RU2660920C2 - Feed additives for poultry - Google Patents

Abstract

FIELD: agriculture.

SUBSTANCE: invention relates to agriculture. Feed additive is proposed for use in poultry farming in a form that contains phosphatidylcholine, maltose and biologically active substances (BAS) with the following ratio of components, by weight: phosphatidylcholine – 14.4–22; maltose – 77.7–85.1; BAS – up to 100.

EFFECT: feed additive increases the growth of liveweight gain of chickens, positively affects egg productivity and reproductive qualities of laying hens.

3 cl, 3 tbl, 6 ex

Description

The invention is intended for use in agriculture, in particular in the production of feed additives for poultry.

The most important factor in increasing the productivity of farm animals is their full feeding, provided that all diets are provided with diets in optimal quantities and ratios. The maximum hereditarily determined productivity, good health and high reproductive abilities of animals are manifested only when all their needs for energy, organic, mineral and biologically active substances are satisfied.

Numerous studies by scientists have shown that balancing feed rations for missing substances through the use of appropriate additives can significantly increase the efficiency of feed nutrients and the level of animal productivity.

In connection with the foregoing, the development of new feed additives using innovative technological approaches that can significantly increase their effectiveness is an urgent task.

Kronvet LLC for use in poultry farming using original technology developed complex feed additives containing plant phospholipids in the form of nanoparticles and topical biologically active compounds. The technology used makes it possible to obtain, in a dry lyophilized form, complexes of irreplaceable ingredients in nanoscale form, characterized by good solubility and high bioavailability.

It is known that the nanoscale form of biologically active compounds significantly increases their absorption in the small intestine, and improves their metabolism. This fact allows us to reduce the dosage of the used feed preparation and, accordingly, the cost of feeding in general. The use of phosphatidylcholine in the developed feed additives, on the one hand, ensures the preparation of the drug in nanoscale form, and on the other hand, enrichment with choline and unsaturated fatty acids indispensable in animal nutrition.

There are a large number of additives on the market containing fat-soluble vitamins, but all of them are insoluble in water, which makes them difficult to use on farms. As an example, we can only give water-soluble complexes of veterinary medicinal products of fat-soluble vitamins - Vitamin A, D3, E, C (Nita-Farm LLC, Aquimag manufactured by Mosagrogen, Miowit AD3EC liquid CJSC (MiavitGmbH, Germany), however, water solubility is achieved by the introduction of solvents and emulsifiers (for example, cremophor, tween-80), which have an adverse effect on the animal organism.

The present invention is devoid of the above disadvantage. Phospholipid particles are biodegradable, biologically inert, do not cause allergic, antigenic or pyrogenic reactions. Obtaining feed additives based on phospholipids using modern technologies allows to obtain new forms of feed additives with high efficiency, bioavailability and reduced side effects.

The invention is characterized by the following examples.

Example 1. Feed additive "Hepavit"

In accordance with the invention describes a feed additive containing phosphatidylcholine, L-lysine, DL-methionine and maltose in the following ratio, wt.%:

Phosphatidylcholine 18-22% Maltose 70.8-73.2% L-lysine 4.5-5.5% DL-methionine 2.7-3.3%

The feed supplement contains plant phosphatidylcholine, DL-methionine and L-lysine hydrochloride. Lysine and methionine, being essential amino acids, are deficient in modern bird diets. Methionine is also a lipotropic substance and helps to normalize the metabolism of lipids and cholesterol in the body, stimulates the mobilization of fat from the liver and its oxidation, which leads to a decrease in the severity of fatty liver infiltration. In addition, it is well known that plant phosphatidylcholine has a pronounced hepatoprotective effect [1].

Indications for use:

- Prevention and therapy of fatty liver disease. This disease is associated with metabolic disorders and is more often manifested in laying hens with cellular content. The disease is facilitated by the lack of active exercise, high-calorie feeding, inadequate supply of vitamins and feeding rancid fat.

- Vitamins.

- Broiler sudden death syndrome.

- Liver diseases in all types of birds.

The finished form of the feed additive in the form of nanoparticles provides good absorption of the ingredients. Moreover, plant phosphatidylcholine has a pronounced hepatoprotective effect.

Example 2. Feed additive "Phosphovit."

In accordance with the invention describes a feed additive containing phosphatidylcholine, biologically active substances: retinol acetate, cholecalciferol, tocopherol acetate and maltose in the following ratio, wt.%:

Phosphatidylcholine 14.4000-17.6000% Maltose 71.8302-85.0258% Retinol Acetate 0.1089-0.1331% Cholecalciferol 0,0009-0,0011% Tocopherol acetate 0.3600 to 0.4400%

The composition of the drug includes plant phosphatidylcholine and fat-soluble vitamins A, D3 and E. Vitamin A regulates the structure, function and regeneration of epithelial tissues and thereby increases resistance against infection. Vitamin D3 regulates the exchange of calcium and phosphorus and affects their absorption in the gastrointestinal tract, has anti-rachitic effect. Vitamin E regulates redox processes and affects carbohydrate-fat metabolism, enhances the effects of vitamins A and D3.

Due to the use of the original production technology, the additive has high bioavailability, almost 2 times higher than the bioavailability of traditionally used similar drugs, and the water-soluble form facilitates dosage and its use.

Indications for use:

- with growth retardation and insufficient gain;

- with infectious and invasive diseases;

- during prophylactic vaccination and deworming;

- with poor egg production and reduced strength of the egg shell;

- under stressful conditions.

Developed feed additives are freeze-dried powder. This form increases the shelf life of the drug up to 4-5 years, protects it from aggregation and oxidation, convenient for transportation, storage and use. The drug is highly soluble in water. Upon dissolution, an ultrafine emulsion is formed in which biologically active substances are “embedded” in phospholipid nanoparticles. It should be noted that the resulting stable ultrathin phospholipid emulsions are produced without the use of any stabilizers and emulsifiers.

Example 3. A dietary supplement based on dietary supplement

In accordance with the invention describes a feed additive containing phosphatidylcholine, maltose and biologically active substances, for example vitamins of group B, in the following ratio, wt.%:

Phosphatidylcholine 14.4-22% Maltose 64.8-85.1% Biologically active substances (vitamins) up to 100%

A method of obtaining feed additives can be demonstrated by the following example.

Example 4. A method of obtaining feed additives based on dietary supplements, including: amino acids and vitamins

1. Weigh the required number of components according to the prescription sheet.

2. Prepare a 10% solution of maltose in distilled water.

3. Phospholipids, as well as amino acids-L-lysine and DL-methionine or fat-soluble vitamins - retinol acetate, cholecalciferol and tocopherol acetate are added to the resulting solution.

4. The initial homogenization of the resulting solution is carried out using a high-speed mechanical mixer until a uniform, rough emulsion is obtained.

5. High-pressure homogenization is carried out at 1000 atm for 5-8 cycles.

6. Pour the resulting solution into pallets with a layer of 1.5-2 cm and carry out its freeze-drying.

7. After drying, the lyophilisate is subjected to dry granulation through a sieve of the required size.

8. Produce packing additives.

9. The content of amino acids or vitamins in feed additives is controlled by HPLC.

Example 5. The study of the effect of amino acid feed additives on broiler chickens

We studied a feed supplement based on amino acids in broiler chickens aged 1-45 days, in an amount of 20 pieces (10 females and 10 males). Animals were divided into 2 groups. The animals of the first group were prescribed the concentration of the amino acid feed additive, diluted in water, in accordance with the instructions. The second group of animals was a control.

In studies on broiler chickens, the main indicator of a neutral / positive effect was the increase in live weight of all groups.

Based on the data shown in Table 1 and the studies performed, it can be concluded that the amino acid-based feed additive does not negatively affect the process of gaining live weight, but rather, on the contrary, can positively affect this process. The general condition of the animals, appearance, mobility, and attitude to food were satisfactory and did not differ in groups. All animals remained alive during the experiment, actively eating food.

The body weight of animals in all experimental groups and in the control group increased equally.

The recorded blood counts in the experimental group are comparable with similar data obtained in the control group and are within the normal range for this type of animal.

At the end of the experiment, a biochemical and morphological blood test did not show significant changes in homeostasis. The results of biochemical and morphological blood tests are presented in table 2.

The functional state of the internal organs was judged by biochemical blood parameters - the content of total protein, albumin, globulins and the A / G ratio, glucose, cholesterol, creatinine concentration and aminotransferase activity (AcAT and AlAT).

The data obtained indicate the absence of any negative effect of the amino acid feed additive on hematological parameters and on the functional activity of the internal organs of animals.

* - reliability p≤0,05 in relation to the control

Example 6. The study of the effect of vitamin feed additives on laying hens.

The test was conducted on a livestock of 200 heads of laying hens, which were kept in cell batteries with 7 goals in each cage. The duration of the experiment was 52 weeks. The conditions of detention, the front of feeding and drinking, the microclimate parameters in the experimental groups were the same and corresponded to the recommendations of the All-Russian Scientific Research and Technological Institute of Poultry.

The control group received standard compound feed; in the experimental group, a feed supplement based on vitamins was added to it at the rate of 500 g per 2 tons of drinking water. Egg productivity was determined by daily counting of laid eggs.

A study of the quality of eggs revealed some positive effect on him of a vitamin-based feed supplement to birds, especially in the midst of egg laying. At the same time, the eggs of the experimental group hens exceeded the control indices for the protein index, Howe units, and shell thickness. Similar data were obtained during the chemical analysis of eggs: there was a slight increase in the dry matter content in eggs at the height of the egg laying (24.1-25.9%) versus 24.0-24.3%. The concentration of "crude" protein in the eggs of laying hens of the experimental group was 13.1-14.7% against 12.8% in the control.

Claims (6)

1. A feed additive for use in poultry, containing vegetable phosphatidylcholine, maltose and biologically active substances (BAS), for example vitamins, in the following ratio, wt.%: Phosphatidylcholine 14,4-22 Maltose 69.2-85.1 Biologically active substance up to 100% 2. The feed additive according to claim 1, in which the amino acids L-lysine and DL-methionine are used as BAS in the following ratio of components, wt.%: Phosphatidylcholine 18-22 Maltose 70.8-73.2 L-lysine 4,5-5,5 DL-methionine 2.7-3.3 3. The feed additive according to claim 1, in which fat-soluble vitamins A, D ₃ and E are used as biologically active substances in the following ratio of components, wt. %: Phosphatidylcholine 14,4000-17,6000 Maltose 71.8302-85.0258 Retinol Acetate 0.1089-0.1331 Cholecalciferol 0,0009-0,0011 Tocopherol acetate 0.3600 to 0.4400