RU2647372C1 - Cream for frostbite prevention - Google Patents

Abstract

FIELD: medicine; pharmaceuticals.

SUBSTANCE: invention relates to the pharmaceutical industry and medicine, in particular to dermatology, and appears as a liquid cream for frostbite prevention containing an oil phase, structure-forming emulsifiers and an aqueous phase with lidocaine hydrochloride, characterized in that the oil phase is a fused bearish fat, and lidocaine hydrochloride is contained in both phases in a ratio of 0.5–10.0 % by weight.

EFFECT: invention provides a high elasticity of the skin, prevents the appearance of a feeling of pain, development of spasm of blood vessels of the skin and prevents its cooling due to warming with warm arterial blood due to the development of maximum hyperemia.

1 cl

Description

The invention relates to medicine, pharmacy, cosmetology, sports medicine, military medicine, in particular to dermatology, and is intended for cosmetic treatment of the skin of the face, ears, fingers and toes before going out to frost to maintain elasticity and prevent frostbite.

Known means for the prevention of frostbite on the frost, which is melted goose fat - lard (http://medvoice.ru/gusinyiy-zhir-kak-i-kogda-primenyat/. Found on the Internet 03.03.2017).

The disadvantage of the tool is low efficiency and safety, because the tool does not contain an anesthetic substance that penetrates easily through the skin, so the tool does not eliminate the spasm of the blood vessels of the skin, reflexively occurring in response to cooling, and does not eliminate the pain that occurs in the skin due to spasm of blood vessels.

In addition, the well-known product due to the lack of a composition with a local anesthetic activity does not exclude the development of a cold spasm of the blood vessels of the skin that occurs reflexively when cooled in the cold. Moreover, the known agent does not provide the rapid development of cold hyperemia, the rapid increase in the flow of warm arterial blood to the cooled area of the body and its rapid warming due to the rapid increase in the flow of warm blood.

Known protective face cream, which is prepared by grinding equal parts of spermaceti or lanolin cream (1 teaspoon), zinc ointment (1 teaspoon) and refined vegetable oil, in particular olive oil (1 teaspoon) (http: //beauty.wild- mistress.ru/wm/beauty.nsf/publicall/2011-12-18-1908227.htmlhttp://beauty.wild-mistress.ru/wm/beauty.nsf/publicall/2011-12-18-1908227.html. Found on the Internet 03/07/2017).

The disadvantage of this tool is low efficiency and safety, since the tool does not have high fusibility and does not contain an anesthetic substance that easily penetrates the skin. Due to the lack of local anesthetic, the product does not eliminate the spasm of blood vessels of the skin that occurs reflexively in response to external cooling, and therefore the product does not eliminate the pain that occurs in the skin due to spasm of blood vessels.

In addition, due to the lack of high fusibility of the forming base, the product does not retain high elasticity of the skin when it is cooled in the cold. In this regard, after the cold and development of blood vessel spasm in the blood vessels of the skin, the agent does not provide the rapid development of cold hyperemia, because when cooling the soft tissues surrounding the vessels harden, and the blood cannot expand the lumen of vessels that have hardened in a state of spasm. Therefore, the tool does not provide a rapid increase in the flow of warm arterial blood to the cooled area of the body and its rapid warming due to warm blood.

Known spray lidocaine hydrochloride for topical use, dosed 10% (4.8 mg / 1 dose), representing a colorless alcohol solution with the smell of menthol for terminal (surface) anesthesia of the skin and mucous membranes during various medical procedures. This solution contains:

Ethanol 96% - 27.3 g

Lidocaine hydrochloride - 3.8 g

Propylene glycol - 6.82 g

Peppermint leaf oil - 0.08 g

(Found on the Internet 03/06/2017: http://www.vidal.ru/drugs/lidocain_2343)

The disadvantages of this tool are low safety and effectiveness. The fact is that the product is not intended for application to wound surfaces of the skin with the aim of local action on them, since the solvent in it is 96% ethyl alcohol, which can cause burns. The product does not have an emollient effect and does not soften the skin in the cold.

In addition, the product has a tanning effect, since ethanol denatures and condenses proteins. In this regard, the known tool when applied to the surface of the skin condenses it. The astringent effect of alcohol slows down the absorption of dissolved ingredients and pushes the moment they reach an effective concentration in the skin and in subcutaneous fat. This pushes back the onset of the local anesthetic effect of lidocaine hydrochloride on blood vessels located in the thickness of the skin.

In addition, the known agent relates to combustible and explosive substances. In this regard, the product can not be used in public places, in places of the likely occurrence of open flame and sparks, as this can lead to an explosion and fire. In particular, it is forbidden to use this tool for air passengers inside the air liner, people on the battlefield, during terrorist attacks, as well as in places designated for smoking, when matches, cigarettes, sparklers and fireworks are burning.

Known means for the prevention and treatment of frostbite, consisting of mefenamic acid (RU 2072847).

The disadvantages of the known funds are low efficiency and safety. The fact is that the product does not contain fusible fat and an anesthetic substance that easily penetrates the skin, therefore it does not preserve skin elasticity when it is cooled and does not eliminate the spasm of the blood vessels of the skin that occurs reflexively in response to cooling, and does not eliminate the pain, arising in the skin due to vasospasm.

Moreover, the product contains mefenamic acid, which has a local irritant effect due to its high acid activity. Such activity of a well-known product is the reason that in some people it causes a burning sensation in the presence of cracks, abrasions and wounds in the skin. Less commonly, in some people, it causes a chemical burn in the mucous membranes. In particular, the product can cause severe local irritation and burns of the mucous membranes of the eyes, into which it gets if the eyes are accidentally rubbed with a finger after treatment with mefenamic acid. In this case, the agent has a local irritating and cauterizing effect on the mucous membranes of the conjunctival cavity.

The known agent does not provide the use as a forming substance of fusible animal fat that easily penetrates the skin, therefore, the agent does not provide an emollient effect on the skin and does not prevent the development of tight mobility in it when the temperature is lowered.

Known means for the prevention and treatment of frostbite, consisting of dibunol (RU 1475669).

A disadvantage of the known means is low efficiency and safety. The fact is that the product does not contain a local anesthetic that easily penetrates the skin, therefore it does not prevent the development of a blood vessel spasm that develops reflexively in response to the action of the cold, and does not eliminate the intense pain that occurs due to spasm of the blood vessels of the skin on frost.

In addition, the known tool does not provide its use in the form of ointments, creams or emulsions. Therefore, the tool does not provide an increase in the elastic properties of the skin and does not prevent its tight mobility during cooling.

In addition, the known agent does not provide with local cooling the rapid development of cold hyperemia, therefore, it does not provide a rapid increase in the flow of warm arterial blood to the cooled area of the skin and its rapid warming due to the rapid increase in the flow of warm blood.

Known means for local anesthesia in the form of a gel containing (in the following ratio of components, wt.%): 0.80-1.20 hydroxyethyl cellulose, 0.80-1.20 papaverine hydrochloride, 0.04-0.06 benzalkonium chloride ( 50%), 0.90-1.10 lidocaine hydrochloride, 0.08-0.12 gentamicin and water - the rest is up to 100 (RU 2262925).

The disadvantage of this product is low efficiency and safety, since it does not ensure the preservation of the elastic properties of the skin when its temperature is lowered, since it does not contain fusible fats and oils. Moreover, it contains water, which crystallizes when the temperature drops below 0 ° C, and therefore contributes to cryodestruction of the skin in cold weather.

Known tool is not intended for fat treatment of the skin of open parts of the body before going out to frost in order to prevent frostbite. The fact is that it is watery, thickens when the temperature drops to 0 ° C and freezes (crystallizes) in frost at a temperature below 0 ° C. In this regard, the product increases skin moisture, and increasing skin moisture helps to reduce elasticity while lowering its temperature, the development of tight mobility, crystallization of extra- and intracellular water in the skin in cold weather and cryodestruction of tissues, that is, it contributes to frostbite.

In addition, a well-known remedy is dangerous for the development of an allergic reaction in some people, because it contains components that some people react to as allergens. In particular, gentamicin and papaverine can cause an allergic reaction in some people.

The objective of the invention is to increase efficiency and safety due to good penetrating, emollient, analgesic, antifreeze, antireflective, antispastic and antispasmodic activity.

This goal is achieved through a liquid cream made from fusible animal fat and an aqueous solution of lidocaine hydrochloride, which maintains high skin elasticity, prevents the sensation of pain, the development of spasm of the blood vessels of the skin and prevents its cooling due to warming with warm arterial blood due to the development of maximum hyperemia.

The essence of the proposed frostbite cream, containing an oil phase, structure-forming emulsifiers and an aqueous phase with lidocaine hydrochloride, consists in the use of melted bear fat as the oil phase, and lidocaine hydrochloride is contained in both phases in a ratio of 0.5-10.0 wt. %

The fact is that the proposed composition of the components and the concentration range of lidocaine hydrochloride in the oil and water phases of the cream are optimal for normalizing the skin with high elasticity and for maintaining elasticity when its temperature drops below normal values, namely when it goes out in the cold. High elasticity of the skin at normal and reduced temperatures is achieved due to the high fluidity and penetrating activity of processed bear fat. High skin elasticity in conditions of normal and low skin temperature after exposure to frost provides maximum hyperemia, which, in turn, warms the skin and prevents its cooling in the cold by increasing the flow of warm arterial blood.

In addition, increasing the elasticity of the skin facilitates the penetration of lidocaine hydrochloride into the skin. In this case, lidocaine hydrochloride inhibits the sensitivity of temperature receptors located in the walls of blood vessels. Inhibition of temperature receptors prevents the reflex development of a cold spasm of blood vessels of the skin when it is exposed to frost and excludes the appearance of a feeling of pain, since by eliminating a cold spasm of blood vessels, mechanical compression of contractile elements of pain receptors located in the vascular wall is excluded.

In case of cutaneous application, a cream in which melted bear fat is used as the oil phase and the oil and water phases contain lidocaine hydrochloride in a ratio of 0.5-10.0 wt. %, has emollient and anesthetic activity. The proposed composition of the ingredients is optimal for safe skin application in order to completely soak the skin and maintain its high elasticity while lowering the local temperature. The fact is that it is processed bear fat that is the leader in soaking the skin of human hands, maintaining skin elasticity when it cools and developing skin hyperemia in the cold, and lidocaine hydrochloride is a local anesthetic that easily penetrates the skin, inhibits the temperature receptors of blood vessels and prevents the development of cold spasm of blood vessels with a local decrease in temperature.

Such a cream has a liquid consistency at room temperature (25 ° C), at normal human body temperature (37 ° C) and at freezing temperature of water (at 0 ° C). In this regard, the claimed cream retains flowing properties in a wide temperature range and is easily squeezed out of the tube and applied to the skin at temperatures above 0 ° C.

When applying the declared cream, the skin is soaked with processed bear fat, which is included in the cream, the skin softens and increases its elasticity due to the fusible processed bear fat, which easily penetrates the skin. At the same time, due to lidocaine hydrochloride, the temperature receptors located in the walls of blood vessels are suppressed, the perception by the vascular walls of the process of heat removal during frost and the reflex spasm of the blood vessels of the skin in frost is eliminated.

The proposed concentration range of lidocaine hydrochloride provides a means of reducing the sensitivity of temperature receptors located in the walls of the blood vessels of the skin, which prevents the reflex development of cold spasm of blood vessels and squeezing smooth muscle myocytes of the vascular wall of pain receptors. Moreover, for terminal anesthesia in medical practice, lidocaine hydrochloride is traditionally used in a concentration range of 0.5-10%.

The developed tool that prevents the development of cold spasm of blood vessels and the appearance of a feeling of pain in the cold can be used for cutaneous applications before going out into the cold. To this end, the cream is applied to a selected area of the skin and rubbed into it 30-60 minutes before frost. The cream quickly impregnates the skin, facilitates the penetration of the main active substance into the tissue and keeps the skin supple and not sensitive to cold for more than 2 hours.

Therefore, the proposed cream expands the range of application, increases the effectiveness and safety, as it creates optimal conditions on the selected skin surface for a long emollient and anesthetic effect on the skin during application. The application of the proposed cream on the skin softens it, increases its elasticity and keeps the skin elastic when its temperature is lowered, excludes the development of cold spasm of blood vessels and the appearance of a feeling of pain in the skin, promotes the development of local hyperemia and the influx of warm arterial blood, prevents excessive cooling and cryodestruction skin, prevents the development of localized cold tissue damage.

The claimed tool can be used for rubbing into the skin of the face, ears, fingers and hands, in the skin of the legs and other parts of the body exposed to cold when exposed to frost or when exposed to cold water to protect the skin from cryodestruction due to frostbite due to skin soaking melted bear fat and deprivation of skin vessels of sensitivity to frost due to local anesthetic action of lidocaine hydrochloride, easily penetrating deep into the skin without irritating and cauterizing effects without the risk of explosion and fire a.

The frostbite liquid cream is a homogeneous mass from white to light cream in color with an almost imperceptible odor.

An experimental batch of liquid frostbite cream has been developed. The inventive cream for frostbite has passed clinical observations. We conducted observations of 5 clinically healthy volunteers without a burdened allergic history at the age of 21-23 years. According to patchwork and application samples, it is shown that liquid frostbite cream is harmless, does not have an irritating and allergenic effect.

In the winter of 2017, clinical observations were made of healthy volunteers - young men aged 22-23 years under the conditions of INSTITUTE OF TERMOLOGY LLC. A study was made of the condition of the hands before, during and after placing them for 2 minutes in water with ice. In this case, we studied the dynamics of skin color in the visible range and local temperature in the infrared range of the radiation spectrum. Infrared thermography was carried out using a ThermoTracer TH9100XX thermal imager (NEC, USA).

Studies were carried out normal and after applying to the skin of the hands of the hands alternately on different days of several funds. The selected funds at room temperature were introduced by application in a continuous layer over the entire area of the selected brush. Each product was applied to a selected area once 55-60 minutes before the brush was lowered into ice water.

In this case, the following products were applied to the skin surface:

Means No. 1 - melted goose fat - lard;

Means No. 2 - a protective face cream prepared by grinding equal parts of spermaceti or lanolin cream (1 teaspoon), zinc ointment (1 teaspoon) and refined vegetable oil, in particular olive oil (1 teaspoon);

Means No. 3 - spray of lidocaine hydrochloride for topical use, dosed 10%;

Means No. 4 is a liquid cream in which melted bear fat is used as the oil phase, and lidocaine hydrochloride is contained in the oil and water phases in a ratio of 0.5 wt. %

Means No. 5 is a liquid cream in which melted bear fat is used as the oil phase, and lidocaine hydrochloride is contained in the oil and water phases in a ratio of 10.0 wt. %

As the results of our studies showed, in the control, placing the right hands in ice-water immediately caused a feeling of severe pain in the hands of all the subjects. The pain persisted for 2 minutes while the hands were in the water. After removing the hands from the water, the skin on them was pale, the feeling of severe pain in the hands of chilled hands persisted for more than 3 minutes, and the natural color of a faint pink color was restored on the back and palms of the hands after 14.5 ± 1.1 and 21, respectively. 0 ± 1.5 min (P≤0.05, n = 5). A thermal imaging study of the dynamics of local temperature showed that the temperature of the skin of the hands of the hands after removing them from the ice water recovered on the back and palmar sides of the hands after 12.5 ± 0.9 and 19.5 ± 1.2 minutes, respectively (P≤0.05 , n = 5).

Application administration of agent No. 1 on the skin of the left hands of volunteers increased the elasticity of the skin, but in no case did it prevent the development of cold spasm of the blood vessels of the skin of the hands and did not reduce the feeling of pain when placing the hands in ice water. Placing the hands treated 55 minutes earlier with lard in water with ice immediately caused a feeling of severe pain in the hands of all the subjects. The pain persisted for 2 minutes while the hands were in the water. After removing the hands from the water, the skin on them was pale, the feeling of severe pain in the hands of chilled hands persisted for more than 3 minutes, and the natural color of a faint pink color was restored on the back and palms of the hands after 13.5 ± 1.1 and 20, respectively. 0 ± 1.3 min (P≤0.05, n = 5). A thermal imaging study of the dynamics of local temperature showed that the temperature of the skin of the hands of the hands after removing them from the ice water recovered on the back and palmar sides of the hands after 11.5 ± 1.0 and 18.5 ± 1.1 min, respectively (P≤0.05 , n = 5).

The application introduction of means No. 2 on another day on the skin of the right hands of volunteers increased the elasticity of the skin normal, but did not prevent stiff mobility during cooling. In addition, in no case did it prevent the development of cold spasm of blood vessels of the skin of the hands and did not reduce the feeling of pain when the hands were placed in ice water. Placing the hands treated 55 minutes earlier with a protective cream in ice water immediately caused a feeling of severe pain in the hands of all the subjects. The pain persisted for 2 minutes while the hands were in the water. After the brushes were removed from the water, the skin on them was pale, the feeling of severe pain in the hands of chilled hands remained for more than 3 minutes, and the natural color of a faint pink color was restored on the back and palms of the hands after 14.0 ± 1.0 and 20, respectively. 0 ± 1.2 min (P≤0.05, n = 5). A thermal imaging study of the dynamics of local temperature showed that the temperature of the skin of the hands after removing them from the ice water recovered on the back and palms of the hands after 12.3 ± 1.1 and 19.0 ± 1.0 minutes, respectively (P≤0.05 , n = 5).

Irrigation with product No. 3 on the same day, the skin of the right hands of volunteers did not increase the elasticity of the skin in the norm and when it was cooled. In addition, in no case did the product prevent the development of cold spasm of blood vessels of the skin of the hands and did not reduce the feeling of pain when the hands were placed in ice water. Placing the hands treated 55 minutes before spraying in water with ice immediately caused a feeling of severe pain in the hands of all subjects. The pain persisted for 2 minutes while the hands were in the water. After the brushes were removed from the water, the skin on them was pale, the feeling of severe pain in the hands of chilled hands persisted for more than 3 minutes, and the natural color of a faint pink color was restored on the back and palms of the hands after 13.0 ± 1.0 and 19, respectively. 0 ± 1.1 min (P≤0.05, n = 5). A thermal imaging study of the dynamics of local temperature showed that the temperature of the skin of the hands after removing them from the ice water recovered on the back and palmar sides of the hands, respectively, after 11.0 ± 1.1 and 17.0 ± 1.0 min (P≤0.05 , n = 5).

The application of funds No. 4 on another day to the skin of the right hands of volunteers increased the elasticity of the skin in normal and when it was cooled, and also prevented the development of cold spasm of the blood vessels of the skin of the hands and reduced the feeling of pain when putting the hands in ice water. The placement of the hands treated 55 minutes before with the claimed product in ice water caused a feeling of moderate pain in some of the subjects, and in some, a feeling of mild pain in the hands. The pain subsided for 2 minutes while the hands were in the water. After removing the hands from the water, the pain passed through 10-30 seconds. The skin on the hands was pale pink, the natural color of the skin was restored on the back and palms of the hands after 9.5 ± 0.2 and 11.0 ± 0.3 minutes, respectively (P≤0.05, n = 5). A thermal imaging study of the dynamics of local temperature showed that the temperature of the skin of the hands of the hands after removing them from the ice water recovered on the back and palms of the hands after 8.5 ± 0.3 and 10.5 ± 0.2 min, respectively (P≤0.05 , n = 5).

The application of the agent No. 5 on another day on the skin of the right hands of volunteers increased the elasticity of the skin during normal and cooling, as well as prevented the development of cold spasm of the blood vessels of the skin of the hands and reduced the feeling of pain when the hands were placed in ice water. The placement of the hands treated 55 minutes before with the claimed agent in water with ice caused a feeling of slight pain in the hands of the subjects. In this case, the pain subsided almost completely by the end of 2 minutes of the brushes in the water. After the brushes were removed from the water, the skin on the hands was pale pink, the natural color of the skin was restored on the back and palms of the hands after 8.5 ± 0.2 and 10.0 ± 0.1 min, respectively (P≤0.05, n = 5). A thermal imaging study of the dynamics of local temperature showed that the temperature of the skin of the hands of the hands after removing them from the ice water recovered on the back and palms of the hands after 7.5 ± 0.1 and 8.5 ± 0.1 min, respectively (P≤0.05 , n = 5).

Thus, the claimed liquid frostbite cream containing an oil phase, structure-forming emulsifiers and an aqueous phase, where melted bear fat is used as the oil phase, and lidocaine hydrochloride is contained in both phases in a ratio of 0.5-10.0 wt. % is the only tool that, when applied to the skin, increases its elasticity at room temperature and at a temperature close to 0 ° C, eliminates the cold spasm of blood vessels and pain when lowering the hands in ice water, and also accelerates and enhances development hyperemia and accelerates the normalization of the temperature of the skin of the hands after cooling. At the same time, an increase in the concentration of lidocaine hydrochloride enhances the local anesthetic and protective effect of the claimed cream with local action of cold.

Therefore, with this it is this remedy that is an effective and safe remedy for frostbite.

Therefore, the proposed liquid frostbite cream containing an oil phase, structure-forming emulsifiers and an aqueous phase, where melted bear fat is used as the oil phase, and lidocaine hydrochloride is contained in both phases in a ratio of 0.5-10.0 wt. %, with application administration, it increases the elasticity of the skin at room temperature and at the temperature of melting ice, eliminates the feeling of pain, prevents the development of cold spasm of blood vessels, accelerates and promotes the development of maximum hyperemia and breaks the vicious circle of the formation of cryodestruction and frostbite during local heat removal under local cooling .

The invention extends the scope, increases efficiency and safety due to good penetrating, emollient, analgesic, antifreeze, antireflective, antispastic and antispasmodic activity.

Claims (1)

A frostbite liquid cream containing an oil phase, structure-forming emulsifiers and an aqueous phase with lidocaine hydrochloride, characterized in that fused bear fat is used as the oil phase, and lidocaine hydrochloride is contained in both phases in a ratio of 0.5-10.0 wt. %