CN104546917A

CN104546917A - External-use scald and burn drug capable of restraining keloid hyperplasia

Info

Publication number: CN104546917A
Application number: CN201410822905.7A
Authority: CN
Inventors: 杨淑珍
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-12-25
Filing date: 2014-12-25
Publication date: 2015-04-29

Abstract

The invention discloses an external-use scald and burn drug capable of restraining keloid hyperplasia. The external-use scald and burn drug is characterized by being powder and being prepared from the following medicinal raw materials in parts by weight: 1-3 parts of mercury, 10-15 parts of sulfur, 15-20 parts of borax, 1-3 parts of borneol, 1-3 parts of musk, 20-30 parts of gypsum and 20-30 parts of calamine. A preparation method for the external-use scald and burn drug comprises the following steps: putting the sulfur, the mercury, the borax, the borneol, the calamine and sesame oil into a marmite in parts by weight; reversely buckling a seal cover by using a china bowl, heating after completely sealing junction of a porcelain bowl and the calamine through mud; after firstly heating for half an hour with strong fire and then heating for two hours with slow fire, naturally cooling to the room temperature, opening the calamine to scrape off medicinal raw materials coated in the porcelain bowl, adding an appropriate amount of musk into the medicinal raw materials to obtain a mixture, mixing and grinding the mixture into powder and passing the powder through a 100-mesh sieve, so as to prepare the external-use scald and burn drug capable of restraining keloid hyperplasia. The external-use scald and burn drug disclosed by the invention has effects of being quick in relieving pain, remarkable in curative effect and capable of restraining keloid hyperplasia, sterilizing, killing insects and inhibiting bacteria, and can be used for quickly restoring an injured cortical tissue and relieving pains of a patient.

Description

A kind of boiling hot external use burn treating medicine thing suppressing paralysed trace hypertrophy

Technical field

The invention belongs to medical art, particularly relate to a kind of boiling hot external use burn treating medicine thing suppressing paralysed trace hypertrophy.

Background technology

Boiling hot burn is disease common in one way of life, and severe patient can affect live and work, causes serious injury to patient's body and mind.It is reported, China about has the boiling hot burns victims of 5% to need hospitalization, and 95% light the wounded can be in and out-patient treatment, and wherein the boiling hot fire victim that is in hospital of 10% causes deformity in various degree, causes irreversible damage to patient and family.Scald mainly due to skin injury that high-temp liquid, high-temp solid or high-temperature vapour cause; Burn is by physics or chemical factor, as the traumatic disease that heating power, chemistry, electric current and lonizing radiation etc. are caused.The cicatrix that boiling hot burnt degree stays can affect physiological function that is attractive in appearance or some organ, produces serious pressure to the health of patient with psychology.Scald burn on clinical medicine, be divided into I degree, II degree and III degree three types, I degree scalds the top layer that burn just compromises skin, there will be erythema, usually can with searing pain sense, and local skin there will be redness or blister; It is dermal lesions that II degree scalds burn, and local occurs red and swollen and with pain, there will be the blister differed in size; It is compromise subcutaneous tissue, muscle or skeleton all to receive infringement that III degree scalds burn, and skin there will be bronzing, if effectively treatment not in time, may cause infection and even cause irreversible initiation sick.

Because burn occurs more in social life, especially medical less-developed rural area and remote districts, once occur scalding disease and can not timely and effectively processing, can cause very serious sequela.But find through retrieving, common drug great majority are scalded in treatment is at present based on Chinese medicine ingredients, is difficult to collection complete, can affects golden hour adversely, even cause the diseases such as shock, infection for remote mountain area medical material.Although be easy to get for its raw material of only a few medicine, there is weak curative effect, patient pain feels strong problem.200910114987.9 patent No. file discloses a kind of burn and scald medicine and preparation method thereof, although solve remote or poverty-stricken area medicinal raw material to be difficult to collect complete problem, but it adopts quicklime to be effective ingredient, after meeting water, release heat patient pain's sense can be increased.CN 2010106075198 patent No. file discloses a kind of Fel Ursi extract, preparation method and preparation treatment thereof and scalds application in burn medicine, achieves effective quick solution patient pain sense, but expensive and medical material is rare rare.CN 101884657 A patent No. file discloses a kind of medicine for the treatment of boiling hot burn, and it has evident in efficacy, cheap advantage, but the material composition adopted is difficult to obtain, and therefore can not apply in remote or Poor Mountainous Area.

Summary of the invention

The object of the invention is to: a kind of scald external used medicine suppressing paralysed trace hypertrophy is provided, the ingredients such as analgesia, antiinflammatory, removing the necrotic tissue and promoting granulation are merged, the medicine of preparation is made to possess effect of quick anti-inflammatory analgetic, removing the necrotic tissue and promoting granulation, suppression paralysis trace hypertrophy, meanwhile, this medicine formula material used medical material is easy to get and cheap.

To achieve these goals, the present invention adopts following technical scheme:

A kind of scald external used medicine suppressing paralysed trace hypertrophy, it is characterized in that: with parts by weight, be made up of following medicinal raw material: hydrargyrum 1 ~ 3 part, 10 ~ 15 parts, sulfur, Borax 15 ~ 20 parts, Borneolum Syntheticum 1 ~ 3 part, 1 ~ 3 part, Moschus, 20 ~ 30 parts, Gypsum Fibrosum, Calamina 20 ~ 30 parts.

Further, described a kind of optimization formula component of the scald external used medicine of paralysed trace hypertrophy that suppresses is: hydrargyrum 1.5 parts, 12.5 parts, sulfur, Borax 18 parts, Borneolum Syntheticum 2.2 parts, 2.5 parts, Moschus, 25 parts, Gypsum Fibrosum, Calamina 25 parts.

Marmite put into by the sulfur of described parts by weight, hydrargyrum, Borax, Borneolum Syntheticum, Calamina, with the capping of china bowl back-off, heat after china bowl and marmite junction being closed completely with earth again, first heat half an hour with high heat, naturally place after heating two hours with slow fire again and be cooled to room temperature, open marmite and scrape the medicine overlayed in china bowl, then add appropriate Moschus, grind into powder with even and cross 100 mesh sieves, the scald external used medicine suppressing paralysed trace hypertrophy can be obtained.

Magistral medicines material component effect:

Sulfur: external removing toxic substances parasite killing, treatment skin ulcer are antipruritic, after contact skin, form hydrogen sulfide and pentathionic acid, hydrogen sulfide then has dissolving cutin, softening epidermis and depilation to skin; Pentathionic acid has parasite killing, antifungal effect;

Hydrargyrum: the effect having parasite killing, counteracting toxic substances, the sulfydryl in contained mercury ion and sex pheromone respiratory enzyme combines and suppresses its vitality, finally makes it suffocate and lethal.In prescription, hydrargyrum consumption is few, refining detoxification, and after powder medicine for removing necrotic tissue and promoting muscle growing places for 3 ~ May at normal temperatures, toxicity is volatilized, to human non-toxic's property;

Borax: external heat-clearing and toxic substances removing, detumescence, anticorrosion, has inhibitory action to multiple bacillus, also has protective effect to skin mucosa;

Borneolum Syntheticum: be commonly called as " Borneolum Syntheticum ", external has the effect of heat-clearing and toxic substances removing, pain relieving, granulation promoting, and its main component Borneolum Syntheticum and isoborneol also have antibacterial action;

Moschus: the effect having blood circulation promoting and dispersing pathogen accumulation, reducing swelling and alleviating pain, has antithrombase effect, and has weak platelet aggregation inhibitory action, and musk tincture diluent has inhibitory action to escherichia coli, staphylococcus aureus in vitro, and has stronger antiinflammatory action;

Calamina: main containing zinc carbonate and a small amount of magnesium, ferrum, calcium etc., have removing dampness, antipruritic, sore and in and the effect of skin acid secretions, and can suppress locally staphylococcic growth.

Pharmacology analysis: the present invention is directed to II degree and III degree scalds bullate pathology, due to blister puncture after have effluent, if carry out smearing treatment with emulsifiable paste medicine, then cause drug diffusion and reduce drug effect, adopting powder then can avoid the generation of this situation.In pharmaceutical formulation of the present invention, with hydrargyrum, Calamina, Moschus, sulfur for sterilization factors, effectively prevent courses of infection; With Borneolum Syntheticum, Borax be pain relieving, antiinflammatory, Myogenic factor, promote that cortical tissue sprouting bears, remove cicatrix, repair damage cortical tissue and paralysed trace hypertrophy can be suppressed, make new cutis plate attractive in appearance without incrustation.

Compared with prior art, the present invention suppresses the beneficial effect of the scald external used medicine of paralysed trace hypertrophy to be:

(1) be effectively combined with removing the necrotic tissue and promoting granulation by bactericidal antiphlogistic, treatment is scalded disease and is had quickly alleviating pain, advantage evident in efficacy, reduces patient suffering to greatest extent;

(2) medicine of the present invention take hydrargyrum as sterilization, active insecticidal components, and have good effect, this composition also can play the object of wound closure simultaneously, air-isolation, avoids dry stimulation and the wound deterioration that causes;

(3) medicine of the present invention has treatment concurrently and prevents and treats the effect infected, and it is primary for treating with removing the necrotic tissue and promoting granulation, repairs damage cortical tissue as early as possible, suppresses paralysed trace hypertrophy, and recovery patient injury is attractive in appearance as far as possible; Control infect with sterilization, parasite killing, antibacterial be, by the mode degerm of biological inhibition, prevent wound infection, deterioration.

Detailed description of the invention

Below in conjunction with instantiation, technical scheme of the present invention is described further.

Embodiment 1

Suppress a scald external used medicine for paralysed trace hypertrophy, this medicine is powder, with parts by weight, is made up of following medicinal raw material: hydrargyrum 1.5 parts, 12.5 parts, sulfur, Borax 18 parts, Borneolum Syntheticum 2.2 parts, 2.5 parts, Moschus, 25 parts, Gypsum Fibrosum, Calamina 25 parts.

Embodiment 2

Suppress a scald external used medicine for paralysed trace hypertrophy, this medicine is powder, with parts by weight, is made up of following medicinal raw material: hydrargyrum 1 part, 10 parts, sulfur, Borax 15 parts, Borneolum Syntheticum 1 part, 1 part, Moschus, 20 parts, Gypsum Fibrosum, Calamina 20 parts.

Embodiment 3

Suppress a scald external used medicine for paralysed trace hypertrophy, this medicine is powder, with parts by weight, is made up of following medicinal raw material: hydrargyrum 3 parts, 15 parts, sulfur, Borax 20 parts, Borneolum Syntheticum 3 parts, 3 parts, Moschus, 30 parts, Gypsum Fibrosum, Calamina 30 parts.

The preparation method of embodiment 1,2,3 is as follows:

Marmite put into by the sulfur of described parts by weight, hydrargyrum, Borax, Borneolum Syntheticum, Calamina, Oleum sesami, with the capping of china bowl back-off, heat after china bowl and marmite junction being closed completely with earth again, first heat half an hour with high heat, naturally place after heating two hours with slow fire again and be cooled to room temperature, open marmite and scrape the medicine overlayed in china bowl, then add appropriate Moschus, grind into powder with even and cross 100 mesh sieves, the scald external used medicine suppressing paralysed trace hypertrophy can be obtained.

Clinical research and interpretation of result:

Research unit or mechanism: Anding District, Dingxi City China bus station, road Community Health Station.

Search time: in January, 1997 ~ 2011 year December.

Scald number of degrees criterion: as shown in table 1.

Table 1-scalds number of degrees criterion

The number of degrees	Trait expression
		I degree	Injured skin top layer, local mild redness, obvious without blister, pain
II degree	Dermal lesions, local congestion and swelling pain, has the blister differed in size
		III degree	Subcutaneous, fat, muscle, skeleton have damage, and in ash or bronzing

Scalding area classification criteria: as shown in table 2.

Table 2-scalding area and degree classification

Object of study: light degree Ⅱ, dark II degree, III degree scald patient, and surrounding area 306 example of energy matching medication scalds patient.

The age distribution of object of study and traumatic condition situation, specifically add up into table 3.

The classification of table 3-conditions of patients

Therapeutic outcome: as shown in table 4.

In above-mentioned therapeutic process, within light degree Ⅱ after topical agent, pain disappears half an hour, and within 2 ~ 3 days, skin color is thin out gradually, and continue medication wound surface dry gradually, within about 7 days, wound surface heals completely; After dark II degree of topical agent, pain alleviates half an hour to 1 hour, avulsion place of 1 ~ 2 day bleb skin has a small amount of pus to ooze out, and within 5 ~ 7 days, wound surface pus reduces and drying gradually, peels off incrustation, wound surface is ruddy, thin out gradually, close to normal color, 15 ~ 17 days wound healings, have or non-pigment calmness, without scar hyperplasia; For III degree of wound surface, as long as hair follicle root is remaining, under drug effect of the present invention, the rapid differentiation and proliferation of skin progenitor cell of hair follicle root generates new skin, a small amount of scar hyperplasia (removing) and pigmentation is in various degree had after healing, but skin is thin soft, do not affect the appearance and functional activity.

List model case below in order to medicine practical feasibility of the present invention to be described.

Case 1: poplar, female, 17 years old, left upper extremity scalded by boiled water, after local hospital treats 15 days, accepts Drug therapy of the present invention on February 10th, 2010, when being admitted to hospital, left upper extremity 4% wound surface is rough granulation tissue, 1% has a small amount of purulent secretion, and 1% wound surface is leather sample eschar, recovery from illness after treatment in 17 days.

Case 2: Zhang, female, 8 years old, boiled water scalded buttocks and two lower limb, accepts Drug therapy of the present invention, fully recover after 7 days on April 20th, 2006.

Case 3: Tang, man, 50 years old, drunk rear scald buttocks, left heel, after outer court's treatment first quarter moon, accepted Drug therapy of the present invention on March 2nd, 2010, infection and necrosis wound surface when being admitted to hospital, recovery from illness after treatment in 30 days.

Case 4: Lee, female, 20 years old, capital jumped Hua Da Hotel Staff, Caustic soda scald after half an hour, within 10th, accept Drug therapy of the present invention in JIUYUE in 2010, wound surface downright bad, depression when being admitted to hospital, recovery from illness after treatment in 20 days.

Case 5: Lee, female, 78 years old, boiled water was scalded outside left knee joint, and after January is treated in locality, downright bad wound surface, blush around wound surface, limb pain can not land, and accepts Drug therapy of the present invention on April 15th, 2009, recovery from illness after treatment in 18 days.

Be more than several examples in numerous case, can find out from case, not obvious through other technologies means therapeutic effect, all can fully recover after then adopting Drug therapy of the present invention, illustrate that medicine of the present invention has good effect, can be applicable.

Claims

1. one kind is suppressed the scald external used medicine of paralysed trace hypertrophy, it is characterized in that: with parts by weight, be made up of following medicinal raw material: hydrargyrum 1 ~ 3 part, 10 ~ 15 parts, sulfur, Borax 15 ~ 20 parts, Borneolum Syntheticum 1 ~ 3 part, 1 ~ 3 part, Moschus, 20 ~ 30 parts, Gypsum Fibrosum, Calamina 20 ~ 30 parts.

2. a kind of scald external used medicine suppressing paralysed trace hypertrophy as claimed in claim 1, it is characterized in that: with parts by weight, the formula of this medicine is: hydrargyrum 1.5 parts, 12.5 parts, sulfur, Borax 18 parts, Borneolum Syntheticum 2.2 parts, 2.5 parts, Moschus, 25 parts, Gypsum Fibrosum, Calamina 25 parts.

3. a kind of scald external used medicine suppressing paralysed trace hypertrophy as claimed in claim 1, is characterized in that: this medicine character is 100 order powder.