RU2663701C2 - Маркеры, ассоциированные с ингибиторами wnt - Google Patents

Маркеры, ассоциированные с ингибиторами wnt Download PDF

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RU2663701C2
RU2663701C2 RU2015138688A RU2015138688A RU2663701C2 RU 2663701 C2 RU2663701 C2 RU 2663701C2 RU 2015138688 A RU2015138688 A RU 2015138688A RU 2015138688 A RU2015138688 A RU 2015138688A RU 2663701 C2 RU2663701 C2 RU 2663701C2
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expression
wnt inhibitor
patient
biomarker
gene
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RU2015138688A
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Russian (ru)
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RU2015138688A (ru
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Цзяньвэй Чэ
Дженнифер ХАРРИС
Хсин-и ХСИЕХ
Цзе ЛИ
Цзюнь ЛЮ
Николас НГ
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Новартис Аг
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    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
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    • A61K31/50—Pyridazines; Hydrogenated pyridazines
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RU2015138688A 2013-03-11 2014-03-10 Маркеры, ассоциированные с ингибиторами wnt RU2663701C2 (ru)

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US201361776334P 2013-03-11 2013-03-11
US61/776,334 2013-03-11
PCT/IB2014/059585 WO2014141038A2 (en) 2013-03-11 2014-03-10 Markers associated with wnt inhibitors

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CN105617359A (zh) * 2015-12-31 2016-06-01 中国科学院成都生物研究所 Wnt信号通路蛋白Frzb在制备抗肝癌药中的应用
WO2017167150A1 (zh) * 2016-03-31 2017-10-05 苏州云轩医药科技有限公司 一种3-氟吡啶杂环化合物及其应用
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EP4671385A3 (en) * 2018-08-07 2026-03-18 Torqur AG Treatment of squamous cell carcinoma
US12195804B2 (en) 2018-08-07 2025-01-14 Board Of Regents, The University Of Texas System Treatment of squamous cell carcinoma
WO2022013328A1 (en) * 2020-07-15 2022-01-20 Université Libre de Bruxelles Method for determining sensitivity to an antineoplastic agent
CN116808027B (zh) * 2023-05-30 2025-08-29 重庆医科大学附属第一医院 化合物或其盐在制备抑制wnt7a基因活性的制剂中的应用

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LIU J. et al. PD08-11: Targeting Porcupine, a Critical Node for Wnt Signalling in Cancer. Cancer Res 2011; 71(24 Suppl): Abstract nr PD08-11 [Найдено 04.09.2017] [он-лайн]. Найдено из Интернет: URL: http://cancerres.aacrjournals.org/content/71/24_Supplement/PD08-11. DATABASE, PubChem, LGK974. Compound Summary for CID 46926973, 01.11.2010, стр.1-19 [Найдено 04.09.2017] [он-лайн]. Найдено из Интернет: URL: https://pubchem.ncbi.nlm.nih.gov/compound/lgk974#section=Top. *
стр.1-19 [Найдено 04.09.2017] [он-лайн]. Найдено из Интернет: URL: https://pubchem.ncbi.nlm.nih.gov/compound/lgk974#section=Top. *

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