RU2665190C2 - Система, генерирующая аэрозоль, содержащая источник соединения, ускоряющего доставку, и источник лекарственного средства - Google Patents
Система, генерирующая аэрозоль, содержащая источник соединения, ускоряющего доставку, и источник лекарственного средства Download PDFInfo
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- RU2665190C2 RU2665190C2 RU2015154179A RU2015154179A RU2665190C2 RU 2665190 C2 RU2665190 C2 RU 2665190C2 RU 2015154179 A RU2015154179 A RU 2015154179A RU 2015154179 A RU2015154179 A RU 2015154179A RU 2665190 C2 RU2665190 C2 RU 2665190C2
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- CKFRRHLHAJZIIN-UHFFFAOYSA-N cobalt lithium Chemical compound [Li].[Co] CKFRRHLHAJZIIN-UHFFFAOYSA-N 0.000 description 1
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- DPNGWXJMIILTBS-UHFFFAOYSA-N dehydronornicotine Natural products C1CCN=C1C1=CC=CN=C1 DPNGWXJMIILTBS-UHFFFAOYSA-N 0.000 description 1
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- 229910052733 gallium Inorganic materials 0.000 description 1
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- 229910052735 hafnium Inorganic materials 0.000 description 1
- VBJZVLUMGGDVMO-UHFFFAOYSA-N hafnium atom Chemical compound [Hf] VBJZVLUMGGDVMO-UHFFFAOYSA-N 0.000 description 1
- 125000000623 heterocyclic group Chemical group 0.000 description 1
- 229930005342 hyoscyamine Natural products 0.000 description 1
- 229960003210 hyoscyamine Drugs 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
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- 229910052742 iron Inorganic materials 0.000 description 1
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- TYZROVQLWOKYKF-ZDUSSCGKSA-N linezolid Chemical compound O=C1O[C@@H](CNC(=O)C)CN1C(C=C1F)=CC=C1N1CCOCC1 TYZROVQLWOKYKF-ZDUSSCGKSA-N 0.000 description 1
- 229960003907 linezolid Drugs 0.000 description 1
- GELKBWJHTRAYNV-UHFFFAOYSA-K lithium iron phosphate Chemical compound [Li+].[Fe+2].[O-]P([O-])([O-])=O GELKBWJHTRAYNV-UHFFFAOYSA-K 0.000 description 1
- FUJCRWPEOMXPAD-UHFFFAOYSA-N lithium oxide Chemical compound [Li+].[Li+].[O-2] FUJCRWPEOMXPAD-UHFFFAOYSA-N 0.000 description 1
- 229910001947 lithium oxide Inorganic materials 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- IMYZQPCYWPFTAG-IQJOONFLSA-N mecamylamine Chemical compound C1C[C@@H]2C(C)(C)[C@@](NC)(C)[C@H]1C2 IMYZQPCYWPFTAG-IQJOONFLSA-N 0.000 description 1
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- YECBIJXISLIIDS-UHFFFAOYSA-N mepyramine Chemical compound C1=CC(OC)=CC=C1CN(CCN(C)C)C1=CC=CC=N1 YECBIJXISLIIDS-UHFFFAOYSA-N 0.000 description 1
- DAHIQPJTGIHDGO-IAGOWNOFSA-N mesembrine Chemical compound C1=C(OC)C(OC)=CC=C1[C@]1(CCC(=O)C2)[C@@H]2N(C)CC1 DAHIQPJTGIHDGO-IAGOWNOFSA-N 0.000 description 1
- DAHIQPJTGIHDGO-UHFFFAOYSA-N mesembrine Natural products C1=C(OC)C(OC)=CC=C1C1(CCC(=O)C2)C2N(C)CC1 DAHIQPJTGIHDGO-UHFFFAOYSA-N 0.000 description 1
- 229910052987 metal hydride Inorganic materials 0.000 description 1
- LMOINURANNBYCM-UHFFFAOYSA-N metaproterenol Chemical compound CC(C)NCC(O)C1=CC(O)=CC(O)=C1 LMOINURANNBYCM-UHFFFAOYSA-N 0.000 description 1
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 1
- SVXZBICQLNEMLC-UHFFFAOYSA-N methyl 1-methyl-3,6-dihydro-2h-pyridine-4-carboxylate Chemical compound COC(=O)C1=CCN(C)CC1 SVXZBICQLNEMLC-UHFFFAOYSA-N 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 229910052750 molybdenum Inorganic materials 0.000 description 1
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- 238000012544 monitoring process Methods 0.000 description 1
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- 229910000623 nickel–chromium alloy Inorganic materials 0.000 description 1
- LBHIOVVIQHSOQN-UHFFFAOYSA-N nicorandil Chemical compound [O-][N+](=O)OCCNC(=O)C1=CC=CN=C1 LBHIOVVIQHSOQN-UHFFFAOYSA-N 0.000 description 1
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- 150000002829 nitrogen Chemical class 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
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- PIJVFDBKTWXHHD-HIFRSBDPSA-N physostigmine Chemical compound C12=CC(OC(=O)NC)=CC=C2N(C)[C@@H]2[C@@]1(C)CCN2C PIJVFDBKTWXHHD-HIFRSBDPSA-N 0.000 description 1
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- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
- A24F40/30—Devices using two or more structurally separated inhalable precursors, e.g. using two liquid precursors in two cartridges
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
- A24F40/40—Constructional details, e.g. connection of cartridges and battery parts
- A24F40/42—Cartridges or containers for inhalable precursors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/06—Inhaling appliances shaped like cigars, cigarettes or pipes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
- A24F40/10—Devices using liquid inhalable precursors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/04—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0003—Details of inhalators; Constructional features thereof with means for dispensing more than one drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/36—General characteristics of the apparatus related to heating or cooling
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Addiction (AREA)
- Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Disinfection, Sterilisation Or Deodorisation Of Air (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13168613 | 2013-05-21 | ||
| EP13168613.1 | 2013-05-21 | ||
| PCT/EP2014/060204 WO2014187763A1 (en) | 2013-05-21 | 2014-05-19 | Aerosol comprising distributing agent and a medicament source |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2015154179A RU2015154179A (ru) | 2017-06-22 |
| RU2015154179A3 RU2015154179A3 (enExample) | 2018-03-27 |
| RU2665190C2 true RU2665190C2 (ru) | 2018-08-28 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015154179A RU2665190C2 (ru) | 2013-05-21 | 2014-05-19 | Система, генерирующая аэрозоль, содержащая источник соединения, ускоряющего доставку, и источник лекарственного средства |
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| AR (1) | AR096354A1 (enExample) |
| AU (1) | AU2014270525B2 (enExample) |
| BR (1) | BR112015027149B1 (enExample) |
| CA (1) | CA2910548C (enExample) |
| ES (1) | ES2630715T3 (enExample) |
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| LT (1) | LT2999507T (enExample) |
| MX (1) | MX368590B (enExample) |
| MY (1) | MY178840A (enExample) |
| NZ (1) | NZ712478A (enExample) |
| PH (1) | PH12015502176B1 (enExample) |
| PL (1) | PL2999507T3 (enExample) |
| PT (1) | PT2999507T (enExample) |
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| SG (1) | SG11201508669UA (enExample) |
| SI (1) | SI2999507T1 (enExample) |
| TW (1) | TWI671020B (enExample) |
| UA (1) | UA117013C2 (enExample) |
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| US20160345631A1 (en) | 2005-07-19 | 2016-12-01 | James Monsees | Portable devices for generating an inhalable vapor |
| US10517530B2 (en) | 2012-08-28 | 2019-12-31 | Juul Labs, Inc. | Methods and devices for delivering and monitoring of tobacco, nicotine, or other substances |
| US10279934B2 (en) | 2013-03-15 | 2019-05-07 | Juul Labs, Inc. | Fillable vaporizer cartridge and method of filling |
| US10653180B2 (en) | 2013-06-14 | 2020-05-19 | Juul Labs, Inc. | Multiple heating elements with separate vaporizable materials in an electric vaporization device |
| ES2999088T3 (en) | 2013-05-06 | 2025-02-24 | Juul Labs Inc | Nicotine salt formulations for aerosol devices and methods thereof |
| US10039321B2 (en) | 2013-11-12 | 2018-08-07 | Vmr Products Llc | Vaporizer |
| IL295735B2 (en) | 2013-12-05 | 2024-04-01 | Juul Labs Inc | Nicotine liquid formulations for aerosol devices and methods thereof |
| US10159282B2 (en) | 2013-12-23 | 2018-12-25 | Juul Labs, Inc. | Cartridge for use with a vaporizer device |
| USD842536S1 (en) | 2016-07-28 | 2019-03-05 | Juul Labs, Inc. | Vaporizer cartridge |
| PL3504991T3 (pl) | 2013-12-23 | 2021-08-16 | Juul Labs International Inc. | Systemy urządzeń do odparowywania |
| US20160366947A1 (en) | 2013-12-23 | 2016-12-22 | James Monsees | Vaporizer apparatus |
| US10076139B2 (en) | 2013-12-23 | 2018-09-18 | Juul Labs, Inc. | Vaporizer apparatus |
| US10058129B2 (en) | 2013-12-23 | 2018-08-28 | Juul Labs, Inc. | Vaporization device systems and methods |
| USD825102S1 (en) | 2016-07-28 | 2018-08-07 | Juul Labs, Inc. | Vaporizer device with cartridge |
| CA2948851A1 (en) | 2014-05-16 | 2015-11-19 | Pax Labs, Inc. | Systems and methods for aerosolizing a smokeable material |
| GB201418817D0 (en) | 2014-10-22 | 2014-12-03 | British American Tobacco Co | Apparatus and method for generating an inhalable medium, and a cartridge for use therewith |
| EP4464356A3 (en) | 2014-12-05 | 2025-01-08 | Juul Labs, Inc. | Calibrated dose control |
| EP3616539B1 (en) | 2015-02-06 | 2023-04-05 | Philip Morris Products S.A. | Containers for aerosol-generating devices |
| GB201503411D0 (en) | 2015-02-27 | 2015-04-15 | British American Tobacco Co | Apparatus and method for generating an inhalable medium, and a cartridge for use therewith |
| GB201511358D0 (en) | 2015-06-29 | 2015-08-12 | Nicoventures Holdings Ltd | Electronic aerosol provision systems |
| GB201511349D0 (en) | 2015-06-29 | 2015-08-12 | Nicoventures Holdings Ltd | Electronic aerosol provision systems |
| GB201511361D0 (en) | 2015-06-29 | 2015-08-12 | Nicoventures Holdings Ltd | Electronic vapour provision system |
| GB201511359D0 (en) | 2015-06-29 | 2015-08-12 | Nicoventures Holdings Ltd | Electronic vapour provision system |
| WO2017108991A1 (en) * | 2015-12-22 | 2017-06-29 | Philip Morris Products S.A. | A cartridge for an aerosol-generating system and an aerosol-generating system comprising a cartridge |
| EP3183980B1 (en) * | 2015-12-22 | 2018-08-08 | Philip Morris Products S.a.s. | A cartridge for an aerosol-generating system and an aerosol-generating system comprising a cartridge |
| KR20240042236A (ko) * | 2015-12-22 | 2024-04-01 | 필립모리스 프로덕츠 에스.에이. | 에어로졸 발생 시스템용 카트리지 및 카트리지를 포함하는 에어로졸 발생 시스템 |
| DE202017007467U1 (de) | 2016-02-11 | 2021-12-08 | Juul Labs, Inc. | Befüllbare Verdampferkartusche |
| EA039727B1 (ru) | 2016-02-11 | 2022-03-04 | Джуул Лэбз, Инк. | Надежно прикрепляющиеся картриджи для испарительных устройств |
| US10405582B2 (en) | 2016-03-10 | 2019-09-10 | Pax Labs, Inc. | Vaporization device with lip sensing |
| USD849996S1 (en) | 2016-06-16 | 2019-05-28 | Pax Labs, Inc. | Vaporizer cartridge |
| USD851830S1 (en) | 2016-06-23 | 2019-06-18 | Pax Labs, Inc. | Combined vaporizer tamp and pick tool |
| USD848057S1 (en) | 2016-06-23 | 2019-05-07 | Pax Labs, Inc. | Lid for a vaporizer |
| USD836541S1 (en) | 2016-06-23 | 2018-12-25 | Pax Labs, Inc. | Charging device |
| US11660403B2 (en) | 2016-09-22 | 2023-05-30 | Juul Labs, Inc. | Leak-resistant vaporizer device |
| GB201618481D0 (en) | 2016-11-02 | 2016-12-14 | British American Tobacco Investments Ltd | Aerosol provision article |
| GB201702206D0 (en) | 2017-02-10 | 2017-03-29 | British American Tobacco Investments Ltd | Vapour provision system |
| USD887632S1 (en) | 2017-09-14 | 2020-06-16 | Pax Labs, Inc. | Vaporizer cartridge |
| GB201721470D0 (en) | 2017-12-20 | 2018-01-31 | British American Tobacco Investments Ltd | Electronic aerosol provision system |
| GB201721477D0 (en) | 2017-12-20 | 2018-01-31 | British American Tobacco Investments Ltd | Electronic aerosol provision system |
| GB201721447D0 (en) | 2017-12-20 | 2018-01-31 | British American Tobacco Investments Ltd | Electronic aerosol provision system |
| KR20210024465A (ko) | 2018-06-29 | 2021-03-05 | 필립모리스 프로덕츠 에스.에이. | 에어로졸 발생 시스템용 카트리지 |
| GB201812373D0 (en) | 2018-07-30 | 2018-09-12 | Nicoventures Trading Ltd | Generation of an inhalable medium |
| KR102385863B1 (ko) * | 2018-09-12 | 2022-04-12 | 주식회사 케이티앤지 | 복합 열원 및 이를 포함하는 흡연 물품 |
| CN115667217A (zh) | 2020-05-19 | 2023-01-31 | 赛本爱尔兰有限公司 | 氘化的色胺衍生物和使用方法 |
| EP4188492A4 (en) | 2020-07-29 | 2024-08-07 | Gregory Ellis | DELIVERY SYSTEM FOR AYAHUSCA-LIKE SUBSTANCES |
| DE102023116424A1 (de) * | 2023-06-22 | 2024-12-24 | Olig Ag | Vorrichtung zur Erzeugung eines Aerosols |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4898190A (en) * | 1989-03-01 | 1990-02-06 | R. J. Reynolds Tabacco Company | Adjustable air dilution cigarette with pressure drop compensation |
| EP0539674A1 (en) * | 1991-10-19 | 1993-05-05 | Solvay Deutschland GmbH | Aerosol generating system |
| US20040129793A1 (en) * | 2002-09-06 | 2004-07-08 | Chrysalis Technologies Incorporated | Aerosol generating device and method of use thereof |
| WO2008015441A1 (en) * | 2006-08-03 | 2008-02-07 | British American Tobacco Japan, Ltd. | Volatilization device |
| WO2010107613A1 (en) * | 2009-03-17 | 2010-09-23 | Duke University | Tobacco-based nicotine aerosol generation system |
| WO2011160788A1 (en) * | 2010-06-23 | 2011-12-29 | Philip Morris Products S.A. | An improved aerosol generator and liquid storage portion for use with the aerosol generator |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN166122B (enExample) | 1985-08-26 | 1990-03-17 | Reynolds Tobacco Co R | |
| US4830028A (en) | 1987-02-10 | 1989-05-16 | R. J. Reynolds Tobacco Company | Salts provided from nicotine and organic acid as cigarette additives |
| ES2043692T3 (es) | 1987-02-10 | 1994-01-01 | Reynolds Tobacco Co R | Cigarrillo. |
| GB8819291D0 (en) | 1988-08-12 | 1988-09-14 | British American Tobacco Co | Improvements relating to smoking articles |
| JPH0349383U (enExample) | 1989-09-21 | 1991-05-14 | ||
| US5546965A (en) * | 1994-06-22 | 1996-08-20 | R. J. Reynolds Tobacco Company | Cigarette with improved fuel element insulator |
| US6196218B1 (en) * | 1999-02-24 | 2001-03-06 | Ponwell Enterprises Ltd | Piezo inhaler |
| US7431570B2 (en) * | 2002-02-19 | 2008-10-07 | Vapore, Inc. | Capillary pumps for vaporization of liquids |
| US10668058B2 (en) | 2007-03-30 | 2020-06-02 | Philip Morris Products S.A. | Device and method for delivery of a medicament |
| BR112012005972B1 (pt) | 2009-09-16 | 2021-10-13 | Philip Morris Products S.A. | Dispositivo e método para distribuir nicotina a um sujeito |
| CN103796537B (zh) | 2011-09-09 | 2017-09-29 | 菲利普莫里斯生产公司 | 包括聚合物插入件的发烟制品过滤嘴 |
-
2014
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- 2014-05-19 NZ NZ712478A patent/NZ712478A/en not_active IP Right Cessation
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-
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- 2015-09-17 ZA ZA2015/06934A patent/ZA201506934B/en unknown
- 2015-09-24 IL IL241811A patent/IL241811B/en active IP Right Grant
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4898190A (en) * | 1989-03-01 | 1990-02-06 | R. J. Reynolds Tabacco Company | Adjustable air dilution cigarette with pressure drop compensation |
| EP0539674A1 (en) * | 1991-10-19 | 1993-05-05 | Solvay Deutschland GmbH | Aerosol generating system |
| US20040129793A1 (en) * | 2002-09-06 | 2004-07-08 | Chrysalis Technologies Incorporated | Aerosol generating device and method of use thereof |
| WO2008015441A1 (en) * | 2006-08-03 | 2008-02-07 | British American Tobacco Japan, Ltd. | Volatilization device |
| WO2010107613A1 (en) * | 2009-03-17 | 2010-09-23 | Duke University | Tobacco-based nicotine aerosol generation system |
| WO2011160788A1 (en) * | 2010-06-23 | 2011-12-29 | Philip Morris Products S.A. | An improved aerosol generator and liquid storage portion for use with the aerosol generator |
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