RU2630301C2 - Устройства и способы для отбора клеток, устойчивых к апоптотическим сигналам, и области их применения - Google Patents

Устройства и способы для отбора клеток, устойчивых к апоптотическим сигналам, и области их применения Download PDF

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RU2630301C2
RU2630301C2 RU2014138001A RU2014138001A RU2630301C2 RU 2630301 C2 RU2630301 C2 RU 2630301C2 RU 2014138001 A RU2014138001 A RU 2014138001A RU 2014138001 A RU2014138001 A RU 2014138001A RU 2630301 C2 RU2630301 C2 RU 2630301C2
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cells
cell
apoptosis
fasl
another embodiment
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RU2014138001A
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RU2014138001A (ru
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Шай ЯРКОНИ
Надир АСКЕНАЗИ
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Сэллект Байотерапьютикс Лтд
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0081—Purging biological preparations of unwanted cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/51—Umbilical cord; Umbilical cord blood; Umbilical stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/25—Tumour necrosing factors [TNF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/599—Cell markers; Cell surface determinants with CD designations not provided for elsewhere

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  • Health & Medical Sciences (AREA)
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  • Cell Biology (AREA)
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  • Wood Science & Technology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Reproductive Health (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
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  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Transplantation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Peptides Or Proteins (AREA)
RU2014138001A 2012-03-06 2013-03-05 Устройства и способы для отбора клеток, устойчивых к апоптотическим сигналам, и области их применения RU2630301C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261607033P 2012-03-06 2012-03-06
US61/607,033 2012-03-06
PCT/IL2013/000026 WO2013132477A1 (en) 2012-03-06 2013-03-05 Devices and methods for selecting apoptosis-signaling resistant cells, and uses thereof

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Publication Number Publication Date
RU2014138001A RU2014138001A (ru) 2016-04-20
RU2630301C2 true RU2630301C2 (ru) 2017-09-06

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US (2) US9783778B2 (enExample)
EP (2) EP2823040B1 (enExample)
JP (1) JP6429191B2 (enExample)
KR (1) KR101912982B1 (enExample)
CN (2) CN104245924B (enExample)
AU (1) AU2013229008B2 (enExample)
CA (1) CA2866358C (enExample)
DK (1) DK2823040T3 (enExample)
IL (1) IL234459B (enExample)
RU (1) RU2630301C2 (enExample)
WO (1) WO2013132477A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2016116732A (ru) * 2013-10-09 2017-11-15 Сэллект Байотерапьютикс Лтд. Активация гемопоэтических клеток-предшественников путем предтрансплантационного воздействия лигандами рецепторов смерти
WO2016193986A2 (en) 2015-06-05 2016-12-08 Cellect Biotherapeutics Ltd. Selective surfaces for, and methods of, selecting a population of stem and progenitor cells, and uses thereof
JP2021534747A (ja) * 2018-08-22 2021-12-16 セレクト バイオセラピューティクス リミテッド アポトーシス感受性細胞のモジュレーション
US20220002363A1 (en) * 2020-07-03 2022-01-06 United States Government As Represented By The Department Of Veterans Affairs Compositions and methods for treating pulmonary disease

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030119185A1 (en) * 2000-02-24 2003-06-26 Xcyte Therapies, Inc. Activation and expansion of cells
WO2007138597A2 (en) * 2006-05-31 2007-12-06 Styx Llc Methods of selecting stem cells and uses thereof
RU2357754C2 (ru) * 2001-07-31 2009-06-10 Генелукс Корпорейшн Микроорганизмы и клетки для диагностики и лечения опухолей

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
JPS61235752A (ja) 1985-04-11 1986-10-21 Asahi Optical Co Ltd 細胞分離材、分離器および分離方法
IT8523298V0 (it) * 1985-10-02 1985-10-02 Pierrel Hospital Spa Catetere venoso centrale.
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
US4979959A (en) 1986-10-17 1990-12-25 Bio-Metric Systems, Inc. Biocompatible coating for solid surfaces
US4885234A (en) 1988-09-29 1989-12-05 Eastman Kodak Company Photographic materials containing stable cyan coupler formulations
US5998024A (en) 1995-02-02 1999-12-07 Rainer H. Frey Biocompatible material and method of manufacture and use thereof
EA002819B1 (ru) 1997-05-14 2002-10-31 Авентис Фармасьютикалз Продактс Инк. Циклическое пептидное соединение и его применение, бициклопептидное соединение, пептидное соединение и его применение, фармацевтическая композиция
US6040182A (en) 1997-11-12 2000-03-21 Becton Dickinson And Company Method and materials for efficiency protein immobilization on tissue culture treated assay plates
GB9724270D0 (en) 1997-11-17 1998-01-14 Babraham The Inst Methods and means for mutagenesis of dna
EP1076635B1 (en) 1998-04-22 2002-03-06 St. Jude Medical AB Biocompatible material for implants
US20010049115A1 (en) * 2000-01-17 2001-12-06 Collins John Kevin Vitro model for gastrointestinal inflammation
US20090130718A1 (en) 1999-02-04 2009-05-21 Diversa Corporation Gene site saturation mutagenesis
WO2003002761A1 (en) 2001-06-29 2003-01-09 Novozymes A/S Method of multimerization and site-directed mutagenesis
US20030044389A1 (en) 2001-07-02 2003-03-06 Brown Patrick O. Microarrays for cell phenotyping and manipulation
DE10144252A1 (de) * 2001-08-31 2003-03-27 Fraunhofer Ges Forschung Nanopartikel mit daran immobilisiertem biologisch aktivem TNF
ATE519115T1 (de) * 2002-06-13 2011-08-15 Merck Patent Gmbh Verfahren für die identifizierung von allo- antigenen und ihre verwendung für krebstherapie und transplantation
US20040115216A1 (en) * 2002-07-12 2004-06-17 The Johns Hopkins University Reagents and methods for engaging unique clonotypic lymphocyte receptors
US20060009623A1 (en) 2004-07-06 2006-01-12 National University Of Singapore C-terminal attachment of ligands to proteins for immobilization onto a support
US20080241109A1 (en) * 2004-10-01 2008-10-02 Marc Dupuis Method for Ex-Vivo Purging in Autologous Transplantation
US8252587B2 (en) * 2004-10-25 2012-08-28 Celerant Therapeutics, Inc. Methods of expanding myeloid cell populations and uses thereof
DE602005008265D1 (de) * 2005-12-23 2008-08-28 Biedermann Motech Gmbh Flexible Stabilisierungsvorrichtung zur dynamischen Stabilisierung von Knochen oder Wirbeln
CN101517070A (zh) * 2006-05-31 2009-08-26 Styx有限责任公司 选择干细胞的方法及其用途
AU2008229636B2 (en) * 2007-03-16 2014-08-14 Qiagen Sciences Llc A cell-mediated immune response assay and kits therefor
KR100920729B1 (ko) 2007-10-01 2009-10-07 한국생명공학연구원 펩타이드 혼성체를 사용한 배향성이 조절된 항체단분자막의 제조방법
WO2009154840A2 (en) 2008-03-27 2009-12-23 Neostem, Inc. Compositions and methods using stem cells in cutaneous wound healing
JP2011522515A (ja) * 2008-04-10 2011-08-04 マサチューセッツ インスティテュート オブ テクノロジー 癌幹細胞を標的とする薬剤を同定する方法およびその使用
EP2282786B1 (en) 2008-06-13 2015-10-28 Smith & Nephew, Inc. Fixation devices for tissue repair
WO2010051032A1 (en) * 2008-10-31 2010-05-06 Synthes Usa, Llc Method and device for activating stem cells
GB0823553D0 (en) 2008-12-24 2009-01-28 Immunosolv Ltd Cell separation technique
JP5327457B2 (ja) * 2009-03-27 2013-10-30 セイコーエプソン株式会社 がん細胞分離装置およびその製造方法
JP2010227313A (ja) * 2009-03-27 2010-10-14 Seiko Epson Corp がん細胞除去システムおよびがん細胞除去装置
EP2595637B1 (en) * 2010-07-22 2017-11-01 Cellect Biotherapeutics Ltd. Regulatory immune cells with enhanced targeted cell death effect

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030119185A1 (en) * 2000-02-24 2003-06-26 Xcyte Therapies, Inc. Activation and expansion of cells
RU2357754C2 (ru) * 2001-07-31 2009-06-10 Генелукс Корпорейшн Микроорганизмы и клетки для диагностики и лечения опухолей
WO2007138597A2 (en) * 2006-05-31 2007-12-06 Styx Llc Methods of selecting stem cells and uses thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SASHCHENKO L.P. ET AL., Cytotoxic T lymphocytes carrying a pattern recognition protein Tag7 can detect evasive, HLA- negative but Hsp70-exposing tumor cells, thereby ensuring FasL/ Fas-mediated contact killing // BLOOD, 15.09.2007, vol. 110, no. 6, стр.1997-2004. *

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CN109116033A (zh) 2019-01-01
JP2015510758A (ja) 2015-04-13
CN104245924B (zh) 2020-05-01
JP6429191B2 (ja) 2018-11-28
CA2866358C (en) 2020-06-23
EP3486315A1 (en) 2019-05-22
EP2823040B1 (en) 2018-08-01
KR20150011796A (ko) 2015-02-02
WO2013132477A1 (en) 2013-09-12
US20150044182A1 (en) 2015-02-12
US20180208888A1 (en) 2018-07-26
CN104245924A (zh) 2014-12-24
KR101912982B1 (ko) 2018-10-29
AU2013229008B2 (en) 2018-11-08
RU2014138001A (ru) 2016-04-20
AU2013229008A1 (en) 2014-09-18
CA2866358A1 (en) 2013-09-12
US9783778B2 (en) 2017-10-10
EP2823040A1 (en) 2015-01-14
EP2823040A4 (en) 2016-01-06
DK2823040T3 (en) 2018-11-19
IL234459B (en) 2020-02-27

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