RU2664678C2 - Композиция, содержащая гидрокортизон - Google Patents

Композиция, содержащая гидрокортизон Download PDF

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Publication number
RU2664678C2
RU2664678C2 RU2015150303A RU2015150303A RU2664678C2 RU 2664678 C2 RU2664678 C2 RU 2664678C2 RU 2015150303 A RU2015150303 A RU 2015150303A RU 2015150303 A RU2015150303 A RU 2015150303A RU 2664678 C2 RU2664678 C2 RU 2664678C2
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RU
Russia
Prior art keywords
composition
hydrocortisone
hydroxypropyl methylcellulose
layer
adrenal insufficiency
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RU2015150303A
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English (en)
Russian (ru)
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RU2015150303A (ru
RU2015150303A3 (enExample
Inventor
Хип ХЬЮТАН
Ричард Росс
Мартин УИТАКЕР
Норберт ПЁЛЛИНГЕР
Аннетте ГРАФЕ
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Дайэрнал Лимитед
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Publication of RU2015150303A publication Critical patent/RU2015150303A/ru
Publication of RU2015150303A3 publication Critical patent/RU2015150303A3/ru
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
RU2015150303A 2013-05-17 2014-05-12 Композиция, содержащая гидрокортизон RU2664678C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1308933.9 2013-05-17
GBGB1308933.9A GB201308933D0 (en) 2013-05-17 2013-05-17 Paediatric composition
PCT/GB2014/051442 WO2014184525A1 (en) 2013-05-17 2014-05-12 Composition comprising hydrocortisone

Publications (3)

Publication Number Publication Date
RU2015150303A RU2015150303A (ru) 2017-06-22
RU2015150303A3 RU2015150303A3 (enExample) 2018-03-26
RU2664678C2 true RU2664678C2 (ru) 2018-08-21

Family

ID=48746932

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2015150303A RU2664678C2 (ru) 2013-05-17 2014-05-12 Композиция, содержащая гидрокортизон

Country Status (25)

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US (1) US9649280B2 (enExample)
EP (1) EP2978414B1 (enExample)
JP (1) JP6371379B2 (enExample)
KR (1) KR102219919B1 (enExample)
CN (1) CN105120848B (enExample)
AU (1) AU2014267041B2 (enExample)
BR (1) BR112015028025B1 (enExample)
CA (1) CA2909060C (enExample)
CY (1) CY1123284T1 (enExample)
DK (1) DK2978414T3 (enExample)
ES (1) ES2813382T3 (enExample)
GB (2) GB201308933D0 (enExample)
HR (1) HRP20201315T1 (enExample)
HU (1) HUE050917T2 (enExample)
IL (1) IL242275B (enExample)
LT (1) LT2978414T (enExample)
MX (1) MX379168B (enExample)
PL (1) PL2978414T3 (enExample)
PT (1) PT2978414T (enExample)
RS (1) RS60734B1 (enExample)
RU (1) RU2664678C2 (enExample)
SI (1) SI2978414T1 (enExample)
SM (1) SMT202000473T1 (enExample)
WO (1) WO2014184525A1 (enExample)
ZA (1) ZA201507210B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201119985D0 (en) 2011-11-19 2012-01-04 Diurnal Ltd Treatment of adrenal insufficiency
GB201308933D0 (en) 2013-05-17 2013-07-03 Diurnal Ltd Paediatric composition
US20190180872A1 (en) * 2017-12-12 2019-06-13 International Business Machines Corporation Second Opinion Decision Support Using Patient Electronic Medical Records
WO2025144994A1 (en) * 2023-12-29 2025-07-03 Regents Of The University Of Minnesota Compositions and methods for intranasal delivery of hydrocortisone
WO2025240605A1 (en) 2024-05-15 2025-11-20 Neurocrine Biosciences, Inc. Combination treatment

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050287211A1 (en) * 2004-04-30 2005-12-29 Astellas Pharma Inc. Oral pharmaceutical compositions in timed-release particle form and fast-disintegrating tablets containing this composition
RU2290940C2 (ru) * 2004-10-18 2007-01-10 Государственное образовательное учреждение высшего профессионального образования "Нижегородская Государственная Медицинская академия" МЗ РФ (ГОУ ВПО НижГМА) Средство для коррекции острой почечной недостаточности при токсическом гепаторенальном синдроме, индуцированном четыреххлористым углеродом, и способ коррекции острой почечной недостаточности при токсическом гепаторенальном синдроме, индуцированном четыреххлористым углеродом
US20080187586A1 (en) * 2004-04-22 2008-08-07 Duocort Ab Pharmaceutical Compositions for Glucocorticoid Replacement Therapy
RU2385156C2 (ru) * 2004-05-31 2010-03-27 Лабораториос Альмираль С.А. Комбинации, содержащие антимускариновые средства и кортикостероиды

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ES2062634T3 (es) 1990-08-30 1994-12-16 Senju Pharma Co Composicion con liberacion controlada del farmaco.
DK0876142T3 (da) 1996-01-16 2001-11-19 Advanced Polymer Systems Inc Topisk tilførsel af lægemidler til den nedre mavetarmkanal
KR20040016202A (ko) * 2002-08-16 2004-02-21 주식회사 제이알팜 쓴맛이 차폐된 히드로코르티손 경구용 약제 조성물 및 그제조방법
JP2007533697A (ja) 2004-04-22 2007-11-22 デュオコート エービー グルココルチコイド救急治療用の医薬組成物
US20070281007A1 (en) * 2004-08-27 2007-12-06 Jacob Jules S Mucoadhesive Oral Formulations of High Permeability, High Solubility Drugs
WO2007053197A2 (en) * 2005-06-03 2007-05-10 Elan Pharma International, Limited Nanoparticulate acetaminophen formulations
WO2008126076A2 (en) * 2007-04-11 2008-10-23 Perrigo Israel Pharmaceuticals Ltd. Low-dose mometasone formulations
GB0817120D0 (en) 2008-09-19 2008-10-29 Diurnal Ltd Treatment of adrenal insufficiency
NZ595428A (en) 2009-04-07 2013-04-26 Duocourt Pharma Ab Improved glucocorticoid therapy
KR20150043548A (ko) * 2009-10-01 2015-04-22 앱탈리스 파마테크, 인코포레이티드 경구 투여용 코르티코스테로이드 조성물
SG10201407965XA (en) * 2009-12-02 2015-02-27 Aptalis Pharma Ltd Fexofenadine microcapsules and compositions containing them
BR112012029466A2 (pt) 2010-05-20 2017-03-01 Duocort Phama Ab "composição de glicocorticoide, método melhorado para tratar a deficiência de glicocorticoide, e, método para dar origem a uma dosagem individualizada de glicocorticoides"
GB201119985D0 (en) * 2011-11-19 2012-01-04 Diurnal Ltd Treatment of adrenal insufficiency
GB201308933D0 (en) 2013-05-17 2013-07-03 Diurnal Ltd Paediatric composition

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080187586A1 (en) * 2004-04-22 2008-08-07 Duocort Ab Pharmaceutical Compositions for Glucocorticoid Replacement Therapy
US20050287211A1 (en) * 2004-04-30 2005-12-29 Astellas Pharma Inc. Oral pharmaceutical compositions in timed-release particle form and fast-disintegrating tablets containing this composition
RU2385156C2 (ru) * 2004-05-31 2010-03-27 Лабораториос Альмираль С.А. Комбинации, содержащие антимускариновые средства и кортикостероиды
RU2290940C2 (ru) * 2004-10-18 2007-01-10 Государственное образовательное учреждение высшего профессионального образования "Нижегородская Государственная Медицинская академия" МЗ РФ (ГОУ ВПО НижГМА) Средство для коррекции острой почечной недостаточности при токсическом гепаторенальном синдроме, индуцированном четыреххлористым углеродом, и способ коррекции острой почечной недостаточности при токсическом гепаторенальном синдроме, индуцированном четыреххлористым углеродом

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Title
Raymond C Rowe, Paul J Sheskey, Marian E Quinn, Handbook of Pharmaceutical Excipients, No 6, 2009, p. 917, 20.06.1998. *
С.И. Ожегов, Н.Ю. Шведова. Толковый словарь Ожегова. - 1949-1992. *

Also Published As

Publication number Publication date
SI2978414T1 (sl) 2020-10-30
BR112015028025A8 (pt) 2019-12-31
IL242275B (en) 2018-08-30
PL2978414T3 (pl) 2020-11-16
EP2978414B1 (en) 2020-07-22
KR20160011205A (ko) 2016-01-29
GB2527233B (en) 2017-07-05
ZA201507210B (en) 2017-07-26
DK2978414T3 (da) 2020-08-24
HUE050917T2 (hu) 2021-01-28
LT2978414T (lt) 2020-09-25
SMT202000473T1 (it) 2020-11-10
AU2014267041B2 (en) 2018-11-22
BR112015028025B1 (pt) 2022-11-29
EP2978414A1 (en) 2016-02-03
ES2813382T3 (es) 2021-03-23
CA2909060A1 (en) 2014-11-20
KR102219919B1 (ko) 2021-02-25
GB201516973D0 (en) 2015-11-11
US9649280B2 (en) 2017-05-16
HRP20201315T1 (hr) 2020-11-27
NZ712756A (en) 2020-12-18
GB201308933D0 (en) 2013-07-03
CY1123284T1 (el) 2021-12-31
RU2015150303A (ru) 2017-06-22
US20160081942A1 (en) 2016-03-24
GB2527233A (en) 2015-12-16
CA2909060C (en) 2020-03-10
RS60734B1 (sr) 2020-09-30
HK1214131A1 (zh) 2016-07-22
JP2016518439A (ja) 2016-06-23
BR112015028025A2 (pt) 2017-07-25
RU2015150303A3 (enExample) 2018-03-26
CN105120848A (zh) 2015-12-02
PT2978414T (pt) 2020-08-27
MX379168B (es) 2025-03-10
CN105120848B (zh) 2019-06-04
MX2015015759A (es) 2016-03-15
AU2014267041A1 (en) 2015-10-15
WO2014184525A1 (en) 2014-11-20
JP6371379B2 (ja) 2018-08-08

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