RU2655811C2 - Терапевтическое средство для бокового амиотрофического склероза - Google Patents

Терапевтическое средство для бокового амиотрофического склероза Download PDF

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Publication number
RU2655811C2
RU2655811C2 RU2015119472A RU2015119472A RU2655811C2 RU 2655811 C2 RU2655811 C2 RU 2655811C2 RU 2015119472 A RU2015119472 A RU 2015119472A RU 2015119472 A RU2015119472 A RU 2015119472A RU 2655811 C2 RU2655811 C2 RU 2655811C2
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amino acid
acid residue
therapeutic agent
ghrelin
group
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RU2015119472A
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English (en)
Russian (ru)
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RU2015119472A (ru
Inventor
Цуеси МАЦУО
Норихито МУРАЯМА
Маюми ФУРУЯ
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Дайити Санкио Компани, Лимитед
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/25—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Cell Biology (AREA)
RU2015119472A 2012-10-24 2013-10-23 Терапевтическое средство для бокового амиотрофического склероза RU2655811C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2012234300 2012-10-24
JP2012-234300 2012-10-24
PCT/JP2013/078743 WO2014065341A1 (ja) 2012-10-24 2013-10-23 筋萎縮性側索硬化症治療剤

Publications (2)

Publication Number Publication Date
RU2015119472A RU2015119472A (ru) 2016-12-20
RU2655811C2 true RU2655811C2 (ru) 2018-05-29

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RU2015119472A RU2655811C2 (ru) 2012-10-24 2013-10-23 Терапевтическое средство для бокового амиотрофического склероза

Country Status (11)

Country Link
US (1) US20150265680A1 (enExample)
EP (1) EP2913063B1 (enExample)
JP (1) JP6262661B2 (enExample)
KR (3) KR102499918B1 (enExample)
CN (2) CN104853778A (enExample)
AU (1) AU2013335678B9 (enExample)
BR (1) BR112015009107A2 (enExample)
CA (1) CA2889499C (enExample)
IN (1) IN2015DN04172A (enExample)
RU (1) RU2655811C2 (enExample)
WO (1) WO2014065341A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2844865C2 (ru) * 2018-12-06 2025-08-08 Байоджен Ма Инк. Нейрофиламентный белок для направления терапевтических вмешательств при боковом амиотрофическом склерозе
US12429487B2 (en) 2018-12-06 2025-09-30 Biogen Ma Inc. Neurofilament protein for guiding therapeutic intervention in amyotrophic lateral sclerosis
US12656353B2 (en) 2019-02-12 2026-06-16 Biogen Ma Inc. Biomarkers of progressive multifocal leukoencephalopathy

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA201791038A1 (ru) 2014-11-12 2017-11-30 Лирик Фармасьютикалз Инк. Лечение непереносимости энтерального питания
WO2017083882A1 (en) * 2015-11-11 2017-05-18 Lyric Pharmaceuticals Inc. Treatment of enteral feeding intolerance and other conditions using ulimorelin analogs
GEAP202516774A (en) 2022-11-03 2025-06-25 Lumos Pharma Inc Compactable oral formulations of ibutamoren

Citations (2)

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AU2006201580A1 (en) * 1999-07-23 2006-05-18 Kenji Kangawa Novel peptides
US20090149518A1 (en) * 2005-10-18 2009-06-11 Ono Pharmaceutical Co., Ltd. Pharmaceutical for protection of motor nerve in patient with amyotrophic lateral sclerosis

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US5663146A (en) 1991-08-22 1997-09-02 Administrators Of The Tulane Educational Fund Polypeptide analogues having growth hormone releasing activity
US5578593A (en) 1992-12-11 1996-11-26 Merck & Co., Inc. Spiro piperidines and homologs promote release of growth hormone
TW432073B (en) 1995-12-28 2001-05-01 Pfizer Pyrazolopyridine compounds
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UA73530C2 (uk) 1999-11-10 2005-08-15 Ново Нордіск А/С Сполука з властивостями вивільнювати гормон росту
ATE304373T1 (de) * 1999-12-28 2005-09-15 Kaken Pharma Co Ltd Nervenschutzmittel
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EP1493747B1 (en) 2002-04-11 2012-12-19 Daiichi Sankyo Company, Limited Process for producing modified peptide
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JP2005239712A (ja) 2004-01-30 2005-09-08 Kaken Pharmaceut Co Ltd 神経突起伸展剤
WO2006079077A2 (en) * 2005-01-20 2006-07-27 Acadia Pharmaceuticals Inc. Use of diltiazem or analogs thereof as modulators of ghrelin receptor
US7829589B2 (en) 2005-06-10 2010-11-09 Elixir Pharmaceuticals, Inc. Sulfonamide compounds and uses thereof
HUE044182T2 (hu) 2006-06-07 2019-10-28 Genzyme Corp Génterápia amiotrófiás laterális szklerózis és más gerincvelõ-rendellenességek kezelésére
JP2008127377A (ja) 2006-11-24 2008-06-05 Jichi Medical Univ Ghs−r作動薬を含有してなるメタボリックシンドローム又は高血圧症の予防・治療剤。
KR100946084B1 (ko) 2008-03-27 2010-03-10 주식회사 하이닉스반도체 반도체 소자의 수직형 트랜지스터 및 그 형성방법
WO2009121759A2 (en) * 2008-04-03 2009-10-08 F. Hoffmann-La Roche Ag Use of pegylated igf-i variants for the treatment of neuromuscular disorders

Patent Citations (2)

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AU2006201580A1 (en) * 1999-07-23 2006-05-18 Kenji Kangawa Novel peptides
US20090149518A1 (en) * 2005-10-18 2009-06-11 Ono Pharmaceutical Co., Ltd. Pharmaceutical for protection of motor nerve in patient with amyotrophic lateral sclerosis

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DEL BARCO DG., ET AL., Therapeutic effect of the combined use of growth hormone releasing peptide-6 and epidermal growth factor in an axonopathy model.Neurotox Res. 2011 Jan;19(1):195-209. doi: 10.1007/s12640-010-9160-8. Epub 2010 Feb 19. *
LEE S., et al., Ghrelin protects spinal cord motoneurons against chronic glutamate excitotoxicity by inhibiting microglial activation.Korean J Physiol Pharmacol. 2012 Feb;16(1):43-8. doi: 10.4196/kjpp.2012.16.1.43. Epub 2012 Feb 28. *
LEE S., et al., Ghrelin protects spinal cord motoneurons against chronic glutamate excitotoxicity by inhibiting microglial activation.Korean J Physiol Pharmacol. 2012 Feb;16(1):43-8. doi: 10.4196/kjpp.2012.16.1.43. Epub 2012 Feb 28. LI S., et al., Structural and functional changes mapped in the brains of amyotrophic lateral sclerosis patients with/without dysphagia: a pilot study.Amyotroph Lateral Scler. 2009 Oct-Dec;10(5-6):280-7. doi: 10.3109/17482960902893342. *
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2844865C2 (ru) * 2018-12-06 2025-08-08 Байоджен Ма Инк. Нейрофиламентный белок для направления терапевтических вмешательств при боковом амиотрофическом склерозе
US12429487B2 (en) 2018-12-06 2025-09-30 Biogen Ma Inc. Neurofilament protein for guiding therapeutic intervention in amyotrophic lateral sclerosis
US12656353B2 (en) 2019-02-12 2026-06-16 Biogen Ma Inc. Biomarkers of progressive multifocal leukoencephalopathy

Also Published As

Publication number Publication date
EP2913063A4 (en) 2016-07-20
RU2015119472A (ru) 2016-12-20
US20150265680A1 (en) 2015-09-24
JPWO2014065341A1 (ja) 2016-09-08
CA2889499C (en) 2019-09-10
AU2013335678A1 (en) 2015-05-21
IN2015DN04172A (enExample) 2015-10-16
EP2913063A1 (en) 2015-09-02
CN104853778A (zh) 2015-08-19
WO2014065341A1 (ja) 2014-05-01
KR20200108494A (ko) 2020-09-18
BR112015009107A2 (pt) 2017-11-14
KR20150070180A (ko) 2015-06-24
CA2889499A1 (en) 2014-05-01
JP6262661B2 (ja) 2018-01-17
KR102499918B1 (ko) 2023-02-14
AU2013335678B2 (en) 2017-10-26
CN110354265A (zh) 2019-10-22
AU2013335678B9 (en) 2024-12-12
KR20220051418A (ko) 2022-04-26
HK1214152A1 (en) 2016-07-22
EP2913063B1 (en) 2019-09-11

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