-01-27 2020-12-16 Kaneka Corporation Endodermal cell mass, and method for producing any one of three primary germ layer cell mass from pluripotent cells
CN111565707A (zh) 2017-06-14 2020-08-21 森玛治疗公司 用于递送治疗物的装置和方法
EP3654996A4 (en) * 2017-07-21 2021-03-24 Semma Therapeutics, Inc. REAGGREGATION OF PANCREAS BETA CELLS FROM STEM CELLS
US20210292708A1 (en) * 2018-08-03 2021-09-23 Kyoto University Cell production method
BR112021004815A2 (pt) * 2018-09-19 2021-06-01 Takeda Pharmaceutical Company Limited células produtoras de insulina, medicamento, e, métodos para produzir células produtoras de insulina, para gerar células do tipo ilhota pancreática, para tratar diabetes mellitus, para melhorar e/ou manter o controle dos níveis de glicose em jejum e pós-prandial em um paciente e para reduzir o risco de hipoglicemia em um paciente com diabetes mellitus
WO2020243665A1 (en) 2019-05-31 2020-12-03 W. L. Gore & Associates, Inc. A biocompatible membrane composite
WO2020243666A1 (en) 2019-05-31 2020-12-03 W. L. Gore & Associates, Inc. A biocompatible membrane composite
AU2020282355B2 (en) 2019-05-31 2023-11-02 Viacyte, Inc. A biocompatible membrane composite
CN114401752B (zh) 2019-05-31 2023-04-04 W.L.戈尔及同仁股份有限公司 具有受控氧扩散距离的细胞封装装置
IL300105A (en) 2020-07-31 2023-03-01 Vertex Pharma Pancreatic endocrine cell differentiation
CN119948151A (zh) * 2022-09-26 2025-05-06 国立大学法人京都大学 胰腺内胚层细胞的制造方法

Citations (2)

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Publication number Priority date Publication date Assignee Title
WO2000059525A2 (en) * 1999-04-06 2000-10-12 Genentech, Inc. USE OF ErbB RECEPTOR LIGANDS IN TREATING DIABETES
US20100272695A1 (en) * 2009-04-22 2010-10-28 Alan Agulnick Cell compositions derived from dedifferentiated reprogrammed cells

Family Cites Families (8)

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US6759039B2 (en) * 2000-06-30 2004-07-06 Amcyte, Inc. Culturing pancreatic stem cells having a specified, intermediate stage of development
CA2435826A1 (en) * 2001-01-24 2002-08-01 The Government Of The United States Of America Differentiation of stem cells to pancreatic endocrine cells
CN101310012B (zh) * 2005-10-14 2012-05-09 明尼苏达大学董事会 非胚胎干细胞分化成具有胰腺表型的细胞
AU2007254766A1 (en) * 2006-06-02 2007-12-13 University Of Georgia Research Foundation, Inc. Pancreatic and liver endoderm cells and tissue by differentiation of definitive endoderm cells obtained from human embryonic stems
AU2009313870B2 (en) 2008-11-14 2013-07-11 Viacyte, Inc. Encapsulation of pancreatic cells derived from human pluripotent stem cells
US9109245B2 (en) * 2009-04-22 2015-08-18 Viacyte, Inc. Cell compositions derived from dedifferentiated reprogrammed cells
US8685726B2 (en) * 2009-04-27 2014-04-01 Viacyte, Inc. Small molecules supporting pluripotent cell growth and methods thereof
EP2436397B1 (en) * 2009-05-29 2017-05-10 Chugai Seiyaku Kabushiki Kaisha Pharmaceutical composition containing antagonist of egf family ligand as component

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000059525A2 (en) * 1999-04-06 2000-10-12 Genentech, Inc. USE OF ErbB RECEPTOR LIGANDS IN TREATING DIABETES
US20100272695A1 (en) * 2009-04-22 2010-10-28 Alan Agulnick Cell compositions derived from dedifferentiated reprogrammed cells

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
HUOTARI MA, et al. "ErbB signaling regulates lineage determination of developing pancreatic islet cells in embryonic organ culture", Endocrinology. 2002; 143(11): 4437-4446. *
HUOTARI MA, et al. "ErbB signaling regulates lineage determination of developing pancreatic islet cells in embryonic organ culture", Endocrinology. 2002; 143(11): 4437-4446. KILSOO J, et al. "Differentiation and Transplantation of Functional Pancreatic Beta Cells Generated from Induced Pluripotent Stem Cells Derived from a Type 1 Diabetes Mouse Model", Stem Cell Dev. 2012; 21(14): 2642-2655. ZHU FF, et al. "Generation of pancreatic insulin-producing cells from rhesus monkey induced pluripotent stem cells", Diabetologia. 2011; 54: 2325. *
KILSOO J, et al. "Differentiation and Transplantation of Functional Pancreatic Beta Cells Generated from Induced Pluripotent Stem Cells Derived from a Type 1 Diabetes Mouse Model", Stem Cell Dev. 2012; 21(14): 2642-2655. *
ZHU FF, et al. "Generation of pancreatic insulin-producing cells from rhesus monkey induced pluripotent stem cells", Diabetologia. 2011; 54: 2325. *
ПОЛЯHОВСКИЙ О.Л. и др. "ERBB-онкогены-мишени моноклональных антител", Биохимия. 2012; 77(3): 289-311. *

Also Published As

Publication number Publication date
RU2018144412A (ru) 2019-03-25
JP6721752B2 (ja) 2020-07-15
JP2016506736A (ja) 2016-03-07
JP7250731B2 (ja) 2023-04-03
IL283088A (en) 2021-06-30
IL290717B1 (en) 2024-06-01
IL290717A (en) 2022-04-01
EP2954045A1 (en) 2015-12-16
IL311689A (en) 2024-05-01
AU2022200075A1 (en) 2022-02-03
JP2020178694A (ja) 2020-11-05
AU2023202507B2 (en) 2025-12-04
AU2023202507A1 (en) 2023-05-11
AU2022200075B2 (en) 2023-02-02
IL239953A0 (en) 2015-08-31
IL311689B2 (en) 2025-12-01
AU2019201314A1 (en) 2019-03-14
WO2014124172A1 (en) 2014-08-14
AU2019201314B2 (en) 2021-10-14
CA3212301A1 (en) 2014-08-14
IL311689B1 (en) 2025-08-01
JP6517702B2 (ja) 2019-05-22
AU2022200075C1 (en) 2023-07-06
RU2018144412A3 (https=) 2020-02-14
IL321825A (en) 2025-08-01
AU2026201562A1 (en) 2026-03-19
RU2754089C2 (ru) 2021-08-26
JP2025000625A (ja) 2025-01-07
JP2019146578A (ja) 2019-09-05
RU2015131279A (ru) 2017-03-13
CA2898431C (en) 2023-10-17
AU2014214879A1 (en) 2015-07-30
IL290717B2 (en) 2024-10-01
IL283088B (en) 2022-04-01
CA2898431A1 (en) 2014-08-14
HK1218139A1 (zh) 2017-02-03
JP2023017838A (ja) 2023-02-07
JP7550830B2 (ja) 2024-09-13
IL239953B (en) 2021-05-31

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