CN105120848B - 包含氢化可的松的组合物 - Google Patents

包含氢化可的松的组合物 Download PDF

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Publication number
CN105120848B
CN105120848B CN201480021880.9A CN201480021880A CN105120848B CN 105120848 B CN105120848 B CN 105120848B CN 201480021880 A CN201480021880 A CN 201480021880A CN 105120848 B CN105120848 B CN 105120848B
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CN
China
Prior art keywords
hydrocortisone
composition
adrenal
dosage
hydroxypropyl methyl
Prior art date
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Active
Application number
CN201480021880.9A
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English (en)
Chinese (zh)
Other versions
CN105120848A (zh
Inventor
希珀·华单
理查德·罗斯
马丁·惠特克
诺伯特·波林吉尔
安妮特·格拉维
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Newrock Lane Uk Ltd
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Diurnal Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201480021880.9A 2013-05-17 2014-05-12 包含氢化可的松的组合物 Active CN105120848B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1308933.9A GB201308933D0 (en) 2013-05-17 2013-05-17 Paediatric composition
GB1308933.9 2013-05-17
PCT/GB2014/051442 WO2014184525A1 (en) 2013-05-17 2014-05-12 Composition comprising hydrocortisone

Publications (2)

Publication Number Publication Date
CN105120848A CN105120848A (zh) 2015-12-02
CN105120848B true CN105120848B (zh) 2019-06-04

Family

ID=48746932

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201480021880.9A Active CN105120848B (zh) 2013-05-17 2014-05-12 包含氢化可的松的组合物

Country Status (25)

Country Link
US (1) US9649280B2 (enExample)
EP (1) EP2978414B1 (enExample)
JP (1) JP6371379B2 (enExample)
KR (1) KR102219919B1 (enExample)
CN (1) CN105120848B (enExample)
AU (1) AU2014267041B2 (enExample)
BR (1) BR112015028025B1 (enExample)
CA (1) CA2909060C (enExample)
CY (1) CY1123284T1 (enExample)
DK (1) DK2978414T3 (enExample)
ES (1) ES2813382T3 (enExample)
GB (2) GB201308933D0 (enExample)
HR (1) HRP20201315T1 (enExample)
HU (1) HUE050917T2 (enExample)
IL (1) IL242275B (enExample)
LT (1) LT2978414T (enExample)
MX (1) MX379168B (enExample)
PL (1) PL2978414T3 (enExample)
PT (1) PT2978414T (enExample)
RS (1) RS60734B1 (enExample)
RU (1) RU2664678C2 (enExample)
SI (1) SI2978414T1 (enExample)
SM (1) SMT202000473T1 (enExample)
WO (1) WO2014184525A1 (enExample)
ZA (1) ZA201507210B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201119985D0 (en) 2011-11-19 2012-01-04 Diurnal Ltd Treatment of adrenal insufficiency
GB201308933D0 (en) 2013-05-17 2013-07-03 Diurnal Ltd Paediatric composition
US20190180872A1 (en) * 2017-12-12 2019-06-13 International Business Machines Corporation Second Opinion Decision Support Using Patient Electronic Medical Records
WO2025144994A1 (en) * 2023-12-29 2025-07-03 Regents Of The University Of Minnesota Compositions and methods for intranasal delivery of hydrocortisone
WO2025240605A1 (en) 2024-05-15 2025-11-20 Neurocrine Biosciences, Inc. Combination treatment

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013072707A1 (en) * 2011-11-19 2013-05-23 Diurnal Limited Treatment of adrenal insufficiency

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ATE102022T1 (de) 1990-08-30 1994-03-15 Senju Pharma Co Zusammensetzung zur kontrollierten abgabe von medikamenten.
DK0876142T3 (da) 1996-01-16 2001-11-19 Advanced Polymer Systems Inc Topisk tilførsel af lægemidler til den nedre mavetarmkanal
KR20040016202A (ko) * 2002-08-16 2004-02-21 주식회사 제이알팜 쓴맛이 차폐된 히드로코르티손 경구용 약제 조성물 및 그제조방법
NZ551336A (en) 2004-04-22 2010-04-30 Acucort Ab Pharmaceutical compositions for acute glucocorticoid therapy
SE0401031D0 (sv) * 2004-04-22 2004-04-22 Duocort Ab A new glucocorticoid replacement therapy
CA2579767A1 (en) * 2004-04-30 2005-11-10 Astellas Pharma Inc. Oral pharmaceutical composition in timed-release particle form and fast-disintegrating tablets containing this composition
PT1765404E (pt) * 2004-05-31 2009-03-31 Almirall Lab Combinações compreendendo agentes antimuscarínicos e agonistas beta-adrenérgicos
WO2006026504A2 (en) * 2004-08-27 2006-03-09 Spherics, Inc. Mucoadhesive oral formulations of high permeability, high solubility drugs
RU2290940C2 (ru) * 2004-10-18 2007-01-10 Государственное образовательное учреждение высшего профессионального образования "Нижегородская Государственная Медицинская академия" МЗ РФ (ГОУ ВПО НижГМА) Средство для коррекции острой почечной недостаточности при токсическом гепаторенальном синдроме, индуцированном четыреххлористым углеродом, и способ коррекции острой почечной недостаточности при токсическом гепаторенальном синдроме, индуцированном четыреххлористым углеродом
EP1901728A2 (en) * 2005-06-03 2008-03-26 Elan Pharma International Limited Nanoparticulate acetaminophen formulations
WO2008126076A2 (en) * 2007-04-11 2008-10-23 Perrigo Israel Pharmaceuticals Ltd. Low-dose mometasone formulations
GB0817120D0 (en) 2008-09-19 2008-10-29 Diurnal Ltd Treatment of adrenal insufficiency
CN102448464A (zh) 2009-04-07 2012-05-09 杜奥科特药物公司 改进的糖皮质激素疗法
EP3403654B1 (en) * 2009-10-01 2019-07-31 Adare Development I, L.P. Orally administered corticosteroid compositions
CN102958515A (zh) * 2009-12-02 2013-03-06 阿普塔利斯制药有限公司 非索非那定微胶囊及含有非索非那定微胶囊的组合物
JP2013526552A (ja) 2010-05-20 2013-06-24 デュオコート・ファーマ・アクチボラゲット グルココルチコイドベース組成物の薬量学および新規な投与方法
GB201308933D0 (en) 2013-05-17 2013-07-03 Diurnal Ltd Paediatric composition

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WO2013072707A1 (en) * 2011-11-19 2013-05-23 Diurnal Limited Treatment of adrenal insufficiency

Also Published As

Publication number Publication date
DK2978414T3 (da) 2020-08-24
US20160081942A1 (en) 2016-03-24
HK1214131A1 (zh) 2016-07-22
RU2015150303A3 (enExample) 2018-03-26
AU2014267041B2 (en) 2018-11-22
GB201308933D0 (en) 2013-07-03
GB201516973D0 (en) 2015-11-11
MX379168B (es) 2025-03-10
HUE050917T2 (hu) 2021-01-28
RU2664678C2 (ru) 2018-08-21
SMT202000473T1 (it) 2020-11-10
SI2978414T1 (sl) 2020-10-30
GB2527233A (en) 2015-12-16
PT2978414T (pt) 2020-08-27
WO2014184525A1 (en) 2014-11-20
BR112015028025A2 (pt) 2017-07-25
CY1123284T1 (el) 2021-12-31
CA2909060C (en) 2020-03-10
CN105120848A (zh) 2015-12-02
HRP20201315T1 (hr) 2020-11-27
KR20160011205A (ko) 2016-01-29
CA2909060A1 (en) 2014-11-20
JP2016518439A (ja) 2016-06-23
PL2978414T3 (pl) 2020-11-16
KR102219919B1 (ko) 2021-02-25
LT2978414T (lt) 2020-09-25
AU2014267041A1 (en) 2015-10-15
ZA201507210B (en) 2017-07-26
IL242275B (en) 2018-08-30
MX2015015759A (es) 2016-03-15
RS60734B1 (sr) 2020-09-30
EP2978414A1 (en) 2016-02-03
JP6371379B2 (ja) 2018-08-08
ES2813382T3 (es) 2021-03-23
US9649280B2 (en) 2017-05-16
EP2978414B1 (en) 2020-07-22
RU2015150303A (ru) 2017-06-22
GB2527233B (en) 2017-07-05
BR112015028025A8 (pt) 2019-12-31
NZ712756A (en) 2020-12-18
BR112015028025B1 (pt) 2022-11-29

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Address after: Cardiff South Glamorgan, UK

Patentee after: Newrock Lane UK Ltd.

Country or region after: Britain

Address before: Cardiff South Glamorgan, UK

Patentee before: Diurnal Ltd.

Country or region before: Britain