RU2595820C1 - Method of producing nanocapsules of potassium iodide - Google Patents

Abstract

FIELD: chemistry.

SUBSTANCE: invention relates to encapsulation. Described is a method of producing nanocapsules of potassium iodide. Envelope of nanocapsules used is konjak gum. According to disclosed method potassium iodide is added to suspension konjak gum in petroleum ether in presence of E472c preparation as a surfactant, at a weight ratio of nucleus: shell 1:1, or 1:2, or 1:3 respectively. Method then includes stirring and adding ethyl acetate. Obtained suspension of nanocapsules is filtered, washed and dried.

EFFECT: invention provides a simpler and faster process of producing nanocapsules, reduces losses during production thereof (high mass output).

1 cl, 1 dwg, 4 ex

Description

The invention relates to pharmaceuticals.

Previously known methods for producing microcapsules of salts.

In US Pat. 2359662 IPC A61K 009/56, A61J 003/07, B01J 013/02, A23L 001/00 publ. 06/27/2009 The Russian Federation has proposed a method for producing sodium chloride microcapsules using spray cooling in a Niro spray tower under the following conditions: inlet air temperature 10 ° C, outlet air temperature 28 ° C, spray drum rotation speed of 10,000 rpm. The microcapsules of the invention have improved stability and provide controlled and / or prolonged release of the active ingredient.

The disadvantages of the proposed method are the duration of the process and the use of special equipment, a set of certain conditions (air temperature at the inlet 10 ° C, air temperature at the outlet 28 ° C, rotation speed of the spray drum 10,000 rpm).

The closest method is the method proposed in US Pat. 2134967 IPC A01N 53/00, A01N 25/28 publ. 08/27/1999 Russian Federation (1999). A solution of a mixture of natural lipids and a pyrethroid insecticide is dispersed in water in a weight ratio (2-4): 1 in an organic solvent, which simplifies the microencapsulation method.

The disadvantage of this method is dispersion in an aqueous medium, which makes the proposed method inapplicable for producing microcapsules of water-soluble preparations in water-soluble polymers.

The technical task is to simplify and accelerate the process of obtaining nanocapsules, reduce losses in obtaining nanocapsules (increase in yield by mass).

The solution to the technical problem is achieved by the method of producing nanocapsules of potassium iodide, characterized in that konjac gum is used as the shell of the nanocapsules in the preparation of nanocapsules of potassium iodide.

A distinctive feature of the proposed method is the preparation of nanocapsules using petroleum ether and ethyl acetate, as well as the use of konjac gum as a particle shell.

The result of the proposed method are obtaining nanocapsules of potassium iodide.

EXAMPLE 1. Obtaining nanocapsules of potassium iodide, the ratio of the core: shell 1: 3

100 mg of potassium iodide is dispersed in a suspension of 300 mg of konjac gum in petroleum ether, in the presence of 0.01 g of the preparation E472c as a surfactant with stirring at 1200 rpm. Next, 5 ml of ethyl acetate are poured. The resulting suspension is filtered and dried at room temperature (see figure 1).

Obtained 0.4 g of nanocapsule powder. The yield was 100%.

EXAMPLE 2. Obtaining nanocapsules of potassium iodide, the ratio of the core: shell 1: 1

100 mg of potassium iodide is dispersed in a suspension of 100 mg of konjac gum in petroleum ether, in the presence of 0.01 g of the preparation E472c as a surfactant with stirring at 1200 rpm. Next, 5 ml of ethyl acetate are poured. The resulting suspension is filtered and dried at room temperature.

Obtained 0.2 g of nanocapsule powder. The yield was 100%.

EXAMPLE 3. Obtaining nanocapsules of potassium iodide, the ratio of the core: shell 1: 2

100 mg of potassium iodide is dispersed in a suspension of 200 mg of konjac gum in petroleum ether, in the presence of 0.01 g of the preparation E472c as a surfactant with stirring at 1200 rpm. Next, 5 ml of ethyl acetate are poured. The resulting suspension is filtered and dried at room temperature.

0.3 g of nanocapsule powder obtained. The yield was 100%.

EXAMPLE 4. Determination of the size of nanocapsules by NTA

The measurements were carried out on a Nanosight LM0 multiparameter nanoparticle analyzer manufactured by Nanosight Ltd (Great Britain) in the HS-BF configuration (Andor Luca high-sensitivity video camera, 405 nm semiconductor laser with a power of 45 mW). The device is based on the Nanoparticle Tracking Analysis (NTA) method described in ASTM E2834.

The optimal dilution for dilution was 1: 100. For measurement, the device parameters were selected: Camera Level = 16, Detection Threshold = 10 (multi), Min Track Length: Auto, Min Expected Size: Auto, duration of a single measurement 215s, use of a syringe pump.

E472c is a glycerol ester with one or two molecules of edible fatty acids and one or two molecules of citric acid, moreover, citric acid as a tribasic acid can be esterified with other glycerides and as an acid with other fatty acids. Free acid groups can be neutralized with sodium.

Nanocapsules of salts with sufficiently high yields were obtained. The proposed technique is quite suitable for use on an industrial scale due to minimal losses and ease of implementation.

Claims (1)

A method of producing nanocapsules of potassium iodide, characterized in that konjac gum is used as the shell of the nanocapsules, while potassium iodide is added to the suspension of konjac gum in petroleum ether in the presence of the preparation E472c, with a mass ratio of core: shell of 1: 1, or 1: 2 or 1: 3, respectively, with stirring at 1200 rpm, then ethyl acetate is added, the resulting suspension of nanocapsules is filtered off and dried at room temperature.

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